Herb-drug interaction of silymarin or silibinin on the pharmacokinetics of trazodone in rats

Chemico-Biological Interactions

Volumn 182, Issue 2-3, 2009, Pages 227-232

  Chang, Jen Chih ^a   Wu, Yu Tse ^a   Lee, Wen Chuan ^a   Lin, Lie Chwen ^a,b   Tsai, Tung Hu ^a,c,d,e  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI CITY HOSPITAL   (Taiwan)

^e TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Herb drug interaction; Microdialysis; Pharmacokinetics; Silibinin; Silymarin; Trazodone

Indexed keywords

SILIBININ; SILYMARIN; TRAZODONE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INHIBITION; DRUG MEGADOSE; DRUG SAFETY; HERB DRUG INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MEAN RESIDENCE TIME; MICRODIALYSIS; NONHUMAN; RAT; REPEATED DRUG DOSE;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIOXIDANTS; BILE; HERB-DRUG INTERACTIONS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SILYMARIN; TRAZODONE;

RATTUS;

EID: 70350128772     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.09.005     Document Type: Article

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