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Volumn 22, Issue 4, 2012, Pages 466-478

STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTINEOPLASTIC AGENT; OPN 301; STAT3 PROTEIN; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

EID: 84867605321     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccr.2012.08.010     Document Type: Article
Times cited : (244)

References (61)
  • 2
    • 79952002141 scopus 로고    scopus 로고
    • Diverse mechanisms of Wnt activation and effects of pathway inhibition on proliferation of human gastric carcinoma cells
    • Asciutti S., Akiri G., Grumolato L., Vijayakumar S., Aaronson S.A. Diverse mechanisms of Wnt activation and effects of pathway inhibition on proliferation of human gastric carcinoma cells. Oncogene 2011, 30:956-966.
    • (2011) Oncogene , vol.30 , pp. 956-966
    • Asciutti, S.1    Akiri, G.2    Grumolato, L.3    Vijayakumar, S.4    Aaronson, S.A.5
  • 3
    • 0033573913 scopus 로고    scopus 로고
    • Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes
    • Beier F., Lee R.J., Taylor A.C., Pestell R.G., LuValle P. Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes. Proc. Natl. Acad. Sci. USA 1999, 96:1433-1438.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1433-1438
    • Beier, F.1    Lee, R.J.2    Taylor, A.C.3    Pestell, R.G.4    LuValle, P.5
  • 4
    • 73849090217 scopus 로고    scopus 로고
    • IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis
    • Bollrath J., Greten F.R. IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis. EMBO Rep. 2009, 10:1314-1319.
    • (2009) EMBO Rep. , vol.10 , pp. 1314-1319
    • Bollrath, J.1    Greten, F.R.2
  • 6
    • 0036839638 scopus 로고    scopus 로고
    • Oct-1 potentiates CREB-driven cyclin D1 promoter activation via a phospho-CREB- and CREB binding protein-independent mechanism
    • Boulon S., Dantonel J.C., Binet V., Vié A., Blanchard J.M., Hipskind R.A., Philips A. Oct-1 potentiates CREB-driven cyclin D1 promoter activation via a phospho-CREB- and CREB binding protein-independent mechanism. Mol. Cell. Biol. 2002, 22:7769-7779.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7769-7779
    • Boulon, S.1    Dantonel, J.C.2    Binet, V.3    Vié, A.4    Blanchard, J.M.5    Hipskind, R.A.6    Philips, A.7
  • 8
    • 34247235029 scopus 로고    scopus 로고
    • Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
    • Cario E., Gerken G., Podolsky D.K. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 2007, 132:1359-1374.
    • (2007) Gastroenterology , vol.132 , pp. 1359-1374
    • Cario, E.1    Gerken, G.2    Podolsky, D.K.3
  • 10
    • 0013575179 scopus 로고    scopus 로고
    • Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994
    • Dixon M.F., Genta R.M., Yardley J.H., Correa P. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am. J. Surg. Pathol. 1996, 20:1161-1181.
    • (1996) Am. J. Surg. Pathol. , vol.20 , pp. 1161-1181
    • Dixon, M.F.1    Genta, R.M.2    Yardley, J.H.3    Correa, P.4
  • 12
    • 33749243597 scopus 로고    scopus 로고
    • Identification of protein expression signatures associated with Helicobacter pylori infection and gastric adenocarcinoma using recombinant antibody microarrays
    • Ellmark P., Ingvarsson J., Carlsson A., Lundin B.S., Wingren C., Borrebaeck C.A. Identification of protein expression signatures associated with Helicobacter pylori infection and gastric adenocarcinoma using recombinant antibody microarrays. Mol. Cell. Proteomics 2006, 5:1638-1646.
    • (2006) Mol. Cell. Proteomics , vol.5 , pp. 1638-1646
    • Ellmark, P.1    Ingvarsson, J.2    Carlsson, A.3    Lundin, B.S.4    Wingren, C.5    Borrebaeck, C.A.6
  • 14
    • 24344455107 scopus 로고    scopus 로고
    • Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo
    • Gao L., Zhang L., Hu J., Li F., Shao Y., Zhao D., Kalvakolanu D.V., Kopecko D.J., Zhao X., Xu D.Q. Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo. Clin. Cancer Res. 2005, 11:6333-6341.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 6333-6341
    • Gao, L.1    Zhang, L.2    Hu, J.3    Li, F.4    Shao, Y.5    Zhao, D.6    Kalvakolanu, D.V.7    Kopecko, D.J.8    Zhao, X.9    Xu, D.Q.10
  • 15
    • 14644437059 scopus 로고    scopus 로고
    • Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer
    • Gong W., Wang L., Yao J.C., Ajani J.A., Wei D., Aldape K.D., Xie K., Sawaya R., Huang S. Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer. Clin. Cancer Res. 2005, 11:1386-1393.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1386-1393
    • Gong, W.1    Wang, L.2    Yao, J.C.3    Ajani, J.A.4    Wei, D.5    Aldape, K.D.6    Xie, K.7    Sawaya, R.8    Huang, S.9
  • 17
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    • Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., Akira S. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 1999, 162:3749-3752.
    • (1999) J. Immunol. , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6    Takeda, K.7    Akira, S.8
  • 19
    • 74549158796 scopus 로고    scopus 로고
    • Mouse gastric tumor models with prostaglandin E2 pathway activation show similar gene expression profiles to intestinal-type human gastric cancer
    • Itadani H., Oshima H., Oshima M., Kotani H. Mouse gastric tumor models with prostaglandin E2 pathway activation show similar gene expression profiles to intestinal-type human gastric cancer. BMC Genomics 2009, 10:615-622.
    • (2009) BMC Genomics , vol.10 , pp. 615-622
    • Itadani, H.1    Oshima, H.2    Oshima, M.3    Kotani, H.4
  • 22
    • 33645513412 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer
    • Kawada M., Seno H., Uenoyama Y., Sawabu T., Kanda N., Fukui H., Shimahara Y., Chiba T. Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer. Cancer Res. 2006, 66:2913-2917.
    • (2006) Cancer Res. , vol.66 , pp. 2913-2917
    • Kawada, M.1    Seno, H.2    Uenoyama, Y.3    Sawabu, T.4    Kanda, N.5    Fukui, H.6    Shimahara, Y.7    Chiba, T.8
  • 24
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • Kawai T., Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 2010, 11:373-384.
    • (2010) Nat. Immunol. , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 25
    • 0034676269 scopus 로고    scopus 로고
    • The RelA NF-kappaB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells
    • Kim D.W., Gazourian L., Quadri S.A., Romieu-Mourez R., Sherr D.H., Sonenshein G.E. The RelA NF-kappaB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells. Oncogene 2000, 19:5498-5506.
    • (2000) Oncogene , vol.19 , pp. 5498-5506
    • Kim, D.W.1    Gazourian, L.2    Quadri, S.A.3    Romieu-Mourez, R.4    Sherr, D.H.5    Sonenshein, G.E.6
  • 27
    • 82655181796 scopus 로고    scopus 로고
    • A possible role of cIAP2 in Helicobacter pylori-associated gastric cancer
    • Li Z., Chen J., Chan K.W., Qiao L., Wong B.C.Y. A possible role of cIAP2 in Helicobacter pylori-associated gastric cancer. Cancer Lett. 2011, 313:192-200.
    • (2011) Cancer Lett. , vol.313 , pp. 192-200
    • Li, Z.1    Chen, J.2    Chan, K.W.3    Qiao, L.4    Wong, B.C.Y.5
  • 28
    • 13544271958 scopus 로고    scopus 로고
    • Increased expression of mitogen-activated protein kinase and its upstream regulating signal in human gastric cancer
    • Liang B., Wang S., Zhu X.G., Yu Y.X., Cui Z.R., Yu Y.Z. Increased expression of mitogen-activated protein kinase and its upstream regulating signal in human gastric cancer. World J. Gastroenterol. 2005, 11:623-628.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 623-628
    • Liang, B.1    Wang, S.2    Zhu, X.G.3    Yu, Y.X.4    Cui, Z.R.5    Yu, Y.Z.6
  • 29
    • 0035086794 scopus 로고    scopus 로고
    • Nuclear factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells
    • Lim J.W., Kim H., Kim K.H. Nuclear factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells. Lab. Invest. 2001, 81:349-360.
    • (2001) Lab. Invest. , vol.81 , pp. 349-360
    • Lim, J.W.1    Kim, H.2    Kim, K.H.3
  • 31
    • 79954993086 scopus 로고    scopus 로고
    • Mal mediates TLR-induced activation of CREB and expression of IL-10
    • Mellett M., Atzei P., Jackson R., O'Neill L.A., Moynagh P.N. Mal mediates TLR-induced activation of CREB and expression of IL-10. J. Immunol. 2011, 186:4925-4935.
    • (2011) J. Immunol. , vol.186 , pp. 4925-4935
    • Mellett, M.1    Atzei, P.2    Jackson, R.3    O'Neill, L.A.4    Moynagh, P.N.5
  • 35
    • 33749345198 scopus 로고    scopus 로고
    • Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway
    • Oshima H., Matsunaga A., Fujimura T., Tsukamoto T., Taketo M.M., Oshima M. Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway. Gastroenterology 2006, 131:1086-1095.
    • (2006) Gastroenterology , vol.131 , pp. 1086-1095
    • Oshima, H.1    Matsunaga, A.2    Fujimura, T.3    Tsukamoto, T.4    Taketo, M.M.5    Oshima, M.6
  • 36
    • 0031427428 scopus 로고    scopus 로고
    • Expression of a novel Bcl-2 related gene, Bfl-1, in various human cancers and cancer cell lines
    • Park I.C., Lee S.H., Whang D.Y., Hong W.S., Choi S.S., Shin H.S., Choe T.B., Hong S.I. Expression of a novel Bcl-2 related gene, Bfl-1, in various human cancers and cancer cell lines. Anticancer Res. 1997, 17(6D):4619-4622.
    • (1997) Anticancer Res. , vol.17 , Issue.6 D , pp. 4619-4622
    • Park, I.C.1    Lee, S.H.2    Whang, D.Y.3    Hong, W.S.4    Choi, S.S.5    Shin, H.S.6    Choe, T.B.7    Hong, S.I.8
  • 38
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    • Rakoff-Nahoum S., Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 2007, 317:124-127.
    • (2007) Science , vol.317 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 42
    • 5144231754 scopus 로고    scopus 로고
    • Immediate early response gene X-1, a stress-inducible antiapoptotic gene, encodes cytotoxic T-lymphocyte (CTL) epitopes capable of inducing human leukocyte antigen-A33-restricted and tumor-reactive CTLs in gastric cancer patients
    • Sasada T., Takedatsu H., Azuma K., Koga M., Maeda Y., Shichijo S., Shoumura H., Hirai T., Takabayashi A., Itoh K. Immediate early response gene X-1, a stress-inducible antiapoptotic gene, encodes cytotoxic T-lymphocyte (CTL) epitopes capable of inducing human leukocyte antigen-A33-restricted and tumor-reactive CTLs in gastric cancer patients. Cancer Res. 2004, 64:2882-2888.
    • (2004) Cancer Res. , vol.64 , pp. 2882-2888
    • Sasada, T.1    Takedatsu, H.2    Azuma, K.3    Koga, M.4    Maeda, Y.5    Shichijo, S.6    Shoumura, H.7    Hirai, T.8    Takabayashi, A.9    Itoh, K.10
  • 45
    • 38949155290 scopus 로고    scopus 로고
    • Microbial patterns signaling via Toll-like receptors 2 and 5 contribute to epithelial repair, growth and survival
    • Shaykhiev R., Behr J., Bals R. Microbial patterns signaling via Toll-like receptors 2 and 5 contribute to epithelial repair, growth and survival. PLoS ONE 2008, 3:e1393.
    • (2008) PLoS ONE , vol.3
    • Shaykhiev, R.1    Behr, J.2    Bals, R.3
  • 46
    • 84867612960 scopus 로고    scopus 로고
    • Triggering of toll-like receptor-2 in mouse myelomonocytic leukaemia cells WEHI-3B leads to the suppression of apoptosis and promotes tumor progression in vivo
    • Shcheblyakov D.V., Logunov D.Y., Rakovskaya I.V., Shmarov M.M., Naroditsky B.S., Ginzburg A.L. Triggering of toll-like receptor-2 in mouse myelomonocytic leukaemia cells WEHI-3B leads to the suppression of apoptosis and promotes tumor progression in vivo. Acta Naturae 2011, 3:83-93.
    • (2011) Acta Naturae , vol.3 , pp. 83-93
    • Shcheblyakov, D.V.1    Logunov, D.Y.2    Rakovskaya, I.V.3    Shmarov, M.M.4    Naroditsky, B.S.5    Ginzburg, A.L.6
  • 47
    • 34748867825 scopus 로고    scopus 로고
    • Toll-like receptor 2-196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer
    • Tahara T., Arisawa T., Wang F., Shibata T., Nakamura M., Sakata M., Hirata I., Nakano H. Toll-like receptor 2-196 to 174del polymorphism influences the susceptibility of Japanese people to gastric cancer. Cancer Sci. 2007, 98:1790-1794.
    • (2007) Cancer Sci. , vol.98 , pp. 1790-1794
    • Tahara, T.1    Arisawa, T.2    Wang, F.3    Shibata, T.4    Nakamura, M.5    Sakata, M.6    Hirata, I.7    Nakano, H.8
  • 48
    • 0033874069 scopus 로고    scopus 로고
    • Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases
    • Takano Y., Kato Y., van Diest P.J., Masuda M., Mitomi H., Okayasu I. Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases. Am. J. Pathol. 2000, 156:585-594.
    • (2000) Am. J. Pathol. , vol.156 , pp. 585-594
    • Takano, Y.1    Kato, Y.2    van Diest, P.J.3    Masuda, M.4    Mitomi, H.5    Okayasu, I.6
  • 49
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi O., Hoshino K., Kawai T., Sanjo H., Takada H., Ogawa T., Takeda K., Akira S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999, 11:443-451.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6    Takeda, K.7    Akira, S.8
  • 53
    • 78751535289 scopus 로고    scopus 로고
    • AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradation
    • Vartanian R., Masri J., Martin J., Cloninger C., Holmes B., Artinian N., Funk A., Ruegg T., Gera J. AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradation. Mol. Cancer Res. 2011, 9:115-130.
    • (2011) Mol. Cancer Res. , vol.9 , pp. 115-130
    • Vartanian, R.1    Masri, J.2    Martin, J.3    Cloninger, C.4    Holmes, B.5    Artinian, N.6    Funk, A.7    Ruegg, T.8    Gera, J.9
  • 56
    • 79953203529 scopus 로고    scopus 로고
    • Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling
    • Wang J., Ma J., Charboneau R., Barke R., Roy S. Morphine inhibits murine dendritic cell IL-23 production by modulating Toll-like receptor 2 and Nod2 signaling. J. Biol. Chem. 2011, 286:10225-10232.
    • (2011) J. Biol. Chem. , vol.286 , pp. 10225-10232
    • Wang, J.1    Ma, J.2    Charboneau, R.3    Barke, R.4    Roy, S.5
  • 58
    • 34047259844 scopus 로고    scopus 로고
    • Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis
    • Yakata Y., Nakayama T., Yoshizaki A., Kusaba T., Inoue K., Sekine I. Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis. Int. J. Oncol. 2007, 30:437-442.
    • (2007) Int. J. Oncol. , vol.30 , pp. 437-442
    • Yakata, Y.1    Nakayama, T.2    Yoshizaki, A.3    Kusaba, T.4    Inoue, K.5    Sekine, I.6
  • 60
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
    • Yang J., Liao X., Agarwal M.K., Barnes L., Auron P.E., Stark G.R. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev. 2007, 21:1396-1408.
    • (2007) Genes Dev. , vol.21 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 61
    • 73449110547 scopus 로고    scopus 로고
    • Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1/2-ERK1/2 mitogen-activated protein kinase pathway
    • Yokota S., Okabayashi T., Rehli M., Fujii N., Amano K. Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1/2-ERK1/2 mitogen-activated protein kinase pathway. Infect. Immun. 2010, 78:468-476.
    • (2010) Infect. Immun. , vol.78 , pp. 468-476
    • Yokota, S.1    Okabayashi, T.2    Rehli, M.3    Fujii, N.4    Amano, K.5


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