-
1
-
-
67649450485
-
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells
-
Back SH, et al. 2009. Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metab. 10:13-26.
-
(2009)
Cell Metab.
, vol.10
, pp. 13-26
-
-
Back, S.H.1
-
2
-
-
27144458505
-
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
-
Bi M, et al. 2005. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J. 24:3470 -3481.
-
(2005)
EMBO J.
, vol.24
-
-
Bi, M.1
-
3
-
-
33845465578
-
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress
-
Blais JD, et al. 2006. Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress. Mol. Cell. Biol. 26:9517-9532.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 9517-9532
-
-
Blais, J.D.1
-
4
-
-
77954535031
-
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage
-
Bobrovnikova-Marjon E, et al. 2010. PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage. Oncogene 29:3881-3895.
-
(2010)
Oncogene
, vol.29
, pp. 3881-3895
-
-
Bobrovnikova-marjon, E.1
-
5
-
-
55849112292
-
PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation
-
Bobrovnikova-Marjon E, et al. 2008. PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation. Proc. Natl. Acad. Sci. U. S. A. 105:16314 -16319.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
-
-
Bobrovnikova-marjon, E.1
-
6
-
-
0033739622
-
PERK mediates cell-cycle exit during the mammalian unfolded protein response
-
Brewer JW, Diehl JA. 2000. PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc. Natl. Acad. Sci. U. S. A. 97:12625-12630.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 12625-12630
-
-
Brewer, J.W.1
Diehl, J.A.2
-
9
-
-
79959973892
-
The cell biology of the unfolded protein response
-
e2
-
Diehl JA, Fuchs SY, Koumenis C. 2011. The cell biology of the unfolded protein response. Gastroenterology 141:38-41.e2.
-
(2011)
Gastroenterology
, vol.141
, pp. 38-41
-
-
Diehl, J.A.1
Fuchs, S.Y.2
Koumenis, C.3
-
10
-
-
70349597373
-
Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation
-
Feng D, Wei J, Gupta S, McGrath BC, Cavener DR. 2009. Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation. BMC Cell Biol. 10:61.
-
(2009)
BMC Cell Biol.
, vol.10
, pp. 61
-
-
Feng, D.1
Wei, J.2
Gupta, S.3
Mcgrath, B.C.4
Cavener, D.R.5
-
11
-
-
64649104150
-
Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo
-
Fiaschi-Taesch N, et al. 2009. Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo. Diabetes 58:882- 893.
-
(2009)
Diabetes
, vol.58
-
-
Fiaschi-taesch, N.1
-
12
-
-
77955357730
-
Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6
-
Fiaschi-Taesch NM, et al. 2010. Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6. Diabetes 59:1926 -1936.
-
(2010)
Diabetes
, vol.59
-
-
Fiaschi-Taesch, N.M.1
-
13
-
-
0028987251
-
Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model
-
Finegood DT, Scaglia L, Bonner-Weir S. 1995. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44:249 -256.
-
(1995)
Diabetes
, vol.44
-
-
Finegood, D.T.1
Scaglia, L.2
Bonner-weir, S.3
-
14
-
-
0036340074
-
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
-
Gu G, Dubauskaite J, Melton DA. 2002. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457.
-
(2002)
Development
, vol.129
, pp. 2447-2457
-
-
Gu, G.1
Dubauskaite, J.2
Melton, D.A.3
-
15
-
-
0025951092
-
Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic beta cell
-
Halban PA. 1991. Structural domains and molecular lifestyles of insulin and its precursors in the pancreatic beta cell. Diabetologia 34:767-778.
-
(1991)
Diabetologia
, vol.34
, pp. 767-778
-
-
Halban, P.A.1
-
16
-
-
28644441875
-
PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway
-
Hamanaka RB, Bennett BS, Cullinan SB, Diehl JA. 2005. PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. Mol. Biol. Cell 16: 5493-5501.
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 5493-5501
-
-
Hamanaka, R.B.1
Bennett, B.S.2
Cullinan, S.B.3
Diehl, J.A.4
-
17
-
-
10244227982
-
Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis
-
Han EK, et al. 1996. Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis. Cell Growth Differ. 7:699 -710.
-
(1996)
Cell Growth Differ.
, vol.7
-
-
Han, E.K.1
-
18
-
-
0034968330
-
Diabetes mellitus and exocrine pancreatic dysfunction in perk -/- mice reveals a role for translational control in secretory cell survival
-
Harding HP, et al. 2001. Diabetes mellitus and exocrine pancreatic dysfunction in perk -/- mice reveals a role for translational control in secretory cell survival. Mol. Cell 7:1153-1163.
-
(2001)
Mol. Cell
, vol.7
, pp. 1153-1163
-
-
Harding, H.P.1
-
19
-
-
0033634641
-
Perk is essential for translational regulation and cell survival during the unfolded protein response
-
Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D. 2000. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol. Cell 5:897-904.
-
(2000)
Mol. Cell
, vol.5
, pp. 897-904
-
-
Harding, H.P.1
Zhang, Y.2
Bertolotti, A.3
Zeng, H.4
Ron, D.5
-
20
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding HP, Zhang Y, Ron D. 1999. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397:271- 274.
-
(1999)
Nature
, vol.397
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
21
-
-
70350445980
-
Cyclin D2 protein stability is regulated in pancreatic beta-cells
-
He LM, et al. 2009. Cyclin D2 protein stability is regulated in pancreatic beta-cells. Mol. Endocrinol. 23:1865-1875.
-
(2009)
Mol. Endocrinol.
, vol.23
, pp. 1865-1875
-
-
He, L.M.1
-
22
-
-
24144479748
-
Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas
-
Holland AM, Gonez LJ, Naselli G, Macdonald RJ, Harrison LC. 2005. Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas. Diabetes 54:2586 -2595.
-
(2005)
Diabetes
, vol.54
-
-
Holland, A.M.1
Gonez, L.J.2
Naselli, G.3
Macdonald, R.J.4
Harrison, L.C.5
-
23
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil GS. 2010. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140:900 -917.
-
(2010)
Cell
, vol.140
-
-
Hotamisligil, G.S.1
-
24
-
-
36048996065
-
PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice
-
Iida K, Li Y, McGrath BC, Frank A, Cavener DR. 2007. PERK eIF2 alpha kinase is required to regulate the viability of the exocrine pancreas in mice. BMC Cell Biol. 8:38.
-
(2007)
BMC Cell Biol.
, vol.8
, pp. 38
-
-
Iida, K.1
Li, Y.2
Mcgrath, B.C.3
Frank, A.4
Cavener, D.R.5
-
25
-
-
0034677634
-
Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes
-
Koster JC, Marshall BA, Ensor N, Corbett JA, Nichols CG. 2000. Targeted overactivity of beta cell K(ATP) channels induces profound neonatal diabetes. Cell 100:645- 654.
-
(2000)
Cell
, vol.100
, pp. 645-654
-
-
Koster, J.C.1
Marshall, B.A.2
Ensor, N.3
Corbett, J.A.4
Nichols, C.G.5
-
26
-
-
33646167400
-
ER stress, hypoxia tolerance and tumor progression
-
Koumenis C. 2006. ER stress, hypoxia tolerance and tumor progression. Curr. Mol. Med. 6:55- 69.
-
(2006)
Curr. Mol. Med.
, vol.6
-
-
Koumenis, C.1
-
27
-
-
77957760755
-
Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl- CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase
-
Li C, et al. 2010. Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl- CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. J. Biol. Chem. 285:31806 -31818.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 31806-31818
-
-
Li, C.1
-
28
-
-
33744951873
-
Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice
-
Li C, et al. 2006. Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice. J. Biol. Chem. 281:15064 -15072.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 15064-15072
-
-
Li, C.1
-
29
-
-
0041814595
-
PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver
-
Li Y, et al. 2003. PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. Endocrinology 144:3505-3513.
-
(2003)
Endocrinology
, vol.144
, pp. 3505-3513
-
-
Li, Y.1
-
30
-
-
84874112079
-
The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies
-
16 April, doi:10.1038/onc.2012.130. Epub ahead of print
-
Luo B, Lee AS. 16 April 2012. The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene. doi:10.1038/onc.2012.130. [Epub ahead of print.
-
(2012)
Oncogene
-
-
Luo, B.1
Lee, A.S.2
-
31
-
-
0028891783
-
Apoptosis, oncosis, and necrosis. An overview of cell death
-
Majno G, Joris I. 1995. Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol. 146:3-15.
-
(1995)
Am. J. Pathol.
, vol.146
, pp. 3-15
-
-
Majno, G.1
Joris, I.2
-
32
-
-
79951705219
-
PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic beta- cells
-
Moore CE, Omikorede O, Gomez E, Willars GB, Herbert TP. 2011. PERK activation at low glucose concentration is mediated by SERCA pump inhibition and confers preemptive cytoprotection to pancreatic beta- cells. Mol. Endocrinol. 25:315-326.
-
(2011)
Mol. Endocrinol.
, vol.25
, pp. 315-326
-
-
Moore, C.E.1
Omikorede, O.2
Gomez, E.3
Willars, G.B.4
Herbert, T.P.5
-
33
-
-
58749114004
-
Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus
-
Remedi MS, et al. 2009. Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus. Cell Metab. 9:140 -151.
-
(2009)
Cell Metab.
, vol.9
-
-
Remedi, M.S.1
-
34
-
-
34249885603
-
Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
-
Ruzankina Y, et al. 2007. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell 1:113-126.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 113-126
-
-
Ruzankina, Y.1
-
35
-
-
0025361036
-
The involvement of calcium in transport of secretory proteins from the endoplasmic reticulum
-
Sambrook JF. 1990. The involvement of calcium in transport of secretory proteins from the endoplasmic reticulum. Cell 61:197-199.
-
(1990)
Cell
, vol.61
, pp. 197-199
-
-
Sambrook, J.F.1
-
36
-
-
0034973982
-
Translational control is required for the unfolded protein response and in vivo glucose homeostasis
-
Scheuner D, et al. 2001. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol. Cell 7:1165-1176.
-
(2001)
Mol. Cell
, vol.7
, pp. 1165-1176
-
-
Scheuner, D.1
-
37
-
-
3042696843
-
Wolcott-Rallison syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity
-
Senée V, et al. 2004. Wolcott-Rallison syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity. Diabetes 53:1876 -1883.
-
(2004)
Diabetes
, vol.53
-
-
Senée, V.1
-
38
-
-
0028171292
-
G1 phase progression: cycling on cue
-
Sherr CJ. 1994. G1 phase progression: cycling on cue. Cell 79:551-555.
-
(1994)
Cell
, vol.79
, pp. 551-555
-
-
Sherr, C.J.1
-
39
-
-
84856523394
-
Regulated and reversible induction of adult human beta-cell replication
-
Takane KK, Kleinberger JW, Salim FG, Fiaschi-Taesch NM, Stewart AF. 2012. Regulated and reversible induction of adult human beta-cell replication. Diabetes 61:418-424.
-
(2012)
Diabetes
, vol.61
, pp. 418-424
-
-
Takane, K.K.1
Kleinberger, J.W.2
Salim, F.G.3
Fiaschi-taesch, N.M.4
Stewart, A.F.5
-
40
-
-
24144473869
-
Very slow turnover of beta-cells in aged adult mice
-
Teta M, Long SY, Wartschow LM, Rankin MM, Kushner JA. 2005. Very slow turnover of beta-cells in aged adult mice. Diabetes 54:2557-2567.
-
(2005)
Diabetes
, vol.54
, pp. 2557-2567
-
-
Teta, M.1
Long, S.Y.2
Wartschow, L.M.3
Rankin, M.M.4
Kushner, J.A.5
-
41
-
-
79952844773
-
The unfolded protein response, degradation from endoplasmic reticulum, and cancer
-
Tsai YC, Weissman AM. 2010. The unfolded protein response, degradation from endoplasmic reticulum, and cancer. Genes Cancer 1:764 -778.
-
(2010)
Genes Cancer
, vol.1
, pp. 764-778
-
-
Tsai, Y.C.1
Weissman, A.M.2
-
42
-
-
0036091476
-
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas
-
Zhang P, et al. 2002. The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol. Cell. Biol. 22:3864- 3874.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 3864-3874
-
-
Zhang, P.1
-
43
-
-
33751430251
-
PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis
-
Zhang W, et al. 2006. PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis. Cell Metab. 4:491- 497.
-
(2006)
Cell Metab.
, vol.4
-
-
Zhang, W.1
|