IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion

Genes and Development

Volumn 24, Issue 3, 2010, Pages 241-255

  Gocheva, Vasilena ^a   Wang, Hao Wei ^a   Gadea, Bedrick B ^a   Shree, Tanaya ^a   Hunter, Karen E ^a   Garfall, Alfred L ^a   Berman, Tara ^a   Joyce, Johanna A ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Cysteine cathepsin; Interleukin 4; Invasion; Protease; Tumor microenvironment; Tumor associated macrophage

Indexed keywords

CATHEPSIN; CATHEPSIN B; CATHEPSIN S; INTERLEUKIN 4; PROTEINASE;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER INVASION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; IN VIVO STUDY; INNATE IMMUNITY; LUNG METASTASIS; MALIGNANT TRANSFORMATION; MICROENVIRONMENT; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; TUMOR ASSOCIATED LEUKOCYTE;

ANIMALS; CATHEPSINS; CELL LINE, TUMOR; FEMALE; INTERLEUKIN-4; LUNG NEOPLASMS; MACROPHAGES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, TRANSGENIC; NEOPLASM INVASIVENESS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

ANIMALIA;

EID: 76149146398     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1874010     Document Type: Article

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