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Volumn 23, Issue 4, 2000, Pages 267-282

The Alcohol-inducible form of Cytochrome P450 (CYP 2E1): Role in Toxicology and Regulation of Expression

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2E1; INSULIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE;

EID: 0034251950     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02975435     Document Type: Article
Times cited : (141)

References (146)
  • 1
    • 0032718355 scopus 로고    scopus 로고
    • Interspecies variations in fatty acid hydroxylations involving cytochromes P450 2E1 and 4A
    • Adas, F., Berthou, F., Salaun, J. P., Dreano, Y., and Amet, Y., Interspecies variations in fatty acid hydroxylations involving cytochromes P450 2E1 and 4A. Toxicol Lett, 110, 43-55 (1999a).
    • (1999) Toxicol Lett , vol.110 , pp. 43-55
    • Adas, F.1    Berthou, F.2    Salaun, J.P.3    Dreano, Y.4    Amet, Y.5
  • 2
    • 0032693381 scopus 로고    scopus 로고
    • Requirement for omega and (omega-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11
    • Adas, F., Salaun, J. P., Berthou, F., Picart, D., Simon, B., and Amet, Y., Requirement for omega and (omega-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11. J. Lipid Res, 40, 1990-1997 (1999b).
    • (1999) J. Lipid Res , vol.40 , pp. 1990-1997
    • Adas, F.1    Salaun, J.P.2    Berthou, F.3    Picart, D.4    Simon, B.5    Amet, Y.6
  • 3
    • 0032563201 scopus 로고    scopus 로고
    • Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP-induced phosphoenolpyruvate carboxykinase gene transcription
    • Agati, J. M., Yeagley, D., and Quinn, P. G., Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP-induced phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem, 273, 18751-18759 (1998).
    • (1998) J Biol Chem , vol.273 , pp. 18751-18759
    • Agati, J.M.1    Yeagley, D.2    Quinn, P.G.3
  • 4
    • 0030045690 scopus 로고    scopus 로고
    • Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damge in rats intragastrically fed with ethanol
    • Albano, E., Clot, P., Morimoto, M., Tomasi, A., Ingelman-Sundberg, M., and French, S. W., Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radical in the development of liver damge in rats intragastrically fed with ethanol. Hepatology, 23, 155-163 (1996).
    • (1996) Hepatology , vol.23 , pp. 155-163
    • Albano, E.1    Clot, P.2    Morimoto, M.3    Tomasi, A.4    Ingelman-Sundberg, M.5    French, S.W.6
  • 5
    • 0021272756 scopus 로고
    • The liver in consecutive patients with morbid obesity. A clinical, morphological and biochemical study
    • Andersen, T. P., Christoffersen, P. and Gluud, C., The liver in consecutive patients with morbid obesity. A clinical, morphological and biochemical study. Int J Obesity, 8, 107-115 (1984).
    • (1984) Int J Obesity , vol.8 , pp. 107-115
    • Andersen, T.P.1    Christoffersen, P.2    Gluud, C.3
  • 6
    • 0033979374 scopus 로고    scopus 로고
    • Identification of a ubiquitination-target/substrate-interaction domain of cytochrome P-450 (CYP) 2E1
    • Banerjee, A., Kocarek, T. A. and Novak, R. F., Identification of a ubiquitination-target/substrate-interaction domain of cytochrome P-450 (CYP) 2E1. Drug Metab Dispos, 28, 118-124 (2000).
    • (2000) Drug Metab Dispos , vol.28 , pp. 118-124
    • Banerjee, A.1    Kocarek, T.A.2    Novak, R.F.3
  • 7
    • 0026533660 scopus 로고
    • Hyperinsulinaemia causes a preferential increase in hepatic P4501A2 activity
    • Barnett, C. R., Wilson, J., Wolf, C. R., Flatt, P. R., and Ioannides, C., Hyperinsulinaemia causes a preferential increase in hepatic P4501A2 activity. Biochem Pharmacol, 43, 1255-1261 (1992).
    • (1992) Biochem Pharmacol , vol.43 , pp. 1255-1261
    • Barnett, C.R.1    Wilson, J.2    Wolf, C.R.3    Flatt, P.R.4    Ioannides, C.5
  • 8
    • 0023730144 scopus 로고
    • Formation of acetaldehyde adducts with ethanol-inducible P-450IIE1 in vivo
    • Behrens, U. J., Hoerner, M., Lasker, J. M. and Lieber, C. S. , Formation of acetaldehyde adducts with ethanol-inducible P-450IIE1 in vivo. Biochem Biophys Res Commun, 154, 584-590 (1988).
    • (1988) Biochem Biophys Res Commun , vol.154 , pp. 584-590
    • Behrens, U.J.1    Hoerner, M.2    Lasker, J.M.3    Lieber, C.S.4
  • 10
    • 0019978350 scopus 로고
    • Halothane biotransformation in obese and nonobese patients
    • Bentley, J. G., Vaughan, R. W., Gandolfi, A. J. and Cork, R. C., Halothane biotransformation in obese and nonobese patients. Anesthesiology, 57, 94-97 (1982).
    • (1982) Anesthesiology , vol.57 , pp. 94-97
    • Bentley, J.G.1    Vaughan, R.W.2    Gandolfi, A.J.3    Cork, R.C.4
  • 12
    • 0029840285 scopus 로고    scopus 로고
    • Molecular and cellular aspects of the glucagon receptor: Role in diabetes and metabolism
    • Burcelin, R., Katz, E. B., and Charron, M. J., Molecular and cellular aspects of the glucagon receptor: role in diabetes and metabolism. Diabetes Metab, 22, 373-396 (1996).
    • (1996) Diabetes Metab , vol.22 , pp. 373-396
    • Burcelin, R.1    Katz, E.B.2    Charron, M.J.3
  • 13
  • 14
    • 0030965155 scopus 로고    scopus 로고
    • Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells overexpressing human cytochrome P4502E1
    • Chen, Q., Galleano, M., and Cederbaum, A. I. Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells overexpressing human cytochrome P4502E1. J Biol Chem, 272, 14532-14541 (1997).
    • (1997) J Biol Chem , vol.272 , pp. 14532-14541
    • Chen, Q.1    Galleano, M.2    Cederbaum, A.I.3
  • 15
    • 0033029460 scopus 로고    scopus 로고
    • Hormonal regulation of microsomal cytochrome P4502E1 and P450 reductase in rat liver and kidney
    • Chen, G. F., Ronis, M. J., Ingelman-Sundberg, M., and Badger, T. M., Hormonal regulation of microsomal cytochrome P4502E1 and P450 reductase in rat liver and kidney. Xenobiotica, 29, 437-451 (1999).
    • (1999) Xenobiotica , vol.29 , pp. 437-451
    • Chen, G.F.1    Ronis, M.J.2    Ingelman-Sundberg, M.3    Badger, T.M.4
  • 16
    • 0022301389 scopus 로고
    • The coordinated control of metabolic pathways by broad-specificity protein kinases an phosphatases
    • Cohen, P., The coordinated control of metabolic pathways by broad-specificity protein kinases an phosphatases. Curr Top Cell Regul, 27, 23-37 (1985).
    • (1985) Curr Top Cell Regul , vol.27 , pp. 23-37
    • Cohen, P.1
  • 17
    • 0023353441 scopus 로고
    • Obesity as a risk factor in drug induced organ injury. Increased liver and kidney damage by acetaminophen in the obese overfed rat
    • Corcoran, G. B. and Wong, B. K., Obesity as a risk factor in drug induced organ injury. Increased liver and kidney damage by acetaminophen in the obese overfed rat. J Pharmacol Exp Ther, 241, 921-927 (1987).
    • (1987) J Pharmacol Exp Ther , vol.241 , pp. 921-927
    • Corcoran, G.B.1    Wong, B.K.2
  • 18
    • 0026356874 scopus 로고
    • Cytochrome P450 turnover
    • Correia, M. A., Cytochrome P450 turnover. Methods Enzymol, 206, 315-325 (1991).
    • (1991) Methods Enzymol , vol.206 , pp. 315-325
    • Correia, M.A.1
  • 19
    • 0024448249 scopus 로고
    • Degradation of rat hepatic cytochrome P450p
    • Correia, M. A., Sugiyama, K., and Yao, K., Degradation of rat hepatic cytochrome P450p. Drug Metab Dispos, 20, 615-628 (1989).
    • (1989) Drug Metab Dispos , vol.20 , pp. 615-628
    • Correia, M.A.1    Sugiyama, K.2    Yao, K.3
  • 20
    • 0030894106 scopus 로고    scopus 로고
    • Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species
    • Court, M. H., Von Moltke, L. L., Shader, R. I., and Greenblatt, D. J., Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species. Biopharm Drug Dispos, 18, 213-226 (1997).
    • (1997) Biopharm Drug Dispos , vol.18 , pp. 213-226
    • Court, M.H.1    Von Moltke, L.L.2    Shader, R.I.3    Greenblatt, D.J.4
  • 21
    • 0027183953 scopus 로고
    • Mouse ethanol-inducible cytochrome P-450 (P450IIE1)
    • Davis, J. F. and Felder, M. R., Mouse ethanol-inducible cytochrome P-450 (P450IIE1). J Biol Chem, 268, 16584-16589 (1993).
    • (1993) J Biol Chem , vol.268 , pp. 16584-16589
    • Davis, J.F.1    Felder, M.R.2
  • 23
    • 0028964669 scopus 로고
    • Insulin down-regulates cytochrome P450 2B and 2E expression at the post-transcriptional level in the rat hepatoma cell line
    • de Waziers, I., Garlatti, M., Bouguet, J., Beaune, P. H., and Barouki, R., Insulin down-regulates cytochrome P450 2B and 2E expression at the post-transcriptional level in the rat hepatoma cell line. Mol Pharmacol, 47, 474-479 (1995).
    • (1995) Mol Pharmacol , vol.47 , pp. 474-479
    • De Waziers, I.1    Garlatti, M.2    Bouguet, J.3    Beaune, P.H.4    Barouki, R.5
  • 24
    • 0023037998 scopus 로고
    • Immunochemical identification of cytochrome P450 isozyme 3a (P450 ACL) in rabbit nasal and kidney microsomes and evidence for differential induction by alcohol
    • Ding, X. X., Koop, D. R., Crump, B. L. and Coon, M. J., Immunochemical identification of cytochrome P450 isozyme 3a (P450 ACL) in rabbit nasal and kidney microsomes and evidence for differential induction by alcohol. Mol Pharmacol, 30, 370-378 (1986).
    • (1986) Mol Pharmacol , vol.30 , pp. 370-378
    • Ding, X.X.1    Koop, D.R.2    Crump, B.L.3    Coon, M.J.4
  • 25
    • 0025335593 scopus 로고
    • Effects of vanadate on hepatic cytochrome P450 expression in streptozotocin-diabetic rats
    • Donahue, B. S., and Morgan, E. T., Effects of vanadate on hepatic cytochrome P450 expression in streptozotocin-diabetic rats. Drug Metab Dispos, 18, 519-526 (1990).
    • (1990) Drug Metab Dispos , vol.18 , pp. 519-526
    • Donahue, B.S.1    Morgan, E.T.2
  • 27
  • 28
    • 0024532095 scopus 로고
    • Human liver microsomal cytochrome P450IIE1. Immunological evaluation of its contribution to microsomal ethanol oxidation, carbon tetrachloride reduction and NADPH oxidase activity
    • Ekstrom, G., von Bahr, C. and Ingelman-Sundberg, M., Human liver microsomal cytochrome P450IIE1. Immunological evaluation of its contribution to microsomal ethanol oxidation, carbon tetrachloride reduction and NADPH oxidase activity. Biochem Pharmacol, 38, 689-693 (1989).
    • (1989) Biochem Pharmacol , vol.38 , pp. 689-693
    • Ekstrom, G.1    Von Bahr, C.2    Ingelman-Sundberg, M.3
  • 29
    • 0023854490 scopus 로고
    • Ligand-dependent maintenance of ethanol-inducible cytochrome P450 in primary rat hepatocyte cell cultures
    • Eliasson, E., Johansson, I., and Ingelman-Sundberg, M., Ligand-dependent maintenance of ethanol-inducible cytochrome P450 in primary rat hepatocyte cell cultures. Biochem Biophys Res Commun, 150, 436-443 (1988).
    • (1988) Biochem Biophys Res Commun , vol.150 , pp. 436-443
    • Eliasson, E.1    Johansson, I.2    Ingelman-Sundberg, M.3
  • 30
    • 0026773423 scopus 로고
    • Hormone- and substrate-regulated intracellular degradation of cytochrome P450 (2E1) involving MgATP-activated rapid proteolysis in the endoplasmic reticulum membranes
    • Eliasson, E., Mkrtchian, S., and Ingelman-Sundberg, M., Hormone- and substrate-regulated intracellular degradation of cytochrome P450 (2E1) involving MgATP-activated rapid proteolysis in the endoplasmic reticulum membranes. J Biol Chem, 267, 15765-15769 (1992).
    • (1992) J Biol Chem , vol.267 , pp. 15765-15769
    • Eliasson, E.1    Mkrtchian, S.2    Ingelman-Sundberg, M.3
  • 31
    • 0033573975 scopus 로고    scopus 로고
    • Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats
    • Enriquez, A., Leclercq, I., Farrell, G. C., and Robertson, G., Altered expression of hepatic CYP2E1 and CYP4A in obese, diabetic ob/ob mice, and fa/fa Zucker rats. Biochem Biophys Res Commun, 255, 300-306 (1999).
    • (1999) Biochem Biophys Res Commun , vol.255 , pp. 300-306
    • Enriquez, A.1    Leclercq, I.2    Farrell, G.C.3    Robertson, G.4
  • 32
    • 0020676757 scopus 로고
    • Pyrazole effects on mutagenicity and toxicity of dimethyl-nitrosamine in Wistar rats
    • Evarts, R .P., Raab, M. M., Haliday, E. and Brown, C., Pyrazole effects on mutagenicity and toxicity of dimethyl-nitrosamine in Wistar rats. Cancer Res, 43, 496-499 (1983).
    • (1983) Cancer Res , vol.43 , pp. 496-499
    • Evarts, R.P.1    Raab, M.M.2    Haliday, E.3    Brown, C.4
  • 33
    • 0023907946 scopus 로고
    • Composition changes in hepatic microsomal cytochrome P450 during onset of streptozocin-induced diabetes and during insulin treatment
    • Favreau, L. V. and Schenkman, J. B., Composition changes in hepatic microsomal cytochrome P450 during onset of streptozocin-induced diabetes and during insulin treatment. Diabetes, 37, 577-584 (1988).
    • (1988) Diabetes , vol.37 , pp. 577-584
    • Favreau, L.V.1    Schenkman, J.B.2
  • 34
    • 0033570101 scopus 로고    scopus 로고
    • NADPH-dependent microsomal electron transfer increases degradation of CYP2E1 by the proteasome complex: Role of reactive oxygen species
    • Goasduff T. and Cederbaum, A. I., NADPH-dependent microsomal electron transfer increases degradation of CYP2E1 by the proteasome complex: role of reactive oxygen species. Arch Biochem Biophys, 370, 258-270 (1999).
    • (1999) Arch Biochem Biophys , vol.370 , pp. 258-270
    • Goasduff, T.1    Cederbaum, A.I.2
  • 35
    • 0034661466 scopus 로고    scopus 로고
    • CYP2E1 degradation by in vitro reconstituted systems: Role of the molecular chaperone hsp90
    • Goasduff, T., and Cederbaum, A. I., CYP2E1 degradation by in vitro reconstituted systems: role of the molecular chaperone hsp90. Arch Biochem Biophys, 379, 321-330 (2000).
    • (2000) Arch Biochem Biophys , vol.379 , pp. 321-330
    • Goasduff, T.1    Cederbaum, A.I.2
  • 36
    • 0022930605 scopus 로고
    • Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. the dominant role of insulin
    • Granner, D. K., Sasaki, K., and Chu, D., Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin. Ann NY Acad Sci, 478, 175-190 (1986).
    • (1986) Ann NY Acad Sci , vol.478 , pp. 175-190
    • Granner, D.K.1    Sasaki, K.2    Chu, D.3
  • 37
    • 0030068202 scopus 로고    scopus 로고
    • Cytochrome P4502E1- And cytochrome P4502B1/ 2B2-catalyzed carbon tetrachloride metabolism. Effects on signal transduction as demonstrated by altered immediate-early (c-Fos and c-Jun) gene expression and nuclear AP-1 and NF-kappa B transcription factor levels
    • Gruebele, A., Zawaski, K., Kaplan, D., and Novak, R. F., Cytochrome P4502E1- and cytochrome P4502B1/ 2B2-catalyzed carbon tetrachloride metabolism. Effects on signal transduction as demonstrated by altered immediate-early (c-Fos and c-Jun) gene expression and nuclear AP-1 and NF-kappa B transcription factor levels. Drug Metab Dispos, 24, 15-22 (1996).
    • (1996) Drug Metab Dispos , vol.24 , pp. 15-22
    • Gruebele, A.1    Zawaski, K.2    Kaplan, D.3    Novak, R.F.4
  • 38
    • 0026035519 scopus 로고
    • Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects
    • Guengerich, F. P., Kim, D-H., and Iwasaki, M., Role of human cytochrome P450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol, 4, 168-179 (1991).
    • (1991) Chem Res Toxicol , vol.4 , pp. 168-179
    • Guengerich, F.P.1    Kim, D.-H.2    Iwasaki, M.3
  • 39
    • 0025992864 scopus 로고
    • Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes
    • Guengerich, F. P. and Shimada, T., Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem Res Toxicol, 4, 391-407 (1991).
    • (1991) Chem Res Toxicol , vol.4 , pp. 391-407
    • Guengerich, F.P.1    Shimada, T.2
  • 41
    • 0027522507 scopus 로고
    • Herbimycin A inhibits the association of pp60src with the cytoskeletal structure and with phosphatidyl-inositol 3-kinase
    • Hamaguchi, M., Xiao, H., Uehara, Y., Ohnishi, Y., and Nagai, Y., Herbimycin A inhibits the association of pp60src with the cytoskeletal structure and with phosphatidyl-inositol 3-kinase. Oncogene, 8, 559-564 (1993).
    • (1993) Oncogene , vol.8 , pp. 559-564
    • Hamaguchi, M.1    Xiao, H.2    Uehara, Y.3    Ohnishi, Y.4    Nagai, Y.5
  • 42
    • 0015977516 scopus 로고
    • Increased carbon tetrachloride hepatotoxicity, and its mechanism, after chronic ethanol consumption
    • Hasumura, Y., Teschke, R., and Lieber, C. S., Increased carbon tetrachloride hepatotoxicity, and its mechanism, after chronic ethanol consumption. Gastroenterology, 66, 415-422 (1974).
    • (1974) Gastroenterology , vol.66 , pp. 415-422
    • Hasumura, Y.1    Teschke, R.2    Lieber, C.S.3
  • 44
    • 0026317745 scopus 로고
    • Regulation of rat hepatic cytochrome P450IIE1 in primary monolayer hepatocyte culture
    • Hunt, C. M., Guzelian, P. S., Molowa, D. T., and Wrighton, S.A., Regulation of rat hepatic cytochrome P450IIE1 in primary monolayer hepatocyte culture. Xenobiotica, 21, 1621-1631 (1991).
    • (1991) Xenobiotica , vol.21 , pp. 1621-1631
    • Hunt, C.M.1    Guzelian, P.S.2    Molowa, D.T.3    Wrighton, S.A.4
  • 45
    • 0026065267 scopus 로고
    • Alcoholic liver disease. Pathologic, pathogenetic and clinical aspects
    • Ishak, K. G., Zimmerman, H. J., and Ray, M. B., Alcoholic liver disease. Pathologic, pathogenetic and clinical aspects. Alcohol Clin Exp Res, 15, 45-66 (1991).
    • (1991) Alcohol Clin Exp Res , vol.15 , pp. 45-66
    • Ishak, K.G.1    Zimmerman, H.J.2    Ray, M.B.3
  • 46
    • 0342369372 scopus 로고    scopus 로고
    • Kupffer cell inactivation alleviates ethanol-induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver
    • Jarvelainen, H. A., Fang, C., Ingelman-Sundberg, M., Lukkari, T. A., Sippel, H., and Lindros, K. O., Kupffer cell inactivation alleviates ethanol-induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver. J Hepatol, 32, 900-910 (2000).
    • (2000) J Hepatol , vol.32 , pp. 900-910
    • Jarvelainen, H.A.1    Fang, C.2    Ingelman-Sundberg, M.3    Lukkari, T.A.4    Sippel, H.5    Lindros, K.O.6
  • 47
    • 0021815153 scopus 로고
    • Carbon tetrachloride-induced lipid peroxidation is dependent on an ethanol-inducible form of rabbit liver microsomal cytochrome P450
    • Johansson, I. and Ingelman-Sundberg, M., Carbon tetrachloride-induced lipid peroxidation is dependent on an ethanol-inducible form of rabbit liver microsomal cytochrome P450. FEBS Lett, 183, 265-269 (1985).
    • (1985) FEBS Lett , vol.183 , pp. 265-269
    • Johansson, I.1    Ingelman-Sundberg, M.2
  • 48
    • 0023685311 scopus 로고
    • Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P450 (IIE1) in rat and rabbit microsomes
    • Johansson, I. and Ingelman-Sundberg, M., Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P450 (IIE1) in rat and rabbit microsomes. Cancer Res, 58, 5387-5390 (1988).
    • (1988) Cancer Res , vol.58 , pp. 5387-5390
    • Johansson, I.1    Ingelman-Sundberg, M.2
  • 49
    • 0023900010 scopus 로고
    • Ethanol-, fasting-, and acetone-inducible cytochromes P450 in rat liver. Regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies
    • Johansson, I., Ekstrom, G., Scholte, B., Puzycki, D., Jornvall, H., and Ingelman-Sundberg, M., Ethanol-, fasting-, and acetone-inducible cytochromes P450 in rat liver. Regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies. Biochemistry, 27, 1925-1934 (1988).
    • (1988) Biochemistry , vol.27 , pp. 1925-1934
    • Johansson, I.1    Ekstrom, G.2    Scholte, B.3    Puzycki, D.4    Jornvall, H.5    Ingelman-Sundberg, M.6
  • 50
    • 0025183258 scopus 로고
    • Role of P450IIE1 in the metabolism of 3-hydroxypyridine, a constituent of tobacco smoke. Redox cycling and DNA strand scission by the metabolite 2,5-dihydroxypyridine
    • Kim, S. G., and Novak, R. F., Role of P450IIE1 in the metabolism of 3-hydroxypyridine, a constituent of tobacco smoke. Redox cycling and DNA strand scission by the metabolite 2,5-dihydroxypyridine. Cancer Res, 50, 5333-5339 (1990a).
    • (1990) Cancer Res , vol.50 , pp. 5333-5339
    • Kim, S.G.1    Novak, R.F.2
  • 51
    • 0025020532 scopus 로고
    • Induction of rat hepatic P450IIE1 (CYP2E1) by pyridine: Evidence for a role of protein synthesis in the absence of transcriptional activation
    • Kim, S. G., and Novak, R. F., Induction of rat hepatic P450IIE1 (CYP2E1) by pyridine: evidence for a role of protein synthesis in the absence of transcriptional activation. Biochem Biophys Res Commun, 166, 1072-1079 (1990b).
    • (1990) Biochem Biophys Res Commun , vol.166 , pp. 1072-1079
    • Kim, S.G.1    Novak, R.F.2
  • 52
    • 0027325387 scopus 로고
    • The induction of cytochrome P4502E1 by nitrogen- And sulfur-containing heterocycles: Expression and molecular regulation
    • Kim, S. G., and Novak, R. F., The induction of cytochrome P4502E1 by nitrogen- and sulfur-containing heterocycles: expression and molecular regulation. Toxicol Appl Pharmacol, 120, 257-265 (1993).
    • (1993) Toxicol Appl Pharmacol , vol.120 , pp. 257-265
    • Kim, S.G.1    Novak, R.F.2
  • 53
    • 0023790333 scopus 로고
    • Pyridine induction of cytochrome P450 in the rat: Role of P450j (alcohol-inducible form) in pyridine N-oxidation
    • Kim, S. G., Williams, D. E., Schuetz, E. G., Guzelian, P. S., and Novak, R. F., Pyridine induction of cytochrome P450 in the rat: role of P450j (alcohol-inducible form) in pyridine N-oxidation. J Pharmacol Exp Ther, 246, 1175-1182 (1988).
    • (1988) J Pharmacol Exp Ther , vol.246 , pp. 1175-1182
    • Kim, S.G.1    Williams, D.E.2    Schuetz, E.G.3    Guzelian, P.S.4    Novak, R.F.5
  • 54
    • 0025091654 scopus 로고
    • Evidence for increased translational efficiency in the induction of P450IIE1 by solvents: Analysis of P450IIE1 mRNA polyribosomal distribution
    • Kim, S. G., Shehin, S. E., States, J. C., and Novak, R. F., Evidence for increased translational efficiency in the induction of P450IIE1 by solvents: analysis of P450IIE1 mRNA polyribosomal distribution. Biochem Biophys Res Commun, 172, 767-774 (1990).
    • (1990) Biochem Biophys Res Commun , vol.172 , pp. 767-774
    • Kim, S.G.1    Shehin, S.E.2    States, J.C.3    Novak, R.F.4
  • 55
  • 56
    • 0034177183 scopus 로고    scopus 로고
    • Post-transciptional regulation of rat CYP2E1 expression. Role of CYP2E1 mRNA untranslated regions in control of translational efficiency and message stability
    • Kocarek, T. A., Zanger, R. C., and Novak, R. F., Post-transciptional regulation of rat CYP2E1 expression. Role of CYP2E1 mRNA untranslated regions in control of translational efficiency and message stability. Arch Biochem Biophys, 376, 180-190 (2000).
    • (2000) Arch Biochem Biophys , vol.376 , pp. 180-190
    • Kocarek, T.A.1    Zanger, R.C.2    Novak, R.F.3
  • 57
    • 0022367655 scopus 로고
    • Identification of ethonol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes
    • Koop, D. R. and Casazza, J. P., Identification of ethonol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes. J Biol Chem, 260, 13607-13612 (1985).
    • (1985) J Biol Chem , vol.260 , pp. 13607-13612
    • Koop, D.R.1    Casazza, J.P.2
  • 58
    • 0021806780 scopus 로고
    • Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents. Ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid
    • Koop, D. R., Crump, B. L., Nordblom, G. D., and Coon, M. J., Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents. Ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid. Proc Natl Acad Sci USA, 82, 4065-4069 (1985).
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 4065-4069
    • Koop, D.R.1    Crump, B.L.2    Nordblom, G.D.3    Coon, M.J.4
  • 59
    • 0033134224 scopus 로고    scopus 로고
    • Proteolytic degradation of heme-modified hepatic cytochromes P450: A role for phosphorylation, ubiquitination, and the 26S proteasome?
    • Korsmeyer, K. K., Davoll, S., Figueiredo-Pereira, M.E., and Correia, M.A., Proteolytic degradation of heme-modified hepatic cytochromes P450: A role for phosphorylation, ubiquitination, and the 26S proteasome? Arch Biochem Biophys, 365, 31-44 (1999).
    • (1999) Arch Biochem Biophys , vol.365 , pp. 31-44
    • Korsmeyer, K.K.1    Davoll, S.2    Figueiredo-Pereira, M.E.3    Correia, M.A.4
  • 61
    • 0021224125 scopus 로고
    • Increased microsomal oxidation of ethanol by cytochrome P450 and hydroxyl radical-dependent pathways after chronic ethanol consumption
    • Krikun, G., Lieber, C. S., and Cederbaum, A. I., Increased microsomal oxidation of ethanol by cytochrome P450 and hydroxyl radical-dependent pathways after chronic ethanol consumption. Biochem Pharmacol, 33, 3306-3309 (1984).
    • (1984) Biochem Pharmacol , vol.33 , pp. 3306-3309
    • Krikun, G.1    Lieber, C.S.2    Cederbaum, A.I.3
  • 62
    • 0023873548 scopus 로고
    • Molecular regulation of ethanol-inducible cytochrome P450-IIE1 in hamsters
    • Kubota, S., Lasker, J. M., and Lieber, C. S., Molecular regulation of ethanol-inducible cytochrome P450-IIE1 in hamsters. Biochem Biophys Res Commun, 150, 304-310 (1988).
    • (1988) Biochem Biophys Res Commun , vol.150 , pp. 304-310
    • Kubota, S.1    Lasker, J.M.2    Lieber, C.S.3
  • 63
    • 0034092716 scopus 로고    scopus 로고
    • CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in marine nonalcoholic steatohepatitis
    • Leclercq, I. A., Farrell, G. C., Field, J., Bell, D. R., Gonzalez, F. J., and Robertson, G. R., CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in marine nonalcoholic steatohepatitis. J Clin Invest, 105, 1067-1075 (2000a).
    • (2000) J Clin Invest , vol.105 , pp. 1067-1075
    • Leclercq, I.A.1    Farrell, G.C.2    Field, J.3    Bell, D.R.4    Gonzalez, F.J.5    Robertson, G.R.6
  • 66
    • 0022456493 scopus 로고
    • N-demethylation of N-nitrosodimethylamine catalyzed by purified rat hepatic microsomal cytochrome P450. Isozyme specificity and role of cytochrome b5
    • Levin, W., Thomas, P. E., Oldfield, N., and Ryan, D. E., N-demethylation of N-nitrosodimethylamine catalyzed by purified rat hepatic microsomal cytochrome P450. Isozyme specificity and role of cytochrome b5. Arch Biochem Biophys, 248, 158-165 (1986).
    • (1986) Arch Biochem Biophys , vol.248 , pp. 158-165
    • Levin, W.1    Thomas, P.E.2    Oldfield, N.3    Ryan, D.E.4
  • 67
    • 0024244685 scopus 로고
    • Biochemical and molecular basis of alcohol-induced injury to liver and other tissues
    • Lieber, C. S., Biochemical and molecular basis of alcohol-induced injury to liver and other tissues. New Eng J Med, 319, 1639-1650 (1988).
    • (1988) New Eng J Med , vol.319 , pp. 1639-1650
    • Lieber, C.S.1
  • 68
    • 0018760756 scopus 로고
    • Alcohol-related diseases and carcinogenesis
    • Lieber, C.S., Zeitz, H. K., Garro, A. J., and Worner, T. M., Alcohol-related diseases and carcinogenesis. Cancer Res, 39, 2863-2866 (1979).
    • (1979) Cancer Res , vol.39 , pp. 2863-2866
    • Lieber, C.S.1    Zeitz, H.K.2    Garro, A.J.3    Worner, T.M.4
  • 69
    • 0025221814 scopus 로고
    • Role of ethanol-inducible cytochrome P-450IIE1 in carbon tetrachloride-induced damage to centrilbular hepatocytes from ethanol-treated rats
    • Lindros, K. O., Cai, Y., and Penttila, K. E., Role of ethanol-inducible cytochrome P-450IIE1 in carbon tetrachloride-induced damage to centrilbular hepatocytes from ethanol-treated rats. Hepatology, 12, 1092-1097 (1990).
    • (1990) Hepatology , vol.12 , pp. 1092-1097
    • Lindros, K.O.1    Cai, Y.2    Penttila, K.E.3
  • 70
    • 0028898120 scopus 로고
    • Role of the liver-enriched transcription factor HNF-1 alpha in expression of the CYP2E1 gene
    • Liu, S. Y., and Gonzalez, F.J ., Role of the liver-enriched transcription factor HNF-1 alpha in expression of the CYP2E1 gene. DNA Cell Biol, 14, 285-293 (1995).
    • (1995) DNA Cell Biol , vol.14 , pp. 285-293
    • Liu, S.Y.1    Gonzalez, F.J..2
  • 71
    • 0024521667 scopus 로고
    • Insulin and phorbol ester induce distinct phosphorylations of pp60c-src in the BC3H-1 murine myocyte cell line
    • Luttrell, L. M., Luttrell, D. K., Parson, S. J., and Rogol, A.D., Insulin and phorbol ester induce distinct phosphorylations of pp60c-src in the BC3H-1 murine myocyte cell line. Oncogene, 4, 317-324 (1989).
    • (1989) Oncogene , vol.4 , pp. 317-324
    • Luttrell, L.M.1    Luttrell, D.K.2    Parson, S.J.3    Rogol, A.D.4
  • 72
    • 0023881605 scopus 로고
    • Biochemical and immunochemical evidence for the induction of an ethanol inducible cytochrome P-450 isozyme in male Syrian golden hamsters
    • McCoy, G. D. and Koop, D. R., Biochemical and immunochemical evidence for the induction of an ethanol inducible cytochrome P-450 isozyme in male Syrian golden hamsters. Biochem Pharmacol, 1563 (1988).
    • (1988) Biochem Pharmacol , pp. 1563
    • McCoy, G.D.1    Koop, D.R.2
  • 73
    • 0030946223 scopus 로고    scopus 로고
    • Regulation of the hepatic CYP2E1 gene during chronic alcohol exposure: Lack of an ethanol response element in the proximal 5′-flanking sequence
    • McGehee, R. E. Jr., Ronis, M. J., and Badger, T. M., Regulation of the hepatic CYP2E1 gene during chronic alcohol exposure: lack of an ethanol response element in the proximal 5′-flanking sequence. DNA Cell Biol, 16, 725-736 (1997).
    • (1997) DNA Cell Biol , vol.16 , pp. 725-736
    • McGehee R.E., Jr.1    Ronis, M.J.2    Badger, T.M.3
  • 74
    • 0027186367 scopus 로고
    • Phosphorylation of cytochrome P4502E1 (CYP2E1) by calmodulin-dependent protein kinase, protein kinase C, and cAMP-dependent protein kinase
    • Menez, J. F., Machu, T. K., Song, B. J., Browning, M. D., and Deitrich, R. A., Phosphorylation of cytochrome P4502E1 (CYP2E1) by calmodulin-dependent protein kinase, protein kinase C, and cAMP-dependent protein kinase. Alcohol Alcohol, 28, 445-451 (1993).
    • (1993) Alcohol Alcohol , vol.28 , pp. 445-451
    • Menez, J.F.1    Machu, T.K.2    Song, B.J.3    Browning, M.D.4    Deitrich, R.A.5
  • 75
    • 0034121761 scopus 로고    scopus 로고
    • A repressive cross-regulation between catalytic and promoter activities of the CYP1A1 and CYP2E1 genes: Role of H2O2
    • Morel, Y., de Waziers, I., and Barouki, R., A repressive cross-regulation between catalytic and promoter activities of the CYP1A1 and CYP2E1 genes: role of H2O2. Mol Pharmacol, 57, 1158-1164 (2000).
    • (2000) Mol Pharmacol , vol.57 , pp. 1158-1164
    • Morel, Y.1    De Waziers, I.2    Barouki, R.3
  • 76
    • 0028850607 scopus 로고
    • CYP2E1 inhibitors partially ameliorate the changes in hepatic fatty acid composition induced in rats by chronic administration of ethanol and a high fat diet
    • Morimoto, M., Reitz, R. C., Morin, R. J., Nguyen, K., Ingelman-Sundberg, M., and French, S. W., CYP2E1 inhibitors partially ameliorate the changes in hepatic fatty acid composition induced in rats by chronic administration of ethanol and a high fat diet. J Nutr, 125, 2953-2964 (1995).
    • (1995) J Nutr , vol.125 , pp. 2953-2964
    • Morimoto, M.1    Reitz, R.C.2    Morin, R.J.3    Nguyen, K.4    Ingelman-Sundberg, M.5    French, S.W.6
  • 77
    • 0033955755 scopus 로고    scopus 로고
    • Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants: Effects of acute and chronic ethanol exposure
    • Navasumrit, P., Ward, T. H., Dodd, N. J., and O'Connor, P. J., Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants: effects of acute and chronic ethanol exposure. Carcinogenesis, 21, 93-99 (2000).
    • (2000) Carcinogenesis , vol.21 , pp. 93-99
    • Navasumrit, P.1    Ward, T.H.2    Dodd, N.J.3    O'Connor, P.J.4
  • 78
    • 0032835657 scopus 로고    scopus 로고
    • CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells
    • Nieto, N., Friedman, S. L., Greenwel, P., and Cederbaum, A. I. CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. Hepatology, 30, 987-996 (1999).
    • (1999) Hepatology , vol.30 , pp. 987-996
    • Nieto, N.1    Friedman, S.L.2    Greenwel, P.3    Cederbaum, A.I.4
  • 79
    • 0034733746 scopus 로고    scopus 로고
    • Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2
    • Nieto, N., Greenwel, P., Friedman, S. L., Zhang, F., Dannenberg, A. J., and Cederbaum, A. I. Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2. J Biol Chem, 275, 20136-20145 (2000).
    • (2000) J Biol Chem , vol.275 , pp. 20136-20145
    • Nieto, N.1    Greenwel, P.2    Friedman, S.L.3    Zhang, F.4    Dannenberg, A.J.5    Cederbaum, A.I.6
  • 80
    • 0028951141 scopus 로고
    • Hydroxyl radical formation in diabetic rats induced by streptozotocin
    • Ohkuwa, T., Sato, Y., and Naoi, M., Hydroxyl radical formation in diabetic rats induced by streptozotocin. Life Sci, 56, 1789-1798 (1995).
    • (1995) Life Sci , vol.56 , pp. 1789-1798
    • Ohkuwa, T.1    Sato, Y.2    Naoi, M.3
  • 81
    • 0023854288 scopus 로고
    • Characterization and identification of a pyrazole-inducible form of cytochrome P450
    • Palakodety, R. B., Clejan, L. A., Krikun, G., Feierman, D. E., and Cederbaum, A. I., Characterization and identification of a pyrazole-inducible form of cytochrome P450. J Biol Chem, 263, 878-884 (1988).
    • (1988) J Biol Chem , vol.263 , pp. 878-884
    • Palakodety, R.B.1    Clejan, L.A.2    Krikun, G.3    Feierman, D.E.4    Cederbaum, A.I.5
  • 83
    • 0031756902 scopus 로고    scopus 로고
    • Regulation of rabbit cytochrome P450 2E1 expression in HepG2 cells by insulin and thyroid hormone
    • Peng, H. M., and Coon, M. J., Regulation of rabbit cytochrome P450 2E1 expression in HepG2 cells by insulin and thyroid hormone. Mol Pharmacol, 54, 740-747 (1998).
    • (1998) Mol Pharmacol , vol.54 , pp. 740-747
    • Peng, H.M.1    Coon, M.J.2
  • 84
    • 0025870495 scopus 로고
    • Effects of ethanol and clofibrate on expression of cytochrome P450 enzymes and epoxide hydrolase in cultures and cocultures of rat hepatocytes
    • Perrot, N., Chesne, C., de Waziers, I., Conner, J., Beaune, P. H., and Guillouzo, A., Effects of ethanol and clofibrate on expression of cytochrome P450 enzymes and epoxide hydrolase in cultures and cocultures of rat hepatocytes. Eur J Biochem, 200, 255-261 (1991).
    • (1991) Eur J Biochem , vol.200 , pp. 255-261
    • Perrot, N.1    Chesne, C.2    De Waziers, I.3    Conner, J.4    Beaune, P.H.5    Guillouzo, A.6
  • 85
    • 0025040813 scopus 로고
    • Cytochrome P-450-dependent formation of reactive oxygen radicals. Isozyme-specific inhibition of P-450-mediated reduction of oxygen and carbon tetrachloride
    • Persson, J. O. Terelius, Y., and Ingelman-Sundberg, M., Cytochrome P-450-dependent formation of reactive oxygen radicals. Isozyme-specific inhibition of P-450-mediated reduction of oxygen and carbon tetrachloride. Xenobiotica, 20, 887-900 (1990).
    • (1990) Xenobiotica , vol.20 , pp. 887-900
    • Persson, J.O.1    Terelius, Y.2    Ingelman-Sundberg, M.3
  • 86
  • 87
    • 0029915031 scopus 로고    scopus 로고
    • P70 S6 kinase: An enigma with variation
    • Proud, C. G., p70 S6 kinase: an enigma with variation. Trends Biochem Sci, 21, 181-185 (1996).
    • (1996) Trends Biochem Sci , vol.21 , pp. 181-185
    • Proud, C.G.1
  • 88
    • 0024401849 scopus 로고
    • Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2
    • Raucy, J. L., Lasker, J. M., Lieber, C. S., and Black, M., Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2. Arch Biochem Biophys, 271, 270-283 (1989).
    • (1989) Arch Biochem Biophys , vol.271 , pp. 270-283
    • Raucy, J.L.1    Lasker, J.M.2    Lieber, C.S.3    Black, M.4
  • 90
    • 0027476657 scopus 로고
    • Bioactivation of halogenated hydrocarbons by cytochrome P4502E1
    • Raucy, J. L., Kraner, J. C., and Lasker, J. M. , Bioactivation of halogenated hydrocarbons by cytochrome P4502E1. Crit Rev Toxicol, 23, 1-20 (1993).
    • (1993) Crit Rev Toxicol , vol.23 , pp. 1-20
    • Raucy, J.L.1    Kraner, J.C.2    Lasker, J.M.3
  • 91
    • 0030986960 scopus 로고    scopus 로고
    • Evidence of proteasome-mediated cytochrome P450 degradation
    • Roberts, B. J., Evidence of proteasome-mediated cytochrome P450 degradation. J Biol Chem, 272, 9771-9778 (1997).
    • (1997) J Biol Chem , vol.272 , pp. 9771-9778
    • Roberts, B.J.1
  • 92
    • 0029618909 scopus 로고
    • Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1
    • Roberts, B. J., Song, B. J., Soh, Y., Park, S. S., and Shoaf, S. E., Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1. J Biol Chem, 270, 29632-29635 (1995).
    • (1995) J Biol Chem , vol.270 , pp. 29632-29635
    • Roberts, B.J.1    Song, B.J.2    Soh, Y.3    Park, S.S.4    Shoaf, S.E.5
  • 93
    • 0024444168 scopus 로고
    • Acetone-dependent regulation of cytochrome P450j (IIE1) and P450b (IIB1) in rat liver
    • Ronis, M. J., and Ingelman-Sundberg, M., Acetone-dependent regulation of cytochrome P450j (IIE1) and P450b (IIB1) in rat liver. Xenobiotica, 19, 1161-1165 (1989).
    • (1989) Xenobiotica , vol.19 , pp. 1161-1165
    • Ronis, M.J.1    Ingelman-Sundberg, M.2
  • 94
    • 0025821699 scopus 로고
    • Acetone-regulated synthesis and degradation of cytochrome P4502E1 and cytochrome P4502B1 in rat liver
    • Ronis, M. J., Johansson, I., Hultenby, K., Lagercrantz, J., Glaumann, H., and Ingelman-Sundberg, M., Acetone-regulated synthesis and degradation of cytochrome P4502E1 and cytochrome P4502B1 in rat liver. Eur J Biochem, 198, 383-389 (1991).
    • (1991) Eur J Biochem , vol.198 , pp. 383-389
    • Ronis, M.J.1    Johansson, I.2    Hultenby, K.3    Lagercrantz, J.4    Glaumann, H.5    Ingelman-Sundberg, M.6
  • 95
    • 0027713235 scopus 로고
    • Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats
    • Ronis, M. J., Huang, J., Crouch, J., Mercado, C., Irby, D., Valentine, C. R., Lumpkin, C. K., Ingelman-Sundberg, M., and Badger, T. M., Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats. J Pharmacol Exp Ther, 264, 944-950 (1993).
    • (1993) J Pharmacol Exp Ther , vol.264 , pp. 944-950
    • Ronis, M.J.1    Huang, J.2    Crouch, J.3    Mercado, C.4    Irby, D.5    Valentine, C.R.6    Lumpkin, C.K.7    Ingelman-Sundberg, M.8    Badger, T.M.9
  • 96
    • 0021795267 scopus 로고
    • Characterization of a major form of rat hepatic microsomal cytochrome P450 induced by isoniazid
    • Ryan, D. E., Ramanathan, L., Iida, S., Thomas, P. E., Haniu, M., Shively, J. E., Lieber, C. S., and Levin, W., Characterization of a major form of rat hepatic microsomal cytochrome P450 induced by isoniazid. J Biol Chem, 260, 6385-6393 (1985).
    • (1985) J Biol Chem , vol.260 , pp. 6385-6393
    • Ryan, D.E.1    Ramanathan, L.2    Iida, S.3    Thomas, P.E.4    Haniu, M.5    Shively, J.E.6    Lieber, C.S.7    Levin, W.8
  • 98
    • 0032143284 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
    • Shepherd, P. R., Withers, D. J., and Siddle, K., Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J. 333, 471-490 (1998).
    • (1998) Biochem J. , vol.333 , pp. 471-490
    • Shepherd, P.R.1    Withers, D.J.2    Siddle, K.3
  • 99
    • 0030959377 scopus 로고    scopus 로고
    • Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans
    • Shimada, T., Mimura, M., Inoue, K., Nakamura, S., Oda, H., Ohmori, S., and Yamazaki, H., Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans. Arch Toxicol, 71, 401-408 (1997).
    • (1997) Arch Toxicol , vol.71 , pp. 401-408
    • Shimada, T.1    Mimura, M.2    Inoue, K.3    Nakamura, S.4    Oda, H.5    Ohmori, S.6    Yamazaki, H.7
  • 100
    • 0027179792 scopus 로고
    • Changes in amounts of cytochrome P450 isozymes and levels of catalytic activities in hepatic and renal microsomes of rats with streptozocin-induced diabetes
    • Shimojo, N., Ishizaki, T., Imaoka, S., Funae, Y., Fujii, S., and Okuda, K., Changes in amounts of cytochrome P450 isozymes and levels of catalytic activities in hepatic and renal microsomes of rats with streptozocin-induced diabetes. Biochem Pharmacol, 46, 621-627 (1993).
    • (1993) Biochem Pharmacol , vol.46 , pp. 621-627
    • Shimojo, N.1    Ishizaki, T.2    Imaoka, S.3    Funae, Y.4    Fujii, S.5    Okuda, K.6
  • 101
    • 0032960971 scopus 로고    scopus 로고
    • Post-translational inhibition of cytochrome P450 2E1 expression by chlomethiazole in Fao hepatoma cells
    • Simi, A., and Ingelman-Sundberg, M., Post-translational inhibition of cytochrome P450 2E1 expression by chlomethiazole in Fao hepatoma cells. J Pharmacol Exp Ther, 289, 847-852 (1999).
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 847-852
    • Simi, A.1    Ingelman-Sundberg, M.2
  • 103
    • 0019351131 scopus 로고
    • Ethanol enhancement of cocaine-induced hepatotoxicity
    • Smith, A. C., Freeman, R. W., and Harbison, R. D., Ethanol enhancement of cocaine-induced hepatotoxicity. Biochem Pharmacol, 30, 453-358 (1981).
    • (1981) Biochem Pharmacol , vol.30 , pp. 453-1358
    • Smith, A.C.1    Freeman, R.W.2    Harbison, R.D.3
  • 104
    • 0028207549 scopus 로고
    • Cytochrome P450-dependent metabolism of acetaminophen in four human transgenic lymphoblastoid cell lines
    • Snawder, J. E., Roe, A. L., Benson, R. W., Casciano, D. A., and Roberts, D. W., Cytochrome P450-dependent metabolism of acetaminophen in four human transgenic lymphoblastoid cell lines. Pharmacogenetics, 4, 43-46 (1994).
    • (1994) Pharmacogenetics , vol.4 , pp. 43-46
    • Snawder, J.E.1    Roe, A.L.2    Benson, R.W.3    Casciano, D.A.4    Roberts, D.W.5
  • 105
    • 0343090856 scopus 로고    scopus 로고
    • Role of glucose utilization in the restoration of hypophysectomy-induced hepatic cytochrome P450 2E1 by growth hormone in rats
    • Son, M. H., Kang, K. W., Kim, E. J., Ryu, J. H., Cho, H., Kim, S. H., Kim, W. B., and Kim, S. G., Role of glucose utilization in the restoration of hypophysectomy-induced hepatic cytochrome P450 2E1 by growth hormone in rats. Chem-Biol Interact, 127, 13-28 (2000).
    • (2000) Chem-Biol Interact , vol.127 , pp. 13-28
    • Son, M.H.1    Kang, K.W.2    Kim, E.J.3    Ryu, J.H.4    Cho, H.5    Kim, S.H.6    Kim, W.B.7    Kim, S.G.8
  • 106
    • 0022869269 scopus 로고
    • Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s: Transcriptional and post-transcriptional regulation of the rat enzyme
    • Song, B-J., Celboin, H. V., Park, S-S., Yang, C. S., and Gonzalez, F. J., Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s: transcriptional and post-transcriptional regulation of the rat enzyme. J Biol Chem, 261, 16689-16697 (1986).
    • (1986) J Biol Chem , vol.261 , pp. 16689-16697
    • Song, B.-J.1    Celboin, H.V.2    Park, S.-S.3    Yang, C.S.4    Gonzalez, F.J.5
  • 108
    • 0024521525 scopus 로고
    • Induction of rat hepatic N-nitroso-dimethylamine demethylase by acetone is due to protein stabilization
    • Song, B.-J., Veech, R. L., Park, S. S., Gelboin, H. V., and Gonzalez, F. J., Induction of rat hepatic N-nitroso-dimethylamine demethylase by acetone is due to protein stabilization. J Biol Chem, 264, 3568-3572 (1989).
    • (1989) J Biol Chem , vol.264 , pp. 3568-3572
    • Song, B.-J.1    Veech, R.L.2    Park, S.S.3    Gelboin, H.V.4    Gonzalez, F.J.5
  • 109
    • 0025074850 scopus 로고
    • Cytochrome P40IIE1 is elevated in lymphocytes from poorly controlled insulin-dependent diabetics
    • Song, B.-J., Veech, R. L., and Saenger, P., Cytochrome P40IIE1 is elevated in lymphocytes from poorly controlled insulin-dependent diabetics. J Clin Endocrinol Metab, 71, 1036-1040 (1990).
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 1036-1040
    • Song, B.-J.1    Veech, R.L.2    Saenger, P.3
  • 111
    • 0027499273 scopus 로고
    • Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA
    • Takahashi, T., Lasker, J. M. Rosman, A. S., and Lieber, C. S., Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology, 17, 236-245 (1993).
    • (1993) Hepatology , vol.17 , pp. 236-245
    • Takahashi, T.1    Lasker, J.M.2    Rosman, A.S.3    Lieber, C.S.4
  • 112
    • 0023180336 scopus 로고
    • Regulation of cytochrome P-450j, a high-affinity N-Nitrosodimethylamine demethylase, in rat hepatic microsomes
    • Thomas, P E., Bandiera, S., Maines, S. L., Ryan, D. E., and Levin, W., Regulation of cytochrome P-450j, a high-affinity N-Nitrosodimethylamine demethylase, in rat hepatic microsomes. Biochemistry, 26, 2280-2289 (1987).
    • (1987) Biochemistry , vol.26 , pp. 2280-2289
    • Thomas, P.E.1    Bandiera, S.2    Maines, S.L.3    Ryan, D.E.4    Levin, W.5
  • 113
    • 0025098444 scopus 로고
    • Effects of testosterone and growth hormone treatment on hepatic microsomal P450 expression in the diabetic rat
    • Thummel, K. E., and Schenkman, J. B., Effects of testosterone and growth hormone treatment on hepatic microsomal P450 expression in the diabetic rat. Mol Pharmacol, 37, 119-129 (1990).
    • (1990) Mol Pharmacol , vol.37 , pp. 119-129
    • Thummel, K.E.1    Schenkman, J.B.2
  • 114
    • 0026546019 scopus 로고
    • Degradation of cytochrome P450 2E1: Selective loss after labilization of the enzyme
    • Tierney, D. J., Haas, A. L., and Koop, D. R., Degradation of cytochrome P450 2E1: selective loss after labilization of the enzyme. Arch Biochem Biophys, 293, 9-16 (1992).
    • (1992) Arch Biochem Biophys , vol.293 , pp. 9-16
    • Tierney, D.J.1    Haas, A.L.2    Koop, D.R.3
  • 115
    • 0027235830 scopus 로고
    • Vivo induction of hepatic P4502E1 by ethanol: Role of increased enzyme synthesis
    • Tsutsumi, M., Lasker, J. M., Takahashi, T., and Lieber, C. S., In vivo induction of hepatic P4502E1 by ethanol: role of increased enzyme synthesis. Arch Biochem Biophys, 304, 209-218 (1993).
    • (1993) Arch Biochem Biophys , vol.304 , pp. 209-218
    • Tsutsumi, M.1    Lasker, J.M.2    Takahashi, T.3    Lieber, C.S.4
  • 116
    • 0025073482 scopus 로고
    • Transcriptional control of the rat hepatic CYP2E1 gene
    • Ueno, T., and Gonzalez, F. J., Transcriptional control of the rat hepatic CYP2E1 gene. Mol Cell Biol 10, 4495-4505 (1990).
    • (1990) Mol Cell Biol , vol.10 , pp. 4495-4505
    • Ueno, T.1    Gonzalez, F.J.2
  • 117
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • Ullrich, A., and Schlessinger, J., Signal transduction by receptors with tyrosine kinase activity. Cell, 61, 203-212 (1990).
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 118
    • 0023818618 scopus 로고
    • The rat P4501IE1 gene: Complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5′ cytosine demethylation
    • Umeno, M., Song, B-J., Kozak, C., Gelboin, H. V., and Gonzalez, F. J., The rat P4501IE1 gene: complete intron and exon sequence, chromosome mapping, and correlation of developmental expression with specific 5′ cytosine demethylation. J Biol Chem, 263, 4956-4962 (1988).
    • (1988) J Biol Chem , vol.263 , pp. 4956-4962
    • Umeno, M.1    Song, B.-J.2    Kozak, C.3    Gelboin, H.V.4    Gonzalez, F.J.5
  • 119
    • 0025025440 scopus 로고
    • Reductive -scission of the hydroperoxides of fatty acids and xenobiotics. Role of alcohol-inducible cytochrome P-450
    • Vaz, A., Roberts, E., Coon, M. J., Reductive (-scission of the hydroperoxides of fatty acids and xenobiotics. Role of alcohol-inducible cytochrome P-450. Proc Natl Acad Sci USA, 87, 5499-5503 (1990).
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5499-5503
    • Vaz, A.1    Roberts, E.2    Coon, M.J.3
  • 120
    • 0029938610 scopus 로고    scopus 로고
    • Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period
    • Vieira, I., Sonnier, M., and Crestell, T., Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period. Eur J Biochem, 238(2), 476-483 (1996).
    • (1996) Eur J Biochem , vol.238 , Issue.2 , pp. 476-483
    • Vieira, I.1    Sonnier, M.2    Crestell, T.3
  • 122
    • 0001320851 scopus 로고
    • Degradation of the hepatic cytochromes P450
    • Guengerich, F.P., (Ed). CRC Press, Inc. Boca Raton, FL
    • Watkins, P. B., Bond, J. S., and Guzelian, P. S., Degradation of the hepatic cytochromes P450. In Guengerich, F.P., (Ed). Mammalian Cytochromes P450, Vol. II. CRC Press, Inc. Boca Raton, FL, pp. 173-193, 1987.
    • (1987) Mammalian Cytochromes P450 , vol.2 , pp. 173-193
    • Watkins, P.B.1    Bond, J.S.2    Guzelian, P.S.3
  • 123
    • 0023921199 scopus 로고
    • The effect of long-term streptozotocin-induced diabetes on the hepatotoxicity of bromobenzene and carbon tetrachloride and hepatic biotransformation in rats
    • Watkins, J. B., Sanders, R. A., and Beck, L. V., The effect of long-term streptozotocin-induced diabetes on the hepatotoxicity of bromobenzene and carbon tetrachloride and hepatic biotransformation in rats. Toxicol Appl Pharmacol, 93, 329-338 (1988).
    • (1988) Toxicol Appl Pharmacol , vol.93 , pp. 329-338
    • Watkins, J.B.1    Sanders, R.A.2    Beck, L.V.3
  • 124
    • 0033051724 scopus 로고    scopus 로고
    • Effect of leptin on cytochrome P450, conjugation, and antioxidant enzymes in the ob/ob mouse
    • Watson, A. M., Poloyac, S. M., Howarc, G., and Blouin, R. A., Effect of leptin on cytochrome P450, conjugation, and antioxidant enzymes in the ob/ob mouse. Drug Metab Dispos, 27, 695-700 (1999).
    • (1999) Drug Metab Dispos , vol.27 , pp. 695-700
    • Watson, A.M.1    Poloyac, S.M.2    Howarc, G.3    Blouin, R.A.4
  • 125
    • 0029829455 scopus 로고    scopus 로고
    • Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation
    • Weltman, M. D., Farrell, G. C., and Liddle, C., Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology, 111, 1645-1653 (1996).
    • (1996) Gastroenterology , vol.111 , pp. 1645-1653
    • Weltman, M.D.1    Farrell, G.C.2    Liddle, C.3
  • 126
    • 0028085078 scopus 로고
    • The insulin signaling system
    • White, M. F., and Kahn, C. R., The insulin signaling system. J Biol Chem, 269, 1-4 (1994).
    • (1994) J Biol Chem , vol.269 , pp. 1-4
    • White, M.F.1    Kahn, C.R.2
  • 127
    • 0030719427 scopus 로고    scopus 로고
    • Insulin effects of CYP2E1, 2B, 3A, and 4A expression in primary cultured rat hepatocytes
    • Woodcroft, K. J., and Novak, R. F., Insulin effects of CYP2E1, 2B, 3A, and 4A expression in primary cultured rat hepatocytes. Chem-Biol Interact, 107, 75-91 (1997).
    • (1997) Chem-Biol Interact , vol.107 , pp. 75-91
    • Woodcroft, K.J.1    Novak, R.F.2
  • 128
    • 0031943842 scopus 로고    scopus 로고
    • Xenobiotic-enhanced expression of cytochromes P450 2E1 and 2B in primary cultured rat hepatocytes
    • Woodcraft, K. J., and Novak, R. F., Xenobiotic-enhanced expression of cytochromes P450 2E1 and 2B in primary cultured rat hepatocytes. Drug Metab Dispos, 26, 372-378 (1998).
    • (1998) Drug Metab Dispos , vol.26 , pp. 372-378
    • Woodcraft, K.J.1    Novak, R.F.2
  • 129
    • 0032957793 scopus 로고    scopus 로고
    • Insulin differentially affects xenobiotic-enhanced cytochrome P450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes
    • Woodcraft, K. J. and Novak, R. F., Insulin differentially affects xenobiotic-enhanced cytochrome P450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes. J Pharmacol Exp Ther, 289, 1121-1127 (1999a).
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 1121-1127
    • Woodcraft, K.J.1    Novak, R.F.2
  • 130
    • 0033590198 scopus 로고    scopus 로고
    • The role of phosphatidylinositol 3-kinase, Src kinase, and protein kinase A signaling pathways in insulin and glucagon regulation of CYP2E1 expression
    • Woodcraft, K. J. and Novak, R. F., The role of phosphatidylinositol 3-kinase, Src kinase, and protein kinase A signaling pathways in insulin and glucagon regulation of CYP2E1 expression. Biochem Biophys Res Commun, 266, 304-307 (1999b).
    • (1999) Biochem Biophys Res Commun , vol.266 , pp. 304-307
    • Woodcraft, K.J.1    Novak, R.F.2
  • 131
    • 0346925289 scopus 로고    scopus 로고
    • Insulin destabilizes CYP2E1, but not CYP2B or CYP3A, mRNA in primary cultured rat hepatocytes
    • Woodcraft, K. J., and Novak, R. F., Insulin destabilizes CYP2E1, but not CYP2B or CYP3A, mRNA in primary cultured rat hepatocytes. Toxicologist, 54, 99 (2000a).
    • (2000) Toxicologist , vol.54 , pp. 99
    • Woodcraft, K.J.1    Novak, R.F.2
  • 132
    • 26744447016 scopus 로고    scopus 로고
    • EGF regulates CYP2E1 mRNA expression in primary cultured rat hepatocytes through Src kinase and P13-kinase signalling pathways
    • Woodcraft, K. J., and Novak, R. F., EGF regulates CYP2E1 mRNA expression in primary cultured rat hepatocytes through Src kinase and P13-kinase signalling pathways. FASEB J, 14, A1333 (2000b).
    • (2000) FASEB J , vol.14
    • Woodcraft, K.J.1    Novak, R.F.2
  • 134
    • 0029816454 scopus 로고    scopus 로고
    • Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1
    • Wu, D., and Cederbaum, A.I., Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. J Biol Chem, 271, 23914-23919 (1996a).
    • (1996) J Biol Chem , vol.271 , pp. 23914-23919
    • Wu, D.1    Cederbaum, A.I.2
  • 135
    • 0029868558 scopus 로고    scopus 로고
    • Expression of cytochrome P4502E1 in rat fetal hepatocyte culture
    • Wu, D., and Cederbaum, A. I., Expression of cytochrome P4502E1 in rat fetal hepatocyte culture. Mol Pharmacol, 49, 802-807 (1996b).
    • (1996) Mol Pharmacol , vol.49 , pp. 802-807
    • Wu, D.1    Cederbaum, A.I.2
  • 136
    • 0033998918 scopus 로고    scopus 로고
    • Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1
    • Wu, D., and Cederbaum, A. I., Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1. Mol Cell Biochem, 204, 157-167 (2000).
    • (2000) Mol Cell Biochem , vol.204 , pp. 157-167
    • Wu, D.1    Cederbaum, A.I.2
  • 137
    • 0030765146 scopus 로고    scopus 로고
    • Effect of pyridine on the expression of cytochrome P450 isozymes in primary rat hepatocyte culture
    • Wu, D., Ramin, S. A., and Cederbaum, A. I., Effect of pyridine on the expression of cytochrome P450 isozymes in primary rat hepatocyte culture. Mol Cell Biochem, 173(1-2), 103-111 (1997).
    • (1997) Mol Cell Biochem , vol.173 , Issue.1-2 , pp. 103-111
    • Wu, D.1    Ramin, S.A.2    Cederbaum, A.I.3
  • 138
    • 0026744568 scopus 로고
    • Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes
    • Yamazaki, H., Inui, Y., Yun, C-H., Guengerich, F. P., and Shimada, T., Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes. Carcinogenesis, 13, 1789-1794 (1992).
    • (1992) Carcinogenesis , vol.13 , pp. 1789-1794
    • Yamazaki, H.1    Inui, Y.2    Yun, C.-H.3    Guengerich, F.P.4    Shimada, T.5
  • 139
    • 0024559080 scopus 로고
    • Cytochrome P450 in livers of diabetic rats: Regulation by growth hormone and insulin
    • Yamazoe, Y., Murayama, N., Shimada, M., Yamauchi, K., and Kato, R., Cytochrome P450 in livers of diabetic rats: regulation by growth hormone and insulin. Arch Biochem Biophys, 268, 567-575 (1989a).
    • (1989) Arch Biochem Biophys , vol.268 , pp. 567-575
    • Yamazoe, Y.1    Murayama, N.2    Shimada, M.3    Yamauchi, K.4    Kato, R.5
  • 140
    • 0024351598 scopus 로고
    • Suppression of hepatic levels of an ethanol-inducible P450DM/j by growth hormone: Relationship between the increased level of P450DM/j and depletion of growth hormone in diabetes
    • Yamazoe, Y., Murayama, N., Shimada, M., Imaoka, S., Funae, Y., and Kato, R., Suppression of hepatic levels of an ethanol-inducible P450DM/j by growth hormone: relationship between the increased level of P450DM/j and depletion of growth hormone in diabetes. Mol Pharmacol, 36, 716-722 (1989b).
    • (1989) Mol Pharmacol , vol.36 , pp. 716-722
    • Yamazoe, Y.1    Murayama, N.2    Shimada, M.3    Imaoka, S.4    Funae, Y.5    Kato, R.6
  • 141
    • 0030956386 scopus 로고    scopus 로고
    • Glycerol increases content and activity of human cytochrome P4502E1 in a transduced HepG2 cell line by protein stabilization
    • Yang, M. X., and Cederbaum, A. I., Glycerol increases content and activity of human cytochrome P4502E1 in a transduced HepG2 cell line by protein stabilization. Alcohol Clin Exp Res, 21, 340-347 (1997a).
    • (1997) Alcohol Clin Exp Res , vol.21 , pp. 340-347
    • Yang, M.X.1    Cederbaum, A.I.2
  • 142
    • 0031149527 scopus 로고    scopus 로고
    • Characterization of cytochrome P4502E1 turnover in transfected HepG2 cells expressing human CYP2E1
    • Yang, M. X., and Cederbaum, A. I., Characterization of cytochrome P4502E1 turnover in transfected HepG2 cells expressing human CYP2E1. Arch Biochem Biophys, 341, 25-33 (1997b).
    • (1997) Arch Biochem Biophys , vol.341 , pp. 25-33
    • Yang, M.X.1    Cederbaum, A.I.2
  • 143
    • 0026523825 scopus 로고
    • Pretranslational activation of cytochrome P450IIE during ketosis induced by a high fat diet
    • Yun, Y-P., Casazza, J. P., Sohn, D., Veech, R. L., and Song, B.J., Pretranslational activation of cytochrome P450IIE during ketosis induced by a high fat diet. Mol Pharmacol, 41, 474-479 (1992).
    • (1992) Mol Pharmacol , vol.41 , pp. 474-479
    • Yun, Y.-P.1    Casazza, J.P.2    Sohn, D.3    Veech, R.L.4    Song, B.J.5
  • 144
    • 0031568250 scopus 로고    scopus 로고
    • Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes
    • Zangar, R. C., and Novak, R. F., Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes. Arch Biochem Biophys, 337, 217-224 (1997).
    • (1997) Arch Biochem Biophys , vol.337 , pp. 217-224
    • Zangar, R.C.1    Novak, R.F.2
  • 145
    • 0028998607 scopus 로고
    • Xenobiotic-enhanced expression of cytochrome P450 2E1 and 2B1/2B2 in primary cultured rat hepatocytes
    • Zangar, R. C., Woodcroft, K. J., Kocarek, T. A., and Novak, R. F., Xenobiotic-enhanced expression of cytochrome P450 2E1 and 2B1/2B2 in primary cultured rat hepatocytes. Drug Metab Dispos, 23, 681-687 (1995).
    • (1995) Drug Metab Dispos , vol.23 , pp. 681-687
    • Zangar, R.C.1    Woodcroft, K.J.2    Kocarek, T.A.3    Novak, R.F.4
  • 146
    • 0027485120 scopus 로고
    • Purification and characterization of two membrane-bound serine proteinases from rat liver microsomes active in degradation of cytochrome P450
    • Zhukov, A., Werlinder, V., and Ingelman-Sundberg, M., Purification and characterization of two membrane-bound serine proteinases from rat liver microsomes active in degradation of cytochrome P450. Biochem Biophys Res Commun, 197, 221-228 (1993).
    • (1993) Biochem Biophys Res Commun , vol.197 , pp. 221-228
    • Zhukov, A.1    Werlinder, V.2    Ingelman-Sundberg, M.3


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