-
1
-
-
34249879045
-
Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis
-
Algul H., Treiber M., Lesina M., Nakhai H., Saur D., Geisler F., Pfeifer A., Paxian S., and Schmid R.M. Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. J. Clin. Invest. 117 (2007) 1490-1501
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1490-1501
-
-
Algul, H.1
Treiber, M.2
Lesina, M.3
Nakhai, H.4
Saur, D.5
Geisler, F.6
Pfeifer, A.7
Paxian, S.8
Schmid, R.M.9
-
2
-
-
1642619154
-
Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis
-
Alonzi T., Newton I.P., Bryce P.J., Di Carlo E., Lattanzio G., Tripodi M., Musiani P., and Poli V. Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine 26 (2004) 45-56
-
(2004)
Cytokine
, vol.26
, pp. 45-56
-
-
Alonzi, T.1
Newton, I.P.2
Bryce, P.J.3
Di Carlo, E.4
Lattanzio, G.5
Tripodi, M.6
Musiani, P.7
Poli, V.8
-
3
-
-
37549036729
-
Survivin, cancer networks and pathway-directed drug discovery
-
Altieri D.C. Survivin, cancer networks and pathway-directed drug discovery. Nat. Rev. Cancer 8 (2008) 61-70
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 61-70
-
-
Altieri, D.C.1
-
4
-
-
34447506658
-
Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis
-
Ancrile B., Lim K.H., and Counter C.M. Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis. Genes Dev. 21 (2007) 1714-1719
-
(2007)
Genes Dev.
, vol.21
, pp. 1714-1719
-
-
Ancrile, B.1
Lim, K.H.2
Counter, C.M.3
-
5
-
-
38949137388
-
Interleukin-6 and cachexia in ApcMin/+ mice
-
Baltgalvis K.A., Berger F.G., Pena M.M., Davis J.M., Muga S.J., and Carson J.A. Interleukin-6 and cachexia in ApcMin/+ mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 (2008) R393-R401
-
(2008)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.294
-
-
Baltgalvis, K.A.1
Berger, F.G.2
Pena, M.M.3
Davis, J.M.4
Muga, S.J.5
Carson, J.A.6
-
6
-
-
5644252874
-
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
-
Becker C., Fantini M.C., Schramm C., Lehr H.A., Wirtz S., Nikolaev A., Burg J., Strand S., Kiesslich R., Huber S., et al. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling. Immunity 21 (2004) 491-501
-
(2004)
Immunity
, vol.21
, pp. 491-501
-
-
Becker, C.1
Fantini, M.C.2
Schramm, C.3
Lehr, H.A.4
Wirtz, S.5
Nikolaev, A.6
Burg, J.7
Strand, S.8
Kiesslich, R.9
Huber, S.10
-
7
-
-
0029813545
-
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
-
Berg D.J., Davidson N., Kuhn R., Muller W., Menon S., Holland G., Thompson-Snipes L., Leach M.W., and Rennick D. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J. Clin. Invest. 98 (1996) 1010-1020
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 1010-1020
-
-
Berg, D.J.1
Davidson, N.2
Kuhn, R.3
Muller, W.4
Menon, S.5
Holland, G.6
Thompson-Snipes, L.7
Leach, M.W.8
Rennick, D.9
-
8
-
-
0037444373
-
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
-
Blaskovich M.A., Sun J., Cantor A., Turkson J., Jove R., and Sebti S.M. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63 (2003) 1270-1279
-
(2003)
Cancer Res.
, vol.63
, pp. 1270-1279
-
-
Blaskovich, M.A.1
Sun, J.2
Cantor, A.3
Turkson, J.4
Jove, R.5
Sebti, S.M.6
-
9
-
-
0032984589
-
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
-
Catlett-Falcone R., Landowski T.H., Oshiro M.M., Turkson J., Levitzki A., Savino R., Ciliberto G., Moscinski L., Fernandez-Luna J.L., Nunez G., et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10 (1999) 105-115
-
(1999)
Immunity
, vol.10
, pp. 105-115
-
-
Catlett-Falcone, R.1
Landowski, T.H.2
Oshiro, M.M.3
Turkson, J.4
Levitzki, A.5
Savino, R.6
Ciliberto, G.7
Moscinski, L.8
Fernandez-Luna, J.L.9
Nunez, G.10
-
10
-
-
4944239032
-
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis
-
Chan K.S., Sano S., Kiguchi K., Anders J., Komazawa N., Takeda J., and DiGiovanni J. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J. Clin. Invest. 114 (2004) 720-728
-
(2004)
J. Clin. Invest.
, vol.114
, pp. 720-728
-
-
Chan, K.S.1
Sano, S.2
Kiguchi, K.3
Anders, J.4
Komazawa, N.5
Takeda, J.6
DiGiovanni, J.7
-
11
-
-
20944441928
-
Validating Stat3 in cancer therapy
-
Darnell J.E. Validating Stat3 in cancer therapy. Nat. Med. 11 (2005) 595-596
-
(2005)
Nat. Med.
, vol.11
, pp. 595-596
-
-
Darnell, J.E.1
-
12
-
-
33846419846
-
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis
-
Dikovskaya D., Schiffmann D., Newton I.P., Oakley A., Kroboth K., Sansom O., Jamieson T.J., Meniel V., Clarke A., and Nathke I.S. Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. J. Cell Biol. 176 (2007) 183-195
-
(2007)
J. Cell Biol.
, vol.176
, pp. 183-195
-
-
Dikovskaya, D.1
Schiffmann, D.2
Newton, I.P.3
Oakley, A.4
Kroboth, K.5
Sansom, O.6
Jamieson, T.J.7
Meniel, V.8
Clarke, A.9
Nathke, I.S.10
-
13
-
-
54449091097
-
Opposing functions of IKKbeta during acute and chronic intestinal inflammation
-
Eckmann L., Nebelsiek T., Fingerle A.A., Dann S.M., Mages J., Lang R., Robine S., Kagnoff M.F., Schmid R.M., Karin M., et al. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc. Natl. Acad. Sci. USA 105 (2008) 15058-15063
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 15058-15063
-
-
Eckmann, L.1
Nebelsiek, T.2
Fingerle, A.A.3
Dann, S.M.4
Mages, J.5
Lang, R.6
Robine, S.7
Kagnoff, M.F.8
Schmid, R.M.9
Karin, M.10
-
14
-
-
33751555600
-
General nature of the STAT3-activated anti-inflammatory response
-
El Kasmi K.C., Holst J., Coffre M., Mielke L., de Pauw A., Lhocine N., Smith A.M., Rutschman R., Kaushal D., Shen Y., et al. General nature of the STAT3-activated anti-inflammatory response. J. Immunol. 177 (2006) 7880-7888
-
(2006)
J. Immunol.
, vol.177
, pp. 7880-7888
-
-
El Kasmi, K.C.1
Holst, J.2
Coffre, M.3
Mielke, L.4
de Pauw, A.5
Lhocine, N.6
Smith, A.M.7
Rutschman, R.8
Kaushal, D.9
Shen, Y.10
-
15
-
-
43049096401
-
STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice
-
Ernst M., Najdovska M., Grail D., Lundgren-May T., Buchert M., Tye H., Matthews V.B., Armes J., Bhathal P.S., Hughes N.R., et al. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. J. Clin. Invest. 118 (2008) 1727-1738
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 1727-1738
-
-
Ernst, M.1
Najdovska, M.2
Grail, D.3
Lundgren-May, T.4
Buchert, M.5
Tye, H.6
Matthews, V.B.7
Armes, J.8
Bhathal, P.S.9
Hughes, N.R.10
-
16
-
-
36849012237
-
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
-
Gao S.P., Mark K.G., Leslie K., Pao W., Motoi N., Gerald W.L., Travis W.D., Bornmann W., Veach D., Clarkson B., et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J. Clin. Invest. 117 (2007) 3846-3856
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3846-3856
-
-
Gao, S.P.1
Mark, K.G.2
Leslie, K.3
Pao, W.4
Motoi, N.5
Gerald, W.L.6
Travis, W.D.7
Bornmann, W.8
Veach, D.9
Clarkson, B.10
-
17
-
-
4043088499
-
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
-
Greten F.R., Eckmann L., Greten T.F., Park J.M., Li Z.W., Egan L.J., Kagnoff M.F., and Karin M. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118 (2004) 285-296
-
(2004)
Cell
, vol.118
, pp. 285-296
-
-
Greten, F.R.1
Eckmann, L.2
Greten, T.F.3
Park, J.M.4
Li, Z.W.5
Egan, L.J.6
Kagnoff, M.F.7
Karin, M.8
-
18
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
this issue
-
Grivennikov S., Karin E., Terzic J., Mucida D., Yu G.-Y., Vallabhapurapu S., Scheller J., Rose-John S., Cheroutre H., Eckmann L., and Karin M. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15 (2009) 103-113 this issue
-
(2009)
Cancer Cell
, vol.15
, pp. 103-113
-
-
Grivennikov, S.1
Karin, E.2
Terzic, J.3
Mucida, D.4
Yu, G.-Y.5
Vallabhapurapu, S.6
Scheller, J.7
Rose-John, S.8
Cheroutre, H.9
Eckmann, L.10
Karin, M.11
-
19
-
-
52949096859
-
The function of Stat3 in tumor cells and their microenvironment
-
Groner B., Lucks P., and Borghouts C. The function of Stat3 in tumor cells and their microenvironment. Semin. Cell Dev. Biol. 19 (2008) 341-350
-
(2008)
Semin. Cell Dev. Biol.
, vol.19
, pp. 341-350
-
-
Groner, B.1
Lucks, P.2
Borghouts, C.3
-
20
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
21
-
-
0345492424
-
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
-
He B., You L., Uematsu K., Zang K., Xu Z., Lee A.Y., Costello J.F., McCormick F., and Jablons D.M. SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc. Natl. Acad. Sci. USA 100 (2003) 14133-14138
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 14133-14138
-
-
He, B.1
You, L.2
Uematsu, K.3
Zang, K.4
Xu, Z.5
Lee, A.Y.6
Costello, J.F.7
McCormick, F.8
Jablons, D.M.9
-
22
-
-
0041677606
-
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
-
Heinrich P.C., Behrmann I., Haan S., Hermanns H.M., Muller-Newen G., and Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 374 (2003) 1-20
-
(2003)
Biochem. J.
, vol.374
, pp. 1-20
-
-
Heinrich, P.C.1
Behrmann, I.2
Haan, S.3
Hermanns, H.M.4
Muller-Newen, G.5
Schaper, F.6
-
23
-
-
23844445451
-
Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling
-
Jenkins B.J., Grail D., Nheu T., Najdovska M., Wang B., Waring P., Inglese M., McLoughlin R.M., Jones S.A., Topley N., et al. Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Nat. Med. 11 (2005) 845-852
-
(2005)
Nat. Med.
, vol.11
, pp. 845-852
-
-
Jenkins, B.J.1
Grail, D.2
Nheu, T.3
Najdovska, M.4
Wang, B.5
Waring, P.6
Inglese, M.7
McLoughlin, R.M.8
Jones, S.A.9
Topley, N.10
-
24
-
-
33749328700
-
STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis
-
Judd L.M., Bredin K., Kalantzis A., Jenkins B.J., Ernst M., and Giraud A.S. STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis. Gastroenterology 131 (2006) 1073-1085
-
(2006)
Gastroenterology
, vol.131
, pp. 1073-1085
-
-
Judd, L.M.1
Bredin, K.2
Kalantzis, A.3
Jenkins, B.J.4
Ernst, M.5
Giraud, A.S.6
-
25
-
-
25844459154
-
NF-kappaB: linking inflammation and immunity to cancer development and progression
-
Karin M., and Greten F.R. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5 (2005) 749-759
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 749-759
-
-
Karin, M.1
Greten, F.R.2
-
26
-
-
0036731485
-
Stats: transcriptional control and biological impact
-
Levy D.E., and Darnell Jr. J.E. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 3 (2002) 651-662
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 651-662
-
-
Levy, D.E.1
Darnell Jr., J.E.2
-
27
-
-
0032506524
-
Control of apoptosis and mitotic spindle checkpoint by survivin
-
Li F., Ambrosini G., Chu E.Y., Plescia J., Tognin S., Marchisio P.C., and Altieri D.C. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 396 (1998) 580-584
-
(1998)
Nature
, vol.396
, pp. 580-584
-
-
Li, F.1
Ambrosini, G.2
Chu, E.Y.3
Plescia, J.4
Tognin, S.5
Marchisio, P.C.6
Altieri, D.C.7
-
28
-
-
50649125816
-
Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma
-
Liu T., Zhang M., Zhang H., Sun C., and Deng Y. Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma. Eur. Arch. Otorhinolaryngol. 265 (2008) 1225-1232
-
(2008)
Eur. Arch. Otorhinolaryngol.
, vol.265
, pp. 1225-1232
-
-
Liu, T.1
Zhang, M.2
Zhang, H.3
Sun, C.4
Deng, Y.5
-
29
-
-
0034101219
-
Death from early colorectal cancer is predicted by the presence of transcripts of the REG gene family
-
Macadam R.C., Sarela A.I., Farmery S.M., Robinson P.A., Markham A.F., and Guillou P.J. Death from early colorectal cancer is predicted by the presence of transcripts of the REG gene family. Br. J. Cancer 83 (2000) 188-195
-
(2000)
Br. J. Cancer
, vol.83
, pp. 188-195
-
-
Macadam, R.C.1
Sarela, A.I.2
Farmery, S.M.3
Robinson, P.A.4
Markham, A.F.5
Guillou, P.J.6
-
30
-
-
0037031856
-
Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine
-
Madison B.B., Dunbar L., Qiao X.T., Braunstein K., Braunstein E., and Gumucio D.L. Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J. Biol. Chem. 277 (2002) 33275-33283
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 33275-33283
-
-
Madison, B.B.1
Dunbar, L.2
Qiao, X.T.3
Braunstein, K.4
Braunstein, E.5
Gumucio, D.L.6
-
32
-
-
33744813002
-
Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation
-
Miyatsuka T., Kaneto H., Shiraiwa T., Matsuoka T.A., Yamamoto K., Kato K., Nakamura Y., Akira S., Takeda K., Kajimoto Y., et al. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev. 20 (2006) 1435-1440
-
(2006)
Genes Dev.
, vol.20
, pp. 1435-1440
-
-
Miyatsuka, T.1
Kaneto, H.2
Shiraiwa, T.3
Matsuoka, T.A.4
Yamamoto, K.5
Kato, K.6
Nakamura, Y.7
Akira, S.8
Takeda, K.9
Kajimoto, Y.10
-
33
-
-
40649109728
-
The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
-
Naugler W.E., and Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol. Med. 14 (2008) 109-119
-
(2008)
Trends Mol. Med.
, vol.14
, pp. 109-119
-
-
Naugler, W.E.1
Karin, M.2
-
34
-
-
0034700154
-
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin
-
O'Connor D.S., Grossman D., Plescia J., Li F., Zhang H., Villa A., Tognin S., Marchisio P.C., and Altieri D.C. Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Proc. Natl. Acad. Sci. USA 97 (2000) 13103-13107
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 13103-13107
-
-
O'Connor, D.S.1
Grossman, D.2
Plescia, J.3
Li, F.4
Zhang, H.5
Villa, A.6
Tognin, S.7
Marchisio, P.C.8
Altieri, D.C.9
-
35
-
-
34447296425
-
Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
-
Rakoff-Nahoum S., and Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317 (2007) 124-127
-
(2007)
Science
, vol.317
, pp. 124-127
-
-
Rakoff-Nahoum, S.1
Medzhitov, R.2
-
36
-
-
34447629700
-
Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon
-
Rigby R.J., Simmons J.G., Greenhalgh C.J., Alexander W.S., and Lund P.K. Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. Oncogene 26 (2007) 4833-4841
-
(2007)
Oncogene
, vol.26
, pp. 4833-4841
-
-
Rigby, R.J.1
Simmons, J.G.2
Greenhalgh, C.J.3
Alexander, W.S.4
Lund, P.K.5
-
37
-
-
19644370614
-
Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer
-
Rodel F., Hoffmann J., Distel L., Herrmann M., Noisternig T., Papadopoulos T., Sauer R., and Rodel C. Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer. Cancer Res. 65 (2005) 4881-4887
-
(2005)
Cancer Res.
, vol.65
, pp. 4881-4887
-
-
Rodel, F.1
Hoffmann, J.2
Distel, L.3
Herrmann, M.4
Noisternig, T.5
Papadopoulos, T.6
Sauer, R.7
Rodel, C.8
-
38
-
-
48449090686
-
DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression
-
Shields B.J., Hauser C., Bukczynska P.E., Court N.W., and Tiganis T. DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression. Cancer Cell 14 (2008) 166-179
-
(2008)
Cancer Cell
, vol.14
, pp. 166-179
-
-
Shields, B.J.1
Hauser, C.2
Bukczynska, P.E.3
Court, N.W.4
Tiganis, T.5
-
39
-
-
34948858508
-
Heat shock response in gastrointestinal tract
-
Sikora A., and Grzesiuk E. Heat shock response in gastrointestinal tract. J. Physiol. Pharmacol. 58 Suppl 3 (2007) 43-62
-
(2007)
J. Physiol. Pharmacol.
, vol.58
, Issue.SUPPL. 3
, pp. 43-62
-
-
Sikora, A.1
Grzesiuk, E.2
-
40
-
-
42949120754
-
Identification of novel direct Stat3 target genes for control of growth and differentiation
-
Snyder M., Huang X.Y., and Zhang J.J. Identification of novel direct Stat3 target genes for control of growth and differentiation. J. Biol. Chem. 283 (2008) 3791-3798
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 3791-3798
-
-
Snyder, M.1
Huang, X.Y.2
Zhang, J.J.3
-
41
-
-
33745598848
-
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells
-
Stuhlmann-Laeisz C., Lang S., Chalaris A., Krzysztof P., Enge S., Eichler J., Klingmuller U., Samuel M., Ernst M., Rose-John S., et al. Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells. Mol. Biol. Cell 17 (2006) 2986-2995
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 2986-2995
-
-
Stuhlmann-Laeisz, C.1
Lang, S.2
Chalaris, A.3
Krzysztof, P.4
Enge, S.5
Eichler, J.6
Klingmuller, U.7
Samuel, M.8
Ernst, M.9
Rose-John, S.10
-
42
-
-
49749129612
-
JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment
-
Su Y., Li G., Zhang X., Gu J., Zhang C., Tian Z., and Zhang J. JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment. Cancer Biol. Ther. 7 (2008) 1243-1249
-
(2008)
Cancer Biol. Ther.
, vol.7
, pp. 1243-1249
-
-
Su, Y.1
Li, G.2
Zhang, X.3
Gu, J.4
Zhang, C.5
Tian, Z.6
Zhang, J.7
-
43
-
-
38849141814
-
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
-
Sugimoto K., Ogawa A., Mizoguchi E., Shimomura Y., Andoh A., Bhan A.K., Blumberg R.S., Xavier R.J., and Mizoguchi A. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118 (2008) 534-544
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 534-544
-
-
Sugimoto, K.1
Ogawa, A.2
Mizoguchi, E.3
Shimomura, Y.4
Andoh, A.5
Bhan, A.K.6
Blumberg, R.S.7
Xavier, R.J.8
Mizoguchi, A.9
-
44
-
-
0032213273
-
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice
-
Takeda K., Kaisho T., Yoshida N., Takeda J., Kishimoto T., and Akira S. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 161 (1998) 4652-4660
-
(1998)
J. Immunol.
, vol.161
, pp. 4652-4660
-
-
Takeda, K.1
Kaisho, T.2
Yoshida, N.3
Takeda, J.4
Kishimoto, T.5
Akira, S.6
-
45
-
-
0033034365
-
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
-
Takeda K., Clausen B.E., Kaisho T., Tsujimura T., Terada N., Forster I., and Akira S. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10 (1999) 39-49
-
(1999)
Immunity
, vol.10
, pp. 39-49
-
-
Takeda, K.1
Clausen, B.E.2
Kaisho, T.3
Tsujimura, T.4
Terada, N.5
Forster, I.6
Akira, S.7
-
46
-
-
34548171423
-
Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis
-
Tanaka K., Namba T., Arai Y., Fujimoto M., Adachi H., Sobue G., Takeuchi K., Nakai A., and Mizushima T. Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. J. Biol. Chem. 282 (2007) 23240-23252
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 23240-23252
-
-
Tanaka, K.1
Namba, T.2
Arai, Y.3
Fujimoto, M.4
Adachi, H.5
Sobue, G.6
Takeuchi, K.7
Nakai, A.8
Mizushima, T.9
-
47
-
-
0036796060
-
Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
-
Tebbutt N.C., Giraud A.S., Inglese M., Jenkins B., Waring P., Clay F.J., Malki S., Alderman B.M., Grail D., Hollande F., et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat. Med. 8 (2002) 1089-1097
-
(2002)
Nat. Med.
, vol.8
, pp. 1089-1097
-
-
Tebbutt, N.C.1
Giraud, A.S.2
Inglese, M.3
Jenkins, B.4
Waring, P.5
Clay, F.J.6
Malki, S.7
Alderman, B.M.8
Grail, D.9
Hollande, F.10
-
48
-
-
33947492645
-
Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease
-
te Velde A.A., de Kort F., Sterrenburg E., Pronk I., ten Kate F.J., Hommes D.W., and van Deventer S.J. Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease. Inflamm. Bowel Dis. 13 (2007) 325-330
-
(2007)
Inflamm. Bowel Dis.
, vol.13
, pp. 325-330
-
-
te Velde, A.A.1
de Kort, F.2
Sterrenburg, E.3
Pronk, I.4
ten Kate, F.J.5
Hommes, D.W.6
van Deventer, S.J.7
-
49
-
-
1042302005
-
The STATs of cancer--new molecular targets come of age
-
Yu H., and Jove R. The STATs of cancer--new molecular targets come of age. Nat. Rev. Cancer 4 (2004) 97-105
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
50
-
-
33845865825
-
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
-
Yu H., Kortylewski M., and Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat. Rev. Immunol. 7 (2007) 41-51
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 41-51
-
-
Yu, H.1
Kortylewski, M.2
Pardoll, D.3
-
51
-
-
34247189533
-
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T
-
Zhang X., Guo A., Yu J., Possemato A., Chen Y., Zheng W., Polakiewicz R.D., Kinzler K.W., Vogelstein B., Velculescu V.E., et al. Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. Proc. Natl. Acad. Sci. USA 104 (2007) 4060-4064
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 4060-4064
-
-
Zhang, X.1
Guo, A.2
Yu, J.3
Possemato, A.4
Chen, Y.5
Zheng, W.6
Polakiewicz, R.D.7
Kinzler, K.W.8
Vogelstein, B.9
Velculescu, V.E.10
-
52
-
-
40049083827
-
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
-
Zheng Y., Valdez P.A., Danilenko D.M., Hu Y., Sa S.M., Gong Q., Abbas A.R., Modrusan Z., Ghilardi N., de Sauvage F.J., et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14 (2008) 282-289
-
(2008)
Nat. Med.
, vol.14
, pp. 282-289
-
-
Zheng, Y.1
Valdez, P.A.2
Danilenko, D.M.3
Hu, Y.4
Sa, S.M.5
Gong, Q.6
Abbas, A.R.7
Modrusan, Z.8
Ghilardi, N.9
de Sauvage, F.J.10
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