FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathways

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Wu, Ai Luen ^a   Coulter, Sally ^b   Liddle, Christopher ^b   Wong, Anne ^a   Eastham Anderson, Jeffrey ^a   French, Dorothy M ^a   Peterson, Andrew S ^a   Sonoda, Junichiro ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA KLOTHO PROTEIN; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR 21; FIBROBLAST GROWTH FACTOR RECEPTOR 4; INSULIN; KLOTHO PROTEIN; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG; BILE ACID; FGF19 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR; GLUCOSE; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BILE ACID METABOLISM; BILE ACID SYNTHESIS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION; GLUCOSE METABOLISM; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; KETOGENESIS; LIVER CELL; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; PROTEIN VARIANT; RAT; RECEPTOR BINDING; WEIGHT REDUCTION; ANIMAL; BIOLOGICAL MODEL; BLOOD; CHEMISTRY; CHO CELL; CRICETULUS; DRUG EFFECT; GLUCOSE TOLERANCE TEST; HAMSTER; HUMAN; HYPERGLYCEMIA; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; PATHOLOGY; SIGNAL TRANSDUCTION;

MUS;

AMINO ACID SEQUENCE; ANIMALS; BILE ACIDS AND SALTS; CELL PROLIFERATION; CHO CELLS; CRICETINAE; CRICETULUS; FIBROBLAST GROWTH FACTORS; GLUCOSE; GLUCOSE TOLERANCE TEST; HEPATOCYTES; HUMANS; HYPERGLYCEMIA; MICE; MICE, OBESE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 4; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 79952803104     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017868     Document Type: Article

References (36)

1. Kharitonenkov A, (2009) FGFs and metabolism. Curr Opin Pharmacol 9: 805-810.
2. Beenken A, Mohammadi M, (2009) The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov 8: 235-253.
3. Fu L, John LM, Adams SH, Yu XX, Tomlinson E, et al. (2004) Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology 145: 2594-2603.
4. Tomlinson E, Fu L, John L, Hultgren B, Huang X, et al. (2002) Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology 143: 1741-1747.
5. Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, et al. (2005) Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metabolism 2: 217-225.
6. Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, et al. (2006) Identification of a hormonal basis for gallbladder filling. Nat Med 12: 1253-1255.
7. Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, et al. (2008) Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 149: 6018-6027.
8. Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, et al. (2005) FGF-21 as a novel metabolic regulator. J Clin Invest 115: 1627-1635.
9. Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, et al. (2009) Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 58: 250-259.
10. Holt JA, Luo G, Billin AN, Bisi J, McNeill YY, et al. (2003) Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes & Development 17: 1581-1591.
11. Lundåsen T, Gälman C, Angelin B, Rudling M, (2006) Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man. J Intern Med 260: 530-536.
12. Shih DM, Kast-Woelbern HR, Wong J, Xia Y-R, Edwards PA, et al. (2006) A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. J Lipid Res 47: 384-392.
13. Tomiyama K, Maeda R, Urakawa I, Yamazaki Y, Tanaka T, et al. (2010) Relevant use of Klotho in FGF19 subfamily signaling system in vivo. Proc Natl Acad Sci U S A 107: 1666-1671.
14. Jung D, Inagaki T, Gerard RD, Dawson PA, Kliewer SA, et al. (2007) FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption. J Lipid Res 48: 2693-2700.
15. Nicholes K, Guillet S, Tomlinson E, Hillan K, Wright B, et al. (2002) A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. Am J Pathol 160: 2295-2307.
16. Wu X, Ge H, Lemon B, Vonderfecht S, Weiszmann J, et al. (2010) FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation. J Biol Chem 285: 5165-5170.
17. Wu X, Ge H, Lemon B, Vonderfecht S, Baribault H, et al. (2010) Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19). Proc Natl Acad Sci USA.
18. Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, et al. (2007) Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem 282: 26687-26695.
19. Lin BC, Wang M, Blackmore C, Desnoyers LR, (2007) Liver-specific activities of FGF19 require Klotho beta. J Biol Chem 282: 27277-27284.
20. Yu C, Wang F, Kan M, Jin C, Jones RB, et al. (2000) Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem 275: 15482-15489.
21. Zollner G, Wagner M, Moustafa T, Fickert P, Silbert D, et al. (2006) Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids. Am J Physiol Gastrointest Liver Physiol 290: G923-932.
22. Thomas C, Pellicciari R, Pruzanski M, Auwerx J, Schoonjans K, (2008) Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov 7: 678-693.
23. Russell D, (2003) THE ENZYMES, REGULATION, AND GENETICS OF BILE ACID SYNTHESIS. Annu Rev Biochem 72: 137-174.
24. Chung KC, Gomes I, Wang D, Lau LF, Rosner MR, (1998) Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as-dependent signaling pathways. Mol Cell Biol 18: 2272-2281.
25. Desnoyers LR, Pai R, Ferrando RE, Hötzel K, Le T, et al. (2008) Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. Oncogene 27: 85-97.
26. Xie MH, Holcomb I, Deuel B, Dowd P, Huang A, et al. (1999) FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine 11: 729-735.
27. Hedbacker K, Birsoy K, Wysocki R, Asilmaz E, Ahima R, et al. (2010) Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene. Cell Metabolism 11: 11-22.
28. Fon Tacer K, Bookout AL, Ding X, Kurosu H, John GB, et al. (2010) Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse. Mol Endocrinol.
29. Huang X, Yang C, Luo Y, Jin C, Wang F, et al. (2007) FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes 56: 2501-2510.
30. Wu X, Ge H, Lemon B, Weiszmann J, Gupte J, et al. (2009) Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice. Proc Natl Acad Sci USA 106: 14379-14384.
31. Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, et al. (2007) Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metabolism 5: 415-425.
32. Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, et al. (2006) Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281: 6120-6123.
33. Suzuki M, Uehara Y, Motomura-Matsuzaka K, Oki J, Koyama Y, et al. (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol 22: 1006-1014.
34. Mohammadi M, Olsen SK, Ibrahimi OA, (2005) Structural basis for fibroblast growth factor receptor activation. Cytokine Growth Factor Rev 16: 107-137.
35. Weinstein M, Xu X, Ohyama K, Deng CX, (1998) FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development 125: 3615-3623.
36. Stedman C, Robertson G, Coulter S, Liddle C, (2004) Feed-forward regulation of bile acid detoxification by CYP3A4: studies in humanized transgenic mice. J Biol Chem 279: 11336-11343.