Population pharmacokinetic modeling of trans-resveratrol and its glucuronide and sulfate conjugates after oral and intravenous administration in rats

Pharmaceutical Research

Volumn 28, Issue 7, 2011, Pages 1606-1621

  Colom, Helena ^a   Alfaras, Irene ^a   Maijó, Mònica ^a   Juan, M Emília ^a   Planas, Joana M ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

glucuronide and sulfate conjugates; NONMEM; polyphenols; population pharmacokinetics; trans resveratrol

Indexed keywords

DRUG METABOLITE; RESVERATROL; RESVERATROL GLUCURONIDE; RESVERATROL SULFATE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG ELIMINATION; MALE; MICHAELIS MENTEN KINETICS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; SEQUENTIAL ANALYSIS; SIMULATION; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; GLUCURONIDES; INFUSIONS, INTRAVENOUS; MALE; MODELS, CHEMICAL; RATS; RATS, SPRAGUE-DAWLEY; STILBENES; SULFATES; VASODILATOR AGENTS;

EID: 79959910572     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-011-0395-8     Document Type: Article

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