A priori prediction of tissue: Plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery

Journal of Pharmaceutical Sciences

Volumn 89, Issue 1, 2000, Pages 16-35

  Poulin, Patrick ^a   Theil, Frank Peter ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Drug discovery; Partition coefficients; PBPK modeling; Pharmacokinetics; QSAR; Toxicokinetics

Indexed keywords

ACECAINIDE; ALFENTANIL; BARBITAL; BIPERIDEN; BROMPERIDOL; CEFAZOLIN; CEFTAZIDIME; CHLORPROMAZINE; CLOBAZAM; CLOMIPRAMINE; CLOTIAZEPAM; CLOZAPINE; COTININE; DIAZEPAM; DICLOXACILLIN; DIGOXIN; DRUG; FENTANYL; FLEROXACIN; FLUPHENAZINE; FLURAZEPAM; HALOPERIDOL; HEXOBARBITAL; MEDAZEPAM; METHOTREXATE; METICILLIN; MILOXACIN; NEOSTIGMINE; NITRAZEPAM; NORFLOXACIN; PEFLOXACIN; PENTAZOCINE; PENTOBARBITAL; PHENYTOIN; PIPEMIDIC ACID; PRAZEPAM; PREDNISOLONE; PROCAINAMIDE; PROMAZINE; UNINDEXED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG SCREENING; DRUG SOLUBILITY; MATHEMATICAL COMPUTING; MOUSE; NONHUMAN; PARTITION COEFFICIENT; RABBIT; RAT;

EID: 0033966128     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6017(200001)89:1<16::AID-JPS3>3.0.CO;2-E     Document Type: Article

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