메뉴 건너뛰기




Volumn 18, Issue 12, 2013, Pages 1447-1468

Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers

Author keywords

Cancer; Fibroblast growth factor receptors; Signal transduction; Targeted therapy

Indexed keywords

AZD 4547; BRIVANIB; DOVITINIB; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 16; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 21; FIBROBLAST GROWTH FACTOR 23; FIBROBLAST GROWTH FACTOR 3; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTOR 5; FIBROBLAST GROWTH FACTOR 6; FIBROBLAST GROWTH FACTOR 9; FIBROBLAST GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FIBROBLAST GROWTH FACTOR RECEPTOR 4; FIBROBLAST GROWTH FACTOR RECEPTOR 5; KERATINOCYTE GROWTH FACTOR; LENVATINIB; NINTEDANIB; PONATINIB; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE SHP; RABEPRAZOLE; UBIQUITIN PROTEIN LIGASE E3; VELAFERMIN;

EID: 84889080157     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0886-7     Document Type: Article
Times cited : (136)

References (306)
  • 1
    • 79953718346 scopus 로고    scopus 로고
    • Biology of FGFRL1, the fifth fibroblast growth factor receptor
    • 10.1007/s00018-010-0576-3 21080029 1:CAS:528:DC%2BC3MXit1Kls74%3D
    • Trueb B (2011) Biology of FGFRL1, the fifth fibroblast growth factor receptor. Cell Mol Life Sci 68(6):951-964. doi: 10.1007/s00018-010-0576-3
    • (2011) Cell Mol Life Sci , vol.68 , Issue.6 , pp. 951-964
    • Trueb, B.1
  • 2
    • 27744534898 scopus 로고    scopus 로고
    • Functions and regulations of fibroblast growth factor signaling during embryonic development
    • 10.1016/j.ydbio.2005.09.011 16216232 1:CAS:528:DC%2BD2MXht1GhtL%2FF
    • Thisse B, Thisse C (2005) Functions and regulations of fibroblast growth factor signaling during embryonic development. Dev Biol 287(2):390-402. doi: 10.1016/j.ydbio.2005.09.011
    • (2005) Dev Biol , vol.287 , Issue.2 , pp. 390-402
    • Thisse, B.1    Thisse, C.2
  • 3
    • 79959713140 scopus 로고    scopus 로고
    • Fibroblast growth factors and their receptors in cancer
    • 10.1042/BJ20101603 21711248 1:CAS:528:DC%2BC3MXotFSmtbc%3D
    • Wesche J, Haglund K, Haugsten EM (2011) Fibroblast growth factors and their receptors in cancer. Biochem J 437(2):199-213. doi: 10.1042/BJ20101603
    • (2011) Biochem J , vol.437 , Issue.2 , pp. 199-213
    • Wesche, J.1    Haglund, K.2    Haugsten, E.M.3
  • 4
    • 78649679778 scopus 로고    scopus 로고
    • Roles of fibroblast growth factor receptors in carcinogenesis
    • 10.1158/1541-7786.MCR-10-0168 21047773 1:CAS:528:DC%2BC3cXhsVOktLnF
    • Haugsten EM, Wiedlocha A, Olsnes S, Wesche J (2010) Roles of fibroblast growth factor receptors in carcinogenesis. Mol Cancer Res 8(11):1439-1452. doi: 10.1158/1541-7786.MCR-10-0168
    • (2010) Mol Cancer Res , vol.8 , Issue.11 , pp. 1439-1452
    • Haugsten, E.M.1    Wiedlocha, A.2    Olsnes, S.3    Wesche, J.4
  • 5
    • 0027344852 scopus 로고
    • Structural and functional diversity in the FGF receptor multigene family
    • 8417497 1:CAS:528:DyaK3sXksVWrurc%3D
    • Johnson DE, Williams LT (1993) Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res 60:1-41
    • (1993) Adv Cancer Res , vol.60 , pp. 1-41
    • Johnson, D.E.1    Williams, L.T.2
  • 6
    • 0035023788 scopus 로고    scopus 로고
    • Modulation of intracellular transport of acidic fibroblast growth factor by mutations in the cytoplasmic receptor domain
    • 11398757 1:CAS:528:DC%2BD3MXjslyqurs%3D
    • Citores L, Khnykin D, Sorensen V, Wesche J, Klingenberg O, Wiedlocha A, Olsnes S (2001) Modulation of intracellular transport of acidic fibroblast growth factor by mutations in the cytoplasmic receptor domain. J Cell Sci 114(Pt 9):1677-1689
    • (2001) J Cell Sci , vol.114 , Issue.PART 9 , pp. 1677-1689
    • Citores, L.1    Khnykin, D.2    Sorensen, V.3    Wesche, J.4    Klingenberg, O.5    Wiedlocha, A.6    Olsnes, S.7
  • 7
    • 0025122589 scopus 로고
    • Diverse forms of a receptor for acidic and basic fibroblast growth factors
    • 2167437 1:CAS:528:DyaK3MXlslKlsA%3D%3D
    • Johnson DE, Lee PL, Lu J, Williams LT (1990) Diverse forms of a receptor for acidic and basic fibroblast growth factors. Mol Cell Biol 10(9):4728-4736
    • (1990) Mol Cell Biol , vol.10 , Issue.9 , pp. 4728-4736
    • Johnson, D.E.1    Lee, P.L.2    Lu, J.3    Williams, L.T.4
  • 9
    • 0025058569 scopus 로고
    • Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain
    • 1689490 1:CAS:528:DyaK3cXksFensr0%3D
    • Reid HH, Wilks AF, Bernard O (1990) Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain. Proc Natl Acad Sci USA 87(4):1596-1600
    • (1990) Proc Natl Acad Sci USA , vol.87 , Issue.4 , pp. 1596-1600
    • Reid, H.H.1    Wilks, A.F.2    Bernard, O.3
  • 10
    • 0025032508 scopus 로고
    • Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors
    • 1697263 1:CAS:528:DyaK3MXhvVyitw%3D%3D
    • Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J (1990) Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J 9(9):2685-2692
    • (1990) EMBO J , vol.9 , Issue.9 , pp. 2685-2692
    • Dionne, C.A.1    Crumley, G.2    Bellot, F.3    Kaplow, J.M.4    Searfoss, G.5    Ruta, M.6    Burgess, W.H.7    Jaye, M.8    Schlessinger, J.9
  • 11
    • 0026347294 scopus 로고
    • High-affinity binding and activation of a truncated FGF receptor by both aFGF and bFGF
    • 1722570 1:CAS:528:DyaK38XhtVSnur8%3D
    • Crumley G, Bellot F, Kaplow JM, Schlessinger J, Jaye M, Dionne CA (1991) High-affinity binding and activation of a truncated FGF receptor by both aFGF and bFGF. Oncogene 6(12):2255-2262
    • (1991) Oncogene , vol.6 , Issue.12 , pp. 2255-2262
    • Crumley, G.1    Bellot, F.2    Kaplow, J.M.3    Schlessinger, J.4    Jaye, M.5    Dionne, C.A.6
  • 12
    • 0035815704 scopus 로고    scopus 로고
    • A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells
    • 10.1074/jbc.M003535200 11134040 1:CAS:528:DC%2BD3MXjvFGjsr0%3D
    • Shimizu A, Tada K, Shukunami C, Hiraki Y, Kurokawa T, Magane N, Kurokawa-Seo M (2001) A novel alternatively spliced fibroblast growth factor receptor 3 isoform lacking the acid box domain is expressed during chondrogenic differentiation of ATDC5 cells. J Biol Chem 276(14):11031-11040. doi: 10.1074/jbc.M003535200
    • (2001) J Biol Chem , vol.276 , Issue.14 , pp. 11031-11040
    • Shimizu, A.1    Tada, K.2    Shukunami, C.3    Hiraki, Y.4    Kurokawa, T.5    Magane, N.6    Kurokawa-Seo, M.7
  • 13
    • 0025912340 scopus 로고
    • The human fibroblast growth factor receptor genes: A common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain
    • 1652059 1:CAS:528:DyaK3MXlslKnurk%3D
    • Johnson DE, Lu J, Chen H, Werner S, Williams LT (1991) The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domain. Mol Cell Biol 11(9):4627-4634
    • (1991) Mol Cell Biol , vol.11 , Issue.9 , pp. 4627-4634
    • Johnson, D.E.1    Lu, J.2    Chen, H.3    Werner, S.4    Williams, L.T.5
  • 14
    • 0026739404 scopus 로고
    • A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity
    • 1400433 1:CAS:528:DyaK3sXktVWhtrc%3D
    • Dell KR, Williams LT (1992) A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity. J Biol Chem 267(29):21225-21229
    • (1992) J Biol Chem , vol.267 , Issue.29 , pp. 21225-21229
    • Dell, K.R.1    Williams, L.T.2
  • 15
    • 0026514045 scopus 로고
    • Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities
    • 1309595 1:STN:280:DyaK387gslajsg%3D%3D
    • Werner S, Duan DS, de Vries C, Peters KG, Johnson DE, Williams LT (1992) Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities. Mol Cell Biol 12(1):82-88
    • (1992) Mol Cell Biol , vol.12 , Issue.1 , pp. 82-88
    • Werner, S.1    Duan, D.S.2    De Vries, C.3    Peters, K.G.4    Johnson, D.E.5    Williams, L.T.6
  • 16
    • 0027255139 scopus 로고
    • A novel form of FGF receptor-3 using an alternative exon in the immunoglobulin domain III
    • 8375495 1:CAS:528:DyaK2cXntVc%3D
    • Avivi A, Yayon A, Givol D (1993) A novel form of FGF receptor-3 using an alternative exon in the immunoglobulin domain III. FEBS Lett 330(3):249-252
    • (1993) FEBS Lett , vol.330 , Issue.3 , pp. 249-252
    • Avivi, A.1    Yayon, A.2    Givol, D.3
  • 17
    • 0028239789 scopus 로고
    • Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1
    • 7512569 1:CAS:528:DyaK2cXkt12gtr4%3D
    • Chellaiah AT, McEwen DG, Werner S, Xu J, Ornitz DM (1994) Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1. J Biol Chem 269(15):11620-11627
    • (1994) J Biol Chem , vol.269 , Issue.15 , pp. 11620-11627
    • Chellaiah, A.T.1    McEwen, D.G.2    Werner, S.3    Xu, J.4    Ornitz, D.M.5
  • 18
    • 0026481988 scopus 로고
    • Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction
    • 1385111 1:CAS:528:DyaK3sXkvVKgu78%3D
    • Vainikka S, Partanen J, Bellosta P, Coulier F, Birnbaum D, Basilico C, Jaye M, Alitalo K (1992) Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction. EMBO J 11(12):4273-4280
    • (1992) EMBO J , vol.11 , Issue.12 , pp. 4273-4280
    • Vainikka, S.1    Partanen, J.2    Bellosta, P.3    Coulier, F.4    Birnbaum, D.5    Basilico, C.6    Jaye, M.7    Alitalo, K.8
  • 20
    • 0025941527 scopus 로고
    • A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1
    • 1656221 1:CAS:528:DyaK3MXmslSqu7s%3D
    • Mohammadi M, Honegger AM, Rotin D, Fischer R, Bellot F, Li W, Dionne CA, Jaye M, Rubinstein M, Schlessinger J (1991) A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Mol Cell Biol 11(10):5068-5078
    • (1991) Mol Cell Biol , vol.11 , Issue.10 , pp. 5068-5078
    • Mohammadi, M.1    Honegger, A.M.2    Rotin, D.3    Fischer, R.4    Bellot, F.5    Li, W.6    Dionne, C.A.7    Jaye, M.8    Rubinstein, M.9    Schlessinger, J.10
  • 21
    • 0027397544 scopus 로고
    • Inositol trisphosphate and calcium signalling
    • 10.1038/361315a0 8381210 1:CAS:528:DyaK3sXhvVGrt7o%3D
    • Berridge MJ (1993) Inositol trisphosphate and calcium signalling. Nature 361(6410):315-325. doi: 10.1038/361315a0
    • (1993) Nature , vol.361 , Issue.6410 , pp. 315-325
    • Berridge, M.J.1
  • 22
    • 0036679107 scopus 로고    scopus 로고
    • The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells
    • 10.1091/mbc.E02-02-0103 12181353 1:CAS:528:DC%2BD38XmsVKlsb8%3D
    • Cross MJ, Lu L, Magnusson P, Nyqvist D, Holmqvist K, Welsh M, Claesson-Welsh L (2002) The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells. Mol Biol Cell 13(8):2881-2893. doi: 10.1091/mbc.E02-02-0103
    • (2002) Mol Biol Cell , vol.13 , Issue.8 , pp. 2881-2893
    • Cross, M.J.1    Lu, L.2    Magnusson, P.3    Nyqvist, D.4    Holmqvist, K.5    Welsh, M.6    Claesson-Welsh, L.7
  • 23
    • 0033520278 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk
    • 10464310 1:CAS:528:DyaK1MXmtVWhsLo%3D
    • Larsson H, Klint P, Landgren E, Claesson-Welsh L (1999) Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. J Biol Chem 274(36):25726-25734
    • (1999) J Biol Chem , vol.274 , Issue.36 , pp. 25726-25734
    • Larsson, H.1    Klint, P.2    Landgren, E.3    Claesson-Welsh, L.4
  • 24
    • 0028122971 scopus 로고
    • CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells
    • 8035825 1:CAS:528:DyaK2cXltVSltLk%3D
    • Matsuda M, Hashimoto Y, Muroya K, Hasegawa H, Kurata T, Tanaka S, Nakamura S, Hattori S (1994) CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cells. Mol Cell Biol 14(8):5495-5500
    • (1994) Mol Cell Biol , vol.14 , Issue.8 , pp. 5495-5500
    • Matsuda, M.1    Hashimoto, Y.2    Muroya, K.3    Hasegawa, H.4    Kurata, T.5    Tanaka, S.6    Nakamura, S.7    Hattori, S.8
  • 26
    • 0029926307 scopus 로고    scopus 로고
    • DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane
    • 8657152 1:CAS:528:DyaK28XhvVags7c%3D
    • Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, Kurata T, Matsuda M (1996) DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. Mol Cell Biol 16(4):1770-1776
    • (1996) Mol Cell Biol , vol.16 , Issue.4 , pp. 1770-1776
    • Hasegawa, H.1    Kiyokawa, E.2    Tanaka, S.3    Nagashima, K.4    Gotoh, N.5    Shibuya, M.6    Kurata, T.7    Matsuda, M.8
  • 27
    • 0029070887 scopus 로고
    • Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
    • 7600582 1:CAS:528:DyaK2MXms1Kmt7c%3D
    • Minden A, Lin A, Claret FX, Abo A, Karin M (1995) Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81(7):1147-1157
    • (1995) Cell , vol.81 , Issue.7 , pp. 1147-1157
    • Minden, A.1    Lin, A.2    Claret, F.X.3    Abo, A.4    Karin, M.5
  • 29
    • 0032416722 scopus 로고    scopus 로고
    • The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway
    • 9860979 1:CAS:528:DyaK1MXhvFaluw%3D%3D
    • Dolfi F, Garcia-Guzman M, Ojaniemi M, Nakamura H, Matsuda M, Vuori K (1998) The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway. Proc Natl Acad Sci USA 95(26):15394-15399
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.26 , pp. 15394-15399
    • Dolfi, F.1    Garcia-Guzman, M.2    Ojaniemi, M.3    Nakamura, H.4    Matsuda, M.5    Vuori, K.6
  • 31
    • 0031941567 scopus 로고    scopus 로고
    • Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases
    • 9430657 1:CAS:528:DyaK1cXktFCruw%3D%3D
    • Tanaka S, Hanafusa H (1998) Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases. J Biol Chem 273(3):1281-1284
    • (1998) J Biol Chem , vol.273 , Issue.3 , pp. 1281-1284
    • Tanaka, S.1    Hanafusa, H.2
  • 32
    • 0030706168 scopus 로고    scopus 로고
    • A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
    • 9182757 1:CAS:528:DyaK2sXjs1ejs78%3D
    • Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J (1997) A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell 89(5):693-702
    • (1997) Cell , vol.89 , Issue.5 , pp. 693-702
    • Kouhara, H.1    Hadari, Y.R.2    Spivak-Kroizman, T.3    Schilling, J.4    Bar-Sagi, D.5    Lax, I.6    Schlessinger, J.7
  • 33
    • 1842850649 scopus 로고    scopus 로고
    • FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts
    • 10.1016/S0014-5793(04)00287-X 15094036 1:CAS:528:DC%2BD2cXjt1Cgtb4%3D
    • Gotoh N, Laks S, Nakashima M, Lax I, Schlessinger J (2004) FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. FEBS Lett 564(1-2):14-18. doi: 10.1016/S0014-5793(04)00287-X
    • (2004) FEBS Lett , vol.564 , Issue.1-2 , pp. 14-18
    • Gotoh, N.1    Laks, S.2    Nakashima, M.3    Lax, I.4    Schlessinger, J.5
  • 34
    • 0031835659 scopus 로고    scopus 로고
    • Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
    • 9632781 1:CAS:528:DyaK1cXkt1WjsL4%3D
    • Hadari YR, Kouhara H, Lax I, Schlessinger J (1998) Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol Cell Biol 18(7):3966-3973
    • (1998) Mol Cell Biol , vol.18 , Issue.7 , pp. 3966-3973
    • Hadari, Y.R.1    Kouhara, H.2    Lax, I.3    Schlessinger, J.4
  • 35
    • 24044544231 scopus 로고    scopus 로고
    • Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells
    • 10.1074/jbc.M411356200 15738000 1:CAS:528:DC%2BD2MXjsl2htLg%3D
    • Harada A, Katoh H, Negishi M (2005) Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells. J Biol Chem 280(18):18418-18424. doi: 10.1074/jbc.M411356200
    • (2005) J Biol Chem , vol.280 , Issue.18 , pp. 18418-18424
    • Harada, A.1    Katoh, H.2    Negishi, M.3
  • 36
    • 0035933094 scopus 로고    scopus 로고
    • Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins
    • 10.1073/pnas.111114298 11353842 1:STN:280:DC%2BD3M3pt1Wmtg%3D%3D
    • Ong SH, Hadari YR, Gotoh N, Guy GR, Schlessinger J, Lax I (2001) Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc Natl Acad Sci USA 98(11):6074-6079. doi: 10.1073/pnas.111114298
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.11 , pp. 6074-6079
    • Ong, S.H.1    Hadari, Y.R.2    Gotoh, N.3    Guy, G.R.4    Schlessinger, J.5    Lax, I.6
  • 37
    • 0037076329 scopus 로고    scopus 로고
    • FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl
    • 10.1073/pnas.052138899 11997436 1:CAS:528:DC%2BD38XjvFCrsL4%3D
    • Wong A, Lamothe B, Lee A, Schlessinger J, Lax I (2002) FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl. Proc Natl Acad Sci USA 99(10):6684-6689. doi: 10.1073/pnas.052138899
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.10 , pp. 6684-6689
    • Wong, A.1    Lamothe, B.2    Lee, A.3    Schlessinger, J.4    Lax, I.5
  • 38
    • 0030027488 scopus 로고    scopus 로고
    • Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction
    • 8622701 1:CAS:528:DyaK28XhtFOlsr0%3D
    • Mohammadi M, Dikic I, Sorokin A, Burgess WH, Jaye M, Schlessinger J (1996) Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol Cell Biol 16(3):977-989
    • (1996) Mol Cell Biol , vol.16 , Issue.3 , pp. 977-989
    • Mohammadi, M.1    Dikic, I.2    Sorokin, A.3    Burgess, W.H.4    Jaye, M.5    Schlessinger, J.6
  • 39
    • 0033594971 scopus 로고    scopus 로고
    • Comparison of the intracellular signaling responses by three chimeric fibroblast growth factor receptors in PC12 cells
    • 10377388 1:CAS:528:DyaK1MXltVOrtLg%3D
    • Raffioni S, Thomas D, Foehr ED, Thompson LM, Bradshaw RA (1999) Comparison of the intracellular signaling responses by three chimeric fibroblast growth factor receptors in PC12 cells. Proc Natl Acad Sci USA 96(13):7178-7183
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.13 , pp. 7178-7183
    • Raffioni, S.1    Thomas, D.2    Foehr, E.D.3    Thompson, L.M.4    Bradshaw, R.A.5
  • 40
    • 0027955135 scopus 로고
    • Fibroblast growth factor receptors have different signaling and mitogenic potentials
    • 8264585 1:CAS:528:DyaK2cXmvFyqsQ%3D%3D
    • Wang JK, Gao G, Goldfarb M (1994) Fibroblast growth factor receptors have different signaling and mitogenic potentials. Mol Cell Biol 14(1):181-188
    • (1994) Mol Cell Biol , vol.14 , Issue.1 , pp. 181-188
    • Wang, J.K.1    Gao, G.2    Goldfarb, M.3
  • 41
    • 0028817834 scopus 로고
    • Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells
    • 7559490 1:CAS:528:DyaK2MXos1eitb8%3D
    • Klint P, Kanda S, Claesson-Welsh L (1995) Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells. J Biol Chem 270(40):23337-23344
    • (1995) J Biol Chem , vol.270 , Issue.40 , pp. 23337-23344
    • Klint, P.1    Kanda, S.2    Claesson-Welsh, L.3
  • 42
    • 0028236448 scopus 로고
    • Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells
    • 7514169 1:CAS:528:DyaK2cXjtFKjtrg%3D
    • Spivak-Kroizman T, Mohammadi M, Hu P, Jaye M, Schlessinger J, Lax I (1994) Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells. J Biol Chem 269(20):14419-14423
    • (1994) J Biol Chem , vol.269 , Issue.20 , pp. 14419-14423
    • Spivak-Kroizman, T.1    Mohammadi, M.2    Hu, P.3    Jaye, M.4    Schlessinger, J.5    Lax, I.6
  • 43
    • 0031786017 scopus 로고    scopus 로고
    • FGF signal transduction in PC12 cells: Comparison of the responses induced by endogenous and chimeric receptors
    • 10.1046/j.1440-1711.1998.00775.x 9797459 1:CAS:528:DyaK1cXntFGitLY%3D
    • Foehr ED, Raffioni S, Fuji R, Bradshaw RA (1998) FGF signal transduction in PC12 cells: comparison of the responses induced by endogenous and chimeric receptors. Immunol Cell Biol 76(5):406-413. doi: 10.1046/j.1440-1711.1998.00775. x
    • (1998) Immunol Cell Biol , vol.76 , Issue.5 , pp. 406-413
    • Foehr, E.D.1    Raffioni, S.2    Fuji, R.3    Bradshaw, R.A.4
  • 45
    • 58149289662 scopus 로고    scopus 로고
    • Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2)
    • 10.1042/BJ20080887 18840094 1:CAS:528:DC%2BD1cXhtlGls7bJ
    • Schuller AC, Ahmed Z, Levitt JA, Suen KM, Suhling K, Ladbury JE (2008) Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2). Biochem J 416(2):189-199. doi: 10.1042/BJ20080887
    • (2008) Biochem J , vol.416 , Issue.2 , pp. 189-199
    • Schuller, A.C.1    Ahmed, Z.2    Levitt, J.A.3    Suen, K.M.4    Suhling, K.5    Ladbury, J.E.6
  • 46
    • 0036683516 scopus 로고    scopus 로고
    • Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity
    • 12145206 1:CAS:528:DC%2BD38XnvVGntbc%3D
    • Skjerpen CS, Nilsen T, Wesche J, Olsnes S (2002) Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity. EMBO J 21(15):4058-4069
    • (2002) EMBO J , vol.21 , Issue.15 , pp. 4058-4069
    • Skjerpen, C.S.1    Nilsen, T.2    Wesche, J.3    Olsnes, S.4
  • 47
    • 0030896404 scopus 로고    scopus 로고
    • Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
    • 10.1038/386288a0 9069288 1:CAS:528:DyaK2sXitVKhsLk%3D
    • Su WC, Kitagawa M, Xue N, Xie B, Garofalo S, Cho J, Deng C, Horton WA, Fu XY (1997) Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature 386(6622):288-292. doi: 10.1038/386288a0
    • (1997) Nature , vol.386 , Issue.6622 , pp. 288-292
    • Su, W.C.1    Kitagawa, M.2    Xue, N.3    Xie, B.4    Garofalo, S.5    Cho, J.6    Deng, C.7    Horton, W.A.8    Fu, X.Y.9
  • 48
    • 0032938128 scopus 로고    scopus 로고
    • A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors
    • 9887329 1:CAS:528:DyaK1MXoslemsQ%3D%3D
    • Li C, Chen L, Iwata T, Kitagawa M, Fu XY, Deng CX (1999) A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum Mol Genet 8(1):35-44
    • (1999) Hum Mol Genet , vol.8 , Issue.1 , pp. 35-44
    • Li, C.1    Chen, L.2    Iwata, T.3    Kitagawa, M.4    Fu, X.Y.5    Deng, C.X.6
  • 49
    • 0034612592 scopus 로고    scopus 로고
    • Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4
    • 10.1038/sj.onc.1203650 10918587 1:CAS:528:DC%2BD3cXltlKnt78%3D
    • Hart KC, Robertson SC, Kanemitsu MY, Meyer AN, Tynan JA, Donoghue DJ (2000) Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene 19(29):3309-3320. doi: 10.1038/sj.onc.1203650
    • (2000) Oncogene , vol.19 , Issue.29 , pp. 3309-3320
    • Hart, K.C.1    Robertson, S.C.2    Kanemitsu, M.Y.3    Meyer, A.N.4    Tynan, J.A.5    Donoghue, D.J.6
  • 50
    • 77951043677 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplification
    • 10.1158/0008-5472.CAN-09-3033 20388777 1:CAS:528:DC%2BC3cXkslSgs74%3D
    • Dudka AA, Sweet SM, Heath JK (2010) Signal transducers and activators of transcription-3 binding to the fibroblast growth factor receptor is activated by receptor amplification. Cancer Res 70(8):3391-3401. doi: 10.1158/0008-5472.CAN- 09-3033
    • (2010) Cancer Res , vol.70 , Issue.8 , pp. 3391-3401
    • Dudka, A.A.1    Sweet, S.M.2    Heath, J.K.3
  • 51
    • 77956565517 scopus 로고    scopus 로고
    • Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo
    • 10.1016/j.devcel.2010.08.007 20833364 1:CAS:528:DC%2BC3cXhtFGht73E
    • Jean S, Mikryukov A, Tremblay MG, Baril J, Guillou F, Bellenfant S, Moss T (2010) Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo. Dev Cell 19(3):426-439. doi: 10.1016/j.devcel.2010.08.007
    • (2010) Dev Cell , vol.19 , Issue.3 , pp. 426-439
    • Jean, S.1    Mikryukov, A.2    Tremblay, M.G.3    Baril, J.4    Guillou, F.5    Bellenfant, S.6    Moss, T.7
  • 52
    • 26244457001 scopus 로고    scopus 로고
    • Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors
    • 10.1242/jcs.02509 16091423 1:CAS:528:DC%2BD2MXhtVOqtr7K
    • Haugsten EM, Sorensen V, Brech A, Olsnes S, Wesche J (2005) Different intracellular trafficking of FGF1 endocytosed by the four homologous FGF receptors. J Cell Sci 118(Pt 17):3869-3881. doi: 10.1242/jcs.02509
    • (2005) J Cell Sci , vol.118 , Issue.PART 17 , pp. 3869-3881
    • Haugsten, E.M.1    Sorensen, V.2    Brech, A.3    Olsnes, S.4    Wesche, J.5
  • 53
    • 54249152045 scopus 로고    scopus 로고
    • Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis
    • 10.1091/mbc.E07-12-1219 18480409 1:CAS:528:DC%2BD1cXpvV2hs7s%3D
    • Haugsten EM, Malecki J, Bjorklund SM, Olsnes S, Wesche J (2008) Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis. Mol Biol Cell 19(8):3390-3403. doi: 10.1091/mbc.E07-12-1219
    • (2008) Mol Biol Cell , vol.19 , Issue.8 , pp. 3390-3403
    • Haugsten, E.M.1    Malecki, J.2    Bjorklund, S.M.3    Olsnes, S.4    Wesche, J.5
  • 54
    • 0035824694 scopus 로고    scopus 로고
    • Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation
    • 10.1074/jbc.M108234200 11585837 1:CAS:528:DC%2BD3MXptVymu74%3D
    • Gross I, Bassit B, Benezra M, Licht JD (2001) Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation. J Biol Chem 276(49):46460-46468. doi: 10.1074/jbc.M108234200
    • (2001) J Biol Chem , vol.276 , Issue.49 , pp. 46460-46468
    • Gross, I.1    Bassit, B.2    Benezra, M.3    Licht, J.D.4
  • 55
    • 0035809919 scopus 로고    scopus 로고
    • Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells
    • 11238463 1:CAS:528:DC%2BD3MXhslGmu78%3D
    • Impagnatiello MA, Weitzer S, Gannon G, Compagni A, Cotten M, Christofori G (2001) Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells. J Cell Biol 152(5):1087-1098
    • (2001) J Cell Biol , vol.152 , Issue.5 , pp. 1087-1098
    • Impagnatiello, M.A.1    Weitzer, S.2    Gannon, G.3    Compagni, A.4    Cotten, M.5    Christofori, G.6
  • 56
    • 0036479310 scopus 로고    scopus 로고
    • Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf
    • 10.1074/jbc.M108368200 11698404 1:CAS:528:DC%2BD38XhtVaks7s%3D
    • Yusoff P, Lao DH, Ong SH, Wong ES, Lim J, Lo TL, Leong HF, Fong CW, Guy GR (2002) Sprouty2 inhibits the Ras/MAP kinase pathway by inhibiting the activation of Raf. J Biol Chem 277(5):3195-3201. doi: 10.1074/jbc.M108368200
    • (2002) J Biol Chem , vol.277 , Issue.5 , pp. 3195-3201
    • Yusoff, P.1    Lao, D.H.2    Ong, S.H.3    Wong, E.S.4    Lim, J.5    Lo, T.L.6    Leong, H.F.7    Fong, C.W.8    Guy, G.R.9
  • 57
    • 0032841608 scopus 로고    scopus 로고
    • Sprouty is a general inhibitor of receptor tyrosine kinase signaling
    • 10457022 1:CAS:528:DyaK1MXmsleqtr4%3D
    • Reich A, Sapir A, Shilo B (1999) Sprouty is a general inhibitor of receptor tyrosine kinase signaling. Development 126(18):4139-4147
    • (1999) Development , vol.126 , Issue.18 , pp. 4139-4147
    • Reich, A.1    Sapir, A.2    Shilo, B.3
  • 58
    • 0033525895 scopus 로고    scopus 로고
    • Sprouty, an intracellular inhibitor of Ras signaling
    • 10089881 1:CAS:528:DyaK1MXitVChsrY%3D
    • Casci T, Vinos J, Freeman M (1999) Sprouty, an intracellular inhibitor of Ras signaling. Cell 96(5):655-665
    • (1999) Cell , vol.96 , Issue.5 , pp. 655-665
    • Casci, T.1    Vinos, J.2    Freeman, M.3
  • 59
    • 12344278405 scopus 로고    scopus 로고
    • FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity
    • 10.1242/jcs.01519 15564375 1:CAS:528:DC%2BD2MXnvFagtA%3D%3D
    • Li X, Brunton VG, Burgar HR, Wheldon LM, Heath JK (2004) FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity. J Cell Sci 117(Pt 25):6007-6017. doi: 10.1242/jcs.01519
    • (2004) J Cell Sci , vol.117 , Issue.PART 25 , pp. 6007-6017
    • Li, X.1    Brunton, V.G.2    Burgar, H.R.3    Wheldon, L.M.4    Heath, J.K.5
  • 60
    • 30644457873 scopus 로고    scopus 로고
    • Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms
    • 10.1242/jcs.02711 16339969 1:CAS:528:DC%2BD28XosFeksg%3D%3D
    • Ozaki K, Miyazaki S, Tanimura S, Kohno M (2005) Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms. J Cell Sci 118(Pt 24):5861-5871. doi: 10.1242/jcs.02711
    • (2005) J Cell Sci , vol.118 , Issue.PART 24 , pp. 5861-5871
    • Ozaki, K.1    Miyazaki, S.2    Tanimura, S.3    Kohno, M.4
  • 61
    • 33749582985 scopus 로고    scopus 로고
    • A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation
    • 10.1074/jbc.M604044200 16893902 1:CAS:528:DC%2BD28XhtVahsb3E
    • Lao DH, Chandramouli S, Yusoff P, Fong CW, Saw TY, Tai LP, Yu CY, Leong HF, Guy GR (2006) A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation. J Biol Chem 281(40):29993-30000. doi: 10.1074/jbc.M604044200
    • (2006) J Biol Chem , vol.281 , Issue.40 , pp. 29993-30000
    • Lao, D.H.1    Chandramouli, S.2    Yusoff, P.3    Fong, C.W.4    Saw, T.Y.5    Tai, L.P.6    Yu, C.Y.7    Leong, H.F.8    Guy, G.R.9
  • 62
    • 30444441147 scopus 로고    scopus 로고
    • Sprouty proteins: Multifaceted negative-feedback regulators of receptor tyrosine kinase signaling
    • 10.1016/j.tcb.2005.11.004 16337795 1:CAS:528:DC%2BD28XksVamsA%3D%3D
    • Mason JM, Morrison DJ, Basson MA, Licht JD (2006) Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends Cell Biol 16(1):45-54. doi: 10.1016/j.tcb.2005.11.004
    • (2006) Trends Cell Biol , vol.16 , Issue.1 , pp. 45-54
    • Mason, J.M.1    Morrison, D.J.2    Basson, M.A.3    Licht, J.D.4
  • 63
    • 0036847930 scopus 로고    scopus 로고
    • Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
    • 10.1038/ncb867 12402043 1:CAS:528:DC%2BD3sXhtVKmsw%3D%3D
    • Hanafusa H, Torii S, Yasunaga T, Nishida E (2002) Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nat Cell Biol 4(11):850-858. doi: 10.1038/ncb867
    • (2002) Nat Cell Biol , vol.4 , Issue.11 , pp. 850-858
    • Hanafusa, H.1    Torii, S.2    Yasunaga, T.3    Nishida, E.4
  • 64
    • 0035830916 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by a mouse sprouty protein
    • 10.1074/jbc.M006922200 11053436 1:CAS:528:DC%2BD3MXht1Gnsr4%3D
    • Lee SH, Schloss DJ, Jarvis L, Krasnow MA, Swain JL (2001) Inhibition of angiogenesis by a mouse sprouty protein. J Biol Chem 276(6):4128-4133. doi: 10.1074/jbc.M006922200
    • (2001) J Biol Chem , vol.276 , Issue.6 , pp. 4128-4133
    • Lee, S.H.1    Schloss, D.J.2    Jarvis, L.3    Krasnow, M.A.4    Swain, J.L.5
  • 65
    • 34548502506 scopus 로고    scopus 로고
    • Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction
    • 10.1016/j.cellsig.2007.07.008 17689925 1:CAS:528:DC%2BD2sXhtVWmtbrN
    • Martinez N, Garcia-Dominguez CA, Domingo B, Oliva JL, Zarich N, Sanchez A, Gutierrez-Eisman S, Llopis J, Rojas JM (2007) Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction. Cell Signal 19(11):2277-2285. doi: 10.1016/j.cellsig.2007.07.008
    • (2007) Cell Signal , vol.19 , Issue.11 , pp. 2277-2285
    • Martinez, N.1    Garcia-Dominguez, C.A.2    Domingo, B.3    Oliva, J.L.4    Zarich, N.5    Sanchez, A.6    Gutierrez-Eisman, S.7    Llopis, J.8    Rojas, J.M.9
  • 66
    • 2342453888 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: A dual feedback loop
    • 10.1091/mbc.E03-07-0503 15004239 1:CAS:528:DC%2BD2cXjvFKjt7o%3D
    • Mason JM, Morrison DJ, Bassit B, Dimri M, Band H, Licht JD, Gross I (2004) Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop. Mol Biol Cell 15(5):2176-2188. doi: 10.1091/mbc.E03-07-0503
    • (2004) Mol Biol Cell , vol.15 , Issue.5 , pp. 2176-2188
    • Mason, J.M.1    Morrison, D.J.2    Bassit, B.3    Dimri, M.4    Band, H.5    Licht, J.D.6    Gross, I.7
  • 67
    • 0036170142 scopus 로고    scopus 로고
    • Identification of Sef, a novel modulator of FGF signalling
    • 10.1038/ncb749 11802164 1:CAS:528:DC%2BD38XhsVKnur8%3D
    • Tsang M, Friesel R, Kudoh T, Dawid IB (2002) Identification of Sef, a novel modulator of FGF signalling. Nat Cell Biol 4(2):165-169. doi: 10.1038/ncb749
    • (2002) Nat Cell Biol , vol.4 , Issue.2 , pp. 165-169
    • Tsang, M.1    Friesel, R.2    Kudoh, T.3    Dawid, I.B.4
  • 68
    • 0036173032 scopus 로고    scopus 로고
    • Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling
    • 10.1038/ncb750 11802165 1:CAS:528:DC%2BD38XhsVKnurw%3D
    • Furthauer M, Lin W, Ang SL, Thisse B, Thisse C (2002) Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling. Nat Cell Biol 4(2):170-174. doi: 10.1038/ncb750
    • (2002) Nat Cell Biol , vol.4 , Issue.2 , pp. 170-174
    • Furthauer, M.1    Lin, W.2    Ang, S.L.3    Thisse, B.4    Thisse, C.5
  • 69
    • 33846829604 scopus 로고    scopus 로고
    • Tyrosine 330 in hSef is critical for the localization and the inhibitory effect on FGF signaling
    • 10.1016/j.bbrc.2007.01.037 17266935 1:CAS:528:DC%2BD2sXhtlOgu7s%3D
    • Ren Y, Li Z, Rong Z, Cheng L, Li Y, Wang Z, Chang Z (2007) Tyrosine 330 in hSef is critical for the localization and the inhibitory effect on FGF signaling. Biochem Biophys Res Commun 354(3):741-746. doi: 10.1016/j.bbrc.2007. 01.037
    • (2007) Biochem Biophys Res Commun , vol.354 , Issue.3 , pp. 741-746
    • Ren, Y.1    Li, Z.2    Rong, Z.3    Cheng, L.4    Li, Y.5    Wang, Z.6    Chang, Z.7
  • 70
    • 0038476592 scopus 로고    scopus 로고
    • Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation
    • 10.1074/jbc.C200606200 12604616 1:CAS:528:DC%2BD3sXjtVSiu7o%3D
    • Kovalenko D, Yang X, Nadeau RJ, Harkins LK, Friesel R (2003) Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation. J Biol Chem 278(16):14087-14091. doi: 10.1074/jbc.C200606200
    • (2003) J Biol Chem , vol.278 , Issue.16 , pp. 14087-14091
    • Kovalenko, D.1    Yang, X.2    Nadeau, R.J.3    Harkins, L.K.4    Friesel, R.5
  • 71
    • 4344682999 scopus 로고    scopus 로고
    • Sef is a spatial regulator for Ras/MAP kinase signaling
    • 10.1016/j.devcel.2004.05.019 15239952 1:CAS:528:DC%2BD2cXntVCiu7w%3D
    • Torii S, Kusakabe M, Yamamoto T, Maekawa M, Nishida E (2004) Sef is a spatial regulator for Ras/MAP kinase signaling. Dev Cell 7(1):33-44. doi: 10.1016/j.devcel.2004.05.019
    • (2004) Dev Cell , vol.7 , Issue.1 , pp. 33-44
    • Torii, S.1    Kusakabe, M.2    Yamamoto, T.3    Maekawa, M.4    Nishida, E.5
  • 72
    • 33845985325 scopus 로고    scopus 로고
    • The human sef-A isoform utilizes different mechanisms to regulate receptor tyrosine kinase signaling pathways and subsequent cell fate
    • 10.1074/jbc.M607327200 17035228 1:CAS:528:DC%2BD28XhtlagsLjE
    • Ziv I, Fuchs Y, Preger E, Shabtay A, Harduf H, Zilpa T, Dym N, Ron D (2006) The human sef-a isoform utilizes different mechanisms to regulate receptor tyrosine kinase signaling pathways and subsequent cell fate. J Biol Chem 281(51):39225-39235. doi: 10.1074/jbc.M607327200
    • (2006) J Biol Chem , vol.281 , Issue.51 , pp. 39225-39235
    • Ziv, I.1    Fuchs, Y.2    Preger, E.3    Shabtay, A.4    Harduf, H.5    Zilpa, T.6    Dym, N.7    Ron, D.8
  • 73
    • 0027358722 scopus 로고
    • MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo
    • 8221888 1:CAS:528:DyaK2cXkvVOgug%3D%3D
    • Sun H, Charles CH, Lau LF, Tonks NK (1993) MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 75(3):487-493
    • (1993) Cell , vol.75 , Issue.3 , pp. 487-493
    • Sun, H.1    Charles, C.H.2    Lau, L.F.3    Tonks, N.K.4
  • 74
    • 0030028222 scopus 로고    scopus 로고
    • MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase
    • 8626780 1:CAS:528:DyaK28XhtlSmt7Y%3D
    • Muda M, Boschert U, Dickinson R, Martinou JC, Martinou I, Camps M, Schlegel W, Arkinstall S (1996) MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase. J Biol Chem 271(8):4319-4326
    • (1996) J Biol Chem , vol.271 , Issue.8 , pp. 4319-4326
    • Muda, M.1    Boschert, U.2    Dickinson, R.3    Martinou, J.C.4    Martinou, I.5    Camps, M.6    Schlegel, W.7    Arkinstall, S.8
  • 75
    • 33846472047 scopus 로고    scopus 로고
    • Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development
    • 10.1242/dev.02701 17164422 1:CAS:528:DC%2BD2sXhsFartb4%3D
    • Li C, Scott DA, Hatch E, Tian X, Mansour SL (2007) Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development. Development 134(1):167-176. doi: 10.1242/dev.02701
    • (2007) Development , vol.134 , Issue.1 , pp. 167-176
    • Li, C.1    Scott, D.A.2    Hatch, E.3    Tian, X.4    Mansour, S.L.5
  • 76
    • 0029910140 scopus 로고    scopus 로고
    • The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases
    • 8910287 1:CAS:528:DyaK28XmvVWnur8%3D
    • Muda M, Theodosiou A, Rodrigues N, Boschert U, Camps M, Gillieron C, Davies K, Ashworth A, Arkinstall S (1996) The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases. J Biol Chem 271(44):27205-27208
    • (1996) J Biol Chem , vol.271 , Issue.44 , pp. 27205-27208
    • Muda, M.1    Theodosiou, A.2    Rodrigues, N.3    Boschert, U.4    Camps, M.5    Gillieron, C.6    Davies, K.7    Ashworth, A.8    Arkinstall, S.9
  • 77
    • 0030845817 scopus 로고    scopus 로고
    • Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: Definition of phenotypic groups
    • 9331099 1:CAS:528:DyaK2sXmsFCgsrs%3D
    • Courjal F, Cuny M, Simony-Lafontaine J, Louason G, Speiser P, Zeillinger R, Rodriguez C, Theillet C (1997) Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: definition of phenotypic groups. Cancer Res 57(19):4360-4367
    • (1997) Cancer Res , vol.57 , Issue.19 , pp. 4360-4367
    • Courjal, F.1    Cuny, M.2    Simony-Lafontaine, J.3    Louason, G.4    Speiser, P.5    Zeillinger, R.6    Rodriguez, C.7    Theillet, C.8
  • 78
    • 0032760412 scopus 로고    scopus 로고
    • Molecular cytogenetic analysis of 11 new breast cancer cell lines
    • 10.1038/sj.bjc.6695007 10604729 1:CAS:528:DC%2BD3cXls1Kksg%3D%3D
    • Forozan F, Veldman R, Ammerman CA, Parsa NZ, Kallioniemi A, Kallioniemi OP, Ethier SP (1999) Molecular cytogenetic analysis of 11 new breast cancer cell lines. Br J Cancer 81(8):1328-1334. doi: 10.1038/sj.bjc.6695007
    • (1999) Br J Cancer , vol.81 , Issue.8 , pp. 1328-1334
    • Forozan, F.1    Veldman, R.2    Ammerman, C.A.3    Parsa, N.Z.4    Kallioniemi, A.5    Kallioniemi, O.P.6    Ethier, S.P.7
  • 83
    • 33646253192 scopus 로고    scopus 로고
    • Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression
    • 10.1158/0008-5472.CAN-05-4083 16618726 1:CAS:528:DC%2BD28XjsFSltrw%3D
    • Yao J, Weremowicz S, Feng B, Gentleman RC, Marks JR, Gelman R, Brennan C, Polyak K (2006) Combined cDNA array comparative genomic hybridization and serial analysis of gene expression analysis of breast tumor progression. Cancer Res 66(8):4065-4078. doi: 10.1158/0008-5472.CAN-05-4083
    • (2006) Cancer Res , vol.66 , Issue.8 , pp. 4065-4078
    • Yao, J.1    Weremowicz, S.2    Feng, B.3    Gentleman, R.C.4    Marks, J.R.5    Gelman, R.6    Brennan, C.7    Polyak, K.8
  • 88
    • 0033545570 scopus 로고    scopus 로고
    • Differential expression assay of chromosome arm 8p genes identifies frizzled-related (FRP1/FRZB) and fibroblast growth factor receptor 1 (FGFR1) as candidate breast cancer genes
    • 10.1038/sj.onc.1202739 10086345 1:CAS:528:DyaK1MXit1ertb0%3D
    • Ugolini F, Adelaide J, Charafe-Jauffret E, Nguyen C, Jacquemier J, Jordan B, Birnbaum D, Pebusque MJ (1999) Differential expression assay of chromosome arm 8p genes identifies frizzled-related (FRP1/FRZB) and fibroblast growth factor receptor 1 (FGFR1) as candidate breast cancer genes. Oncogene 18(10):1903-1910. doi: 10.1038/sj.onc.1202739
    • (1999) Oncogene , vol.18 , Issue.10 , pp. 1903-1910
    • Ugolini, F.1    Adelaide, J.2    Charafe-Jauffret, E.3    Nguyen, C.4    Jacquemier, J.5    Jordan, B.6    Birnbaum, D.7    Pebusque, M.J.8
  • 91
    • 1642535541 scopus 로고    scopus 로고
    • Genomic and expression analysis of the 8p11-12 amplicon in human breast cancer cell lines
    • 14729606 1:CAS:528:DC%2BD2cXkslyqsw%3D%3D
    • Ray ME, Yang ZQ, Albertson D, Kleer CG, Washburn JG, Macoska JA, Ethier SP (2004) Genomic and expression analysis of the 8p11-12 amplicon in human breast cancer cell lines. Cancer Res 64(1):40-47
    • (2004) Cancer Res , vol.64 , Issue.1 , pp. 40-47
    • Ray, M.E.1    Yang, Z.Q.2    Albertson, D.3    Kleer, C.G.4    Washburn, J.G.5    Macoska, J.A.6    Ethier, S.P.7
  • 93
    • 52049083886 scopus 로고    scopus 로고
    • Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer
    • 10.1158/0008-5472.CAN-08-1360 18757432 1:CAS:528:DC%2BD1cXhtVCrs7bF
    • Bernard-Pierrot I, Gruel N, Stransky N, Vincent-Salomon A, Reyal F, Raynal V, Vallot C, Pierron G, Radvanyi F, Delattre O (2008) Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer. Cancer Res 68(17):7165-7175. doi: 10.1158/0008-5472.CAN-08-1360
    • (2008) Cancer Res , vol.68 , Issue.17 , pp. 7165-7175
    • Bernard-Pierrot, I.1    Gruel, N.2    Stransky, N.3    Vincent-Salomon, A.4    Reyal, F.5    Raynal, V.6    Vallot, C.7    Pierron, G.8    Radvanyi, F.9    Delattre, O.10
  • 95
    • 0026696081 scopus 로고
    • Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues
    • 1380281 1:STN:280:DyaK38zmvVynuw%3D%3D
    • Luqmani YA, Graham M, Coombes RC (1992) Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues. Br J Cancer 66(2):273-280
    • (1992) Br J Cancer , vol.66 , Issue.2 , pp. 273-280
    • Luqmani, Y.A.1    Graham, M.2    Coombes, R.C.3
  • 96
    • 0034785851 scopus 로고    scopus 로고
    • CGH, cDNA and tissue microarray analyses implicate FGFR2 amplification in a small subset of breast tumors
    • 11564899 1:CAS:528:DC%2BD38XhtlWhtw%3D%3D
    • Heiskanen M, Kononen J, Barlund M, Torhorst J, Sauter G, Kallioniemi A, Kallioniemi O (2001) CGH, cDNA and tissue microarray analyses implicate FGFR2 amplification in a small subset of breast tumors. Anal Cell Pathol 22(4):229-234
    • (2001) Anal Cell Pathol , vol.22 , Issue.4 , pp. 229-234
    • Heiskanen, M.1    Kononen, J.2    Barlund, M.3    Torhorst, J.4    Sauter, G.5    Kallioniemi, A.6    Kallioniemi, O.7
  • 97
    • 84889087089 scopus 로고    scopus 로고
    • FGFR2 amplification in gastric cancer
    • 10.1016/j.jss.2004.07.208
    • Dahlberg PS, Ferrin LJ, Dahal G (2004) FGFR2 amplification in gastric cancer. J Surg Res 121(2):331. doi: 10.1016/j.jss.2004.07.208
    • (2004) J Surg Res , vol.121 , Issue.2 , pp. 331
    • Dahlberg, P.S.1    Ferrin, L.J.2    Dahal, G.3
  • 98
    • 42049120475 scopus 로고    scopus 로고
    • FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
    • 10.1158/0008-5472.CAN-07-5229 18381441 1:CAS:528:DC%2BD1cXktV2jsr0%3D
    • Kunii K, Davis L, Gorenstein J, Hatch H, Yashiro M, Di Bacco A, Elbi C, Lutterbach B (2008) FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival. Cancer Res 68(7):2340-2348. doi: 10.1158/0008-5472.CAN-07-5229
    • (2008) Cancer Res , vol.68 , Issue.7 , pp. 2340-2348
    • Kunii, K.1    Davis, L.2    Gorenstein, J.3    Hatch, H.4    Yashiro, M.5    Di Bacco, A.6    Elbi, C.7    Lutterbach, B.8
  • 101
    • 0027547226 scopus 로고
    • Amplified genes in cancer in upper digestive tract
    • 8095412 1:CAS:528:DyaK3sXlslyns7k%3D
    • Yoshida T, Sakamoto H, Terada M (1993) Amplified genes in cancer in upper digestive tract. Semin Cancer Biol 4(1):33-40
    • (1993) Semin Cancer Biol , vol.4 , Issue.1 , pp. 33-40
    • Yoshida, T.1    Sakamoto, H.2    Terada, M.3
  • 102
    • 0031657056 scopus 로고    scopus 로고
    • Amplification of c-myc, K-sam, and c-met in gastric cancers: Detection by fluorescence in situ hybridization
    • 9759658 1:STN:280:DyaK1cvjtVCmug%3D%3D
    • Hara T, Ooi A, Kobayashi M, Mai M, Yanagihara K, Nakanishi I (1998) Amplification of c-myc, K-sam, and c-met in gastric cancers: detection by fluorescence in situ hybridization. Lab Invest 78(9):1143-1153
    • (1998) Lab Invest , vol.78 , Issue.9 , pp. 1143-1153
    • Hara, T.1    Ooi, A.2    Kobayashi, M.3    Mai, M.4    Yanagihara, K.5    Nakanishi, I.6
  • 103
    • 0033572418 scopus 로고    scopus 로고
    • Deletion of the carboxyl-terminal exons of K-sam/FGFR2 by short homology-mediated recombination, generating preferential expression of specific messenger RNAs
    • 10626794 1:CAS:528:DC%2BD3cXktFyitw%3D%3D
    • Ueda T, Sasaki H, Kuwahara Y, Nezu M, Shibuya T, Sakamoto H, Ishii H, Yanagihara K, Mafune K, Makuuchi M, Terada M (1999) Deletion of the carboxyl-terminal exons of K-sam/FGFR2 by short homology-mediated recombination, generating preferential expression of specific messenger RNAs. Cancer Res 59(24):6080-6086
    • (1999) Cancer Res , vol.59 , Issue.24 , pp. 6080-6086
    • Ueda, T.1    Sasaki, H.2    Kuwahara, Y.3    Nezu, M.4    Shibuya, T.5    Sakamoto, H.6    Ishii, H.7    Yanagihara, K.8    Mafune, K.9    Makuuchi, M.10    Terada, M.11
  • 104
    • 0030812901 scopus 로고    scopus 로고
    • Ligand-independent activation of fibroblast growth factor receptor-2 by carboxyl terminal alterations
    • 10.1038/sj.onc.1201242 9266968 1:CAS:528:DyaK2sXls1Krsrs%3D
    • Lorenzi MV, Castagnino P, Chen Q, Chedid M, Miki T (1997) Ligand-independent activation of fibroblast growth factor receptor-2 by carboxyl terminal alterations. Oncogene 15(7):817-826. doi: 10.1038/sj.onc.1201242
    • (1997) Oncogene , vol.15 , Issue.7 , pp. 817-826
    • Lorenzi, M.V.1    Castagnino, P.2    Chen, Q.3    Chedid, M.4    Miki, T.5
  • 105
    • 84860255645 scopus 로고    scopus 로고
    • Enhanced expression of fibroblast growth factor receptor 2 IIIc promotes human pancreatic cancer cell proliferation
    • 10.1016/j.ajpath.2012.01.020 22440254 1:CAS:528:DC%2BC38XnsF2ksbc%3D
    • Ishiwata T, Matsuda Y, Yamamoto T, Uchida E, Korc M, Naito Z (2012) Enhanced expression of fibroblast growth factor receptor 2 IIIc promotes human pancreatic cancer cell proliferation. Am J Pathol 180(5):1928-1941. doi: 10.1016/j.ajpath.2012.01.020
    • (2012) Am J Pathol , vol.180 , Issue.5 , pp. 1928-1941
    • Ishiwata, T.1    Matsuda, Y.2    Yamamoto, T.3    Uchida, E.4    Korc, M.5    Naito, Z.6
  • 106
    • 79960845455 scopus 로고    scopus 로고
    • Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: A potential therapeutic target in colorectal cancer
    • 10.1016/j.canlet.2011.06.009 21745712 1:CAS:528:DC%2BC3MXpsFartLc%3D
    • Matsuda Y, Ishiwata T, Yamahatsu K, Kawahara K, Hagio M, Peng WX, Yamamoto T, Nakazawa N, Seya T, Ohaki Y, Naito Z (2011) Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: a potential therapeutic target in colorectal cancer. Cancer Lett 309(2):209-219. doi: 10.1016/j.canlet.2011.06.009
    • (2011) Cancer Lett , vol.309 , Issue.2 , pp. 209-219
    • Matsuda, Y.1    Ishiwata, T.2    Yamahatsu, K.3    Kawahara, K.4    Hagio, M.5    Peng, W.X.6    Yamamoto, T.7    Nakazawa, N.8    Seya, T.9    Ohaki, Y.10    Naito, Z.11
  • 107
    • 0034652452 scopus 로고    scopus 로고
    • Relating genotype and phenotype in breast cancer: An analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations
    • 10706127 1:CAS:528:DC%2BD3cXhs1ShsLc%3D
    • Cuny M, Kramar A, Courjal F, Johannsdottir V, Iacopetta B, Fontaine H, Grenier J, Culine S, Theillet C (2000) Relating genotype and phenotype in breast cancer: an analysis of the prognostic significance of amplification at eight different genes or loci and of p53 mutations. Cancer Res 60(4):1077-1083
    • (2000) Cancer Res , vol.60 , Issue.4 , pp. 1077-1083
    • Cuny, M.1    Kramar, A.2    Courjal, F.3    Johannsdottir, V.4    Iacopetta, B.5    Fontaine, H.6    Grenier, J.7    Culine, S.8    Theillet, C.9
  • 109
    • 0034687699 scopus 로고    scopus 로고
    • Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome
    • 10.1073/pnas.97.26.14536 11121055 1:CAS:528:DC%2BD3MXitVGjsQ%3D%3D
    • Yu K, Herr AB, Waksman G, Ornitz DM (2000) Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome. Proc Natl Acad Sci USA 97(26):14536-14541. doi: 10.1073/pnas.97.26.14536
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.26 , pp. 14536-14541
    • Yu, K.1    Herr, A.B.2    Waksman, G.3    Ornitz, D.M.4
  • 110
    • 34548250374 scopus 로고    scopus 로고
    • A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases
    • 10.1016/j.molcel.2007.06.028 17803937
    • Chen H, Ma J, Li W, Eliseenkova AV, Xu C, Neubert TA, Miller WT, Mohammadi M (2007) A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases. Mol Cell 27(5):717-730. doi: 10.1016/j.molcel.2007.06.028
    • (2007) Mol Cell , vol.27 , Issue.5 , pp. 717-730
    • Chen, H.1    Ma, J.2    Li, W.3    Eliseenkova, A.V.4    Xu, C.5    Neubert, T.A.6    Miller, W.T.7    Mohammadi, M.8
  • 116
    • 34250829395 scopus 로고    scopus 로고
    • Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
    • 10.1038/sj.onc.1210529 17525745 1:CAS:528:DC%2BD2sXht1eqs7vF
    • Pollock PM, Gartside MG, Dejeza LC, Powell MA, Mallon MA, Davies H, Mohammadi M, Futreal PA, Stratton MR, Trent JM, Goodfellow PJ (2007) Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Oncogene 26(50):7158-7162. doi: 10.1038/sj.onc.1210529
    • (2007) Oncogene , vol.26 , Issue.50 , pp. 7158-7162
    • Pollock, P.M.1    Gartside, M.G.2    Dejeza, L.C.3    Powell, M.A.4    Mallon, M.A.5    Davies, H.6    Mohammadi, M.7    Futreal, P.A.8    Stratton, M.R.9    Trent, J.M.10    Goodfellow, P.J.11
  • 117
    • 79959289734 scopus 로고    scopus 로고
    • Utilization of unlabeled probes for the detection of fibroblast growth factor receptor 2 exons 7 and 12 mutations in endometrial carcinoma
    • 10.1097/PAI.0b013e318201dae8 21285871 1:CAS:528:DC%2BC3MXntF2isbk%3D
    • Liu T, Willmore-Payne C, Wallander ML, Layfield LJ (2011) Utilization of unlabeled probes for the detection of fibroblast growth factor receptor 2 exons 7 and 12 mutations in endometrial carcinoma. Appl Immunohistochem Mol Morphol 19(4):341-346. doi: 10.1097/PAI.0b013e318201dae8
    • (2011) Appl Immunohistochem Mol Morphol , vol.19 , Issue.4 , pp. 341-346
    • Liu, T.1    Willmore-Payne, C.2    Wallander, M.L.3    Layfield, L.J.4
  • 118
    • 84876742959 scopus 로고    scopus 로고
    • Oncogenic role of fibroblast growth factor receptor 3 in tumorigenesis of urinary bladder cancer
    • 10.1016/j.urolonc.2010.07.014 20822928
    • Pandith AA, Shah ZA, Siddiqi MA (2010) Oncogenic role of fibroblast growth factor receptor 3 in tumorigenesis of urinary bladder cancer. Urol Oncol. doi: 10.1016/j.urolonc.2010.07.014
    • (2010) Urol Oncol
    • Pandith, A.A.1    Shah, Z.A.2    Siddiqi, M.A.3
  • 120
    • 33747079040 scopus 로고    scopus 로고
    • Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas
    • 10.1200/JCO.2005.05.1771 16877735 1:CAS:528:DC%2BD28XovVSjsbc%3D
    • Hernandez S, Lopez-Knowles E, Lloreta J, Kogevinas M, Amoros A, Tardon A, Carrato A, Serra C, Malats N, Real FX (2006) Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas. J Clin Oncol 24(22):3664-3671. doi: 10.1200/JCO.2005.05.1771
    • (2006) J Clin Oncol , vol.24 , Issue.22 , pp. 3664-3671
    • Hernandez, S.1    Lopez-Knowles, E.2    Lloreta, J.3    Kogevinas, M.4    Amoros, A.5    Tardon, A.6    Carrato, A.7    Serra, C.8    Malats, N.9    Real, F.X.10
  • 121
    • 0031985174 scopus 로고    scopus 로고
    • Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type i
    • 9438390
    • d'Avis PY, Robertson SC, Meyer AN, Bardwell WM, Webster MK, Donoghue DJ (1998) Constitutive activation of fibroblast growth factor receptor 3 by mutations responsible for the lethal skeletal dysplasia thanatophoric dysplasia type I. Cell Growth Differ 9(1):71-78
    • (1998) Cell Growth Differ , vol.9 , Issue.1 , pp. 71-78
    • D'Avis, P.Y.1    Robertson, S.C.2    Meyer, A.N.3    Bardwell, W.M.4    Webster, M.K.5    Donoghue, D.J.6
  • 122
    • 0029935895 scopus 로고    scopus 로고
    • Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia
    • 10.1038/ng0696-233 8640234 1:CAS:528:DyaK28XktlOhurc%3D
    • Naski MC, Wang Q, Xu J, Ornitz DM (1996) Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet 13(2):233-237. doi: 10.1038/ng0696-233
    • (1996) Nat Genet , vol.13 , Issue.2 , pp. 233-237
    • Naski, M.C.1    Wang, Q.2    Xu, J.3    Ornitz, D.M.4
  • 123
    • 0036239904 scopus 로고    scopus 로고
    • Differential activation of cysteine-substitution mutants of fibroblast growth factor receptor 3 is determined by cysteine localization
    • 10.1359/jbmr.2002.17.5.860 12009017 1:CAS:528:DC%2BD38XktVSktrg%3D
    • Adar R, Monsonego-Ornan E, David P, Yayon A (2002) Differential activation of cysteine-substitution mutants of fibroblast growth factor receptor 3 is determined by cysteine localization. J Bone Miner Res 17(5):860-868. doi: 10.1359/jbmr.2002.17.5.860
    • (2002) J Bone Miner Res , vol.17 , Issue.5 , pp. 860-868
    • Adar, R.1    Monsonego-Ornan, E.2    David, P.3    Yayon, A.4
  • 125
    • 48249118837 scopus 로고    scopus 로고
    • Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression
    • 18670643 1:CAS:528:DC%2BD1cXht1Kgs7rK
    • Wang J, Yu W, Cai Y, Ren C, Ittmann MM (2008) Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression. Neoplasia 10(8):847-856
    • (2008) Neoplasia , vol.10 , Issue.8 , pp. 847-856
    • Wang, J.1    Yu, W.2    Cai, Y.3    Ren, C.4    Ittmann, M.M.5
  • 126
    • 77957686550 scopus 로고    scopus 로고
    • FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex
    • 10.1073/pnas.0914459107 20798051 1:CAS:528:DC%2BC3cXhtFOru7zP
    • Sugiyama N, Varjosalo M, Meller P, Lohi J, Chan KM, Zhou Z, Alitalo K, Taipale J, Keski-Oja J, Lehti K (2010) FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex. Proc Natl Acad Sci USA 107(36):15786-15791. doi: 10.1073/pnas. 0914459107
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.36 , pp. 15786-15791
    • Sugiyama, N.1    Varjosalo, M.2    Meller, P.3    Lohi, J.4    Chan, K.M.5    Zhou, Z.6    Alitalo, K.7    Taipale, J.8    Keski-Oja, J.9    Lehti, K.10
  • 127
    • 33644686223 scopus 로고    scopus 로고
    • Functional FGFR4 Gly388Arg polymorphism predicts prognosis in lung adenocarcinoma patients
    • 10.1200/JCO.2005.17.350 16061909 1:CAS:528:DC%2BD2MXhtF2nsLrM
    • Spinola M, Leoni V, Pignatiello C, Conti B, Ravagnani F, Pastorino U, Dragani TA (2005) Functional FGFR4 Gly388Arg polymorphism predicts prognosis in lung adenocarcinoma patients. J Clin Oncol 23(29):7307-7311. doi: 10.1200/JCO.2005.17.350
    • (2005) J Clin Oncol , vol.23 , Issue.29 , pp. 7307-7311
    • Spinola, M.1    Leoni, V.2    Pignatiello, C.3    Conti, B.4    Ravagnani, F.5    Pastorino, U.6    Dragani, T.A.7
  • 129
    • 33747363496 scopus 로고    scopus 로고
    • FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer
    • 10.1200/JCO.2005.04.8587 16822847 1:CAS:528:DC%2BD28XpsVaqsrc%3D
    • Thussbas C, Nahrig J, Streit S, Bange J, Kriner M, Kates R, Ulm K, Kiechle M, Hoefler H, Ullrich A, Harbeck N (2006) FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer. J Clin Oncol 24(23):3747-3755. doi: 10.1200/JCO.2005.04.8587
    • (2006) J Clin Oncol , vol.24 , Issue.23 , pp. 3747-3755
    • Thussbas, C.1    Nahrig, J.2    Streit, S.3    Bange, J.4    Kriner, M.5    Kates, R.6    Ulm, K.7    Kiechle, M.8    Hoefler, H.9    Ullrich, A.10    Harbeck, N.11
  • 132
    • 1642421743 scopus 로고    scopus 로고
    • Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations
    • 15050920 1:CAS:528:DC%2BD2cXjtVarurw%3D
    • Roumiantsev S, Krause DS, Neumann CA, Dimitri CA, Asiedu F, Cross NC, Van Etten RA (2004) Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. Cancer Cell 5(3):287-298
    • (2004) Cancer Cell , vol.5 , Issue.3 , pp. 287-298
    • Roumiantsev, S.1    Krause, D.S.2    Neumann, C.A.3    Dimitri, C.A.4    Asiedu, F.5    Cross, N.C.6    Van Etten, R.A.7
  • 133
    • 0347597750 scopus 로고    scopus 로고
    • FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice
    • 10.1182/blood-2003-05-1690 12969958 1:CAS:528:DC%2BD2cXhsFGhtA%3D%3D
    • Guasch G, Delaval B, Arnoulet C, Xie MJ, Xerri L, Sainty D, Birnbaum D, Pebusque MJ (2004) FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice. Blood 103(1):309-312. doi: 10.1182/blood-2003-05-1690
    • (2004) Blood , vol.103 , Issue.1 , pp. 309-312
    • Guasch, G.1    Delaval, B.2    Arnoulet, C.3    Xie, M.J.4    Xerri, L.5    Sainty, D.6    Birnbaum, D.7    Pebusque, M.J.8
  • 135
    • 70349580691 scopus 로고    scopus 로고
    • Genetic fingerprinting of the development and progression of T-cell lymphoma in a murine model of atypical myeloproliferative disorder initiated by the ZNF198-fibroblast growth factor receptor-1 chimeric tyrosine kinase
    • 10.1182/blood-2009-03-212704 19506298 1:CAS:528:DC%2BD1MXhtVyiurrM
    • Ren M, Li X, Cowell JK (2009) Genetic fingerprinting of the development and progression of T-cell lymphoma in a murine model of atypical myeloproliferative disorder initiated by the ZNF198-fibroblast growth factor receptor-1 chimeric tyrosine kinase. Blood 114(8):1576-1584. doi: 10.1182/blood-2009-03-212704
    • (2009) Blood , vol.114 , Issue.8 , pp. 1576-1584
    • Ren, M.1    Li, X.2    Cowell, J.K.3
  • 137
    • 0038156100 scopus 로고    scopus 로고
    • Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients
    • 10.1182/blood-2003-04-1204 12835230 1:CAS:528:DC%2BD3sXlslGiurY%3D
    • Onwuazor ON, Wen XY, Wang DY, Zhuang L, Masih-Khan E, Claudio J, Barlogie B, Shaughnessy JD Jr, Stewart AK (2003) Mutation, SNP, and isoform analysis of fibroblast growth factor receptor 3 (FGFR3) in 150 newly diagnosed multiple myeloma patients. Blood 102(2):772-773. doi: 10.1182/blood-2003-04-1204
    • (2003) Blood , vol.102 , Issue.2 , pp. 772-773
    • Onwuazor, O.N.1    Wen, X.Y.2    Wang, D.Y.3    Zhuang, L.4    Masih-Khan, E.5    Claudio, J.6    Barlogie, B.7    Shaughnessy Jr., J.D.8    Stewart, A.K.9
  • 138
    • 38349087546 scopus 로고    scopus 로고
    • The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity
    • 10.1182/blood-2007-05-088674 17942756 1:CAS:528:DC%2BD1cXns1Cksg%3D%3D
    • Lauring J, Abukhdeir AM, Konishi H, Garay JP, Gustin JP, Wang Q, Arceci RJ, Matsui W, Park BH (2008) The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. Blood 111(2):856-864. doi: 10.1182/blood-2007-05-088674
    • (2008) Blood , vol.111 , Issue.2 , pp. 856-864
    • Lauring, J.1    Abukhdeir, A.M.2    Konishi, H.3    Garay, J.P.4    Gustin, J.P.5    Wang, Q.6    Arceci, R.J.7    Matsui, W.8    Park, B.H.9
  • 139
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • 10647931 1:CAS:528:DC%2BD3cXks1CktA%3D%3D
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1):57-70
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 140
    • 0030855812 scopus 로고    scopus 로고
    • Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth
    • 9256280 1:CAS:528:DyaK2sXltVKqu74%3D
    • Wang Y, Becker D (1997) Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth. Nat Med 3(8):887-893
    • (1997) Nat Med , vol.3 , Issue.8 , pp. 887-893
    • Wang, Y.1    Becker, D.2
  • 143
    • 36649036989 scopus 로고    scopus 로고
    • Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor
    • 10.1016/j.ccr.2007.11.002 18068633 1:CAS:528:DC%2BD2sXhsVGmu73K
    • Memarzadeh S, Xin L, Mulholland DJ, Mansukhani A, Wu H, Teitell MA, Witte ON (2007) Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell 12(6):572-585. doi: 10.1016/j.ccr.2007.11.002
    • (2007) Cancer Cell , vol.12 , Issue.6 , pp. 572-585
    • Memarzadeh, S.1    Xin, L.2    Mulholland, D.J.3    Mansukhani, A.4    Wu, H.5    Teitell, M.A.6    Witte, O.N.7
  • 144
    • 78650732630 scopus 로고    scopus 로고
    • Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling
    • 10.1073/pnas.1007863107 21098263 1:CAS:528:DC%2BC3cXhs1WjsrnI
    • Fillmore CM, Gupta PB, Rudnick JA, Caballero S, Keller PJ, Lander ES, Kuperwasser C (2010) Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci USA 107(50):21737-21742. doi: 10.1073/pnas.1007863107
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.50 , pp. 21737-21742
    • Fillmore, C.M.1    Gupta, P.B.2    Rudnick, J.A.3    Caballero, S.4    Keller, P.J.5    Lander, E.S.6    Kuperwasser, C.7
  • 145
    • 34548481970 scopus 로고    scopus 로고
    • Downregulation of Sef, an inhibitor of receptor tyrosine kinase signaling, is common to a variety of human carcinomas
    • 10.1038/sj.onc.1210424 17420726 1:CAS:528:DC%2BD2sXpvFWmtbs%3D
    • Zisman-Rozen S, Fink D, Ben-Izhak O, Fuchs Y, Brodski A, Kraus MH, Bejar J, Ron D (2007) Downregulation of Sef, an inhibitor of receptor tyrosine kinase signaling, is common to a variety of human carcinomas. Oncogene 26(41):6093-6098. doi: 10.1038/sj.onc.1210424
    • (2007) Oncogene , vol.26 , Issue.41 , pp. 6093-6098
    • Zisman-Rozen, S.1    Fink, D.2    Ben-Izhak, O.3    Fuchs, Y.4    Brodski, A.5    Kraus, M.H.6    Bejar, J.7    Ron, D.8
  • 146
    • 70649099057 scopus 로고    scopus 로고
    • Similar expression to FGF (Sef) inhibits fibroblast growth factor-induced tumourigenic behaviour in prostate cancer cells and is downregulated in aggressive clinical disease
    • 10.1038/sj.bjc.6605379 19888221 1:CAS:528:DC%2BD1MXhsVOhtLjL
    • Darby S, Murphy T, Thomas H, Robson CN, Leung HY, Mathers ME, Gnanapragasam VJ (2009) Similar expression to FGF (Sef) inhibits fibroblast growth factor-induced tumourigenic behaviour in prostate cancer cells and is downregulated in aggressive clinical disease. Br J Cancer 101(11):1891-1899. doi: 10.1038/sj.bjc.6605379
    • (2009) Br J Cancer , vol.101 , Issue.11 , pp. 1891-1899
    • Darby, S.1    Murphy, T.2    Thomas, H.3    Robson, C.N.4    Leung, H.Y.5    Mathers, M.E.6    Gnanapragasam, V.J.7
  • 148
    • 76749136307 scopus 로고    scopus 로고
    • Evidence for distinct alterations in the FGF axis in prostate cancer progression to an aggressive clinical phenotype
    • 10.1002/path.2657 19960500 1:CAS:528:DC%2BC3cXjsFent7c%3D
    • Murphy T, Darby S, Mathers ME, Gnanapragasam VJ (2010) Evidence for distinct alterations in the FGF axis in prostate cancer progression to an aggressive clinical phenotype. J Pathol 220(4):452-460. doi: 10.1002/path.2657
    • (2010) J Pathol , vol.220 , Issue.4 , pp. 452-460
    • Murphy, T.1    Darby, S.2    Mathers, M.E.3    Gnanapragasam, V.J.4
  • 149
    • 66149149720 scopus 로고    scopus 로고
    • Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases
    • 10.1152/ajpendo.90857.2008 19240253 1:CAS:528:DC%2BD1MXlvFagsrc%3D
    • Abella JV, Park M (2009) Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases. Am J Physiol Endocrinol Metab 296(5):E973-E984. doi: 10.1152/ajpendo.90857.2008
    • (2009) Am J Physiol Endocrinol Metab , vol.296 , Issue.5
    • Abella, J.V.1    Park, M.2
  • 150
    • 34548543308 scopus 로고    scopus 로고
    • Aberrant receptor signaling and trafficking as mechanisms in oncogenesis
    • 17956217
    • Haglund K, Rusten TE, Stenmark H (2007) Aberrant receptor signaling and trafficking as mechanisms in oncogenesis. Crit Rev Oncog 13(1):39-74
    • (2007) Crit Rev Oncog , vol.13 , Issue.1 , pp. 39-74
    • Haglund, K.1    Rusten, T.E.2    Stenmark, H.3
  • 151
    • 0345743700 scopus 로고    scopus 로고
    • Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia
    • 10.1073/pnas.2237184100 14699054 1:CAS:528:DC%2BD2cXmsFGmtg%3D%3D
    • Cho JY, Guo C, Torello M, Lunstrum GP, Iwata T, Deng C, Horton WA (2004) Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia. Proc Natl Acad Sci USA 101(2):609-614. doi: 10.1073/pnas.2237184100
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.2 , pp. 609-614
    • Cho, J.Y.1    Guo, C.2    Torello, M.3    Lunstrum, G.P.4    Iwata, T.5    Deng, C.6    Horton, W.A.7
  • 152
    • 65249140043 scopus 로고    scopus 로고
    • Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform
    • 10.1074/jbc.M803998200 19103595 1:CAS:528:DC%2BD1MXisVSktLk%3D
    • Cha JY, Maddileti S, Mitin N, Harden TK, Der CJ (2009) Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform. J Biol Chem 284(10):6227-6240. doi: 10.1074/jbc.M803998200
    • (2009) J Biol Chem , vol.284 , Issue.10 , pp. 6227-6240
    • Cha, J.Y.1    Maddileti, S.2    Mitin, N.3    Harden, T.K.4    Der, C.J.5
  • 154
    • 34447318647 scopus 로고    scopus 로고
    • Enhanced expression of keratinocyte growth factor and its receptor correlates with venous invasion in pancreatic cancer
    • 10.2353/ajpath.2007.060935 17525264 1:CAS:528:DC%2BD2sXntlOhtLw%3D
    • Cho K, Ishiwata T, Uchida E, Nakazawa N, Korc M, Naito Z, Tajiri T (2007) Enhanced expression of keratinocyte growth factor and its receptor correlates with venous invasion in pancreatic cancer. Am J Pathol 170(6):1964-1974. doi: 10.2353/ajpath.2007.060935
    • (2007) Am J Pathol , vol.170 , Issue.6 , pp. 1964-1974
    • Cho, K.1    Ishiwata, T.2    Uchida, E.3    Nakazawa, N.4    Korc, M.5    Naito, Z.6    Tajiri, T.7
  • 156
    • 33750980657 scopus 로고    scopus 로고
    • Expression of keratinocyte growth factor receptor correlates with expansive growth and early stage of gastric cancer
    • 16391783 1:CAS:528:DC%2BD28XhsFSgtLs%3D
    • Matsunobu T, Ishiwata T, Yoshino M, Watanabe M, Kudo M, Matsumoto K, Tokunaga A, Tajiri T, Naito Z (2006) Expression of keratinocyte growth factor receptor correlates with expansive growth and early stage of gastric cancer. Int J Oncol 28(2):307-314
    • (2006) Int J Oncol , vol.28 , Issue.2 , pp. 307-314
    • Matsunobu, T.1    Ishiwata, T.2    Yoshino, M.3    Watanabe, M.4    Kudo, M.5    Matsumoto, K.6    Tokunaga, A.7    Tajiri, T.8    Naito, Z.9
  • 157
    • 28544435982 scopus 로고    scopus 로고
    • Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines
    • 16288035 1:CAS:528:DC%2BD2MXht1Wgu7%2FN
    • Tomlinson DC, L'Hote CG, Kennedy W, Pitt E, Knowles MA (2005) Alternative splicing of fibroblast growth factor receptor 3 produces a secreted isoform that inhibits fibroblast growth factor-induced proliferation and is repressed in urothelial carcinoma cell lines. Cancer Res 65(22):10441-10449
    • (2005) Cancer Res , vol.65 , Issue.22 , pp. 10441-10449
    • Tomlinson, D.C.1    L'Hote, C.G.2    Kennedy, W.3    Pitt, E.4    Knowles, M.A.5
  • 158
    • 0031577732 scopus 로고    scopus 로고
    • Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer
    • 9444954 1:CAS:528:DyaK1cXmtFKqtg%3D%3D
    • Carstens RP, Eaton JV, Krigman HR, Walther PJ, Garcia-Blanco MA (1997) Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. Oncogene 15(25):3059-3065
    • (1997) Oncogene , vol.15 , Issue.25 , pp. 3059-3065
    • Carstens, R.P.1    Eaton, J.V.2    Krigman, H.R.3    Walther, P.J.4    Garcia-Blanco, M.A.5
  • 159
    • 70349245552 scopus 로고    scopus 로고
    • FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: Results of a case control study in Japan
    • 19582883 1:CAS:528:DC%2BD1MXhtVGju7fJ
    • Kawase T, Matsuo K, Suzuki T, Hiraki A, Watanabe M, Iwata H, Tanaka H, Tajima K (2009) FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: results of a case control study in Japan. Int J Cancer 125(8):1946-1952
    • (2009) Int J Cancer , vol.125 , Issue.8 , pp. 1946-1952
    • Kawase, T.1    Matsuo, K.2    Suzuki, T.3    Hiraki, A.4    Watanabe, M.5    Iwata, H.6    Tanaka, H.7    Tajima, K.8
  • 160
    • 7444220147 scopus 로고    scopus 로고
    • Aberrant and alternative splicing in cancer
    • 15520162 1:CAS:528:DC%2BD2cXptFemtb8%3D
    • Venables JP (2004) Aberrant and alternative splicing in cancer. Cancer Res 64(21):7647-7654
    • (2004) Cancer Res , vol.64 , Issue.21 , pp. 7647-7654
    • Venables, J.P.1
  • 161
    • 0036144332 scopus 로고    scopus 로고
    • Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis
    • 11781352 1:CAS:528:DC%2BD38Xjtlakug%3D%3D
    • Ezzat S, Zheng L, Zhu XF, Wu GE, Asa SL (2002) Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis. J Clin Investig 109(1):69-78
    • (2002) J Clin Investig , vol.109 , Issue.1 , pp. 69-78
    • Ezzat, S.1    Zheng, L.2    Zhu, X.F.3    Wu, G.E.4    Asa, S.L.5
  • 162
    • 84895057195 scopus 로고    scopus 로고
    • FGF receptors: Cancer biology and therapeutics
    • 10.1002/med.21288 23696246
    • Katoh M, Nakagama H (2013) FGF receptors: cancer biology and therapeutics. Med Res Rev. doi: 10.1002/med.21288
    • (2013) Med Res Rev
    • Katoh, M.1    Nakagama, H.2
  • 163
    • 84876048479 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor inhibitors as a cancer treatment: From a biologic rationale to medical perspectives
    • 10.1158/2159-8290.CD-12-0362 23418312 1:CAS:528:DC%2BC3sXltVOktL4%3D
    • Dieci MV, Arnedos M, Andre F, Soria JC (2013) Fibroblast growth factor receptor inhibitors as a cancer treatment: from a biologic rationale to medical perspectives. Cancer Discov 3(3):264-279. doi: 10.1158/2159-8290.CD-12-0362
    • (2013) Cancer Discov , vol.3 , Issue.3 , pp. 264-279
    • Dieci, M.V.1    Arnedos, M.2    Andre, F.3    Soria, J.C.4
  • 164
    • 79952116987 scopus 로고    scopus 로고
    • Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate
    • 10.1007/s10549-009-0677-6 20024612 1:CAS:528:DC%2BC3cXhtFOqtL%2FE
    • Shiang CY, Qi Y, Wang B, Lazar V, Wang J, Fraser Symmans W, Hortobagyi GN, Andre F, Pusztai L (2010) Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate. Breast Cancer Res Treat 123(3):747-755. doi: 10.1007/s10549-009-0677-6
    • (2010) Breast Cancer Res Treat , vol.123 , Issue.3 , pp. 747-755
    • Shiang, C.Y.1    Qi, Y.2    Wang, B.3    Lazar, V.4    Wang, J.5    Fraser Symmans, W.6    Hortobagyi, G.N.7    Andre, F.8    Pusztai, L.9
  • 165
    • 84860878985 scopus 로고    scopus 로고
    • FGF receptor inhibitors: Role in cancer therapy
    • 10.1007/s11912-012-0225-0 22311684 1:CAS:528:DC%2BC38Xjs1Okt7w%3D
    • Daniele G, Corral J, Molife LR, de Bono JS (2012) FGF receptor inhibitors: role in cancer therapy. Curr Oncol Rep 14(2):111-119. doi: 10.1007/s11912-012-0225-0
    • (2012) Curr Oncol Rep , vol.14 , Issue.2 , pp. 111-119
    • Daniele, G.1    Corral, J.2    Molife, L.R.3    De Bono, J.S.4
  • 167
    • 84860120185 scopus 로고    scopus 로고
    • AZD4547: An orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family
    • 10.1158/0008-5472.CAN-11-3034 22369928 1:CAS:528:DC%2BC38Xls1Wgsrs%3D
    • Gavine PR, Mooney L, Kilgour E, Thomas AP, Al-Kadhimi K, Beck S, Rooney C, Coleman T, Baker D, Mellor MJ, Brooks AN, Klinowska T (2012) AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res 72(8):2045-2056. doi: 10.1158/0008-5472.CAN-11-3034
    • (2012) Cancer Res , vol.72 , Issue.8 , pp. 2045-2056
    • Gavine, P.R.1    Mooney, L.2    Kilgour, E.3    Thomas, A.P.4    Al-Kadhimi, K.5    Beck, S.6    Rooney, C.7    Coleman, T.8    Baker, D.9    Mellor, M.J.10    Brooks, A.N.11    Klinowska, T.12
  • 169
    • 21044433871 scopus 로고    scopus 로고
    • A neutralizing anti-fibroblast growth factor 8 monoclonal antibody shows potent antitumor activity against androgen-dependent mouse mammary tumors in vivo
    • 10.1158/1078-0432.CCR-04-2358 15897591 1:CAS:528:DC%2BD2MXktFyqs78%3D
    • Shimada N, Ishii T, Imada T, Takaba K, Sasaki Y, Maruyama-Takahashi K, Maekawa-Tokuda Y, Kusaka H, Akinaga S, Tanaka A, Shitara K (2005) A neutralizing anti-fibroblast growth factor 8 monoclonal antibody shows potent antitumor activity against androgen-dependent mouse mammary tumors in vivo. Clin Cancer Res 11(10):3897-3904. doi: 10.1158/1078-0432.CCR-04-2358
    • (2005) Clin Cancer Res , vol.11 , Issue.10 , pp. 3897-3904
    • Shimada, N.1    Ishii, T.2    Imada, T.3    Takaba, K.4    Sasaki, Y.5    Maruyama-Takahashi, K.6    Maekawa-Tokuda, Y.7    Kusaka, H.8    Akinaga, S.9    Tanaka, A.10    Shitara, K.11
  • 170
    • 42949151299 scopus 로고    scopus 로고
    • A neutralizing anti-fibroblast growth factor (FGF) 8 monoclonal antibody shows anti-tumor activity against FGF8b-expressing LNCaP xenografts in androgen-dependent and -independent conditions
    • 10.1002/pros.20728 18213631 1:CAS:528:DC%2BD1cXms1Wis70%3D
    • Maruyama-Takahashi K, Shimada N, Imada T, Maekawa-Tokuda Y, Ishii T, Ouchi J, Kusaka H, Miyaji H, Akinaga S, Tanaka A, Shitara K (2008) A neutralizing anti-fibroblast growth factor (FGF) 8 monoclonal antibody shows anti-tumor activity against FGF8b-expressing LNCaP xenografts in androgen-dependent and -independent conditions. Prostate 68(6):640-650. doi: 10.1002/pros.20728
    • (2008) Prostate , vol.68 , Issue.6 , pp. 640-650
    • Maruyama-Takahashi, K.1    Shimada, N.2    Imada, T.3    Maekawa-Tokuda, Y.4    Ishii, T.5    Ouchi, J.6    Kusaka, H.7    Miyaji, H.8    Akinaga, S.9    Tanaka, A.10    Shitara, K.11
  • 171
    • 84889095316 scopus 로고    scopus 로고
    • An anti-FGF8 antibody reduced joint inflammation and bone destruction in Rat adjuvant-induced arthritis and mouse type II collagen-induced arthritis
    • I. Miki TT, M. Uchii, T. Suda, A. Tanaka (2008) An anti-FGF8 antibody reduced joint inflammation and bone destruction in Rat adjuvant-induced arthritis and mouse type II collagen-induced arthritis. In: American College of Rheumatology 2008 annual scientific meeting
    • (2008) American College of Rheumatology 2008 Annual Scientific Meeting
    • Miki, I.T.T.1    Uchii, M.2    Suda, T.3    Tanaka, A.4
  • 174
    • 33646555792 scopus 로고    scopus 로고
    • The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells
    • 10.1182/blood-2005-10-4179 16467200 1:CAS:528:DC%2BD28XkvFWgsr0%3D
    • Trudel S, Stewart AK, Rom E, Wei E, Li ZH, Kotzer S, Chumakov I, Singer Y, Chang H, Liang SB, Yayon A (2006) The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells. Blood 107(10):4039-4046. doi: 10.1182/blood-2005-10-4179
    • (2006) Blood , vol.107 , Issue.10 , pp. 4039-4046
    • Trudel, S.1    Stewart, A.K.2    Rom, E.3    Wei, E.4    Li, Z.H.5    Kotzer, S.6    Chumakov, I.7    Singer, Y.8    Chang, H.9    Liang, S.B.10    Yayon, A.11
  • 175
    • 66449083374 scopus 로고    scopus 로고
    • FGFR3-targeted mAb therapy for bladder cancer and multiple myeloma
    • 19422094 1:CAS:528:DC%2BD1MXlsFyrsLw%3D
    • Hadari Y, Schlessinger J (2009) FGFR3-targeted mAb therapy for bladder cancer and multiple myeloma. J Clin Invest 119(5):1077-1079
    • (2009) J Clin Invest , vol.119 , Issue.5 , pp. 1077-1079
    • Hadari, Y.1    Schlessinger, J.2
  • 177
    • 80051690789 scopus 로고    scopus 로고
    • Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition
    • 10.1158/1078-0432.CCR-10-2847 21622725 1:CAS:528:DC%2BC3MXhtVajs7jM
    • Allen E, Walters IB, Hanahan D (2011) Brivanib, a dual FGF/VEGF inhibitor, is active both first and second line against mouse pancreatic neuroendocrine tumors developing adaptive/evasive resistance to VEGF inhibition. Clin Cancer Res 17(16):5299-5310. doi: 10.1158/1078-0432.CCR-10-2847
    • (2011) Clin Cancer Res , vol.17 , Issue.16 , pp. 5299-5310
    • Allen, E.1    Walters, I.B.2    Hanahan, D.3
  • 179
    • 79960999875 scopus 로고    scopus 로고
    • Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells
    • 10.1158/1078-0432.CCR-11-0050 21673064 1:CAS:528:DC%2BC3MXpsFSksrw%3D
    • Marshall ME, Hinz TK, Kono SA, Singleton KR, Bichon B, Ware KE, Marek L, Frederick BA, Raben D, Heasley LE (2011) Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells. Clin Cancer Res 17(15):5016-5025. doi: 10.1158/1078-0432.CCR- 11-0050
    • (2011) Clin Cancer Res , vol.17 , Issue.15 , pp. 5016-5025
    • Marshall, M.E.1    Hinz, T.K.2    Kono, S.A.3    Singleton, K.R.4    Bichon, B.5    Ware, K.E.6    Marek, L.7    Frederick, B.A.8    Raben, D.9    Heasley, L.E.10
  • 180
    • 64249151246 scopus 로고    scopus 로고
    • FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review)
    • 19212647 1:CAS:528:DC%2BD1MXjs1Kiur4%3D
    • Katoh Y, Katoh M (2009) FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review). Int J Mol Med 23(3):307-311
    • (2009) Int J Mol Med , vol.23 , Issue.3 , pp. 307-311
    • Katoh, Y.1    Katoh, M.2
  • 181
    • 22244492038 scopus 로고    scopus 로고
    • Cartilage dysplasia and tissue mineralization in the rat following administration of a FGF receptor tyrosine kinase inhibitor
    • 10.1080/01926230590961845 16036862 1:CAS:528:DC%2BD2MXksVejsLc%3D
    • Brown AP, Courtney CL, King LM, Groom SC, Graziano MJ (2005) Cartilage dysplasia and tissue mineralization in the rat following administration of a FGF receptor tyrosine kinase inhibitor. Toxicol Pathol 33(4):449-455. doi: 10.1080/01926230590961845
    • (2005) Toxicol Pathol , vol.33 , Issue.4 , pp. 449-455
    • Brown, A.P.1    Courtney, C.L.2    King, L.M.3    Groom, S.C.4    Graziano, M.J.5
  • 183
    • 33845631059 scopus 로고    scopus 로고
    • Klotho converts canonical FGF receptor into a specific receptor for FGF23
    • 10.1038/nature05315 17086194 1:CAS:528:DC%2BD28Xht1OntbzF
    • Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T (2006) Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444(7120):770-774. doi: 10.1038/nature05315
    • (2006) Nature , vol.444 , Issue.7120 , pp. 770-774
    • Urakawa, I.1    Yamazaki, Y.2    Shimada, T.3    Iijima, K.4    Hasegawa, H.5    Okawa, K.6    Fujita, T.7    Fukumoto, S.8    Yamashita, T.9
  • 185
    • 57149099628 scopus 로고    scopus 로고
    • FGFR3 and FGFR4 do not mediate renal effects of FGF23
    • 10.1681/ASN.2007121301 1:CAS:528:DC%2BD1MXlvF2gsg%3D%3D
    • Liu S, Vierthaler L, Tang W, Zhou J, Quarles LD (2008) FGFR3 and FGFR4 do not mediate renal effects of FGF23. J Am Soc Nephrol JASN 19(12):2342-2350. doi: 10.1681/ASN.2007121301
    • (2008) J Am Soc Nephrol JASN , vol.19 , Issue.12 , pp. 2342-2350
    • Liu, S.1    Vierthaler, L.2    Tang, W.3    Zhou, J.4    Quarles, L.D.5
  • 186
    • 79961141521 scopus 로고    scopus 로고
    • Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4
    • 10.1152/ajprenal.00740.2010 21561999 1:CAS:528:DC%2BC3MXhtFSrtbjL
    • Gattineni J, Twombley K, Goetz R, Mohammadi M, Baum M (2011) Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4. Am J Physiol Renal physiol 301(2):F371-F377. doi: 10.1152/ajprenal.00740.2010
    • (2011) Am J Physiol Renal Physiol , vol.301 , Issue.2
    • Gattineni, J.1    Twombley, K.2    Goetz, R.3    Mohammadi, M.4    Baum, M.5
  • 187
    • 68049085792 scopus 로고    scopus 로고
    • FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1
    • 10.1152/ajprenal.90742.2008 19515808 1:CAS:528:DC%2BD1MXhtVaht73I
    • Gattineni J, Bates C, Twombley K, Dwarakanath V, Robinson ML, Goetz R, Mohammadi M, Baum M (2009) FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1. Am J Physiol Renal physiol 297(2):F282-F291. doi: 10.1152/ajprenal.90742.2008
    • (2009) Am J Physiol Renal Physiol , vol.297 , Issue.2
    • Gattineni, J.1    Bates, C.2    Twombley, K.3    Dwarakanath, V.4    Robinson, M.L.5    Goetz, R.6    Mohammadi, M.7    Baum, M.8
  • 188
    • 5444250989 scopus 로고    scopus 로고
    • Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities
    • 10.1093/hmg/ddh235 15282208 1:CAS:528:DC%2BD2cXns1Onu78%3D
    • Ibrahimi OA, Zhang F, Eliseenkova AV, Itoh N, Linhardt RJ, Mohammadi M (2004) Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities. Hum Mol Genet 13(19):2313-2324. doi: 10.1093/hmg/ddh235
    • (2004) Hum Mol Genet , vol.13 , Issue.19 , pp. 2313-2324
    • Ibrahimi, O.A.1    Zhang, F.2    Eliseenkova, A.V.3    Itoh, N.4    Linhardt, R.J.5    Mohammadi, M.6
  • 189
    • 0028882525 scopus 로고
    • FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development
    • 8582274 1:CAS:528:DyaK2MXps1aktbk%3D
    • MacArthur CA, Lawshe A, Xu J, Santos-Ocampo S, Heikinheimo M, Chellaiah AT, Ornitz DM (1995) FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development. Development 121(11):3603-3613
    • (1995) Development , vol.121 , Issue.11 , pp. 3603-3613
    • Macarthur, C.A.1    Lawshe, A.2    Xu, J.3    Santos-Ocampo, S.4    Heikinheimo, M.5    Chellaiah, A.T.6    Ornitz, D.M.7
  • 191
    • 0032991511 scopus 로고    scopus 로고
    • Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas
    • 10339576 1:CAS:528:DyaK1MXksFKksb0%3D
    • Miralles F, Czernichow P, Ozaki K, Itoh N, Scharfmann R (1999) Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc Natl Acad Sci USA 96(11):6267-6272
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.11 , pp. 6267-6272
    • Miralles, F.1    Czernichow, P.2    Ozaki, K.3    Itoh, N.4    Scharfmann, R.5
  • 192
    • 0032557548 scopus 로고    scopus 로고
    • Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7)
    • 9582367 1:CAS:528:DyaK1cXjsVGitbg%3D
    • Igarashi M, Finch PW, Aaronson SA (1998) Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7). J Biol Chem 273(21):13230-13235
    • (1998) J Biol Chem , vol.273 , Issue.21 , pp. 13230-13235
    • Igarashi, M.1    Finch, P.W.2    Aaronson, S.A.3
  • 193
    • 0028808094 scopus 로고
    • Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4
    • 8619928 1:STN:280:DyaK287pt1Gquw%3D%3D
    • Hecht D, Zimmerman N, Bedford M, Avivi A, Yayon A (1995) Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4. Growth Factors 12(3):223-233
    • (1995) Growth Factors , vol.12 , Issue.3 , pp. 223-233
    • Hecht, D.1    Zimmerman, N.2    Bedford, M.3    Avivi, A.4    Yayon, A.5
  • 194
    • 0030051793 scopus 로고    scopus 로고
    • Expression and biological activity of mouse fibroblast growth factor-9
    • 8576175 1:CAS:528:DyaK28XlsVymuw%3D%3D
    • Santos-Ocampo S, Colvin JS, Chellaiah A, Ornitz DM (1996) Expression and biological activity of mouse fibroblast growth factor-9. J Biol Chem 271(3):1726-1731
    • (1996) J Biol Chem , vol.271 , Issue.3 , pp. 1726-1731
    • Santos-Ocampo, S.1    Colvin, J.S.2    Chellaiah, A.3    Ornitz, D.M.4
  • 195
    • 23744475256 scopus 로고    scopus 로고
    • Distinct fibroblast growth factor (FGF)/FGF receptor signaling pairs initiate diverse cellular responses in the oligodendrocyte lineage
    • 10.1523/JNEUROSCI.2120-05.2005 16093398 1:CAS:528:DC%2BD2MXpsFGiu7o%3D
    • Fortin D, Rom E, Sun H, Yayon A, Bansal R (2005) Distinct fibroblast growth factor (FGF)/FGF receptor signaling pairs initiate diverse cellular responses in the oligodendrocyte lineage. J Neurosci 25(32):7470-7479. doi: 10.1523/JNEUROSCI.2120-05.2005
    • (2005) J Neurosci , vol.25 , Issue.32 , pp. 7470-7479
    • Fortin, D.1    Rom, E.2    Sun, H.3    Yayon, A.4    Bansal, R.5
  • 196
    • 0033007224 scopus 로고    scopus 로고
    • Genomic structure, mapping, activity and expression of fibroblast growth factor 17
    • 10381577 1:CAS:528:DyaK1MXjs1Sht7s%3D
    • Xu J, Lawshe A, MacArthur CA, Ornitz DM (1999) Genomic structure, mapping, activity and expression of fibroblast growth factor 17. Mech Dev 83(1-2):165-178
    • (1999) Mech Dev , vol.83 , Issue.1-2 , pp. 165-178
    • Xu, J.1    Lawshe, A.2    Macarthur, C.A.3    Ornitz, D.M.4
  • 197
    • 23944492860 scopus 로고    scopus 로고
    • Expression of the fetal-oncogenic fibroblast growth factor-8/17/18 subfamily in human hematopoietic tumors
    • 10.1016/j.bbrc.2005.07.153 16095560 1:CAS:528:DC%2BD2MXpsVCgu7g%3D
    • Nezu M, Tomonaga T, Sakai C, Ishii A, Itoga S, Nishimura M, Matsuo Y, Tagawa M, Nomura F (2005) Expression of the fetal-oncogenic fibroblast growth factor-8/17/18 subfamily in human hematopoietic tumors. Biochem Biophys Res Commun 335(3):843-849. doi: 10.1016/j.bbrc.2005.07.153
    • (2005) Biochem Biophys Res Commun , vol.335 , Issue.3 , pp. 843-849
    • Nezu, M.1    Tomonaga, T.2    Sakai, C.3    Ishii, A.4    Itoga, S.5    Nishimura, M.6    Matsuo, Y.7    Tagawa, M.8    Nomura, F.9
  • 198
    • 0037447999 scopus 로고    scopus 로고
    • Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c
    • 10.1002/jnr.10592 12704805 1:CAS:528:DC%2BD3sXjs1ensL0%3D
    • Ohmachi S, Mikami T, Konishi M, Miyake A, Itoh N (2003) Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c. J Neurosci Res 72(4):436-443. doi: 10.1002/jnr.10592
    • (2003) J Neurosci Res , vol.72 , Issue.4 , pp. 436-443
    • Ohmachi, S.1    Mikami, T.2    Konishi, M.3    Miyake, A.4    Itoh, N.5
  • 199
    • 77956484079 scopus 로고    scopus 로고
    • Fibroblast growth factor (FGF)-21 signals through both FGF receptor-1 and 2
    • 10.1007/s11427-010-4035-z 20821299 1:CAS:528:DC%2BC3cXhtFWqtLjO
    • Ren G, Yin J, Wang W, Li L, Li D (2010) Fibroblast growth factor (FGF)-21 signals through both FGF receptor-1 and 2. Sci China Life Sci 53(8):1000-1008. doi: 10.1007/s11427-010-4035-z
    • (2010) Sci China Life Sci , vol.53 , Issue.8 , pp. 1000-1008
    • Ren, G.1    Yin, J.2    Wang, W.3    Li, L.4    Li, D.5
  • 200
    • 79952803104 scopus 로고    scopus 로고
    • FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways
    • 10.1371/journal.pone.0017868 21437243 1:CAS:528:DC%2BC3MXkt1Slsb8%3D
    • Wu AL, Coulter S, Liddle C, Wong A, Eastham-Anderson J, French DM, Peterson AS, Sonoda J (2011) FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways. PLoS ONE 6(3):e17868. doi: 10.1371/journal.pone.0017868
    • (2011) PLoS ONE , vol.6 , Issue.3 , pp. 17868
    • Wu, A.L.1    Coulter, S.2    Liddle, C.3    Wong, A.4    Eastham-Anderson, J.5    French, D.M.6    Peterson, A.S.7    Sonoda, J.8
  • 201
    • 34848869695 scopus 로고    scopus 로고
    • Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21
    • 10.1074/jbc.M704165200 17623664 1:CAS:528:DC%2BD2sXhtVWjsL3K
    • Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-o M (2007) Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem 282(37):26687-26695. doi: 10.1074/jbc.M704165200
    • (2007) J Biol Chem , vol.282 , Issue.37 , pp. 26687-26695
    • Kurosu, H.1    Choi, M.2    Ogawa, Y.3    Dickson, A.S.4    Goetz, R.5    Eliseenkova, A.V.6    Mohammadi, M.7    Rosenblatt, K.P.8    Kliewer, S.A.9    Kuro-O, M.10
  • 202
    • 34548099690 scopus 로고    scopus 로고
    • High-resolution single nucleotide polymorphism array analysis of epithelial ovarian cancer reveals numerous microdeletions and amplifications
    • 10.1158/1078-0432.CCR-07-0502 17699850 1:CAS:528:DC%2BD2sXptVGmtro%3D
    • Gorringe KL, Jacobs S, Thompson ER, Sridhar A, Qiu W, Choong DY, Campbell IG (2007) High-resolution single nucleotide polymorphism array analysis of epithelial ovarian cancer reveals numerous microdeletions and amplifications. Clin Cancer Res 13(16):4731-4739. doi: 10.1158/1078-0432.CCR-07-0502
    • (2007) Clin Cancer Res , vol.13 , Issue.16 , pp. 4731-4739
    • Gorringe, K.L.1    Jacobs, S.2    Thompson, E.R.3    Sridhar, A.4    Qiu, W.5    Choong, D.Y.6    Campbell, I.G.7
  • 204
    • 65349108616 scopus 로고    scopus 로고
    • Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: An approach to identify candidate genes involved in tumor development
    • 10.1002/gcc.20655 19235922 1:CAS:528:DC%2BD1MXltlagsrs%3D
    • Missiaglia E, Selfe J, Hamdi M, Williamson D, Schaaf G, Fang C, Koster J, Summersgill B, Messahel B, Versteeg R, Pritchard-Jones K, Kool M, Shipley J (2009) Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development. Genes Chromosom Cancer 48(6):455-467. doi: 10.1002/gcc.20655
    • (2009) Genes Chromosom Cancer , vol.48 , Issue.6 , pp. 455-467
    • Missiaglia, E.1    Selfe, J.2    Hamdi, M.3    Williamson, D.4    Schaaf, G.5    Fang, C.6    Koster, J.7    Summersgill, B.8    Messahel, B.9    Versteeg, R.10    Pritchard-Jones, K.11    Kool, M.12    Shipley, J.13
  • 206
    • 78650501317 scopus 로고    scopus 로고
    • A therapeutic target for smoking-associated lung cancer
    • 10.1126/scitranslmed.3001942 21160076 1:CAS:528:DC%2BC3MXhsFWisLk%3D
    • Turner NC, Seckl MJ (2010) A therapeutic target for smoking-associated lung cancer. Sci Transl Med 2(62):62ps56. doi: 10.1126/scitranslmed.3001942
    • (2010) Sci Transl Med , vol.2 , Issue.62
    • Turner, N.C.1    Seckl, M.J.2
  • 207
    • 34249783442 scopus 로고    scopus 로고
    • AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor
    • 10.1158/1078-0432.CCR-06-2743 17505008 1:CAS:528:DC%2BD2sXlt1KrtLs%3D
    • Takeda M, Arao T, Yokote H, Komatsu T, Yanagihara K, Sasaki H, Yamada Y, Tamura T, Fukuoka K, Kimura H, Saijo N, Nishio K (2007) AZD2171 shows potent antitumor activity against gastric cancer over-expressing fibroblast growth factor receptor 2/keratinocyte growth factor receptor. Clin Cancer Res 13(10):3051-3057. doi: 10.1158/1078-0432.CCR-06-2743
    • (2007) Clin Cancer Res , vol.13 , Issue.10 , pp. 3051-3057
    • Takeda, M.1    Arao, T.2    Yokote, H.3    Komatsu, T.4    Yanagihara, K.5    Sasaki, H.6    Yamada, Y.7    Tamura, T.8    Fukuoka, K.9    Kimura, H.10    Saijo, N.11    Nishio, K.12
  • 208
    • 0034469902 scopus 로고    scopus 로고
    • Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE
    • 11056689 1:CAS:528:DC%2BD3cXlvFOgtb4%3D
    • Tannheimer SL, Rehemtulla A, Ethier SP (2000) Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE. Breast Cancer Res 2(4):311-320
    • (2000) Breast Cancer Res , vol.2 , Issue.4 , pp. 311-320
    • Tannheimer, S.L.1    Rehemtulla, A.2    Ethier, S.P.3
  • 213
    • 34250665448 scopus 로고    scopus 로고
    • DNA copy number gains at loci of growth factors and their receptors in salivary gland adenoid cystic carcinoma
    • 10.1158/1078-0432.CCR-06-2555 17545515 1:CAS:528:DC%2BD2sXmtVajtbo%3D
    • Vekony H, Ylstra B, Wilting SM, Meijer GA, van de Wiel MA, Leemans CR, van der Waal I, Bloemena E (2007) DNA copy number gains at loci of growth factors and their receptors in salivary gland adenoid cystic carcinoma. Clin Cancer Res 13(11):3133-3139. doi: 10.1158/1078-0432.CCR-06-2555
    • (2007) Clin Cancer Res , vol.13 , Issue.11 , pp. 3133-3139
    • Vekony, H.1    Ylstra, B.2    Wilting, S.M.3    Meijer, G.A.4    Van De Wiel, M.A.5    Leemans, C.R.6    Van Der Waal, I.7    Bloemena, E.8
  • 224
    • 52049086201 scopus 로고    scopus 로고
    • Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation
    • 10.1158/0008-5472.CAN-08-0770 18757403 1:CAS:528:DC%2BD1cXhtVCrs7%2FO
    • Byron SA, Gartside MG, Wellens CL, Mallon MA, Keenan JB, Powell MA, Goodfellow PJ, Pollock PM (2008) Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation. Cancer Res 68(17):6902-6907. doi: 10.1158/0008-5472.CAN-08-0770
    • (2008) Cancer Res , vol.68 , Issue.17 , pp. 6902-6907
    • Byron, S.A.1    Gartside, M.G.2    Wellens, C.L.3    Mallon, M.A.4    Keenan, J.B.5    Powell, M.A.6    Goodfellow, P.J.7    Pollock, P.M.8
  • 227
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network 10.1038/nature07385
    • Cancer Genome Atlas Research Network (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455(7216):1061-1068. doi: 10.1038/nature07385
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
  • 228
    • 23944446080 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2, gain-of-function mutations, and tumourigenesis: Investigating a potential link
    • 10.1002/path.1816 16010693 1:CAS:528:DC%2BD2MXhtVemtrzE
    • Hansen RM, Goriely A, Wall SA, Roberts IS, Wilkie AO (2005) Fibroblast growth factor receptor 2, gain-of-function mutations, and tumourigenesis: investigating a potential link. J Pathol 207(1):27-31. doi: 10.1002/path.1816
    • (2005) J Pathol , vol.207 , Issue.1 , pp. 27-31
    • Hansen, R.M.1    Goriely, A.2    Wall, S.A.3    Roberts, I.S.4    Wilkie, A.O.5
  • 229
    • 77949277517 scopus 로고    scopus 로고
    • FGFR2 mutations are rare across histologic subtypes of ovarian cancer
    • 10.1016/j.ygyno.2009.12.002 20106510 1:CAS:528:DC%2BC3cXjs1WqtL8%3D
    • Byron SA, Gartside MG, Wellens CL, Goodfellow PJ, Birrer MJ, Campbell IG, Pollock PM (2010) FGFR2 mutations are rare across histologic subtypes of ovarian cancer. Gynecol Oncol 117(1):125-129. doi: 10.1016/j.ygyno.2009.12.002
    • (2010) Gynecol Oncol , vol.117 , Issue.1 , pp. 125-129
    • Byron, S.A.1    Gartside, M.G.2    Wellens, C.L.3    Goodfellow, P.J.4    Birrer, M.J.5    Campbell, I.G.6    Pollock, P.M.7
  • 230
    • 0035328856 scopus 로고    scopus 로고
    • Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers
    • 11325814 1:CAS:528:DC%2BD3MXjsFCgt7s%3D
    • Jang JH, Shin KH, Park JG (2001) Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. Cancer Res 61(9):3541-3543
    • (2001) Cancer Res , vol.61 , Issue.9 , pp. 3541-3543
    • Jang, J.H.1    Shin, K.H.2    Park, J.G.3
  • 233
    • 0034888840 scopus 로고    scopus 로고
    • Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14)
    • 11529856 1:CAS:528:DC%2BD3MXmsVyhu7o%3D
    • Intini D, Baldini L, Fabris S, Lombardi L, Ciceri G, Maiolo AT, Neri A (2001) Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14). Br J Haematol 114(2):362-364
    • (2001) Br J Haematol , vol.114 , Issue.2 , pp. 362-364
    • Intini, D.1    Baldini, L.2    Fabris, S.3    Lombardi, L.4    Ciceri, G.5    Maiolo, A.T.6    Neri, A.7
  • 234
    • 0030842266 scopus 로고    scopus 로고
    • A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene
    • 9354676 1:CAS:528:DyaK2sXnt12rurk%3D
    • Richelda R, Ronchetti D, Baldini L, Cro L, Viggiano L, Marzella R, Rocchi M, Otsuki T, Lombardi L, Maiolo AT, Neri A (1997) A novel chromosomal translocation t(4; 14)(p16.3; q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene. Blood 90(10):4062-4070
    • (1997) Blood , vol.90 , Issue.10 , pp. 4062-4070
    • Richelda, R.1    Ronchetti, D.2    Baldini, L.3    Cro, L.4    Viggiano, L.5    Marzella, R.6    Rocchi, M.7    Otsuki, T.8    Lombardi, L.9    Maiolo, A.T.10    Neri, A.11
  • 235
    • 0030922231 scopus 로고    scopus 로고
    • Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
    • 10.1038/ng0797-260 9207791 1:CAS:528:DyaK2sXktFGjsrc%3D
    • Chesi M, Nardini E, Brents LA, Schrock E, Ried T, Kuehl WM, Bergsagel PL (1997) Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 16(3):260-264. doi: 10.1038/ng0797-260
    • (1997) Nat Genet , vol.16 , Issue.3 , pp. 260-264
    • Chesi, M.1    Nardini, E.2    Brents, L.A.3    Schrock, E.4    Ried, T.5    Kuehl, W.M.6    Bergsagel, P.L.7
  • 236
    • 0035858985 scopus 로고    scopus 로고
    • Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): Comparative analysis of Y373C, K650E and the novel G384D mutations
    • 10.1038/sj.onc.1204465 11429702 1:CAS:528:DC%2BD3MXkvValsL0%3D
    • Ronchetti D, Greco A, Compasso S, Colombo G, Dell'Era P, Otsuki T, Lombardi L, Neri A (2001) Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations. Oncogene 20(27):3553-3562. doi: 10.1038/sj.onc.1204465
    • (2001) Oncogene , vol.20 , Issue.27 , pp. 3553-3562
    • Ronchetti, D.1    Greco, A.2    Compasso, S.3    Colombo, G.4    Dell'Era, P.5    Otsuki, T.6    Lombardi, L.7    Neri, A.8
  • 237
    • 0035254612 scopus 로고    scopus 로고
    • Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
    • 11157491 1:CAS:528:DC%2BD3MXhtVSjsbg%3D
    • Chesi M, Brents LA, Ely SA, Bais C, Robbiani DF, Mesri EA, Kuehl WM, Bergsagel PL (2001) Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma. Blood 97(3):729-736
    • (2001) Blood , vol.97 , Issue.3 , pp. 729-736
    • Chesi, M.1    Brents, L.A.2    Ely, S.A.3    Bais, C.4    Robbiani, D.F.5    Mesri, E.A.6    Kuehl, W.M.7    Bergsagel, P.L.8
  • 238
    • 67649392392 scopus 로고    scopus 로고
    • The G1138A mutation rate in the fibroblast growth factor receptor 3 (FGFR3) gene is increased in cells carrying the t (4; 14) translocation
    • 19551630 1:CAS:528:DC%2BD1MXltlGhtLg%3D
    • Reddy PL, Grewal RP (2009) The G1138A mutation rate in the fibroblast growth factor receptor 3 (FGFR3) gene is increased in cells carrying the t (4; 14) translocation. Genet Mol Res 8(2):435-439
    • (2009) Genet Mol Res , vol.8 , Issue.2 , pp. 435-439
    • Reddy, P.L.1    Grewal, R.P.2
  • 239
    • 0032532626 scopus 로고    scopus 로고
    • FGFR3 gene mutations associated with human skeletal disorders occur rarely in multiple myeloma
    • 9763594 1:CAS:528:DyaK1cXms1elu7g%3D
    • Fracchiolla NS, Luminari S, Baldini L, Lombardi L, Maiolo AT, Neri A (1998) FGFR3 gene mutations associated with human skeletal disorders occur rarely in multiple myeloma. Blood 92(8):2987-2989
    • (1998) Blood , vol.92 , Issue.8 , pp. 2987-2989
    • Fracchiolla, N.S.1    Luminari, S.2    Baldini, L.3    Lombardi, L.4    Maiolo, A.T.5    Neri, A.6
  • 240
    • 34548407864 scopus 로고    scopus 로고
    • FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer
    • 10.1002/path.2207 17668422 1:CAS:528:DC%2BD2sXhtFSksLjN
    • Tomlinson DC, Baldo O, Harnden P, Knowles MA (2007) FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. J Pathol 213(1):91-98. doi: 10.1002/path.2207
    • (2007) J Pathol , vol.213 , Issue.1 , pp. 91-98
    • Tomlinson, D.C.1    Baldo, O.2    Harnden, P.3    Knowles, M.A.4
  • 241
    • 79951868916 scopus 로고    scopus 로고
    • Integrated genetic and epigenetic analysis of bladder cancer reveals an additive diagnostic value of FGFR3 mutations and hypermethylation events
    • 10.1002/ijc.25651 20824703 1:CAS:528:DC%2BC3MXltFGksr4%3D
    • Serizawa RR, Ralfkiaer U, Steven K, Lam GW, Schmiedel S, Schuz J, Hansen AB, Horn T, Guldberg P (2011) Integrated genetic and epigenetic analysis of bladder cancer reveals an additive diagnostic value of FGFR3 mutations and hypermethylation events. Int J Cancer 129(1):78-87. doi: 10.1002/ijc.25651
    • (2011) Int J Cancer , vol.129 , Issue.1 , pp. 78-87
    • Serizawa, R.R.1    Ralfkiaer, U.2    Steven, K.3    Lam, G.W.4    Schmiedel, S.5    Schuz, J.6    Hansen, A.B.7    Horn, T.8    Guldberg, P.9
  • 242
    • 78149483788 scopus 로고    scopus 로고
    • FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy
    • 10.1371/journal.pone.0013821 21072204
    • Kompier LC, Lurkin I, van der Aa MN, van Rhijn BW, van der Kwast TH, Zwarthoff EC (2010) FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy. PLoS One 5(11):e13821. doi: 10.1371/journal.pone.0013821
    • (2010) PLoS One , vol.5 , Issue.11 , pp. 13821
    • Kompier, L.C.1    Lurkin, I.2    Van Der Aa, M.N.3    Van Rhijn, B.W.4    Van Der Kwast, T.H.5    Zwarthoff, E.C.6
  • 243
    • 27744515561 scopus 로고    scopus 로고
    • Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors
    • 10.1158/1078-0432.CCR-05-1130 16278391 1:CAS:528:DC%2BD2MXhtF2is7fE
    • Zieger K, Dyrskjot L, Wiuf C, Jensen JL, Andersen CL, Jensen KM, Orntoft TF (2005) Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors. Clin Cancer Res 11(21):7709-7719. doi: 10.1158/1078-0432.CCR-05-1130
    • (2005) Clin Cancer Res , vol.11 , Issue.21 , pp. 7709-7719
    • Zieger, K.1    Dyrskjot, L.2    Wiuf, C.3    Jensen, J.L.4    Andersen, C.L.5    Jensen, K.M.6    Orntoft, T.F.7
  • 244
    • 27744600116 scopus 로고    scopus 로고
    • A simple and fast method for the simultaneous detection of nine fibroblast growth factor receptor 3 mutations in bladder cancer and voided urine
    • 10.1158/1078-0432.CCR-05-1045 16278395
    • van Oers JM, Lurkin I, van Exsel AJ, Nijsen Y, van Rhijn BW, van der Aa MN, Zwarthoff EC (2005) A simple and fast method for the simultaneous detection of nine fibroblast growth factor receptor 3 mutations in bladder cancer and voided urine. Clin Cancer Res 11(21):7743-7748. doi: 10.1158/1078-0432.CCR-05- 1045
    • (2005) Clin Cancer Res , vol.11 , Issue.21 , pp. 7743-7748
    • Van Oers, J.M.1    Lurkin, I.2    Van Exsel, A.J.3    Nijsen, Y.4    Van Rhijn, B.W.5    Van Der Aa, M.N.6    Zwarthoff, E.C.7
  • 246
    • 23444440484 scopus 로고    scopus 로고
    • FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma
    • 10.1038/sj.onc.1208705 15897885 1:CAS:528:DC%2BD2MXmvFemsbo%3D
    • Jebar AH, Hurst CD, Tomlinson DC, Johnston C, Taylor CF, Knowles MA (2005) FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma. Oncogene 24(33):5218-5225. doi: 10.1038/sj.onc. 1208705
    • (2005) Oncogene , vol.24 , Issue.33 , pp. 5218-5225
    • Jebar, A.H.1    Hurst, C.D.2    Tomlinson, D.C.3    Johnston, C.4    Taylor, C.F.5    Knowles, M.A.6
  • 249
    • 0042572486 scopus 로고    scopus 로고
    • Identification of fibroblast growth factor receptor 3 mutations in urine sediment DNA samples complements cytology in bladder tumor detection
    • 10.1002/cncr.11536 12910517 1:CAS:528:DC%2BD3sXntVWgurw%3D
    • Rieger-Christ KM, Mourtzinos A, Lee PJ, Zagha RM, Cain J, Silverman M, Libertino JA, Summerhayes IC (2003) Identification of fibroblast growth factor receptor 3 mutations in urine sediment DNA samples complements cytology in bladder tumor detection. Cancer 98(4):737-744. doi: 10.1002/cncr.11536
    • (2003) Cancer , vol.98 , Issue.4 , pp. 737-744
    • Rieger-Christ, K.M.1    Mourtzinos, A.2    Lee, P.J.3    Zagha, R.M.4    Cain, J.5    Silverman, M.6    Libertino, J.A.7    Summerhayes, I.C.8
  • 250
    • 0038011950 scopus 로고    scopus 로고
    • Molecular grading of urothelial cell carcinoma with fibroblast growth factor receptor 3 and MIB-1 is superior to pathologic grade for the prediction of clinical outcome
    • 10.1200/JCO.2003.05.073 12743143
    • van Rhijn BW, Vis AN, van der Kwast TH, Kirkels WJ, Radvanyi F, Ooms EC, Chopin DK, Boeve ER, Jobsis AC, Zwarthoff EC (2003) Molecular grading of urothelial cell carcinoma with fibroblast growth factor receptor 3 and MIB-1 is superior to pathologic grade for the prediction of clinical outcome. J Clin Oncol 21(10):1912-1921. doi: 10.1200/JCO.2003.05.073
    • (2003) J Clin Oncol , vol.21 , Issue.10 , pp. 1912-1921
    • Van Rhijn, B.W.1    Vis, A.N.2    Van Der Kwast, T.H.3    Kirkels, W.J.4    Radvanyi, F.5    Ooms, E.C.6    Chopin, D.K.7    Boeve, E.R.8    Jobsis, A.C.9    Zwarthoff, E.C.10
  • 251
    • 62849109580 scopus 로고    scopus 로고
    • Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip
    • 10.1016/j.tripleo.2008.12.050 19327639
    • Chou A, Dekker N, Jordan RC (2009) Identification of novel fibroblast growth factor receptor 3 gene mutations in actinic cheilitis and squamous cell carcinoma of the lip. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107(4):535-541. doi: 10.1016/j.tripleo.2008.12.050
    • (2009) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.107 , Issue.4 , pp. 535-541
    • Chou, A.1    Dekker, N.2    Jordan, R.C.3
  • 252
    • 0035513427 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 S249C mutation in virus associated squamous cell carcinomas
    • 11605053 1:CAS:528:DC%2BD3MXotl2iurc%3D
    • Shotelersuk V, Ittiwut C, Shotelersuk K, Triratanachat S, Poovorawan Y, Mutirangura A (2001) Fibroblast growth factor receptor 3 S249C mutation in virus associated squamous cell carcinomas. Oncol Rep 8(6):1301-1304
    • (2001) Oncol Rep , vol.8 , Issue.6 , pp. 1301-1304
    • Shotelersuk, V.1    Ittiwut, C.2    Shotelersuk, K.3    Triratanachat, S.4    Poovorawan, Y.5    Mutirangura, A.6
  • 253
    • 24344468707 scopus 로고    scopus 로고
    • Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas
    • 10.1002/ijc.21145 15880580 1:CAS:528:DC%2BD2MXhtVaht7jN
    • Zhang Y, Hiraishi Y, Wang H, Sumi KS, Hayashido Y, Toratani S, Kan M, Sato JD, Okamoto T (2005) Constitutive activating mutation of the FGFR3b in oral squamous cell carcinomas. Int J Cancer 117(1):166-168. doi: 10.1002/ijc.21145
    • (2005) Int J Cancer , vol.117 , Issue.1 , pp. 166-168
    • Zhang, Y.1    Hiraishi, Y.2    Wang, H.3    Sumi, K.S.4    Hayashido, Y.5    Toratani, S.6    Kan, M.7    Sato, J.D.8    Okamoto, T.9
  • 254
    • 0035913187 scopus 로고    scopus 로고
    • Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours
    • 11466624 1:CAS:528:DC%2BD3MXlvFOisLc%3D
    • Sibley K, Stern P, Knowles MA (2001) Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours. Oncogene 20(32):4416-4418
    • (2001) Oncogene , vol.20 , Issue.32 , pp. 4416-4418
    • Sibley, K.1    Stern, P.2    Knowles, M.A.3
  • 255
    • 0034676335 scopus 로고    scopus 로고
    • Somatic mutations of fibroblast growth factor receptor 3 (FGFR3) are uncommon in carcinomas of the uterine cervix
    • 10.1038/sj.onc.1203934 11114733 1:CAS:528:DC%2BD3cXosl2msrg%3D
    • Wu R, Connolly D, Ngelangel C, Bosch FX, Munoz N, Cho KR (2000) Somatic mutations of fibroblast growth factor receptor 3 (FGFR3) are uncommon in carcinomas of the uterine cervix. Oncogene 19(48):5543-5546. doi: 10.1038/sj.onc.1203934
    • (2000) Oncogene , vol.19 , Issue.48 , pp. 5543-5546
    • Wu, R.1    Connolly, D.2    Ngelangel, C.3    Bosch, F.X.4    Munoz, N.5    Cho, K.R.6
  • 261
    • 58149340186 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer
    • 18949411 1:CAS:528:DC%2BD1cXhsVaqtrzN
    • Sasaki H, Okuda K, Kawano O, Yukiue H, Yano M, Fujii Y (2008) Fibroblast growth factor receptor 4 mutation and polymorphism in Japanese lung cancer. Oncol Rep 20(5):1125-1130
    • (2008) Oncol Rep , vol.20 , Issue.5 , pp. 1125-1130
    • Sasaki, H.1    Okuda, K.2    Kawano, O.3    Yukiue, H.4    Yano, M.5    Fujii, Y.6
  • 263
    • 78649631410 scopus 로고    scopus 로고
    • FGFR4 transmembrane domain polymorphism and cancer risk: A meta-analysis including 8555 subjects
    • 10.1016/j.ejca.2010.06.017 20638838 1:CAS:528:DC%2BC3cXhsVyqurfO
    • Xu W, Li Y, Wang X, Chen B, Wang Y, Liu S, Xu J, Zhao W, Wu J (2010) FGFR4 transmembrane domain polymorphism and cancer risk: a meta-analysis including 8555 subjects. Eur J Cancer 46(18):3332-3338. doi: 10.1016/j.ejca.2010.06.017
    • (2010) Eur J Cancer , vol.46 , Issue.18 , pp. 3332-3338
    • Xu, W.1    Li, Y.2    Wang, X.3    Chen, B.4    Wang, Y.5    Liu, S.6    Xu, J.7    Zhao, W.8    Wu, J.9
  • 264
    • 78650976905 scopus 로고    scopus 로고
    • The fibroblast growth factor receptor-4 Arg388 allele is associated with gastric cancer progression
    • 10.1245/s10434-010-1323-6 20844967
    • Ye Y, Shi Y, Zhou Y, Du C, Wang C, Zhan H, Zheng B, Cao X, Sun MH, Fu H (2010) The fibroblast growth factor receptor-4 Arg388 allele is associated with gastric cancer progression. Ann Surg Oncol 17(12):3354-3361. doi: 10.1245/s10434-010-1323-6
    • (2010) Ann Surg Oncol , vol.17 , Issue.12 , pp. 3354-3361
    • Ye, Y.1    Shi, Y.2    Zhou, Y.3    Du, C.4    Wang, C.5    Zhan, H.6    Zheng, B.7    Cao, X.8    Sun, M.H.9    Fu, H.10
  • 265
    • 33745099963 scopus 로고    scopus 로고
    • FGFR4 Arg388 allele correlates with tumour thickness and FGFR4 protein expression with survival of melanoma patients
    • 10.1038/sj.bjc.6603181 16721364 1:CAS:528:DC%2BD28XlsFequrs%3D
    • Streit S, Mestel DS, Schmidt M, Ullrich A, Berking C (2006) FGFR4 Arg388 allele correlates with tumour thickness and FGFR4 protein expression with survival of melanoma patients. Br J Cancer 94(12):1879-1886. doi: 10.1038/sj.bjc.6603181
    • (2006) Br J Cancer , vol.94 , Issue.12 , pp. 1879-1886
    • Streit, S.1    Mestel, D.S.2    Schmidt, M.3    Ullrich, A.4    Berking, C.5
  • 266
    • 56949101730 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention
    • 10.1016/j.jhep.2008.08.015 19008009 1:CAS:528:DC%2BD1cXhsVCkt77I
    • Ho HK, Pok S, Streit S, Ruhe JE, Hart S, Lim KS, Loo HL, Aung MO, Lim SG, Ullrich A (2009) Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention. J Hepatol 50(1):118-127. doi: 10.1016/j.jhep.2008.08.015
    • (2009) J Hepatol , vol.50 , Issue.1 , pp. 118-127
    • Ho, H.K.1    Pok, S.2    Streit, S.3    Ruhe, J.E.4    Hart, S.5    Lim, K.S.6    Loo, H.L.7    Aung, M.O.8    Lim, S.G.9    Ullrich, A.10
  • 267
    • 0242526859 scopus 로고    scopus 로고
    • Single nucleotide polymorphism in fibroblast growth factor receptor 4 at codon 388 is associated with prognosis in high-grade soft tissue sarcoma
    • 10.1002/cncr.11778 14601095 1:CAS:528:DC%2BD3sXps1ars7g%3D
    • Morimoto Y, Ozaki T, Ouchida M, Umehara N, Ohata N, Yoshida A, Shimizu K, Inoue H (2003) Single nucleotide polymorphism in fibroblast growth factor receptor 4 at codon 388 is associated with prognosis in high-grade soft tissue sarcoma. Cancer 98(10):2245-2250. doi: 10.1002/cncr.11778
    • (2003) Cancer , vol.98 , Issue.10 , pp. 2245-2250
    • Morimoto, Y.1    Ozaki, T.2    Ouchida, M.3    Umehara, N.4    Ohata, N.5    Yoshida, A.6    Shimizu, K.7    Inoue, H.8
  • 268
    • 4644223140 scopus 로고    scopus 로고
    • The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression
    • 10.1158/1078-0432.CCR-04-0408 15448004 1:CAS:528:DC%2BD2cXnvVOjs7g%3D
    • Wang J, Stockton DW, Ittmann M (2004) The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression. Clin Cancer Res 10(18 Pt 1):6169-6178. doi: 10.1158/1078-0432.CCR- 04-0408
    • (2004) Clin Cancer Res , vol.10 , Issue.18 PART 1 , pp. 6169-6178
    • Wang, J.1    Stockton, D.W.2    Ittmann, M.3
  • 269
    • 79951947756 scopus 로고    scopus 로고
    • FGFR4 Gly388Arg polymorphism contributes to prostate cancer development and progression: A meta-analysis of 2618 cases and 2305 controls
    • 10.1186/1471-2407-11-84 21349172 1:CAS:528:DC%2BC3MXjtVyltrw%3D
    • Xu B, Tong N, Chen SQ, Hua LX, Wang ZJ, Zhang ZD, Chen M (2011) FGFR4 Gly388Arg polymorphism contributes to prostate cancer development and progression: a meta-analysis of 2618 cases and 2305 controls. BMC Cancer 11:84. doi: 10.1186/1471-2407-11-84
    • (2011) BMC Cancer , vol.11 , pp. 84
    • Xu, B.1    Tong, N.2    Chen, S.Q.3    Hua, L.X.4    Wang, Z.J.5    Zhang, Z.D.6    Chen, M.7
  • 270
    • 57349143287 scopus 로고    scopus 로고
    • Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population
    • 10.1002/ijc.23578 18756523 1:CAS:528:DC%2BD1cXhtlyru7vF
    • Ma Z, Tsuchiya N, Yuasa T, Inoue T, Kumazawa T, Narita S, Horikawa Y, Tsuruta H, Obara T, Saito M, Satoh S, Ogawa O, Habuchi T (2008) Polymorphisms of fibroblast growth factor receptor 4 have association with the development of prostate cancer and benign prostatic hyperplasia and the progression of prostate cancer in a Japanese population. Int J Cancer 123(11):2574-2579. doi: 10.1002/ijc.23578
    • (2008) Int J Cancer , vol.123 , Issue.11 , pp. 2574-2579
    • Ma, Z.1    Tsuchiya, N.2    Yuasa, T.3    Inoue, T.4    Kumazawa, T.5    Narita, S.6    Horikawa, Y.7    Tsuruta, H.8    Obara, T.9    Saito, M.10    Satoh, S.11    Ogawa, O.12    Habuchi, T.13
  • 272
    • 3142726255 scopus 로고    scopus 로고
    • Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma
    • 10.1002/ijc.20204 15197773 1:CAS:528:DC%2BD2cXlvFWnsLg%3D
    • Streit S, Bange J, Fichtner A, Ihrler S, Issing W, Ullrich A (2004) Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma. Int J Cancer 111(2):213-217. doi: 10.1002/ijc.20204
    • (2004) Int J Cancer , vol.111 , Issue.2 , pp. 213-217
    • Streit, S.1    Bange, J.2    Fichtner, A.3    Ihrler, S.4    Issing, W.5    Ullrich, A.6
  • 273
    • 33845922164 scopus 로고    scopus 로고
    • The fibroblast growth factor receptor 4 (FGFR4) Arg388 allele correlates with survival in head and neck squamous cell carcinoma
    • 10.1016/j.yexmp.2006.05.003 17084840
    • da Costa Andrade VC, Parise O Jr, Hors CP, de Melo Martins PC, Silva AP, Garicochea B (2007) The fibroblast growth factor receptor 4 (FGFR4) Arg388 allele correlates with survival in head and neck squamous cell carcinoma. Exp Mol Pathol 82(1):53-57. doi: 10.1016/j.yexmp.2006.05.003
    • (2007) Exp Mol Pathol , vol.82 , Issue.1 , pp. 53-57
    • Da Costa Andrade, V.C.1    Parise Jr., O.2    Hors, C.P.3    De Melo Martins, P.C.4    Silva, A.P.5    Garicochea, B.6
  • 274
    • 77349112658 scopus 로고    scopus 로고
    • FGFR4 polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma
    • 20127014 1:CAS:528:DC%2BC3cXjtlGrtrc%3D
    • Tanuma J, Izumo T, Hirano M, Oyazato Y, Hori F, Umemura E, Shisa H, Hiai H, Kitano M (2010) FGFR4 polymorphism, TP53 mutation, and their combinations are prognostic factors for oral squamous cell carcinoma. Oncol Rep 23(3):739-744
    • (2010) Oncol Rep , vol.23 , Issue.3 , pp. 739-744
    • Tanuma, J.1    Izumo, T.2    Hirano, M.3    Oyazato, Y.4    Hori, F.5    Umemura, E.6    Shisa, H.7    Hiai, H.8    Kitano, M.9
  • 278
    • 6844255886 scopus 로고    scopus 로고
    • The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP
    • 9499416 1:CAS:528:DyaK1cXisVemu70%3D
    • Smedley D, Hamoudi R, Clark J, Warren W, Abdul-Rauf M, Somers G, Venter D, Fagan K, Cooper C, Shipley J (1998) The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP. Hum Mol Genet 7(4):637-642
    • (1998) Hum Mol Genet , vol.7 , Issue.4 , pp. 637-642
    • Smedley, D.1    Hamoudi, R.2    Clark, J.3    Warren, W.4    Abdul-Rauf, M.5    Somers, G.6    Venter, D.7    Fagan, K.8    Cooper, C.9    Shipley, J.10
  • 279
    • 33845225471 scopus 로고    scopus 로고
    • Clonal evolution of 8p11 stem cell syndrome in a 14-year-old Chinese boy: A review of literature of t(8;13) associated myeloproliferative diseases
    • 10.1016/j.leukres.2006.04.015 16777224 1:CAS:528:DC%2BD28Xht12ksL7M
    • Wong WS, Cheng KC, Lau KM, Chan NP, Shing MM, Cheng SH, Chik KW, Li CK, Ng MH (2007) Clonal evolution of 8p11 stem cell syndrome in a 14-year-old Chinese boy: a review of literature of t(8;13) associated myeloproliferative diseases. Leuk Res 31(2):235-238. doi: 10.1016/j.leukres.2006.04.015
    • (2007) Leuk Res , vol.31 , Issue.2 , pp. 235-238
    • Wong, W.S.1    Cheng, K.C.2    Lau, K.M.3    Chan, N.P.4    Shing, M.M.5    Cheng, S.H.6    Chik, K.W.7    Li, C.K.8    Ng, M.H.9
  • 280
    • 0033251639 scopus 로고    scopus 로고
    • A chronic myelogenous leukemia-like myeloproliferative disorder accompanied by T-cell lymphoblastic lymphoma with chromosome translocation t(8;13)(p11;q12): A Japanese case
    • 10643154 1:STN:280:DC%2BD3c7gslOltA%3D%3D
    • Matsumoto K, Morita K, Takada S, Sakura T, Shiozaki H, Murakami H, Miyawaki S (1999) A chronic myelogenous leukemia-like myeloproliferative disorder accompanied by T-cell lymphoblastic lymphoma with chromosome translocation t(8;13)(p11;q12): a Japanese case. Int J Hematol 70(4):278-282
    • (1999) Int J Hematol , vol.70 , Issue.4 , pp. 278-282
    • Matsumoto, K.1    Morita, K.2    Takada, S.3    Sakura, T.4    Shiozaki, H.5    Murakami, H.6    Miyawaki, S.7
  • 282
    • 0033558253 scopus 로고    scopus 로고
    • The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1
    • 9949182 1:CAS:528:DyaK1MXht1Cju7w%3D
    • Popovici C, Zhang B, Gregoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pebusque MJ (1999) The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1. Blood 93(4):1381-1389
    • (1999) Blood , vol.93 , Issue.4 , pp. 1381-1389
    • Popovici, C.1    Zhang, B.2    Gregoire, M.J.3    Jonveaux, P.4    Lafage-Pochitaloff, M.5    Birnbaum, D.6    Pebusque, M.J.7
  • 283
    • 11044238012 scopus 로고    scopus 로고
    • Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: Two further cases
    • 10.1038/sj.thj.6200561 15570299 1:CAS:528:DC%2BD2cXhtVagtr3O
    • Vizmanos JL, Hernandez R, Vidal MJ, Larrayoz MJ, Odero MD, Marin J, Ardanaz MT, Calasanz MJ, Cross NC (2004) Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: two further cases. Hematol J 5(6):534-537. doi: 10.1038/sj.thj.6200561
    • (2004) Hematol J , vol.5 , Issue.6 , pp. 534-537
    • Vizmanos, J.L.1    Hernandez, R.2    Vidal, M.J.3    Larrayoz, M.J.4    Odero, M.D.5    Marin, J.6    Ardanaz, M.T.7    Calasanz, M.J.8    Cross, N.C.9
  • 285
    • 35548992255 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer
    • 10.1111/j.1349-7006.2007.00610.x 17888034 1:CAS:528:DC%2BD2sXhsVahur7N
    • Mano Y, Takahashi K, Ishikawa N, Takano A, Yasui W, Inai K, Nishimura H, Tsuchiya E, Nakamura Y, Daigo Y (2007) Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer. Cancer Sci 98(12):1902-1913. doi: 10.1111/j.1349-7006.2007.00610.x
    • (2007) Cancer Sci , vol.98 , Issue.12 , pp. 1902-1913
    • Mano, Y.1    Takahashi, K.2    Ishikawa, N.3    Takano, A.4    Yasui, W.5    Inai, K.6    Nishimura, H.7    Tsuchiya, E.8    Nakamura, Y.9    Daigo, Y.10
  • 286
    • 39449120487 scopus 로고    scopus 로고
    • 8p11 myeloproliferative syndrome preceded by t(8;9)(p11;q33), CEP110/FGFR1 fusion transcript: Morphologic, molecular, and cytogenetic characterization of myeloid neoplasms associated with eosinophilia and FGFR1 abnormality
    • 10.1016/j.cancergencyto.2007.11.011 18295660 1:CAS:528: DC%2BD1cXisVWitb0%3D
    • Park TS, Song J, Kim JS, Yang WI, Song S, Kim SJ, Suh B, Choi JR (2008) 8p11 myeloproliferative syndrome preceded by t(8;9)(p11;q33), CEP110/FGFR1 fusion transcript: morphologic, molecular, and cytogenetic characterization of myeloid neoplasms associated with eosinophilia and FGFR1 abnormality. Cancer Genet Cytogenet 181(2):93-99. doi: 10.1016/j.cancergencyto.2007.11.011
    • (2008) Cancer Genet Cytogenet , vol.181 , Issue.2 , pp. 93-99
    • Park, T.S.1    Song, J.2    Kim, J.S.3    Yang, W.I.4    Song, S.5    Kim, S.J.6    Suh, B.7    Choi, J.R.8
  • 287
    • 0034161335 scopus 로고    scopus 로고
    • FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)
    • 10688839 1:CAS:528:DC%2BD3cXhsVGgurs%3D
    • Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ (2000) FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33). Blood 95(5):1788-1796
    • (2000) Blood , vol.95 , Issue.5 , pp. 1788-1796
    • Guasch, G.1    Mack, G.J.2    Popovici, C.3    Dastugue, N.4    Birnbaum, D.5    Rattner, J.B.6    Pebusque, M.J.7
  • 288
    • 33748357533 scopus 로고    scopus 로고
    • A biphenotypic transformation of 8p11 myeloproliferative syndrome with CEP1/FGFR1 fusion gene
    • 10.1111/j.1600-0609.2006.00723.x 16879608 1:CAS:528:DC%2BD28XhtF2lsLnF
    • Yamamoto K, Kawano H, Nishikawa S, Yakushijin K, Okamura A, Matsui T (2006) A biphenotypic transformation of 8p11 myeloproliferative syndrome with CEP1/FGFR1 fusion gene. Eur J Haematol 77(4):349-354. doi: 10.1111/j.1600-0609. 2006.00723.x
    • (2006) Eur J Haematol , vol.77 , Issue.4 , pp. 349-354
    • Yamamoto, K.1    Kawano, H.2    Nishikawa, S.3    Yakushijin, K.4    Okamura, A.5    Matsui, T.6
  • 289
    • 42749083134 scopus 로고    scopus 로고
    • Common features of myeloproliferative disorders with t(8;9)(p12;q33) and CEP110-FGFR1 fusion: Report of a new case and review of the literature
    • 10.1016/j.leukres.2007.11.012 18096225 1:CAS:528:DC%2BD1cXlvVSqsLk%3D
    • Mozziconacci MJ, Carbuccia N, Prebet T, Charbonnier A, Murati A, Vey N, Chaffanet M, Birnbaum D (2008) Common features of myeloproliferative disorders with t(8;9)(p12;q33) and CEP110-FGFR1 fusion: report of a new case and review of the literature. Leuk Res 32(8):1304-1308. doi: 10.1016/j.leukres.2007.11.012
    • (2008) Leuk Res , vol.32 , Issue.8 , pp. 1304-1308
    • Mozziconacci, M.J.1    Carbuccia, N.2    Prebet, T.3    Charbonnier, A.4    Murati, A.5    Vey, N.6    Chaffanet, M.7    Birnbaum, D.8
  • 290
    • 79954575639 scopus 로고    scopus 로고
    • 8p11 Myeloproliferative syndrome with BCR-FGFR1 rearrangement presenting with T-lymphoblastic lymphoma and bone marrow stromal cell proliferation: A case report and review of the literature
    • 10.1016/j.leukres.2010.12.014 21239058 1:CAS:528:DC%2BC3MXkvFWqu7Y%3D
    • Kim SY, Oh B, She CJ, Kim HK, Jeon YK, Shin MG, Yoon SS, Lee DS (2011) 8p11 Myeloproliferative syndrome with BCR-FGFR1 rearrangement presenting with T-lymphoblastic lymphoma and bone marrow stromal cell proliferation: a case report and review of the literature. Leuk Res 35(5):e30-e34. doi: 10.1016/j.leukres.2010.12.014
    • (2011) Leuk Res , vol.35 , Issue.5
    • Kim, S.Y.1    Oh, B.2    She, C.J.3    Kim, H.K.4    Jeon, Y.K.5    Shin, M.G.6    Yoon, S.S.7    Lee, D.S.8
  • 291
    • 34249081692 scopus 로고    scopus 로고
    • Fusion gene-mediated truncation of RUNX1 as a potential mechanism underlying disease progression in the 8p11 myeloproliferative syndrome
    • 10.1002/gcc.20442 17394134
    • Agerstam H, Lilljebjorn H, Lassen C, Swedin A, Richter J, Vandenberghe P, Johansson B, Fioretos T (2007) Fusion gene-mediated truncation of RUNX1 as a potential mechanism underlying disease progression in the 8p11 myeloproliferative syndrome. Genes Chromosom Cancer 46(7):635-643. doi: 10.1002/gcc.20442
    • (2007) Genes Chromosom Cancer , vol.46 , Issue.7 , pp. 635-643
    • Agerstam, H.1    Lilljebjorn, H.2    Lassen, C.3    Swedin, A.4    Richter, J.5    Vandenberghe, P.6    Johansson, B.7    Fioretos, T.8
  • 293
    • 0035159831 scopus 로고    scopus 로고
    • Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: The first fusion gene involving BCR but not ABL
    • 10.1002/gcc.1195 11746971 1:CAS:528:DC%2BD3MXovVKgtbw%3D
    • Fioretos T, Panagopoulos I, Lassen C, Swedin A, Billstrom R, Isaksson M, Strombeck B, Olofsson T, Mitelman F, Johansson B (2001) Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL. Genes Chromosom Cancer 32(4):302-310. doi: 10.1002/gcc.1195
    • (2001) Genes Chromosom Cancer , vol.32 , Issue.4 , pp. 302-310
    • Fioretos, T.1    Panagopoulos, I.2    Lassen, C.3    Swedin, A.4    Billstrom, R.5    Isaksson, M.6    Strombeck, B.7    Olofsson, T.8    Mitelman, F.9    Johansson, B.10
  • 294
    • 67650825472 scopus 로고    scopus 로고
    • LRRFIP1, a new FGFR1 partner gene associated with 8p11 myeloproliferative syndrome
    • 10.1038/leu.2009.79 19369959 1:CAS:528:DC%2BD1MXoslOhsrw%3D
    • Soler G, Nusbaum S, Varet B, Macintyre EA, Vekemans M, Romana SP, Radford-Weiss I (2009) LRRFIP1, a new FGFR1 partner gene associated with 8p11 myeloproliferative syndrome. Leukemia 23(7):1359-1361. doi: 10.1038/leu.2009.79
    • (2009) Leukemia , vol.23 , Issue.7 , pp. 1359-1361
    • Soler, G.1    Nusbaum, S.2    Varet, B.3    Macintyre, E.A.4    Vekemans, M.5    Romana, S.P.6    Radford-Weiss, I.7
  • 295
    • 1942422114 scopus 로고    scopus 로고
    • Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome
    • 10.1002/gcc.20023 15034873 1:CAS:528:DC%2BD2cXjslCqtL0%3D
    • Grand EK, Grand FH, Chase AJ, Ross FM, Corcoran MM, Oscier DG, Cross NC (2004) Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. Genes Chromosom Cancer 40(1):78-83. doi: 10.1002/gcc.20023
    • (2004) Genes Chromosom Cancer , vol.40 , Issue.1 , pp. 78-83
    • Grand, E.K.1    Grand, F.H.2    Chase, A.J.3    Ross, F.M.4    Corcoran, M.M.5    Oscier, D.G.6    Cross, N.C.7
  • 296
    • 33845501610 scopus 로고    scopus 로고
    • Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia
    • 10.1182/blood-2006-06-026666 16946300 1:CAS:528:DC%2BD28XhtlWqsrnM
    • Gu TL, Goss VL, Reeves C, Popova L, Nardone J, Macneill J, Walters DK, Wang Y, Rush J, Comb MJ, Druker BJ, Polakiewicz RD (2006) Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. Blood 108(13):4202-4204. doi: 10.1182/blood-2006-06-026666
    • (2006) Blood , vol.108 , Issue.13 , pp. 4202-4204
    • Gu, T.L.1    Goss, V.L.2    Reeves, C.3    Popova, L.4    Nardone, J.5    Macneill, J.6    Walters, D.K.7    Wang, Y.8    Rush, J.9    Comb, M.J.10    Druker, B.J.11    Polakiewicz, R.D.12
  • 300
    • 0037216062 scopus 로고    scopus 로고
    • Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3)
    • 10.1182/blood-2002-02-0577 12393597 1:CAS:528:DC%2BD3sXhtFWhtw%3D%3D
    • Guasch G, Popovici C, Mugneret F, Chaffanet M, Pontarotti P, Birnbaum D, Pebusque MJ (2003) Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3). Blood 101(1):286-288. doi: 10.1182/blood-2002-02-0577
    • (2003) Blood , vol.101 , Issue.1 , pp. 286-288
    • Guasch, G.1    Popovici, C.2    Mugneret, F.3    Chaffanet, M.4    Pontarotti, P.5    Birnbaum, D.6    Pebusque, M.J.7
  • 301
    • 43449125270 scopus 로고    scopus 로고
    • High-resolution array CGH analysis of salivary gland tumors reveals fusion and amplification of the FGFR1 and PLAG1 genes in ring chromosomes
    • 10.1038/sj.onc.1210961 18059337 1:CAS:528:DC%2BD1cXlsFCltrk%3D
    • Persson F, Winnes M, Andren Y, Wedell B, Dahlenfors R, Asp J, Mark J, Enlund F, Stenman G (2008) High-resolution array CGH analysis of salivary gland tumors reveals fusion and amplification of the FGFR1 and PLAG1 genes in ring chromosomes. Oncogene 27(21):3072-3080. doi: 10.1038/sj.onc.1210961
    • (2008) Oncogene , vol.27 , Issue.21 , pp. 3072-3080
    • Persson, F.1    Winnes, M.2    Andren, Y.3    Wedell, B.4    Dahlenfors, R.5    Asp, J.6    Mark, J.7    Enlund, F.8    Stenman, G.9
  • 302
    • 79958051808 scopus 로고    scopus 로고
    • The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11)
    • 10.3324/haematol.2010.036558 21330321 1:CAS:528:DC%2BC38Xhs1Wnsb%2FM
    • Wasag B, Lierman E, Meeus P, Cools J, Vandenberghe P (2011) The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11). Haematologica 96(6):922-926. doi: 10.3324/haematol.2010.036558
    • (2011) Haematologica , vol.96 , Issue.6 , pp. 922-926
    • Wasag, B.1    Lierman, E.2    Meeus, P.3    Cools, J.4    Vandenberghe, P.5
  • 305
    • 0035577690 scopus 로고    scopus 로고
    • Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t(4;12)(p16;p13) chromosomal translocation
    • 11731410 1:CAS:528:DC%2BD3MXptFCkt7Y%3D
    • Yagasaki F, Wakao D, Yokoyama Y, Uchida Y, Murohashi I, Kayano H, Taniwaki M, Matsuda A, Bessho M (2001) Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t(4;12)(p16;p13) chromosomal translocation. Cancer Res 61(23):8371-8374
    • (2001) Cancer Res , vol.61 , Issue.23 , pp. 8371-8374
    • Yagasaki, F.1    Wakao, D.2    Yokoyama, Y.3    Uchida, Y.4    Murohashi, I.5    Kayano, H.6    Taniwaki, M.7    Matsuda, A.8    Bessho, M.9
  • 306
    • 84873045850 scopus 로고    scopus 로고
    • Oncogenic FGFR3 gene fusions in bladder cancer
    • 10.1093/hmg/dds486 23175443 1:CAS:528:DC%2BC3sXhsV2ksLs%3D
    • Williams SV, Hurst CD, Knowles MA (2013) Oncogenic FGFR3 gene fusions in bladder cancer. Hum Mol Genet 22(4):795-803. doi: 10.1093/hmg/dds486
    • (2013) Hum Mol Genet , vol.22 , Issue.4 , pp. 795-803
    • Williams, S.V.1    Hurst, C.D.2    Knowles, M.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.