The safety and efficacy of a silymarin and selenium combination in men after radical prostatectomy - a six month placebo-controlled double-blind clinical trial

Biomedical Papers

Volumn 154, Issue 3, 2010, Pages 239-244

  Vidlar, Ales ^a   Vostalova, Jitka ^b   Ulrichova, Jitka ^b   Student, Vladimir ^a   Krajicek, Milan ^c   Vrbkova, Jana ^b   Simanek, Vilim ^b  

^a UNIVERSITY HOSPITAL OLOMOUC   (Czech Republic)

^b PALACKÝ UNIVERSITY   (Czech Republic)

^c Favea spol s ro   (Czech Republic)

Author keywords

Blood cholesterol; Clinical chemistry; Plasma lipoproteins; Prostate cancer; Radical prostatectomy; Selenium; Silymarin

Indexed keywords

SILYBUM MARIANUM;

EID: 78049242047     PISSN: 12138118     EISSN: 12138118     Source Type: Journal    
DOI: 10.5507/bp.2010.036     Document Type: Article

References (22)

1. Boyle P, Ferlay J. Cancer incidence and mortality in Europe, 2004. Annals Oncol 2005; 16:481-88.
2. Nelson WG, De Marzo AM, Isaacs WB. Prostate cancer. N Engl J Med 2003; 349:366-381.
3. Lophatananon A, Archer J, Easton D, Pocock R, Dearnaley D, Guy M, Kote-Jarai Z, O'Brien L, Wilkinson RA, Hall AL, Sawyer E, Page E, Liu JF, Barratt S, Rahman AA. Dietary fat and early-onset prostate cancer risk. Br J Nutr 2010; 103:1375-1380.
4. Ma RW-L, Chapman K. A systematic review of the effect of diet in prostate cancer prevention and treatment. J Hum Nutr Diet 2009; 22:187-19.
5. Allen NE, Appleby PN, Roddam AW, Tjønneland A, Johnsen NF, Overvad K, Boeing H, Weikert S, Kaaks R, Linseisen J, Trichopoulou A, Misirli G, Trichopoulos D, Sacerdote C, Grioni S, Palli D, Tumino R, Bueno-de-Mesquita HB, Kiemeney LA, Barricarte A, Larrañaga N, Sánchez MJ, Agudo A, Tormo MJ, Rodriguez L, Stattin P, Hallmans G, Bingham S, Khaw KT, Slimani N, Rinaldi S, Boffetta P, Riboli E, Key TJ. Plasma selenium concentration and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Clin Nutr 2008; 88:1567-1575.
6. Yoshizawa K, Willet WC, Morris SJ, Stampfer MJ, Spiegelman D, Rimm EB, Giovannucci E. Study of prediagnostic level in toenails and the risk of advanced prostate cancer. J Nat Cancer Inst 1998; 90:1219-1224.
7. Wing Ying Cheung C, Gibbons N, Johnson DW, Nicol DL. Silibinin - A promising new treatment for cancer. Anti-Cancer Agents Med Chem 2010; 10:186-195.
8. Flaig TW, Glodé M, Gustafson D, van Bokhoven A, Tao Y, Wilson S, Su LJ, Li Y, Harrison G, Agarwal R, Crawford ED, Lucia MS, Pollak M. A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. Prostate 2010; 70:848-855.
9. Singh RP, Raina K, Sharma G, Agarwal R. Silibinin inhibits established prostate tumor growth, progression, invasion, and metastasis and suppresses tumor angiogenesis and epithelial-mesenchymal transition in transgenic adenocarcinoma of the mouse prostate model mice. Clin Cancer Res 2008; 14:7773-7780.
10. Vidlar A, Vostalova J, Ulrichova J, Student V, Stejskal D, Reichenbach R, Vrbkova J, Ruzicka F, Simanek V. The effectiveness of dried cranberries (Vaccinium macrocarpon) in men with lower urinary tract symptoms. Br J Nutr 2010, doi:10.1017/S0007114510002059.
11. Stephenson AJ, Abouassaly R, Klein EA. Chemoprevention of prostate cancer. Urol Clin North Am 2010; 37:11-21.
12. Gann PH. Risk factors for prostate cancer. Rev Urol 2002; 4(Suppl. 5):S3-S11.
13. Rastogi T, Deves S, Mangtani P, Mathew A, Cooper N, Kao R, Sinha R. Cancer incidence rates among South Asians in four geographic regions: India, Singapore, UK and US. Int J Epidemiol 2008; 34:147-160.
14. Kucuk O, Sarkar FH, Sakr W, Djuric Z, Pollak MN, Khachik F, Li YW, Banerjee M, Grignon D, Bertram JS, Crissman JD, Pontes EJ, Wood DP Jr. Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy. Cancer Epidemiol Biomarkers Prev 2001; 10:861-868.
15. Vaishampayan U, Hussain M, Banerjee M, Seren S, Sarkar FH, Fontana J, Forman JD, Cher ML, Powell I, Pontes JE, Kucuk O. Lycopene and soy isoflavones in the treatment of prostate cancer. Nutr Cancer 2007; 59:1-7.
16. Flaig TW, Glodé M, Gustafson D, van Bokhoven A, Tao Y, Wilson S, Su LJ, Li Y, Harrison G, Agarwal R, Crawford ED, Lucia MS, Pollak M. A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer. The Prostate 2010; 70:848-855.
17. van Weerden WM, Schröder FH. The use of PSA as biomarker in nutritional intervention studies of prostate cancer. Chem-Biol Interact 2008; 171:204-211.
18. Šimánek V, Křen V, Ulrichová J, Vičar J, Cvak L. Silymarin: What is in the Name? Hepatology 2000; 32:442-43.
19. Polyak SJ, Morishima C, Lohmann V, Pal S, Lee DY, Liu Y, Graf TN, Oberlies NH. Identification of hepatoprotective flavonolignans from silymarin. PNAS 2010; 107:5995-5999.
20. Radko L, Cybulski W. Application of silymarin in human and animal medicine. J Pre-Clin Clin Res 2007; 1:22-26.
21. Šimánek V, Škottová N, Bartek, J, Psotová J, Kosina P, Balejová L, Ulrichová J. Extract from Silybum marianum as a nutraceutical; A double-blind placebo-controlled study in healthy young men. Czech J Food Sci 2001; 19:106-110.
22. Šimánek V, Škottová N, Ulrichová J. Perspective nutraceutical - milk thistle extract with polyunsaturated fatty acids. In Biologically-Active Phytochemicals in Food (W. Pfannhauser, G.R. Fenwick, S. Khokhar, editors). RCS, London; 2001. pp 65-68.