Amplification of fibroblast growth factor receptor-1 in breast cancer and the effects of brivanib alaninate

Breast Cancer Research and Treatment

Volumn 123, Issue 3, 2010, Pages 747-755

  Shiang, Christine Y ^a   Qi, Yuan ^a   Wang, Bailiang ^a   Lazar, Vladimir ^b   Wang, Jing ^a   Symmans, W Fraser ^a   Hortobagyi, Gabriel N ^a   Andre, Fabrice ^b   Pusztai, Lajos ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Breast cancer cell lines; Brivanib alaninate; DNA amplification; Fibroblast growth factor receptor 1; Gene expression profiling; Targeted therapy

Indexed keywords

BRIVANIB ALANINATE; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE B; ALANINE; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; FGFR1 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE 3; TRIAZINE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CELL STIMULATION; COMPARATIVE GENOMIC HYBRIDIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG EXPOSURE; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INDUCTION; FIBROBLAST GROWTH FACTOR RECEPTOR 1 GENE; GENE AMPLIFICATION; GENE DOSAGE; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR GENE; BREAST TUMOR; DOSE RESPONSE; DRUG ANTAGONISM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IC 50; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ALANINE; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; COMPARATIVE GENOMIC HYBRIDIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FIBROBLAST GROWTH FACTOR 2; GENE AMPLIFICATION; GENE DOSAGE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INHIBITORY CONCENTRATION 50; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRIAZINES;

EID: 79952116987     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-009-0677-6     Document Type: Article

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