Enhanced expression of fibroblast growth factor receptor 2 IIIc promotes human pancreatic cancer cell proliferation

American Journal of Pathology

Volumn 180, Issue 5, 2012, Pages 1928-1941

  Ishiwata, Toshiyuki ^a   Matsuda, Yoko ^a   Yamamoto, Tetsushi ^a   Uchida, Eiji ^a   Korc, Murray ^b   Naito, Zenya ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 2 IIIC; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER SURVIVAL; CARCINOGENESIS; CARCINOGENICITY; CELL INVASION; CELL MIGRATION; CELL MOTION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME PHOSPHORYLATION; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; PROTEIN ISOFORMS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RNA, MESSENGER; RNA, NEOPLASM; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 84860255645     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.01.020     Document Type: Article

References (40)

1. A. Lemal, R. Siegel, E. Ward, T. Murray, J. Xu, M.J. Thun Cancer statistics, 2007 CA Cancer J Clin 57 2007 43 66
2. M. Korc Role of growth factors in pancreatic cancer Surg Oncol Clin N Am 7 1998 25 41
3. N. Bardeesy, R.A. DePinho Pancreatic cancer biology and genetics Nat Rev Cancer 2 2002 897 909
4. M. Kornmann, H.G. Beger, M. Korc Role of fibroblast growth factors and their receptors in pancreatic cancer and chronic pancreatitis Pancreas 17 1998 169 175
5. K. Cho, T. Ishiwata, E. Uchida, N. Nakazawa, M. Korc, Z. Naito, T. Tajiri Enhanced expression of keratinocyte growth factor and its receptor correlates with venous invasion in pancreatic cancer Am J Pathol 170 2007 1964 1974
6. N. Itoh, D.M. Ornitz Evolution of the Fgf and Fgfr gene families Trends Genet 20 2004 563 569
7. N. Itoh The Fgf families in humans, mice, and zebrafish: their evolutional processes and roles in development, metabolism, and disease Biol Pharm Bull 30 2007 1819 1825
8. M. Kornmann, T. Ishiwata, K. Matsuda, M.E. Lopez, K. Fukahi, G. Asano, H.G. Beger, M. Korc IIIc isoform of fibroblast growth factor receptor 1 is overexpressed in human pancreatic cancer and enhances tumorigenicity of hamster ductal cells Gastroenterology 123 2002 301 313
9. M. Kornmann, M. Lopez, H. Beger, M. Korc Expression of the IIIc Variant of FGF Receptor-1 Confers Mitogenic Responsiveness to Heparin and FGF-5 in TAKA-1 Pancreatic Ductal Cells Int J Gastrointest Cancer 29 2001 85 92
10. Z. Liu, T. Ishiwata, S. Zhou, S. Maier, D. Henne-Bruns, M. Korc, M. Bachem, M. Kornmann Human fibroblast growth factor receptor 1-IIIb is a functional fibroblast growth factor receptor expressed in the pancreas and involved in proliferation and movement of pancreatic ductal cells Pancreas 35 2007 147 157
11. Z. Liu, N. Neiss, S. Zhou, D. Henne-Bruns, M. Korc, M. Bachem, M. Kornmann Identification of a fibroblast growth factor receptor 1 splice variant that inhibits pancreatic cancer cell growth Cancer Res 67 2007 2712 2719
12. T. Miki, D.P. Bottaro, T.P. Fleming, C.L. Smith, W.H. Burgess, A.M. Chan, S.A. Aaronson Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene Proc Natl Acad Sci USA 289 1992 246 250
13. V.P. Eswarakumar, I. Lax, J. Schlessinger Cellular signaling by fibroblast growth factor receptors Cytokine Growth Factor Rev 16 2005 139 149
14. M. Mohammadi, S.K. Olsen, O.A. Ibrahimi Structural basis for fibroblast growth factor receptor activation Cytokine Growth Factor Rev 16 2005 107 137
15. Y. Yamanaka, H. Friess, M. Buchler, H.G. Beger, E. Uchida, M. Onda, M.S. Kobrin, M. Korc Overexpression of acidic and basic fibroblast growth factors in human pancreatic cancer correlates with advanced tumor stage Cancer Res 53 1993 5289 5296
16. I. Siddiqi, H. Funatomi, M.S. Kobrin, H. Friess, M.W. Bchler, M. Korc Increased expression of keratinocyte growth factor in human pancreatic cancer Biochem Biophys Res Commun 215 1995 309 315
17. T. Ishiwata, H. Friess, M.W. Bchler, M.E. Lopez, M. Korc Characterization of keratinocyte growth factor and receptor expression in human pancreatic cancer Am J Pathol 153 1998 213 222
18. B. Kwabi-Addo, F. Ropiquet, D. Giri, M. Ittmann Alternative splicing of fibroblast growth factor receptors in human prostate cancer Prostate 46 2001 163 172
19. E. Valve, P. Martikainen, J. Seppnen, S. Oksjoki, S. Hinkka, L. Anttila, S. Grenman, P. Klemi, P. Hrknen Expression of fibroblast growth factor (FGF)-8 isoforms and FGF receptors in human ovarian tumors Int J Cancer 88 2000 718 725
20. C.S. Drugan, I.C. Paterson, S.S. Prime Fibroblast growth factor receptor expression reflects cellular differentiation in human oral squamous carcinoma cell lines Carcinogenesis 19 1998 1153 1156
21. J.Y. Cha, Q.T. Lambert, G.W. Reuther, C.J. Der Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis Mol Cancer Res 6 2008 435 445
22. C.L. Chaffer, J.P. Brennan, J.L. Slavin, T. Blick, E.W. Thompson, E.D. Williams Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2 Cancer Res 66 2006 11271 11278
23. L. Marek, K.E. Ware, A. Fritzsche, P. Hercule, W.R. Helton, J.E. Smith, L.A. McDermott, C.D. Coldren, R.A. Nemenoff, D.T. Merrick, B.A. Helfrich, P.A. Bunn Jr, L.E. Heasley Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells Mol Pharmacol 75 2009 196 207
24. G. Yan, Y. Fukabori, G. McBride, S. Nikolaropolous, W.L. McKeehan Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy Mol Cell Biol 13 1993 4513 4522
25. B. Baum, J. Settleman, M.P. Quinlan Transitions between epithelial and mesenchymal states in development and disease Semin Cell Dev Biol 19 2008 294 308
26. Y.A. Luqmani, G.S. Bansal, C. Mortimer, L. Buluwela, R.C. Coombes Expression of FGFR2 BEK and K-SAM mRNA variants in normal and malignant human breast Eur J Cancer 32A 1996 518 524
27. M. Kawamoto, T. Ishiwata, K. Cho, E. Uchida, M. Korc, Z. Naito, T. Tajiri Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer Hum Pathol 40 2009 189 198
28. R. Kawase, T. Ishiwata, Y. Matsuda, M. Onda, M. Kudo, T. Takeshita, Z. Naito Expression of fibroblast growth factor receptor 2 IIIc in human uterine cervical intraepithelial neoplasia and cervical cancer Int J Oncol 36 2010 331 340
29. T. Ishiwata Immunohistochemical and in situ hybridization analysis of lumican in colorectal carcinoma Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas M.A. Hayat, Molecular Pathology, Colorectal Carcinoma, and Prostate Carcinoma 2 2004 Elsevier Academic Press Burlington 237 243
30. B. Vuillermoz, A. Khoruzhenko, M.F. D'Onofrio, L. Ramont, L. Venteo, C. Perreau, F. Antonicelli, F.X. Maquart, Y. Wegrowski The small leucine-rich proteoglycan lumican inhibits melanoma progression Exp Cell Res 296 2004 294 306
31. I. Seiden-Long, R. Navab, W. Shih, M. Li, J. Chow, C.Q. Zhu, N. Radulovich, C. Saucier, M.S. Tsao Gab1 but not Grb2 mediates tumor progression in Met overexpressing colorectal cancer cells Carcinogenesis 29 2008 647 655
32. S.K. Singh, C. Hawkins, I.D. Clarke, J.A. Squire, J. Bayani, T. Hide, R.M. Henkelman, M.D. Cusimano, P.B. Dirks Identification of human brain tumour initiating cells Nature 432 2004 396 401
33. M. Korc, R.E. Friesel The role of fibroblast growth factors in tumor growth Curr Cancer Drug Targets 9 2009 639 651
34. Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA, Velculescu VE, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA: Distant metastasis occurs late during the genetic evolution of pancreatic cancer, Nature 467:1114-1117
35. C.C. Warzecha, T.K. Sato, B. Nabet, J.B. Hogenesch, R.P. Carstens ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing Mol Cell 33 2009 591 601
36. C.C. Warzecha, S. Shen, Y. Xing, R.P. Carstens The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events RNA Biol 6 2009 546 562
37. H. Immervoll, D. Hoem, P.O. Sakariassen, O.J. Steffensen, and A. Molven Expression of the "stem cell marker" CD133 in pancreas and pancreatic ductal adenocarcinomas BMC Cancer 8 2008 48
38. C. Li, D.G. Heidt, P. Dalerba, C.F. Burant, L. Zhang, V. Adsay, M. Wicha, M.F. Clarke, D.M. Simeone Identification of pancreatic cancer stem cells Cancer Res 67 2007 1030 1037
39. N. Ikenaga, K. Ohuchida, K. Mizumoto, J. Yu, T. Kayashima, A. Hayashi, K. Nakata, M. Tanaka Characterization of CD24 expression in intraductal papillary mucinous neoplasms and ductal carcinoma of the pancreas Hum Pathol 41 2010 1466 1474
40. M.T. Mueller, P.C. Hermann, C. Heeschen Cancer stem cells as new therapeutic target to prevent tumour progression and metastasis Front Biosci (Elite Ed) 2 2010 602 613