메뉴 건너뛰기




Volumn 57, Issue 7, 2013, Pages 1170-1181

Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death

Author keywords

Cell cycle; Colon cancer; Metabolites; Polyphenols; Resveratrol

Indexed keywords

ANTINEOPLASTIC AGENT; GLUCURONIDE; POLYPHENOL; RESVERATROL; RESVERATROL 4' O GLUCURONIDE; RESVERATROL-4'-O-GLUCURONIDE; STILBENE DERIVATIVE;

EID: 84879799217     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201200766     Document Type: Article
Times cited : (135)

References (49)
  • 1
    • 0345487505 scopus 로고    scopus 로고
    • Alcohol and mortality in middle-aged men from eastern France
    • Renaud, S. C., Gueguen, R., Schenker, J., d'Houtaud, A., Alcohol and mortality in middle-aged men from eastern France. Epidemiology 1998, 9, 184-188.
    • (1998) Epidemiology , vol.9 , pp. 184-188
    • Renaud, S.C.1    Gueguen, R.2    Schenker, J.3    d'Houtaud, A.4
  • 2
    • 20344378481 scopus 로고    scopus 로고
    • Resveratrol: preventing properties against vascular alterations and ageing
    • Delmas, D., Jannin, B., Latruffe, N., Resveratrol: preventing properties against vascular alterations and ageing. Mol. Nutr. Food Res. 2005, 49, 377-395.
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 377-395
    • Delmas, D.1    Jannin, B.2    Latruffe, N.3
  • 3
    • 33646068410 scopus 로고    scopus 로고
    • Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer
    • Delmas, D., Lancon, A., Colin, D., Jannin, B. et al., Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer. Curr. Drug Targets. 2006, 7, 423-442.
    • (2006) Curr. Drug Targets. , vol.7 , pp. 423-442
    • Delmas, D.1    Lancon, A.2    Colin, D.3    Jannin, B.4
  • 4
    • 77954363244 scopus 로고    scopus 로고
    • The cardiovascular nutrapharmacology of resveratrol: pharmacokinetics, molecular mechanisms and therapeutic potential
    • Kroon, P. A., Iyer, A., Chunduri, P., Chan, V. et al., The cardiovascular nutrapharmacology of resveratrol: pharmacokinetics, molecular mechanisms and therapeutic potential. Curr. Med. Chem. 2010, 17, 2442-2455.
    • (2010) Curr. Med. Chem. , vol.17 , pp. 2442-2455
    • Kroon, P.A.1    Iyer, A.2    Chunduri, P.3    Chan, V.4
  • 5
    • 9444240465 scopus 로고    scopus 로고
    • Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha
    • Shih, A., Zhang, S., Cao, H. J., Boswell, S. et al., Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha. Mol. Cancer Ther. 2004, 3, 1355-1364.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1355-1364
    • Shih, A.1    Zhang, S.2    Cao, H.J.3    Boswell, S.4
  • 6
    • 0036072056 scopus 로고    scopus 로고
    • Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line
    • Lin, H. Y., Shih, A., Davis, F. B., Tang, H. Y. et al., Resveratrol induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line. J. Urol. 2002, 168, 748-755.
    • (2002) J. Urol. , vol.168 , pp. 748-755
    • Lin, H.Y.1    Shih, A.2    Davis, F.B.3    Tang, H.Y.4
  • 7
    • 65649131881 scopus 로고    scopus 로고
    • Effects of resveratrol analogs on cell cycle progression, cell cycle associated proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells
    • Colin, D., Gimazane, A., Lizard, G., Izard, J. C. et al., Effects of resveratrol analogs on cell cycle progression, cell cycle associated proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells. Int. J. Cancer 2009, 124, 2780-2788.
    • (2009) Int. J. Cancer , vol.124 , pp. 2780-2788
    • Colin, D.1    Gimazane, A.2    Lizard, G.3    Izard, J.C.4
  • 8
    • 48649105934 scopus 로고    scopus 로고
    • Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells
    • Marel, A. K., Lizard, G., Izard, J. C., Latruffe, N. et al., Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells. Mol. Nutr. Food Res. 2008, 52, 538-548.
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 538-548
    • Marel, A.K.1    Lizard, G.2    Izard, J.C.3    Latruffe, N.4
  • 9
    • 16744364517 scopus 로고    scopus 로고
    • Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells
    • Delmas, D., Rebe, C., Lacour, S., Filomenko, R. et al., Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. J. Biol. Chem. 2003, 278, 41482-41490.
    • (2003) J. Biol. Chem. , vol.278 , pp. 41482-41490
    • Delmas, D.1    Rebe, C.2    Lacour, S.3    Filomenko, R.4
  • 10
    • 77953703732 scopus 로고    scopus 로고
    • Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer
    • Harikumar, K. B., Kunnumakkara, A. B., Sethi, G., Diagaradjane, P. et al., Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer. Int. J. Cancer 2010, 127, 257-268.
    • (2010) Int. J. Cancer , vol.127 , pp. 257-268
    • Harikumar, K.B.1    Kunnumakkara, A.B.2    Sethi, G.3    Diagaradjane, P.4
  • 11
    • 4644327128 scopus 로고    scopus 로고
    • Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol
    • Fulda, S., Debatin, K. M., Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol. Oncogene 2004, 23, 6702-6711.
    • (2004) Oncogene , vol.23 , pp. 6702-6711
    • Fulda, S.1    Debatin, K.M.2
  • 12
    • 10644246821 scopus 로고    scopus 로고
    • Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells
    • Delmas, D., Rebe, C., Micheau, O., Athias, A. et al., Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. Oncogene 2004, 23, 8979-8986.
    • (2004) Oncogene , vol.23 , pp. 8979-8986
    • Delmas, D.1    Rebe, C.2    Micheau, O.3    Athias, A.4
  • 13
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: the in vivo evidence
    • Baur, J. A., Sinclair, D. A., Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 2006, 5, 493-506.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 14
    • 0142243190 scopus 로고    scopus 로고
    • Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum
    • Gescher, A. J., Steward, W. P., Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum. Cancer Epidemiol. Biomarkers Prev. 2003, 12, 953-957.
    • (2003) Cancer Epidemiol. Biomarkers Prev. , vol.12 , pp. 953-957
    • Gescher, A.J.1    Steward, W.P.2
  • 15
    • 79961045982 scopus 로고    scopus 로고
    • Role of membrane dynamics processes and exogenous molecules in cellular resveratrol uptake: consequences in bioavailability and activities
    • Delmas, D., Lin, H. Y., Role of membrane dynamics processes and exogenous molecules in cellular resveratrol uptake: consequences in bioavailability and activities. Mol. Nutr. Food Res. 2011, 55, 1142-1153.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 1142-1153
    • Delmas, D.1    Lin, H.Y.2
  • 16
    • 34247399158 scopus 로고    scopus 로고
    • Resveratrol in human hepatoma HepG2 cells: metabolism and inducibility of detoxifying enzymes
    • Lancon, A., Hanet, N., Jannin, B., Delmas, D. et al., Resveratrol in human hepatoma HepG2 cells: metabolism and inducibility of detoxifying enzymes. Drug Metab. Dispos. 2007, 35, 699-703.
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 699-703
    • Lancon, A.1    Hanet, N.2    Jannin, B.3    Delmas, D.4
  • 17
    • 20344371723 scopus 로고    scopus 로고
    • Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats
    • Wenzel, E., Soldo, T., Erbersdobler, H., Somoza, V., Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats. Mol. Nutr. Food Res. 2005, 49, 482-494.
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 482-494
    • Wenzel, E.1    Soldo, T.2    Erbersdobler, H.3    Somoza, V.4
  • 18
    • 20344364428 scopus 로고    scopus 로고
    • Metabolism and bioavailability of trans-resveratrol
    • Wenzel, E., Somoza, V., Metabolism and bioavailability of trans-resveratrol. Mol. Nutr. Food Res. 2005, 49, 472-481.
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 472-481
    • Wenzel, E.1    Somoza, V.2
  • 19
    • 34250901592 scopus 로고    scopus 로고
    • Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent
    • Boocock, D. J., Faust, G. E., Patel, K. R., Schinas, A. M. et al., Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol. Biomarkers Prev. 2007, 16, 1246-1252.
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , pp. 1246-1252
    • Boocock, D.J.1    Faust, G.E.2    Patel, K.R.3    Schinas, A.M.4
  • 20
    • 77957355158 scopus 로고    scopus 로고
    • Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients
    • Patel, K. R., Brown, V. A., Jones, D. J., Britton, R. G. et al., Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res. 2010, 70, 7392-7399.
    • (2010) Cancer Res. , vol.70 , pp. 7392-7399
    • Patel, K.R.1    Brown, V.A.2    Jones, D.J.3    Britton, R.G.4
  • 21
    • 9444296057 scopus 로고    scopus 로고
    • High absorption but very low bioavailability of oral resveratrol in humans
    • Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., Jr., Walle, U. K., High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab. Dispos. 2004, 32, 1377-1382.
    • (2004) Drug Metab. Dispos. , vol.32 , pp. 1377-1382
    • Walle, T.1    Hsieh, F.2    DeLegge, M.H.3    Oatis Jr, J.E.4    Walle, U.K.5
  • 22
    • 67649999248 scopus 로고    scopus 로고
    • Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers
    • Almeida, L., Vaz-da-Silva, M., Falcao, A., Soares, E. et al., Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol. Nutr. Food Res. 2009, 53, S7-15.
    • (2009) Mol. Nutr. Food Res. , vol.53
    • Almeida, L.1    Vaz-da-Silva, M.2    Falcao, A.3    Soares, E.4
  • 23
    • 71449113221 scopus 로고    scopus 로고
    • Pharmacokinetics of trans-resveratrol following repeated administration in healthy elderly and young subjects
    • Nunes, T., Almeida, L., Rocha, J. F., Falcao, A. et al., Pharmacokinetics of trans-resveratrol following repeated administration in healthy elderly and young subjects. J. Clin. Pharmacol. 2009, 49, 1477-1482.
    • (2009) J. Clin. Pharmacol. , vol.49 , pp. 1477-1482
    • Nunes, T.1    Almeida, L.2    Rocha, J.F.3    Falcao, A.4
  • 25
    • 79959261445 scopus 로고    scopus 로고
    • What is new for an old molecule? Systematic review and recommendations on the use of resveratrol
    • Vang, O., Ahmad, N., Baile, C. A., Baur, J. A. et al., What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS One, 6, e19881.
    • PLoS One , vol.6
    • Vang, O.1    Ahmad, N.2    Baile, C.A.3    Baur, J.A.4
  • 26
    • 0034219435 scopus 로고    scopus 로고
    • Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines
    • Delmas, D., Jannin, B., Malki, M. C., Latruffe, N., Inhibitory effect of resveratrol on the proliferation of human and rat hepatic derived cell lines. Oncol. Rep. 2000, 7, 847-852.
    • (2000) Oncol. Rep. , vol.7 , pp. 847-852
    • Delmas, D.1    Jannin, B.2    Malki, M.C.3    Latruffe, N.4
  • 27
    • 0036676571 scopus 로고    scopus 로고
    • Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells
    • Delmas, D., Passilly-Degrace, P., Jannin, B., Malki, M. C., Latruffe, N., Resveratrol, a chemopreventive agent, disrupts the cell cycle control of human SW480 colorectal tumor cells. Int. J. Mol. Med. 2002, 10, 193-199.
    • (2002) Int. J. Mol. Med. , vol.10 , pp. 193-199
    • Delmas, D.1    Passilly-Degrace, P.2    Jannin, B.3    Malki, M.C.4    Latruffe, N.5
  • 28
    • 58149481278 scopus 로고    scopus 로고
    • Simple spectrophotometric assessment of the trans-/cis-resveratrol ratio in aqueous solutions
    • Camont, L., Cottart, C. H., Rhayem, Y., Nivet-Antoine, V. et al., Simple spectrophotometric assessment of the trans-/cis-resveratrol ratio in aqueous solutions. Anal. Chim. Acta 2009, 634, 121-128.
    • (2009) Anal. Chim. Acta , vol.634 , pp. 121-128
    • Camont, L.1    Cottart, C.H.2    Rhayem, Y.3    Nivet-Antoine, V.4
  • 29
    • 79960105173 scopus 로고    scopus 로고
    • Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells
    • Colin, D., Limagne, E., Jeanningros, S., Jacquel, A. et al., Endocytosis of resveratrol via lipid rafts and activation of downstream signaling pathways in cancer cells. Cancer Prev. Res. (Phila) 2011, 4, 1095-1106.
    • (2011) Cancer Prev. Res. (Phila) , vol.4 , pp. 1095-1106
    • Colin, D.1    Limagne, E.2    Jeanningros, S.3    Jacquel, A.4
  • 30
    • 0027513590 scopus 로고
    • Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts
    • Pagano, M., Pepperkok, R., Lukas, J., Baldin, V. et al., Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J. Cell Biol. 1993, 121, 101-111.
    • (1993) J. Cell Biol. , vol.121 , pp. 101-111
    • Pagano, M.1    Pepperkok, R.2    Lukas, J.3    Baldin, V.4
  • 31
    • 34848928166 scopus 로고    scopus 로고
    • Chronic treatment with resveratrol induces redox stress- and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells
    • Heiss, E. H., Schilder, Y. D., Dirsch, V. M., Chronic treatment with resveratrol induces redox stress- and ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells. J. Biol. Chem. 2007, 282, 26759-26766.
    • (2007) J. Biol. Chem. , vol.282 , pp. 26759-26766
    • Heiss, E.H.1    Schilder, Y.D.2    Dirsch, V.M.3
  • 32
    • 31544482401 scopus 로고    scopus 로고
    • Time-dependent resveratrol-mediated mRNA and protein expression associated with cell cycle in WR-21 cells containing mutated human c-Ha-Ras
    • Young, L. F., Martin, K. R., Time-dependent resveratrol-mediated mRNA and protein expression associated with cell cycle in WR-21 cells containing mutated human c-Ha-Ras. Mol. Nutr. Food Res. 2006, 50, 70-77.
    • (2006) Mol. Nutr. Food Res. , vol.50 , pp. 70-77
    • Young, L.F.1    Martin, K.R.2
  • 33
    • 27744485649 scopus 로고    scopus 로고
    • Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells
    • Tyagi, A., Singh, R. P., Agarwal, C., Siriwardana, S. et al., Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells. Carcinogenesis 2005, 26, 1978-1987.
    • (2005) Carcinogenesis , vol.26 , pp. 1978-1987
    • Tyagi, A.1    Singh, R.P.2    Agarwal, C.3    Siriwardana, S.4
  • 34
    • 40949127382 scopus 로고    scopus 로고
    • Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner
    • Gatz, S. A., Keimling, M., Baumann, C., Dork, T. et al., Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner. Carcinogenesis 2008, 29, 519-527.
    • (2008) Carcinogenesis , vol.29 , pp. 519-527
    • Gatz, S.A.1    Keimling, M.2    Baumann, C.3    Dork, T.4
  • 35
    • 0033790098 scopus 로고    scopus 로고
    • Colorectal cancer chemotherapy: irinotecan
    • Rougier, P., Mitry, E., Colorectal cancer chemotherapy: irinotecan. Semin. Oncol. 2000, 27, 138-143.
    • (2000) Semin. Oncol. , vol.27 , pp. 138-143
    • Rougier, P.1    Mitry, E.2
  • 36
    • 79957518861 scopus 로고    scopus 로고
    • New Topoisomerase I mutations are associated with resistance to camptothecin
    • Gongora, C., Vezzio-Vie, N., Tuduri, S., Denis, V. et al., New Topoisomerase I mutations are associated with resistance to camptothecin. Mol. Cancer 2011, 10, 64.
    • (2011) Mol. Cancer , vol.10 , pp. 64
    • Gongora, C.1    Vezzio-Vie, N.2    Tuduri, S.3    Denis, V.4
  • 38
    • 0036569696 scopus 로고    scopus 로고
    • Resveratrol induces prostate cancer cell entry into s phase and inhibits DNA synthesis
    • Kuwajerwala, N., Cifuentes, E., Gautam, S., Menon, M. et al., Resveratrol induces prostate cancer cell entry into s phase and inhibits DNA synthesis. Cancer Res. 2002, 62, 2488-2492.
    • (2002) Cancer Res. , vol.62 , pp. 2488-2492
    • Kuwajerwala, N.1    Cifuentes, E.2    Gautam, S.3    Menon, M.4
  • 39
    • 0033828138 scopus 로고    scopus 로고
    • Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells
    • Bernhard, D., Tinhofer, I., Tonko, M., Hubl, H. et al., Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells. Cell Death Differ. 2000, 7, 834-842.
    • (2000) Cell Death Differ. , vol.7 , pp. 834-842
    • Bernhard, D.1    Tinhofer, I.2    Tonko, M.3    Hubl, H.4
  • 40
    • 0035874886 scopus 로고    scopus 로고
    • Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells
    • Dorrie, J., Gerauer, H., Wachter, Y., Zunino, S. J., Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res. 2001, 61, 4731-4739.
    • (2001) Cancer Res. , vol.61 , pp. 4731-4739
    • Dorrie, J.1    Gerauer, H.2    Wachter, Y.3    Zunino, S.J.4
  • 41
    • 70349104624 scopus 로고    scopus 로고
    • Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions
    • Reis-Sobreiro, M., Gajate, C., Mollinedo, F., Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions. Oncogene 2009, 28, 3221-3234.
    • (2009) Oncogene , vol.28 , pp. 3221-3234
    • Reis-Sobreiro, M.1    Gajate, C.2    Mollinedo, F.3
  • 42
    • 0035866404 scopus 로고    scopus 로고
    • Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase
    • She, Q. B., Bode, A. M., Ma, W. Y., Chen, N. Y. et al., Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res. 2001, 61, 1604-1610.
    • (2001) Cancer Res. , vol.61 , pp. 1604-1610
    • She, Q.B.1    Bode, A.M.2    Ma, W.Y.3    Chen, N.Y.4
  • 43
    • 68149124472 scopus 로고    scopus 로고
    • Dietary phenolics: chemistry, bioavailability and effects on health
    • Crozier, A., Jaganath, I. B., Clifford, M. N., Dietary phenolics: chemistry, bioavailability and effects on health. Nat. Prod. Rep. 2009, 26, 1001-1043.
    • (2009) Nat. Prod. Rep. , vol.26 , pp. 1001-1043
    • Crozier, A.1    Jaganath, I.B.2    Clifford, M.N.3
  • 44
    • 78549288940 scopus 로고    scopus 로고
    • Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis
    • Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A. et al., Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res. 2010, 70, 9003-9011.
    • (2010) Cancer Res. , vol.70 , pp. 9003-9011
    • Brown, V.A.1    Patel, K.R.2    Viskaduraki, M.3    Crowell, J.A.4
  • 45
    • 77954331919 scopus 로고    scopus 로고
    • Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites
    • Hoshino, J., Park, E. J., Kondratyuk, T. P., Marler, L. et al., Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J. Med. Chem. 2011, 53, 5033-5043.
    • (2011) J. Med. Chem. , vol.53 , pp. 5033-5043
    • Hoshino, J.1    Park, E.J.2    Kondratyuk, T.P.3    Marler, L.4
  • 46
    • 77954701127 scopus 로고    scopus 로고
    • Pleiotropic mechanisms facilitated by resveratrol and its metabolites
    • Calamini, B., Ratia, K., Malkowski, M. G., Cuendet, M. et al., Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem. J. 2010, 429, 273-282.
    • (2010) Biochem. J. , vol.429 , pp. 273-282
    • Calamini, B.1    Ratia, K.2    Malkowski, M.G.3    Cuendet, M.4
  • 47
    • 0027494125 scopus 로고
    • Reversal of terminal differentiation and control of DNA replication: cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication
    • Cardoso, M. C., Leonhardt, H., Nadal-Ginard, B., Reversal of terminal differentiation and control of DNA replication: cyclin A and Cdk2 specifically localize at subnuclear sites of DNA replication. Cell 1993, 74, 979-992.
    • (1993) Cell , vol.74 , pp. 979-992
    • Cardoso, M.C.1    Leonhardt, H.2    Nadal-Ginard, B.3
  • 48
    • 84857897864 scopus 로고    scopus 로고
    • Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells
    • Yun, H. J., Hyun, S. K., Park, J. H., Kim, B. W. et al., Widdrol activates DNA damage checkpoint through the signaling Chk2-p53-Cdc25A-p21-MCM4 pathway in HT29 cells. Mol. Cell. Biochem. 2012, 363, 281-289.
    • (2012) Mol. Cell. Biochem. , vol.363 , pp. 281-289
    • Yun, H.J.1    Hyun, S.K.2    Park, J.H.3    Kim, B.W.4
  • 49
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova, J., Horejsi, Z., Koed, K., Kramer, A. et al., DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005, 434, 864-870.
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1    Horejsi, Z.2    Koed, K.3    Kramer, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.