Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform

Journal of Biological Chemistry

Volumn 284, Issue 10, 2009, Pages 6227-6240

  Cha, Jiyoung Y ^a   Maddileti, Savitri ^a   Mitin, Natalia ^a   Harden, T Kendall ^a   Der, Channing J ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYL-TERMINAL; DATA SUPPORT; DUAL MECHANISMS; FIBROBLAST GROWTH FACTOR RECEPTOR 2; HUMAN CANCER; ISOFORM; ISOFORMS; RECEPTOR RECYCLING; SINGLE MUTATION; SPLICE VARIANTS; TRANSFORMING ACTIVITY; TYROSINE PHOSPHORYLATION; TYROSINE RESIDUES;

AMINO ACIDS; BIOACTIVITY; CELL CULTURE; FIBROBLASTS; PEPTIDES; PHOSPHORYLATION;

SIGNALING;

FIBROBLAST GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 2 IIIB C1; FIBROBLAST GROWTH FACTOR RECEPTOR 2 IIIB C3; GROWTH FACTOR RECEPTOR; LEUCINE; TYROSINE; UNCLASSIFIED DRUG; FGFR2 PROTEIN, HUMAN; FGFR2 PROTEIN, RAT; FRS2 PROTEIN, HUMAN; ISOENZYME; MEMBRANE PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE DELETION; HUMAN; HUMAN CELL; INTERNALIZATION; MALIGNANT TRANSFORMATION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN TARGETING; PROTEIN TRANSPORT; RAT; RESIDUE ANALYSIS; SIGNAL TRANSDUCTION; ALTERNATIVE RNA SPLICING; AMINO ACID SUBSTITUTION; ANIMAL; CELL LINE; CELL TRANSFORMATION; ENZYME ACTIVATION; ENZYME STABILITY; GENETICS; METABOLISM; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALTERNATIVE SPLICING; AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; ENZYME ACTIVATION; ENZYME STABILITY; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2;

EID: 65249140043     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803998200     Document Type: Article

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