FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: Results of a case control study in Japan

International Journal of Cancer

Volumn 125, Issue 8, 2009, Pages 1946-1952

  Kawase, Takakazu ^a   Matsuo, Keitaro ^a,b   Suzuki, Takeshi ^a   Hiraki, Akio ^a   Watanabe, Miki ^a   Iwata, Hiroji ^a   Tanaka, Hideo ^a,b   Tajima, Kazuo ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Breast cancer; FGFR2 intronic polymorphisms; Reproductive hormone

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 2; SEX HORMONE; FGFR2 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; ATTRIBUTABLE RISK; BODY MASS; BREAST CANCER; CANCER RISK; CASE CONTROL STUDY; CONTROLLED STUDY; DRINKING BEHAVIOR; EXERCISE; FAMILY HISTORY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; HISTOLOGY; HORMONE SUBSTITUTION; HUMAN; INTRON; JAPANESE; MAJOR CLINICAL STUDY; MENARCHE; MENOPAUSE; NULLIPARA; PARITY; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; AGE; BREAST TUMOR; CANCER STAGING; COMPARATIVE STUDY; GENETICS; JAPAN; MIDDLE AGED; PATHOLOGY; PREGNANCY; PROGNOSIS; REPRODUCTION; RISK FACTOR;

ADULT; AGE FACTORS; AGED; BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; HUMANS; INTRONS; JAPAN; LINKAGE DISEQUILIBRIUM; MENARCHE; MENOPAUSE; MIDDLE AGED; NEOPLASM STAGING; PARITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PROGNOSIS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; REPRODUCTION; RISK FACTORS;

EID: 70349245552     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24505     Document Type: Article

References (27)

1. IARC. Breast cancer. In: Stewart BW, Kleihues P, eds. World cancer report. Lyon: IARC, 2003:188-193.
2. Bray F, McCarron P, Parkin DM. The changing global patterns of female breast cancer incidence and mortality. Breast Cancer Res 2004;6:229-239 (Pubitemid 39440251)
3. Matsuno RK, Anderson WF, Yamamoto S, Tsukuma H, Pfeiffer RM, Kobayashi K, Devesa SS, Levine PH. Early- and late-onset breast cancer types among women in the United States and Japan. Cancer Epidemiol Biomarkers Prev 2007;16:1437-1442 (Pubitemid 47076875)
4. IARC. Cancer incidence in five continents, vol.IX. Lyon: IARC, 2007.
5. Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG, Struewing JP, Morrison J, Field H, Luben R, Wareham N, Ahmed S, et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 2007;447:1087-1093 (Pubitemid 47014426)
6. Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 2007;39:870-874 (Pubitemid 47014500)
7. Raskin L, Pinchev M, Arad C, Lejbkowicz F, Tamir A, Rennert HS, Rennert G, Gruber SB. FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations. Cancer Epidemiol Biomarkers Prev 2008;17:1060-1065
8. Liang J, Chen P, Hu Z, Zhou X, Chen L, Li M, Wang Y, Tang J, Wang H, Shen H. Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women. Carcinogenesis 2008;29:2341-2346
9. Rebbeck TR, DeMichele A, Tran TV, Panossian S, Bunin GR, Troxel AB, Strom BL. Hormone-dependent effects of FGFR2 and MAP3K1 in breast cancer susceptibility in a population-based sample of postmenopausal African-American and European-American women. Carcinogenesis 2009;30:269-274
10. Adnane J, Gaudray P, Dionne CA, Crumley G, Jaye M, Schlessinger J, Jeanteur P, Birnbaum D, Theillet C. BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers. Oncogene 1991;6:659-663 (Pubitemid 21924133)
11. Pollock PM, Gartside MG, Dejeza LC, Powell MA, Mallon MA, Davies H, Mohammadi M, Futreal PA, Stratton MR, Trent JM, Goodfellow PJ. Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Oncogene 2007;26:7158-7162 (Pubitemid 350059681)
12. Davies H, Hunter C, Smith R, Stephens P, Greenman C, Bignell G, Teague J, Butler A, Edkins S, Stevens C, Parker A, O'Meara S, et al. Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 2005;65:7591-7595 (Pubitemid 41297230)
13. Jang JH, Shin KH, Park JG. Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. Cancer Res 2001;61:3541-3543
14. Suzuki T, Matsuo K, Hirose K, Hiraki A, Kawase T, Watanabe M, Yamashita T, Iwata H, Tajima K. One-carbon metabolism-related gene polymorphisms and risk of breast cancer. Carcinogenesis 2008;29:356-362 (Pubitemid 351359675)
15. Inoue M, Tajima K, Hirose K, Hamajima N, Takezaki T, Kuroishi T, Tominaga S. Epidemiological features of first-visit outpatients in Japan: comparison with general population and variation by sex, age, and season. J Clin Epidemiol 1997;50:69-77. (Pubitemid 27089209)
16. Hamajima N, Hirose K, Takazaki T, Kuroishi T, Tajima K. Age-specific risk factors of breast cancer estimated by a case-control study in Japan. J Epidemiol 1995;5:99-105.
17. Hamajima N, Matsuo K, Saito T, Hirose K, Inoue M, Takezaki T, Kuroishi T, Tajima K. Gene-environment Interactions and Polymorphism Studies of cancer risk in the Hospital-based Epidemiologic Research Program at Aichi Cancer Center II (HERPACC-II). Asian Pac J Cancer Prev 2001;2:99-107.
18. Tajima K, Hirose K, Inoue M, Takezaki T, Hamajima N, Kuroishi T. A model of practical cancer prevention for out-patients visiting a hospital: the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC). Asian Pac J Cancer Prev 2000;1:35-47.
19. Livak KJ. Allelic discrimination using fluorogenic probes and the 50 nuclease assay. Genet Anal 1999;14:143-149 (Pubitemid 29095371)
20. Klatsky AL, Siegelaub AB, Landy C, Friedman GD. Racial patterns of alcoholic beverage use. Alcohol Clin Exp Res 1983;7:372-377 (Pubitemid 14234469)
21. Hunter DJ, Willett WC. Diet, body size, and breast cancer. Epidemiol Rev 1993;15:110-132
22. Key TJ, Appleby PN, Reeves GK, Roddam A, Dorgan JF, Longcope C, Stanczyk FZ, Stephenson HE, Jr, Falk RT, Miller R, Schatzkin A, Allen DS, et al. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 2003;95:1218-1226 (Pubitemid 37069552)
23. Ursin G, Longnecker MP, Haile RW, Greenland S. A meta-analysis of body mass index and risk of premenopausal breast cancer. Epidemiology 1995;6:137-141
24. Kelsey JL, Gammon MD, John EM. Reproductive factors and breast cancer. Epidemiol Rev 1993;15:36-47.
25. Bernstein L, Ross RK. Endogenous hormones and breast cancer risk. Epidemiol Rev 1993;15:48-65. (Pubitemid 23269070)
26. Meyer KB, Maia AT, O'Reilly M, Teschendorff AE, Chin SF, Caldas C, Ponder BA. Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer. PLoS Biol 2008;6:e108. (Pubitemid 351824744)
27. Hishikawa Y, Tamaru N, Ejima K, Hayashi T, Koji T. Expression of keratinocyte growth factor and its receptor in human breast cancer: its inhibitory role in the induction of apoptosis possibly through the overexpression of Bcl-2. Arch Histol Cytol 2004;67:455-464 (Pubitemid 40417402)