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Volumn 31, Issue 4, 2013, Pages 398-406

Oncogenic role of fibroblast growth factor receptor 3 in tumorigenesis of urinary bladder cancer

Author keywords

Bladder; Fibroblast growth factor; Mutation; Transitional call carcinoma

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 3;

EID: 84876742959     PISSN: 10781439     EISSN: 18732496     Source Type: Journal    
DOI: 10.1016/j.urolonc.2010.07.014     Document Type: Review
Times cited : (44)

References (87)
  • 1
    • 67349258581 scopus 로고    scopus 로고
    • The present and future burden of urinary bladder cancer in the world
    • Ploeg M., Aben K.K.H., Kiemeney L.A. The present and future burden of urinary bladder cancer in the world. World J Urol 2009, 27:289-293.
    • (2009) World J Urol , vol.27 , pp. 289-293
    • Ploeg, M.1    Aben, K.K.H.2    Kiemeney, L.A.3
  • 2
    • 0003964361 scopus 로고    scopus 로고
    • American Cancer Society, American Cancer Society, Atlanta
    • Cancer Facts and Figures 2009 2009, American Cancer Society, American Cancer Society, Atlanta.
    • (2009) Cancer Facts and Figures 2009
  • 3
    • 36849068956 scopus 로고    scopus 로고
    • Declining mortality from bladder cancer in Europe
    • Ferlay J., Randi G., Bosetti C., et al. Declining mortality from bladder cancer in Europe. Br J Urol 2007, 101:11-19.
    • (2007) Br J Urol , vol.101 , pp. 11-19
    • Ferlay, J.1    Randi, G.2    Bosetti, C.3
  • 4
    • 33745050371 scopus 로고    scopus 로고
    • Mechanisms of disease: The epidemiology of bladder cancer
    • Pelucchi C., Bosetti C., Negri E., et al. Mechanisms of disease: The epidemiology of bladder cancer. Nat Clin Pract Urol 2006, 3:327-340.
    • (2006) Nat Clin Pract Urol , vol.3 , pp. 327-340
    • Pelucchi, C.1    Bosetti, C.2    Negri, E.3
  • 7
    • 0027326197 scopus 로고
    • Epidemiologic trend in the distribution of cancer in Kashmir Valley
    • Dhar G.M., Shah G.N., Naheed B., et al. Epidemiologic trend in the distribution of cancer in Kashmir Valley. J Epidemiol Community Health 1993, 47:290-292.
    • (1993) J Epidemiol Community Health , vol.47 , pp. 290-292
    • Dhar, G.M.1    Shah, G.N.2    Naheed, B.3
  • 9
    • 0029353226 scopus 로고
    • Medicare payments from diagnosis to death for elderly cancer patients by stage at diagnosis
    • Riley G.F., Potosky A.L., Lubitz J.D., et al. Medicare payments from diagnosis to death for elderly cancer patients by stage at diagnosis. Med Care 1995, 33:828-841.
    • (1995) Med Care , vol.33 , pp. 828-841
    • Riley, G.F.1    Potosky, A.L.2    Lubitz, J.D.3
  • 10
    • 46049114088 scopus 로고    scopus 로고
    • The origins of bladder cancer
    • Crawford J.M. The origins of bladder cancer. Lab Investig 2008, 88:686-693.
    • (2008) Lab Investig , vol.88 , pp. 686-693
    • Crawford, J.M.1
  • 11
    • 0026636646 scopus 로고
    • Natural history of superficial bladder cancer. Prognostic features and long term disease course
    • Heney N.M. Natural history of superficial bladder cancer. Prognostic features and long term disease course. Urol Clin North Am 1992, 19:429-433.
    • (1992) Urol Clin North Am , vol.19 , pp. 429-433
    • Heney, N.M.1
  • 12
    • 3042809910 scopus 로고    scopus 로고
    • The association between smoking, beverage consumption, diet, and bladder cancer: A systematic literature review
    • Zeegers M.P., Kellen E., Buntinx F., et al. The association between smoking, beverage consumption, diet, and bladder cancer: A systematic literature review. World J Urol 2004, 21:392-401.
    • (2004) World J Urol , vol.21 , pp. 392-401
    • Zeegers, M.P.1    Kellen, E.2    Buntinx, F.3
  • 13
    • 0020318119 scopus 로고
    • Specific aromatic amines as occupational bladder carcinogens
    • Clayson D.B. Specific aromatic amines as occupational bladder carcinogens. Natl Cancer Inst Monogr 1981, 58:15-19.
    • (1981) Natl Cancer Inst Monogr , vol.58 , pp. 15-19
    • Clayson, D.B.1
  • 14
    • 33645343309 scopus 로고    scopus 로고
    • Alterations of the p53 gene in occupational bladder cancer in workers exposed to aromatic amines
    • Droller M.J. Alterations of the p53 gene in occupational bladder cancer in workers exposed to aromatic amines. J Urol 1998, 160:618-623.
    • (1998) J Urol , vol.160 , pp. 618-623
    • Droller, M.J.1
  • 15
    • 25444467767 scopus 로고    scopus 로고
    • Urothelial tumorigenesis: A tale of divergent pathways
    • Wu X.R. Urothelial tumorigenesis: A tale of divergent pathways. Nat Rev Cancer 2005, 5:713-725.
    • (2005) Nat Rev Cancer , vol.5 , pp. 713-725
    • Wu, X.R.1
  • 16
    • 33644868287 scopus 로고    scopus 로고
    • Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?
    • Knowles M.A. Molecular subtypes of bladder cancer: Jekyll and Hyde or chalk and cheese?. Carcinogenesis 2006, 27:361-373.
    • (2006) Carcinogenesis , vol.27 , pp. 361-373
    • Knowles, M.A.1
  • 17
    • 0029042453 scopus 로고
    • The relationship among multiple recurrences, progression, and prognosis of patients with stages Ta and T1 transitional cell cancer of the bladder followed for at least 20 years
    • Discussion 1826-7
    • Holmang S., Hedelin H., Anderstrom C., et al. The relationship among multiple recurrences, progression, and prognosis of patients with stages Ta and T1 transitional cell cancer of the bladder followed for at least 20 years. J Urol 1995, 153:1823-1826. Discussion 1826-7.
    • (1995) J Urol , vol.153 , pp. 1823-1826
    • Holmang, S.1    Hedelin, H.2    Anderstrom, C.3
  • 18
    • 0028817977 scopus 로고
    • Factors affecting recurrence and progression in superficial bladder tumors
    • Kurth K.H., Denis L., Bouffioux C., et al. Factors affecting recurrence and progression in superficial bladder tumors. Eur J Cancer 1995, 31A:1840-1846.
    • (1995) Eur J Cancer , vol.31 A , pp. 1840-1846
    • Kurth, K.H.1    Denis, L.2    Bouffioux, C.3
  • 19
    • 0034969685 scopus 로고    scopus 로고
    • Frequent FGFR3 mutations in papillary noninvasive bladder (pTa) tumors
    • Billerey C., Chopin D., Aubriot-Lorton M.H., et al. Frequent FGFR3 mutations in papillary noninvasive bladder (pTa) tumors. Am J Pathol 2001, 158:1955-1959.
    • (2001) Am J Pathol , vol.158 , pp. 1955-1959
    • Billerey, C.1    Chopin, D.2    Aubriot-Lorton, M.H.3
  • 20
    • 0032841519 scopus 로고    scopus 로고
    • Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas
    • Cappellen D., De Oliveira C., Ricol D., et al. Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nat Genet 1999, 23:18-20.
    • (1999) Nat Genet , vol.23 , pp. 18-20
    • Cappellen, D.1    De Oliveira, C.2    Ricol, D.3
  • 21
    • 0035825598 scopus 로고    scopus 로고
    • Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma
    • Sibley K., Cuthbert-Heavens D., Knowles M.A. Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma. Oncogene 2001, 20:686-691.
    • (2001) Oncogene , vol.20 , pp. 686-691
    • Sibley, K.1    Cuthbert-Heavens, D.2    Knowles, M.A.3
  • 22
    • 0035889913 scopus 로고    scopus 로고
    • The incidence of thanatophoric dysplasia mutations in FGFR3 gene is higher in low-grade or superficial bladder carcinomas
    • Kimura T., Suzuki H., Ohashi T., et al. The incidence of thanatophoric dysplasia mutations in FGFR3 gene is higher in low-grade or superficial bladder carcinomas. Cancer 2001, 92:2555-2561.
    • (2001) Cancer , vol.92 , pp. 2555-2561
    • Kimura, T.1    Suzuki, H.2    Ohashi, T.3
  • 23
    • 0035866380 scopus 로고    scopus 로고
    • The fibroblast growth factor receptor 3 (FGFR3) mutations is a strong indicator of superficial bladder cancer with low recurrence rate
    • van Rhijn B.W., Lurkin I., Radvanyi F., et al. The fibroblast growth factor receptor 3 (FGFR3) mutations is a strong indicator of superficial bladder cancer with low recurrence rate. Cancer Res 2001, 61:1265-1268.
    • (2001) Cancer Res , vol.61 , pp. 1265-1268
    • van Rhijn, B.W.1    Lurkin, I.2    Radvanyi, F.3
  • 24
    • 0027344852 scopus 로고
    • Structural and functional diversity in the FGF receptor multigene family
    • Johnson D.E., Williams L.T. Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res 1993, 60:1-41.
    • (1993) Adv Cancer Res , vol.60 , pp. 1-41
    • Johnson, D.E.1    Williams, L.T.2
  • 25
    • 0027255139 scopus 로고
    • A novel form of FGF receptor- 3 using an alternative exon in the immunoglobulin domain III
    • Avivi A., Yayon A., Givol D. A novel form of FGF receptor- 3 using an alternative exon in the immunoglobulin domain III. FEBS Lett 1993, 330:249-252.
    • (1993) FEBS Lett , vol.330 , pp. 249-252
    • Avivi, A.1    Yayon, A.2    Givol, D.3
  • 26
    • 15844368097 scopus 로고    scopus 로고
    • Receptor specificity of the fibroblast growth factor family
    • Ornitz D.M., Xu J., Colvin J.S., et al. Receptor specificity of the fibroblast growth factor family. J Biol Chem 1996, 271:15292-15297.
    • (1996) J Biol Chem , vol.271 , pp. 15292-15297
    • Ornitz, D.M.1    Xu, J.2    Colvin, J.S.3
  • 27
    • 0026514045 scopus 로고
    • Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities
    • Werner S., Duan D.S., de Vries C., et al. Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificities. Mol Cell Biol 1992, 12:82-88.
    • (1992) Mol Cell Biol , vol.12 , pp. 82-88
    • Werner, S.1    Duan, D.S.2    de Vries, C.3
  • 28
    • 0346100499 scopus 로고    scopus 로고
    • The health economics of bladder cancer: A comprehensive review of the published literature
    • Botteman M.F., Pashos C.L., Redaelli A., et al. The health economics of bladder cancer: A comprehensive review of the published literature. Pharmacoeconomics 2003, 21:1315-1330.
    • (2003) Pharmacoeconomics , vol.21 , pp. 1315-1330
    • Botteman, M.F.1    Pashos, C.L.2    Redaelli, A.3
  • 29
    • 0026345681 scopus 로고
    • A gene encoding a fibroblast growth factor receptor isolated from the Huntington disease gene region of human chromosome 4
    • Thompson L.M., Plummer S., Schalling M., et al. A gene encoding a fibroblast growth factor receptor isolated from the Huntington disease gene region of human chromosome 4. Genomics 1991, 11:1133-1142.
    • (1991) Genomics , vol.11 , pp. 1133-1142
    • Thompson, L.M.1    Plummer, S.2    Schalling, M.3
  • 30
    • 0031127116 scopus 로고    scopus 로고
    • Genomic organization of the human fibroblast growth factor receptor 3 (FGFR3) gene and comparative sequence analysis with the mouse Fgfr3 gene
    • Perez-Castro A.V., Wilson J., Altherr M.R. Genomic organization of the human fibroblast growth factor receptor 3 (FGFR3) gene and comparative sequence analysis with the mouse Fgfr3 gene. Genomics 1997, 41:10-16.
    • (1997) Genomics , vol.41 , pp. 10-16
    • Perez-Castro, A.V.1    Wilson, J.2    Altherr, M.R.3
  • 31
    • 0026020296 scopus 로고
    • Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3
    • Keegan K., Johnson D.E., Williams L.T., et al. Isolation of an additional member of the fibroblast growth factor receptor family, FGFR-3. Proc Natl Acad Sci U S A 1991, 88:1095-1099.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 1095-1099
    • Keegan, K.1    Johnson, D.E.2    Williams, L.T.3
  • 32
    • 1842329140 scopus 로고    scopus 로고
    • Human fibroblast growth factor receptor 3 gene (FGFR3): Genomic sequence and primer set information for gene analysis
    • Wuchner C., Hilbert K., Zabel B., et al. Human fibroblast growth factor receptor 3 gene (FGFR3): Genomic sequence and primer set information for gene analysis. Hum Genet 1997, 100:215-219.
    • (1997) Hum Genet , vol.100 , pp. 215-219
    • Wuchner, C.1    Hilbert, K.2    Zabel, B.3
  • 33
    • 0027344852 scopus 로고
    • Structural and functional diversity in the FGF receptor multigene family
    • Johnson D.E., Williams L.T. Structural and functional diversity in the FGF receptor multigene family. Adv Cancer Res 1993, 60:1-41.
    • (1993) Adv Cancer Res , vol.60 , pp. 1-41
    • Johnson, D.E.1    Williams, L.T.2
  • 34
    • 0032170311 scopus 로고    scopus 로고
    • Spatio-temporal expression of FGFR 1, 2, and 3 genes during human embryo fetal ossification
    • Delezoide A.L., Benoist-Lasselin C., Legeai-Mallet L., et al. Spatio-temporal expression of FGFR 1, 2, and 3 genes during human embryo fetal ossification. Mech Dev 1998, 77:19-30.
    • (1998) Mech Dev , vol.77 , pp. 19-30
    • Delezoide, A.L.1    Benoist-Lasselin, C.2    Legeai-Mallet, L.3
  • 35
    • 0028114645 scopus 로고
    • Identification of a novel variant form of fibroblast growth factor receptor 3 (FGFR3 IIIb) in human colonic epithelium
    • Murgue B., Tsunekawa S., Rosenberg I., et al. Identification of a novel variant form of fibroblast growth factor receptor 3 (FGFR3 IIIb) in human colonic epithelium. Cancer Res 1994, 54:5206-5211.
    • (1994) Cancer Res , vol.54 , pp. 5206-5211
    • Murgue, B.1    Tsunekawa, S.2    Rosenberg, I.3
  • 36
    • 0028239789 scopus 로고
    • Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1
    • Chellaiah A.T., McEwen D.G., Werner S., et al. Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1. J Biol Chem 1994, 269:11620-11627.
    • (1994) J Biol Chem , vol.269 , pp. 11620-11627
    • Chellaiah, A.T.1    McEwen, D.G.2    Werner, S.3
  • 37
    • 0032774475 scopus 로고    scopus 로고
    • Clinical spectrum of fibroblast growth factor receptor mutations
    • Passos-Bueno M.R., Wilcox W.R., Jabs E.W., et al. Clinical spectrum of fibroblast growth factor receptor mutations. Hum Mutat 1999, 14:115-125.
    • (1999) Hum Mutat , vol.14 , pp. 115-125
    • Passos-Bueno, M.R.1    Wilcox, W.R.2    Jabs, E.W.3
  • 39
    • 0037097976 scopus 로고    scopus 로고
    • FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
    • Ornitz D.M., Marie P.J. FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev 2002, 16:1446-1465.
    • (2002) Genes Dev , vol.16 , pp. 1446-1465
    • Ornitz, D.M.1    Marie, P.J.2
  • 40
    • 0033659625 scopus 로고    scopus 로고
    • Distinct missense mutations of the FGFR3 Lys 650 codon modulates receptor kinase activation and the severity of the skeletal dysplasia phenotype
    • Bellus G.A., Spector E.B., Speiser P.W., et al. Distinct missense mutations of the FGFR3 Lys 650 codon modulates receptor kinase activation and the severity of the skeletal dysplasia phenotype. Am J Hum Genet 2000, 67:1411-1421.
    • (2000) Am J Hum Genet , vol.67 , pp. 1411-1421
    • Bellus, G.A.1    Spector, E.B.2    Speiser, P.W.3
  • 41
    • 0029935895 scopus 로고    scopus 로고
    • Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia
    • Naski M.C., Wang Q., Xu J., et al. Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat Genet 1996, 13:233-237.
    • (1996) Nat Genet , vol.13 , pp. 233-237
    • Naski, M.C.1    Wang, Q.2    Xu, J.3
  • 42
    • 0030922231 scopus 로고    scopus 로고
    • Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
    • Chesi M., Nardini E., Brents L.A., et al. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 1997, 16:260-264.
    • (1997) Nat Genet , vol.16 , pp. 260-264
    • Chesi, M.1    Nardini, E.2    Brents, L.A.3
  • 43
    • 0030842266 scopus 로고    scopus 로고
    • A novel chromosomal translocation t(4;14)(p16.3;q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene
    • Richelda R., Ronchetti D., Baldini L., et al. A novel chromosomal translocation t(4;14)(p16.3;q32) in multiple myeloma involves the fibroblast growth-factor receptor 3 gene. Blood 1997, 90:4062-4070.
    • (1997) Blood , vol.90 , pp. 4062-4070
    • Richelda, R.1    Ronchetti, D.2    Baldini, L.3
  • 44
    • 23444440484 scopus 로고    scopus 로고
    • FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma
    • Jebar A.H., Hurst C.D., Tomlinson D.C., et al. FGFR3 and Ras gene mutations are mutually exclusive genetic events in urothelial cell carcinoma. Oncogene 2005, 24:5218-5225.
    • (2005) Oncogene , vol.24 , pp. 5218-5225
    • Jebar, A.H.1    Hurst, C.D.2    Tomlinson, D.C.3
  • 45
    • 0028890851 scopus 로고
    • Achondroplasia is defined by recurrent G380R mutations of FGFR3
    • Bellus G.A., Hefferon T.W., Ortiz de Luna R.I., et al. Achondroplasia is defined by recurrent G380R mutations of FGFR3. Am J Hum Genet 1995, 56:368-373.
    • (1995) Am J Hum Genet , vol.56 , pp. 368-373
    • Bellus, G.A.1    Hefferon, T.W.2    Ortiz de Luna, R.I.3
  • 46
    • 0036926992 scopus 로고    scopus 로고
    • Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders
    • van Rhijn B.W., van Tilborg A.A., Lurkin I., et al. Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders. Eur J Hum Genet 2002, 10:819-824.
    • (2002) Eur J Hum Genet , vol.10 , pp. 819-824
    • van Rhijn, B.W.1    van Tilborg, A.A.2    Lurkin, I.3
  • 47
    • 34250200790 scopus 로고    scopus 로고
    • Whole genome oligonucleotide based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage serous ovarian adenocarcinomas
    • Birrer M.J., Johnson M.E., Sameul C.M., et al. Whole genome oligonucleotide based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage serous ovarian adenocarcinomas. J Clin Oncol 2007, 25:2281-2287.
    • (2007) J Clin Oncol , vol.25 , pp. 2281-2287
    • Birrer, M.J.1    Johnson, M.E.2    Sameul, C.M.3
  • 48
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signaling: Transient vs. sustained extracellular signal-regulated kinase activation
    • Marshall C.J. Specificity of receptor tyrosine kinase signaling: Transient vs. sustained extracellular signal-regulated kinase activation. Cell 1995, 80:179-185.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 49
    • 23044479419 scopus 로고    scopus 로고
    • FGFR3 and Tp53 mutations in T1G3 transitional bladder carcinomas: Independent distribution and lack of association with prognosis
    • Hernandez S., Lopez-Knowles E., Lloreta J., et al. FGFR3 and Tp53 mutations in T1G3 transitional bladder carcinomas: Independent distribution and lack of association with prognosis. Clin Cancer Res 2005, 11:5444-5450.
    • (2005) Clin Cancer Res , vol.11 , pp. 5444-5450
    • Hernandez, S.1    Lopez-Knowles, E.2    Lloreta, J.3
  • 50
    • 27744515561 scopus 로고    scopus 로고
    • Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors
    • Zieger K., Dyrskjot L., Wiuf C., et al. Role of activating fibroblast growth factor receptor 3 mutations in the development of bladder tumors. Clin Cancer Res 2005, 11:7709-7719.
    • (2005) Clin Cancer Res , vol.11 , pp. 7709-7719
    • Zieger, K.1    Dyrskjot, L.2    Wiuf, C.3
  • 51
    • 0027964261 scopus 로고
    • Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia
    • Shiang R., Thompson L.M., Zhu Y.Z., et al. Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 1994, 78:335-342.
    • (1994) Cell , vol.78 , pp. 335-342
    • Shiang, R.1    Thompson, L.M.2    Zhu, Y.Z.3
  • 52
    • 33747873545 scopus 로고    scopus 로고
    • PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors
    • Lopez-Knowles E., Hernandez S., Malats N., et al. PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors. Cancer Res 2006, 66:7401-7404.
    • (2006) Cancer Res , vol.66 , pp. 7401-7404
    • Lopez-Knowles, E.1    Hernandez, S.2    Malats, N.3
  • 53
    • 33747079040 scopus 로고    scopus 로고
    • Prospective study of FGFR3 mutations as a prognostic factor in non-muscle-invasive urothelial bladder carcinomas
    • Hernandez S., Lopez-Knowles E., Lloreta J., et al. Prospective study of FGFR3 mutations as a prognostic factor in non-muscle-invasive urothelial bladder carcinomas. J Clin Oncol 2006, 24:3664-3671.
    • (2006) J Clin Oncol , vol.24 , pp. 3664-3671
    • Hernandez, S.1    Lopez-Knowles, E.2    Lloreta, J.3
  • 54
    • 0033786871 scopus 로고    scopus 로고
    • Inverted papilloma as a cause of high-grade ureteral obstruction
    • Cosgrove D.J., Monga M. Inverted papilloma as a cause of high-grade ureteral obstruction. Urology 2000, 56:856.
    • (2000) Urology , vol.56 , pp. 856
    • Cosgrove, D.J.1    Monga, M.2
  • 55
    • 0343907262 scopus 로고    scopus 로고
    • Urothelial transitional cell carcinoma with endophytic growth patterns: A discussion of patterns of invasion and problems associated with assessment of invasion in 18 cases
    • Amin M.B., Gomez J.A., Young R.H. Urothelial transitional cell carcinoma with endophytic growth patterns: A discussion of patterns of invasion and problems associated with assessment of invasion in 18 cases. Am J Surg Pathol 1997, 21:1057-1068.
    • (1997) Am J Surg Pathol , vol.21 , pp. 1057-1068
    • Amin, M.B.1    Gomez, J.A.2    Young, R.H.3
  • 56
    • 34447301827 scopus 로고    scopus 로고
    • Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract
    • Eiber M., van Oers J.M., Zwarthoff E.C., et al. Low frequency of molecular changes and tumor recurrence in inverted papillomas of the urinary tract. Am J Surg Pathol 2007, 31:938-946.
    • (2007) Am J Surg Pathol , vol.31 , pp. 938-946
    • Eiber, M.1    van Oers, J.M.2    Zwarthoff, E.C.3
  • 57
    • 16544376302 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 protein expression in urothelial carcinoma of the urinary bladder, exhibiting no association with low-grade and/or noninvasive lesions
    • Matsumoto M., Ohtsuki Y., Ochii K., et al. Fibroblast growth factor receptor 3 protein expression in urothelial carcinoma of the urinary bladder, exhibiting no association with low-grade and/or noninvasive lesions. Oncol Rep 2004, 12:967-971.
    • (2004) Oncol Rep , vol.12 , pp. 967-971
    • Matsumoto, M.1    Ohtsuki, Y.2    Ochii, K.3
  • 58
    • 19944426549 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 is over expressed in urinary tract carcinomas and modulates the neoplastic cell growth
    • Gomez-Roman J.J., Saenz P., Molina M., et al. Fibroblast growth factor receptor 3 is over expressed in urinary tract carcinomas and modulates the neoplastic cell growth. Clin Cancer Res 2005, 11:459-465.
    • (2005) Clin Cancer Res , vol.11 , pp. 459-465
    • Gomez-Roman, J.J.1    Saenz, P.2    Molina, M.3
  • 59
    • 34548407864 scopus 로고    scopus 로고
    • FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer
    • Tomlinson D., Baldo O., Knowles M.A. FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. J Pathol 2007, 213:91-98.
    • (2007) J Pathol , vol.213 , pp. 91-98
    • Tomlinson, D.1    Baldo, O.2    Knowles, M.A.3
  • 60
    • 33646359953 scopus 로고    scopus 로고
    • Molecular characterization of early stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q
    • Lindgren D., Liedberg F., Andersson A., et al. Molecular characterization of early stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q. Oncogene 2006, 25:2685-2696.
    • (2006) Oncogene , vol.25 , pp. 2685-2696
    • Lindgren, D.1    Liedberg, F.2    Andersson, A.3
  • 61
    • 0035895993 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 3 induces gene expression primarily through Ras-independent signal transduction pathways
    • Choi D.-Y., Toledo-Aral J.-J., Lin H.Y., et al. Fibroblast growth factor receptor 3 induces gene expression primarily through Ras-independent signal transduction pathways. J Biol Chem 2001, 276:5116-5122.
    • (2001) J Biol Chem , vol.276 , pp. 5116-5122
    • Choi, D.-Y.1    Toledo-Aral, J.-J.2    Lin, H.Y.3
  • 62
    • 10744222289 scopus 로고    scopus 로고
    • FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder
    • Bakkar A.A., Wallerand H., Radvanyi F., et al. FGFR3 and TP53 gene mutations define two distinct pathways in urothelial cell carcinoma of the bladder. Cancer Res 2003, 63:8108-8112.
    • (2003) Cancer Res , vol.63 , pp. 8108-8112
    • Bakkar, A.A.1    Wallerand, H.2    Radvanyi, F.3
  • 63
    • 12544256265 scopus 로고    scopus 로고
    • The economic consequences of prostate and bladder cancer in the UK
    • Sangar V.K., Ragavan N., Matanhelia S.S., et al. The economic consequences of prostate and bladder cancer in the UK. BJU Int 2005, 95:59-63.
    • (2005) BJU Int , vol.95 , pp. 59-63
    • Sangar, V.K.1    Ragavan, N.2    Matanhelia, S.S.3
  • 64
    • 0042572486 scopus 로고    scopus 로고
    • Identification of fibroblast growth factor receptor 3 mutations in urine sediment DNA samples complements cytology in bladder tumor detection
    • Rieger-Christ K., Mourtzinos A., Lee P., et al. Identification of fibroblast growth factor receptor 3 mutations in urine sediment DNA samples complements cytology in bladder tumor detection. Cancer 2003, 98:737-744.
    • (2003) Cancer , vol.98 , pp. 737-744
    • Rieger-Christ, K.1    Mourtzinos, A.2    Lee, P.3
  • 65
    • 0030970602 scopus 로고    scopus 로고
    • Detection of bladder cancer recurrence by microsatellite analysis of urine
    • Steiner G., Schoenberg M.P., Linn J.F., et al. Detection of bladder cancer recurrence by microsatellite analysis of urine. Nat Med 1997, 3:621-624.
    • (1997) Nat Med , vol.3 , pp. 621-624
    • Steiner, G.1    Schoenberg, M.P.2    Linn, J.F.3
  • 66
    • 0141508014 scopus 로고    scopus 로고
    • High-throughput molecular analysis of urine sediment for the detection of bladder cancer by high-density single-nucleotide polymorphism array
    • Hoque M.O., Lee J., Begum S., et al. High-throughput molecular analysis of urine sediment for the detection of bladder cancer by high-density single-nucleotide polymorphism array. Cancer Res 2003, 63:5723-5726.
    • (2003) Cancer Res , vol.63 , pp. 5723-5726
    • Hoque, M.O.1    Lee, J.2    Begum, S.3
  • 67
    • 0034662623 scopus 로고    scopus 로고
    • Evaluation of microsatellite analysis in urine sediment for diagnosis of bladder cancer
    • Schneider A., Borgnat S., Lang H., et al. Evaluation of microsatellite analysis in urine sediment for diagnosis of bladder cancer. Cancer Res 2000, 60:4617-4622.
    • (2000) Cancer Res , vol.60 , pp. 4617-4622
    • Schneider, A.1    Borgnat, S.2    Lang, H.3
  • 68
    • 0037239824 scopus 로고    scopus 로고
    • Combined microsatellite and FGFR3 mutation analysis enables a highly sensitive detection of urothelial cell carcinoma in voided urine
    • van Rhijn B.W., Lurkin I., Chopin D.K., et al. Combined microsatellite and FGFR3 mutation analysis enables a highly sensitive detection of urothelial cell carcinoma in voided urine. Clin Cancer Res 2003, 9:257-263.
    • (2003) Clin Cancer Res , vol.9 , pp. 257-263
    • van Rhijn, B.W.1    Lurkin, I.2    Chopin, D.K.3
  • 69
    • 10744222289 scopus 로고    scopus 로고
    • FGFR3 and TP53 gene mutations define 2 distinct pathways in urothelial cell carcinoma of the bladder
    • Bakkar A.A., Wallerand H., Radvanyi F., et al. FGFR3 and TP53 gene mutations define 2 distinct pathways in urothelial cell carcinoma of the bladder. Cancer Res 2003, 63:8108-8112.
    • (2003) Cancer Res , vol.63 , pp. 8108-8112
    • Bakkar, A.A.1    Wallerand, H.2    Radvanyi, F.3
  • 71
    • 0035168141 scopus 로고    scopus 로고
    • Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation
    • Hart K.C., Robertson S.C., Donoghue D.J. Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Mol Biol Cell 2001, 12:931-942.
    • (2001) Mol Biol Cell , vol.12 , pp. 931-942
    • Hart, K.C.1    Robertson, S.C.2    Donoghue, D.J.3
  • 72
    • 0029945085 scopus 로고    scopus 로고
    • Profound ligand independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II
    • Webster M.K., D'Avis P.Y., Robertson S.C., et al. Profound ligand independent kinase activation of fibroblast growth factor receptor 3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II. Mol Cell Biol 1996, 16:4081-4087.
    • (1996) Mol Cell Biol , vol.16 , pp. 4081-4087
    • Webster, M.K.1    D'Avis, P.Y.2    Robertson, S.C.3
  • 73
    • 0030706168 scopus 로고    scopus 로고
    • A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
    • Kouhara H., Hadari Y.R., Spivak-Kroizman T., et al. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell 1997, 89:693-702.
    • (1997) Cell , vol.89 , pp. 693-702
    • Kouhara, H.1    Hadari, Y.R.2    Spivak-Kroizman, T.3
  • 74
    • 0242490120 scopus 로고    scopus 로고
    • The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3
    • Agazie Y.M., Movilla N., Ischenko I., et al. The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3. Oncogene 2003, 22:6909-6918.
    • (2003) Oncogene , vol.22 , pp. 6909-6918
    • Agazie, Y.M.1    Movilla, N.2    Ischenko, I.3
  • 75
    • 0035865690 scopus 로고    scopus 로고
    • Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development
    • Qu C.K., Nguyen S., Chen J., et al. Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development. Blood 2001, 97:911-914.
    • (2001) Blood , vol.97 , pp. 911-914
    • Qu, C.K.1    Nguyen, S.2    Chen, J.3
  • 76
    • 0036771763 scopus 로고    scopus 로고
    • The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors
    • Lax I., Wong A., Lamothe B., et al. The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors. Mol Cell 2002, 10:709-719.
    • (2002) Mol Cell , vol.10 , pp. 709-719
    • Lax, I.1    Wong, A.2    Lamothe, B.3
  • 77
    • 20444497711 scopus 로고    scopus 로고
    • Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells
    • Nowroozi N., Raffioni S., Wang T., et al. Sustained ERK1/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells. Hum Mol Genet 2005, 14:1529-1538.
    • (2005) Hum Mol Genet , vol.14 , pp. 1529-1538
    • Nowroozi, N.1    Raffioni, S.2    Wang, T.3
  • 78
    • 23944438393 scopus 로고    scopus 로고
    • Differential PTEN protein expression profiles in superficial versus invasive bladder cancers
    • Koksal I.T., Yasar D., Dirice E., et al. Differential PTEN protein expression profiles in superficial versus invasive bladder cancers. Urol Int 2005, 75:102-106.
    • (2005) Urol Int , vol.75 , pp. 102-106
    • Koksal, I.T.1    Yasar, D.2    Dirice, E.3
  • 79
    • 0037174151 scopus 로고    scopus 로고
    • FGF receptors ubiquitination: Dependence on tyrosine kinase activity and role in down-regulation
    • Monsonego-Ornan E., Adar R., Rom E., et al. FGF receptors ubiquitination: Dependence on tyrosine kinase activity and role in down-regulation. FEBS Lett 2002, 528:83-89.
    • (2002) FEBS Lett , vol.528 , pp. 83-89
    • Monsonego-Ornan, E.1    Adar, R.2    Rom, E.3
  • 80
    • 0038607097 scopus 로고    scopus 로고
    • The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum
    • Lievens P.M., Liboi E. The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum. J Biol Chem 2003, 278:17344-17349.
    • (2003) J Biol Chem , vol.278 , pp. 17344-17349
    • Lievens, P.M.1    Liboi, E.2
  • 81
    • 5644241730 scopus 로고    scopus 로고
    • The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling
    • Lievens P.M., Mutinelli C., Baynes D., et al. The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling. J Biol Chem 2004, 279:43254-43260.
    • (2004) J Biol Chem , vol.279 , pp. 43254-43260
    • Lievens, P.M.1    Mutinelli, C.2    Baynes, D.3
  • 82
    • 33644956734 scopus 로고    scopus 로고
    • K644E/M FGFR3 mutants activate Erk1/2 from the endoplasmic reticulum through FRS2 &;α- and PLC γ-independent pathways
    • Lievens P.M., Roncador A., Liboi E. K644E/M FGFR3 mutants activate Erk1/2 from the endoplasmic reticulum through FRS2 &;α- and PLC γ-independent pathways. J Mol Biol 2006, 357:783-792.
    • (2006) J Mol Biol , vol.357 , pp. 783-792
    • Lievens, P.M.1    Roncador, A.2    Liboi, E.3
  • 83
    • 0030764173 scopus 로고    scopus 로고
    • Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domain
    • Webster M., Donoghue D. Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domain. Molecular and Cellular Biology 1997, 17:5739-5747.
    • (1997) Molecular and Cellular Biology , vol.17 , pp. 5739-5747
    • Webster, M.1    Donoghue, D.2
  • 84
    • 33645288557 scopus 로고    scopus 로고
    • Oncogenic properties of the mutated forms of fibroblast growth factor receptor 3b
    • Isabelle B.P., Claire D.L., Radvanyi F., et al. Oncogenic properties of the mutated forms of fibroblast growth factor receptor 3b. Carcinogenesis 2006, 27:740-747.
    • (2006) Carcinogenesis , vol.27 , pp. 740-747
    • Isabelle, B.P.1    Claire, D.L.2    Radvanyi, F.3
  • 85
    • 34548386127 scopus 로고    scopus 로고
    • Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer
    • Tomlinson D.C., Hurst C.D., Knowles M.A. Knockdown by shRNA identifies S249C mutant FGFR3 as a potential therapeutic target in bladder cancer. Oncogene 2007, 26:5889-5899.
    • (2007) Oncogene , vol.26 , pp. 5889-5899
    • Tomlinson, D.C.1    Hurst, C.D.2    Knowles, M.A.3
  • 86
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes-the Achilles heel of cancer
    • Weinstein I.B. Cancer. Addiction to oncogenes-the Achilles heel of cancer. Science 2002, 297:63-64.
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 87
    • 24344461320 scopus 로고    scopus 로고
    • Targeting the extracellular domain of fibroblast growth factor receptor 3 with human single-chain Fv antibodies inhibits bladder carcinoma cell line proliferation
    • Martinez-Torrecuadrada J., Cifuentes G., Lopez-Serra P., et al. Targeting the extracellular domain of fibroblast growth factor receptor 3 with human single-chain Fv antibodies inhibits bladder carcinoma cell line proliferation. Clin Cancer Res 2005, 11:6280-6290.
    • (2005) Clin Cancer Res , vol.11 , pp. 6280-6290
    • Martinez-Torrecuadrada, J.1    Cifuentes, G.2    Lopez-Serra, P.3


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