Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 368, Issue 3, 2003, Pages 200-209

  Václavíková, Radka ^a   Horský, Stanislav ^a   Šimek, Petr ^b   Gut, Ivan ^a  

^a NATIONAL INSTITUTE OF PUBLIC HEALTH   (Czech Republic)

^b INSTITUTE OF MATHEMATICS   (Czech Republic)

Author keywords

Cytochrome P450; Human; Inhibition; Liver microsomes; Paclitaxel; Pharmacokinetics; Phenolic antioxidants; Rat

Indexed keywords

6 ALPHA HYDROPACLITAXEL; ANTIOXIDANT; C 2 HYDROPACLITAXEL; C 3 HYDROPACLITAXEL; CATECHIN; CYTOCHROME P450; CYTOCHROME P450 2C8; EPICATECHIN; FISETIN; FLAVANOL DERIVATIVE; GALLIC ACID; MORIN; MYRICETIN; NARINGENIN; PACLITAXEL; QUERCETIN; RESVERATROL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CHEMOTHERAPY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG INHIBITION; DRUG METABOLISM; HUMAN; KINETICS; LIVER MICROSOME; MALE; MICHAELIS CONSTANT; NONHUMAN; RAT; RAT STRAIN;

ADOLESCENT; ADULT; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; DRUG ANTAGONISM; HUMANS; MALE; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; PACLITAXEL; PHENOLS; RATS; RATS, WISTAR; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0141993644     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-003-0781-9     Document Type: Article

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