Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line

Biochemical Pharmacology

Volumn 83, Issue 2, 2012, Pages 269-278

  Ménez, Cécile ^a   Mselli Lakhal, Laïla ^a   Foucaud Vignault, Magali ^a   Balaguer, Patrick ^b,c,d   Alvinerie, Michel ^a   Lespine, Anne ^a  

^a TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

^b INSTITUT DE RECHERCHE EN CANCÉROLOGIE DE MONTPELLIER   (France)

^c UNIV MONTPELLIER   (France)

^d CENTRE VAL D AURELLE   (France)

Author keywords

Hepatocytes; Ivermectin; Macrocyclic lactones; Mdr1; P glycoprotein

Indexed keywords

CALCEIN; CELL NUCLEUS RECEPTOR; DACTINOMYCIN; GLYCOPROTEIN P; IVERMECTIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; VALSPODAR;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CONCENTRATION RESPONSE; DRUG HALF LIFE; DRUG MECHANISM; GENE OVEREXPRESSION; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RNA STABILITY; UPREGULATION;

ANIMALS; CELL LINE; CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HEPATOCYTES; IVERMECTIN; MICE; P-GLYCOPROTEIN; RNA STABILITY; RNA, MESSENGER; SUBSTRATE SPECIFICITY;

EID: 83955165411     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.10.010     Document Type: Article

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