FGFR4 Arg388 allele correlates with tumour thickness and FGFR4 protein expression with survival of melanoma patients

British Journal of Cancer

Volumn 94, Issue 12, 2006, Pages 1879-1886

  Streit, S ^a,d   Mestel, D S ^b   Schmidt, M ^c   Ullrich, A ^a   Berking, C ^b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d AGENCY FOR SCIENCE   (Singapore)

Author keywords

FGFR4 Arg388 polymorphism; FGFR4 protein expression; Melanoma; Microvessel density; Survival; Tumour thickness

Indexed keywords

ARGININE; FIBROBLAST GROWTH FACTOR RECEPTOR 4; TUMOR MARKER;

ADULT; AGED; ALLELE; ARTICLE; CANCER INVASION; CANCER PATIENT; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE FREE SURVIVAL; FEMALE; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; METASTASIS; OVERALL SURVIVAL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SKIN NODULE; SKIN ULCER; THICKNESS; TISSUE SECTION; TUMOR VASCULARIZATION;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 4; SKIN NEOPLASMS; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 33745099963     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603181     Document Type: Article

References (47)

1. Albino AP, Davis BM, Nanus DM (1991) Induction of growth factor RNA expression in human malignant melanoma: markers of transformation. Cancer Res 51(18): 4815-4820
2. al-Alousi S, Barnhill R, Blessing K, Barksdale S (1996a) The prognostic significance of basic fibroblast growth factor in cutaneous malignant melanoma. J Cutan Pathol 23(6): 506-510
3. al-Alousi S, Carlson JA, Blessing K, Cook M, Karaoli T, Barnhill RL (1996b) Expression of basic fibroblast growth factor in desmoplastic melanoma. J Cutan Pathol 23(2): 118-125
4. Balasubramanian SP, Brown NJ, Reed MW (2002) Role of genetic polymorphisms in tumour angiogenesis. Br J Cancer 87(10): 1057-1065
5. Balch CM, Buzaid AC, Atkins MB, Cascinelli N, Coit DG, Fleming ID, Houghton Jr A, Kirkwood MD, Mihm MF, Morton DL, Reinigen D, Ross MI, Sober A, Soong SJ, Thompsom JA, Thompson JF, Gershenwald JE, McMasters KM (2000) A new American Joint Committee on Cancer staging system for cutaneous melanoma. Cancer 88(6): 1484-1491
6. Bange J, Prechtl D, Cheburkin Y, Specht K, Harbeck N, Schmitt M, Knyazeva T, Muller S, Gartner S, Sures I, Wang H, Imyanitov E, Häring HU, Knayzev P, Iacobelli S, Höfler H, Ullrich A (2002) Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele. Cancer Res 62(3): 840-847
7. Berking C, Takemoto R, Satyamoorthy K, Elenitsas R, Herlyn M (2001) Basic fibroblast growth factor and ultraviolet B transform melanocytes in human skin. Am J Pathol 158(3): 943-953
8. Berwick M, Armstrong BK, Ben-Porat L, Fine J, Kricker A, Eberle C, Barnhill R (2005) Sun exposure and mortality from melanoma. J Natl Cancer Inst 97(3): 195-199
9. Bikfalvi A, Klein S, Pintucci G, Rifkin DB (1997) Biological roles of fibroblast growth factor-2. Endocr Rev 18(1): 26-45
10. Cappellen D, De Oliveira C, Ricol D, de Medina S, Bourdin J, Sastre-Garau X, Chopin D, Thiery JP, Radvanyi F (1999) Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nat Genet 23(1): 18-20
11. Carlson JA, Ross JS, Slominski A, Linette G, Mysliborski J, Hill J, Miham Jr M (2005) Molecular diagnostics in melanoma. J Am Acad Dermatol 52(5): 743-775
12. Compagni A, Wilgenbus P, Impagnatiello MA, Cotten M, Christofori G (2000) Fibroblast growth factors are required for efficient tumor angiogenesis. Cancer Res 60(24): 7163-7169
13. Garland CF, Garland FC, Gorham ED (2003) Epidemiologic evidence for different roles of ultraviolet A and B radiation in melanoma mortality rates. Ann Epidemiol 13(6): 395-404
14. Gowardhan B, Douglas DA, Mathers ME, McKie AB, McCracken SR, Robson CN, Leung HY (2005) Evaluation of the fibroblast growth factor system as a potential target for therapy in human prostate cancer. Br J Cancer 92(2): 320-327
15. Graeven U, Rodeck U, Karpinski S, Jost M, Philippou S, Schmiegel W (2001) Modulation of angiogenesis and tumorigenicity of human melanocytic cells by vascular endothelial growth factor and basic fibroblast growth factor. Cancer Res 61(19): 7282-7290
16. Halaban R, Ghosh S, Baird A (1987) bFGF is the putative natural growth factor for human melanocytes. In vitro Cell Dev Biol 23(1): 47-52
17. Halaban R, Kwon BS, Ghosh S, Delli Bovi P, Baird A (1988b) bFGF as an autocrine growth factor for human melanomas. Oncogene Res 3(2): 177-186
18. Halaban R, Langdon R, Birchall N, Cuono C, Baird A, Scott G, Moellmann G, McGuire J (1988a) Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes. J Cell Biol 107(4): 1611-1619
19. Halaban R, Langdon R, Birchall N, Cuono C, Baird A, Scott G, Moellmann G, McGuire J (1988c) Paracrine stimulation of melanocytes by keratinocytes through basic fibroblast growth factor. Ann NY Acad Sci 548: 180-190
20. Jaakkola S, Salmikangas P, Nylund S, Partanen J, Armstrong E, Pyrhonen S, Lehtovirta P, Nevanlinna H (1993) Amplification of fgfr4 gene in human breast and gynecological cancers. Int J Cancer 54(3): 378-382
21. Jang JH, Shin KH, Park JG (2001) Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. Cancer Res 61(9): 3541-3543
22. Kaipainen A, Vlaykova T, Hatva E, Bohling T, Jekunen A, Pyrhonen S, Alitalo K (1994) Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas. Cancer Res 54(24): 6571-6577
23. Kashani-Sabet M, Sagebiel RW, Ferreira CM, Nosrati M, Miller III JR (2002) Tumor vascularity in the prognostic assessment of primary cutaneous melanoma. J Clin Oncol 20(7): 1826-1831
24. Klagsbrun M, Baird A (1991) A dual receptor system is required for basic fibroblast growth factor activity. Cell 67(2): 229-231
25. Krasagakis K, Garbe C, Zouboulis CC, Orfanos CE (1995) Growth control of melanoma cells and melanocytes by cytokines. Recent Results Cancer Res 139: 169-182
26. Lehtola L, Partanen J, Sistonen L, Korhonen J, Warri A, Harkonen P, Clarke R, Alitalo K (1992) Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast-cancer cells. Int J Cancer 50(4): 598-603
27. Leung HY, Gullick WJ, Lemoine NR (1994) Expression and functional activity of fibroblast growth factors and their receptors in human pancreatic cancer. Int J Cancer 59(5): 667-675
28. Maher PA (1996) Identification and characterization of a novel, intracellular isoform of fibroblast growth factor receptor-1(FGFR-1). J Cell Physiol 169(2): 380-390
29. Mawrin C, Kirches E, Diete S, Wiedemann FR, Schneider T, Firsching R, Kropf S, Bogerts B, Vorwerk CK, Krüger S, Dietzmann K (2005) Analysis of a single nucleotide polymorphism in codon 388 of the FGFR4 gene in malignant gliomas. Cancer Lett xx: 1-7, in press
30. Meier F, Caroli U, Satyamoorthy K, Schittek B, Bauer J, Berking C, Moller H, Maczey E, Rassner G, Herlyn M, Garbe C (2003) Fibroblast growth factor-2 but not Mel-CAM and/or beta3 integrin promotes progression of melanocytes to melanoma. Exp Dermatol 12(3): 296-306
31. Morimoto Y, Ozaki T, Ouchida M, Umehara N, Ohata N, Yoshida A, Shimizu K, Inoue H (2003) Single nucleotide polymorphism in fibroblast growth factor receptor 4 at codon 388 is associated with prognosis in high-grade soft tissue sarcoma. Cancer 98(10): 2245-2250
32. Muenke M, Schell U (1995) Fibroblast-growth-factor receptor mutations in human skeletal disorders. Trends Genet 11(8): 308-313
33. Rak J, Kerbel RS (1997) bFGF and tumor angiogenesis - back in the limelight? Nat Med 3(10): 1083-1084
34. Reed JA, McNutt NS, Albino AP (1994) Differential expression of basic fibroblast growth factor (bFGF) in melanocytic lesions demonstrated by in situ hybridisation. Implications for tumor progression. Am J Pathol 144(2): 329-336
35. Root LL, Shipley GD (1999) Human dermal fibroblasts express multiple bFGF and aFGF proteins. In vitro Cell Dev Biol 27A(10): 815-822
36. Scott G, Stoler M, Sarkar S, Halaban R (1991) Localization of basic fibroblast growth factor mRNA in melanocytic lesions by in situ hybridization. J Invest Dermatol 96(3): 318-322
37. Shih IM, Herlyn M (1994) Autocrine and paracrine roles for growth factors in melanoma. In vivo 8(1): 113-123
38. Spinola M, Leoni V, Pignatiello C, Conti B, Ravagnani F, Pastorino U, Dragani TA (2005) Functional FGFR4 Gly388Arg polymorphism predicts prognosis in lung adenocarcinoma patients. J Clin Oncol 23(29): 7307-7311
39. Stachowiak EK, Maher PA, Tucholski J, Mordechai E, Joy A, Moffett J, Coons S, Stachowiak MK (1997) Nuclear accumulation of fibroblast growth factor receptors in human glial cells - association with cell proliferation. Oncogene 14(18): 2201-2211
40. Straume O, Akslen LA (2002) Importance of vascular phenotype by basic fibroblast growth factor, and influence of the angiogenic factors basic fibroblast growth factor/fibroblast growth factor receptor-1 and ephrin-A1/EphA2 on melanoma progression. Am J Pathol 160(3): 1009-1019
41. Streit S, Bange J, Fichtner A, Ihrler S, Issing W, Ullrich A (2004) Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma. Int J Cancer 111(2): 213-217
42. Takahashi A, Sasaki H, Kim SJ, Kakizoe T, Miyao N, Sugimura T, Terada M, Tsukamoto T (1999) Identification of receptor genes in renal cell carcinoma associated with angiogenesis by differential hybridization technique. Biochem Biophys Res Commun 257(3): 855-859
43. Tucker MA, Goldstein AM (2003) Melanoma etiology: where are we? Oncogene 22: 3042-3052
44. Valesky M, Spang AJ, Fisher GW, Farkas DL, Becker D (2002) Noninvasive dynamic fluorescence imaging of human melanomas reveals that targeted inhibition of bFGF or FGFR-1 in melanoma cells blocks tumor growth by apoptosis. Mol Med 8(2): 103-112
45. Wang J, Stockton DW, Ittmann M (2004) The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression. Clin Cancer Res 10(18 Part 1): 6169-6178
46. Wang Y, Becker D (1997) Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth. Nat Med 3(8): 887-893
47. Yayon A, Ma YS, Safran M, Klagsbrun M, Halaban R (1997) Suppression of autocrine cell proliferation and tumorigenesis of human melanoma cells and fibroblast growth factor transformed fibroblasts by a kinase-deficient FGF receptor 1: evidence for the involvement of Src-family kinases. Oncogene 14(25): 2999-3009