Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition

Journal of Clinical Investigation

Volumn 122, Issue 7, 2012, Pages 2405-2416

  Mori, Hiroyuki ^a   Prestwich, Tyler C ^b   Reid, Michael A ^a   Longo, Kenneth A ^c   Gerin, Isabelle ^a   Cawthorn, William P ^a   Susulic, Vedrana S ^d   Krishnan, Venkatesh ^e   Greenfield, Andy ^f   MacDougald, Ormond A ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c Proteostasis Therapeutics Inc   (United States)

^d CENTOCOR INC   (United States)

^e ELI LILLY AND COMPANY   (United States)

^f MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL TRANSCRIPTION FACTOR A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; SECRETED FRIZZLED RELATED PROTEIN 5; WNT PROTEIN; WNT3A PROTEIN;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; OXYGEN CONSUMPTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE TRANSPLANTATION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ADIPOSE TISSUE, WHITE; ANIMALS; CELL ENLARGEMENT; CELLS, CULTURED; EAR, EXTERNAL; ENERGY METABOLISM; EXTRACELLULAR MATRIX; FEMALE; GLUCOSE; INSULIN RESISTANCE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; OBESITY; OXYGEN CONSUMPTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; WNT SIGNALING PATHWAY; WNT3A PROTEIN;

EID: 84863545499     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI63604     Document Type: Article

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