Mutational analysis of the tyrosine kinome in colorectal cancers

Science

Volumn 300, Issue 5621, 2003, Pages 949-

  Bardelli, Alberto ^a,b   Parsons, D Williams ^a   Silliman, Natalie ^a   Ptak, Janine ^a   Szabo, Steve ^a   Saha, Saurabh ^a   Markowitz, Sanford ^c   Willson, James K V ^c   Parmigiani, Giovanni ^a   Kinzler, Kenneth W ^a   Vogelstein, Bert ^a   Velculescu, Victor E ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b UNIVERSITY OF TURIN   (Italy)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

GUANYLATE CYCLASE; PROTEIN TYROSINE KINASE;

CANCER; MUTATION;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER CELL CULTURE; COLORECTAL CANCER; EXON; GENE ACTIVATION; GENE AMPLIFICATION; GENE MUTATION; GENETIC SELECTION; GENOME; HUMAN; MULTIGENE FAMILY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; COLORECTAL NEOPLASMS; COMPUTATIONAL BIOLOGY; DNA MUTATIONAL ANALYSIS; EXONS; FUSION PROTEINS, GAG-ONC; GUANYLATE CYCLASE; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; RECEPTOR, EPHA3; RECEPTOR, TRKB; RECEPTOR, TRKC; SEQUENCE ANALYSIS, DNA; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 0038670241     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1082596     Document Type: Article

References (6)

1. P. Blume-Jensen, T. Hunter, Nature 411, 355 (2001).
2. G. Manning, D. B. Whyte, R. Martinez, T. Hunter, S. Sudarsanam, Science 298, 1912 (2002).
3. Materials and methods are available as supporting material on Science Online.
4. B. J. Druker, Cancer Cell 1, 31. (2002).
5. Single-letter abbreviations for the amino acid residues are as follows: A, Ala; C, Cys; D, Asp; E, Glu; F, Phe; G, Gly; H, His; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; P, Pro; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; W, Trp; and Y, Tyr.
6. Supported by The Benjamin Baker Scholarship Fund, The National Colorectal Cancer Research Alliance, and by NIH grants CA57345, CA62924, and CA43460.