메뉴 건너뛰기




Volumn 86, Issue 8, 2013, Pages 1054-1062

Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies

Author keywords

Allosteric modulation; Animal behavioral studies; Cognition; Nicotinic acetylcholine receptor; Pain; Positive allosteric modulators

Indexed keywords


EID: 84885652983     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.05.018     Document Type: Review
Times cited : (58)

References (126)
  • 2
    • 79953684899 scopus 로고    scopus 로고
    • A structural and mutagenic blueprint for molecular recognition of strychnine and dtubocurarine by different cys-loop receptors
    • BramsM, Pandya A, Kuzmin D, van Elk R, Krijnen L, Yakel JL, et al. A structural and mutagenic blueprint for molecular recognition of strychnine and dtubocurarine by different cys-loop receptors. PLoS Biol 2011;9:e1001034.
    • (2011) PLoS Biol , vol.9
    • BramsM Pandya, A.1    Kuzmin, D.2    Van Elk, R.3    Krijnen, L.4    Yakel, J.L.5
  • 4
    • 33747422892 scopus 로고    scopus 로고
    • Brain nicotinic acetylcholine receptors: Native subtypes and their relevance
    • DOI 10.1016/j.tips.2006.07.004, PII S0165614706001751
    • Gotti C, Zoli M, Clementi F. Brain nicotinic acetylcholine receptors: native subtypes and their relevance. Trends Pharmacol Sci 2006;27:482-91. (Pubitemid 44251225)
    • (2006) Trends in Pharmacological Sciences , vol.27 , Issue.9 , pp. 482-491
    • Gotti, C.1    Zoli, M.2    Clementi, F.3
  • 5
    • 0025074862 scopus 로고
    • Changes in the expression of the cholinergic structures of human T lymphocytes due to maturation and stimulation
    • Paldi-Haris P, Szelenyi JG, Nguyen TH, Hollan SR. Changes in the expression of the cholinergic structures of human T lymphocytes due to maturation and stimulation. Thymus 1990;16:119-22. (Pubitemid 20322425)
    • (1990) Thymus , vol.16 , Issue.2 , pp. 119-122
    • Paldi-Haris, P.1    Szelenyi, J.G.2    Nguyen, T.H.3    Hollan, S.R.4
  • 7
    • 0035668362 scopus 로고    scopus 로고
    • Receptor-mediated action of nicotine in human skin
    • DOI 10.1046/j.1365-4362.2001.01293.x
    • Grando SA. Receptor-mediated action of nicotine in human skin. Int J Dermatol 2001;40:691-3. (Pubitemid 34023638)
    • (2001) International Journal of Dermatology , vol.40 , Issue.11 , pp. 691-693
    • Grando, S.A.1
  • 10
    • 0026593533 scopus 로고
    • A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment
    • Flores CM, Rogers SW, Pabreza LA, Wolfe BB, Kellar KJ. A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment. Mol Pharmacol 1992;41:31-7.
    • (1992) Mol Pharmacol , vol.41 , pp. 31-37
    • Flores, C.M.1    Rogers, S.W.2    Pabreza, L.A.3    Wolfe, B.B.4    Kellar, K.J.5
  • 12
    • 80052032018 scopus 로고    scopus 로고
    • Allosteric modulators of the alpha4beta2 subtype of neuronal nicotinic acetylcholine receptors
    • Pandya A, Yakel JL. Allosteric modulators of the alpha4beta2 subtype of neuronal nicotinic acetylcholine receptors. Biochem Pharmacol 2011;82:952-8.
    • (2011) Biochem Pharmacol , vol.82 , pp. 952-958
    • Pandya, A.1    Yakel, J.L.2
  • 13
    • 0029690580 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptors
    • Lindstrom J. Neuronal nicotinic acetylcholine receptors. Ion Channels 1996;4:377-450.
    • (1996) Ion Channels , vol.4 , pp. 377-450
    • Lindstrom, J.1
  • 15
    • 0023278032 scopus 로고
    • Functional acetylcholine receptor in PC12 cells reacts with a monoclonal antibody to brain nicotinic receptors
    • DOI 10.1038/327515a0
    • Whiting PJ, Schoepfer R, Swanson LW, Simmons DM, Lindstrom JM. Functional acetylcholine receptor in PC12 cells reacts with amonoclonal antibody to brain nicotinic receptors. Nature 1987;327:515-8. (Pubitemid 17085819)
    • (1987) Nature , vol.327 , Issue.6122 , pp. 515-518
    • Whiting, P.J.1    Schoepfer, R.2    Swanson, L.W.3
  • 16
    • 59649090731 scopus 로고    scopus 로고
    • A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides
    • Liu Q, Huang Y, Xue F, Simard A, DeChon J, Li G, et al. A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides. J Neurosci 2009;29:918-29.
    • (2009) J Neurosci , vol.29 , pp. 918-929
    • Liu, Q.1    Huang, Y.2    Xue, F.3    Simard, A.4    DeChon, J.5    Li, G.6
  • 17
    • 0037092335 scopus 로고    scopus 로고
    • Rat nicotinic ACh receptor α7 and β2 subunits co-assemble to form functional heteromeric nicotinic receptor channels
    • DOI 10.1113/jphysiol.2001.013847
    • Khiroug SS, Harkness PC, Lamb PW, Sudweeks SN, Khiroug L, Millar NS, et al. Rat nicotinic ACh receptor alpha7 and beta2 subunits co-Assemble to form functional heteromeric nicotinic receptor channels. J Physiol 2002;540:425-34. (Pubitemid 35190121)
    • (2002) Journal of Physiology , vol.540 , Issue.2 , pp. 425-434
    • Khiroug, S.S.1    Harkness, P.C.2    Lamb, P.W.3    Sudweeks, S.N.4    Khiroug, L.5    Millar, N.S.6    Yakel, J.L.7
  • 18
    • 84871543510 scopus 로고    scopus 로고
    • Functional alpha7beta2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid beta peptides
    • Liu Q, Huang Y, Shen J, Steffensen S, Wu J. Functional alpha7beta2 nicotinic acetylcholine receptors expressed in hippocampal interneurons exhibit high sensitivity to pathological level of amyloid beta peptides. BMC Neurosci 2013;13:155.
    • (2013) BMC Neurosci , vol.13 , pp. 155
    • Liu, Q.1    Huang, Y.2    Shen, J.3    Steffensen, S.4    Wu, J.5
  • 19
    • 19444381231 scopus 로고    scopus 로고
    • 2+ permeability of nicotinic acetylcholine receptors from rat dorsal root ganglion neurones
    • DOI 10.1113/jphysiol.2005.084871
    • Fucile S, Sucapane A, Eusebi F. Ca2+ permeability of nicotinic acetylcholine receptors from rat dorsal root ganglion neurones. J Physiol 2005;565:219-28. (Pubitemid 40723704)
    • (2005) Journal of Physiology , vol.565 , Issue.1 , pp. 219-228
    • Fucile, S.1    Sucapane, A.2    Eusebi, F.3
  • 20
    • 34447286657 scopus 로고    scopus 로고
    • 2+ signalling due to activation of α7-containing nicotinic acetylcholine receptors in rat hippocampal neurons
    • DOI 10.1113/jphysiol.2007.135319
    • Fayuk D, Yakel JL. Dendritic Ca2+ signalling due to activation of alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal neurons. J Physiol 2007;582:597-611. (Pubitemid 47040547)
    • (2007) Journal of Physiology , vol.582 , Issue.2 , pp. 597-611
    • Fayuk, D.1    Yakel, J.L.2
  • 21
    • 23744469015 scopus 로고    scopus 로고
    • 2+ permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneurones
    • DOI 10.1113/jphysiol.2005.089789
    • Fayuk D, Yakel JL. Ca2+ permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneurones. J Physiol 2005;566:759-68. (Pubitemid 41122659)
    • (2005) Journal of Physiology , vol.566 , Issue.3 , pp. 759-768
    • Fayuk, D.1    Yakel, J.L.2
  • 22
    • 0032426910 scopus 로고    scopus 로고
    • Four pharmacologically distinct subtypes of α4β2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes
    • Zwart R, Vijverberg HP. Four pharmacologically distinct subtypes of alpha4-beta2 nicotinic acetylcholine receptor expressed in Xenopus laevis oocytes. Mol Pharmacol 1998;54:1124-31. (Pubitemid 29002058)
    • (1998) Molecular Pharmacology , vol.54 , Issue.6 , pp. 1124-1131
    • Zwart, R.1    Vijverberg, H.P.M.2
  • 23
    • 1542380972 scopus 로고    scopus 로고
    • Rat nicotinic acetylcholine receptor α2β2 channels: Comparison of functional properties with α4β2 channels in Xenopus oocytes
    • DOI 10.1016/j.neuroscience.2004.01.017, PII S0306452204000557
    • Khiroug SS, Khiroug L, Yakel JL. Rat nicotinic acetylcholine receptor alpha2-beta2 channels: comparison of functional properties with alpha4beta2 channels in Xenopus oocytes. Neuroscience 2004;124:817-22. (Pubitemid 38328771)
    • (2004) Neuroscience , vol.124 , Issue.4 , pp. 817-822
    • Khiroug, S.S.1    Khiroug, L.2    Yakel, J.L.3
  • 24
    • 0030941561 scopus 로고    scopus 로고
    • Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors hα2β2, hα2β4, hα3β2, hα3β4, hα4β2, hα4β4 and hα7 expressed in xenopus oocytes
    • Chavez-Noriega LE, Crona JH, Washburn MS, Urrutia A, Elliott KJ, Johnson EC. Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes. J Pharmacol Exp Ther 1997;280:346-56. (Pubitemid 27171421)
    • (1997) Journal of Pharmacology and Experimental Therapeutics , vol.280 , Issue.1 , pp. 346-356
    • Chavez-Noriega, L.E.1    Crona, J.H.2    Washburn, M.S.3    Urrutia, A.4    Elliott, K.J.5    Johnson, E.C.6
  • 25
    • 67650589051 scopus 로고    scopus 로고
    • Pentameric concatenated (alpha4)(2)(beta2)(3) and (alpha4)(3)(beta2)(2) nicotinic acetylcholine receptors: Subunit arrangement determines functional expression
    • Carbone AL, Moroni M, Groot-Kormelink PJ, Bermudez I. Pentameric concatenated (alpha4)(2)(beta2)(3) and (alpha4)(3)(beta2)(2) nicotinic acetylcholine receptors: subunit arrangement determines functional expression. Br J Pharmacol 2009;156:970-81.
    • (2009) Br J Pharmacol , vol.156 , pp. 970-981
    • Carbone, A.L.1    Moroni, M.2    Groot-Kormelink, P.J.3    Bermudez, I.4
  • 26
    • 33746238089 scopus 로고    scopus 로고
    • α4β2 nicotinic receptors with high and low acetylcholine sensitivity: Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine
    • DOI 10.1124/mol.106.023044
    • Moroni M, Zwart R, Sher E, Cassels BK, Bermudez I. alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-Term exposure to nicotine. Mol Pharmacol 2006;70:755-68. (Pubitemid 44092336)
    • (2006) Molecular Pharmacology , vol.70 , Issue.2 , pp. 755-768
    • Moroni, M.1    Zwart, R.2    Sher, E.3    Cassels, B.K.4    Bermudez, I.5
  • 27
    • 0032530368 scopus 로고    scopus 로고
    • Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission
    • Radcliffe KA, Dani JA. Nicotinic stimulation produces multiple forms of increased glutamatergic synaptic transmission. J Neurosci 1998;18:7075-83. (Pubitemid 28425795)
    • (1998) Journal of Neuroscience , vol.18 , Issue.18 , pp. 7075-7083
    • Radcliffe, K.A.1    Dani, J.A.2
  • 28
    • 70449467106 scopus 로고    scopus 로고
    • Expression of slurp-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells
    • Horiguchi K, Horiguchi S, Yamashita N, Irie K, Masuda J, Takano-Ohmuro H, et al. Expression of SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, in murine bronchial epithelial cells. J Neurosci Res 2009;87:2740-7.
    • (2009) J Neurosci Res , vol.87 , pp. 2740-2747
    • Horiguchi, K.1    Horiguchi, S.2    Yamashita, N.3    Irie, K.4    Masuda, J.5    Takano-Ohmuro, H.6
  • 29
    • 79959207290 scopus 로고    scopus 로고
    • The presence and origin of autoantibodies against alpha4 and alpha7 nicotinic acetylcholine receptors in the human blood: Possible relevance to alzheimer's pathology
    • Koval L, Lykhmus O, Kalashnyk O, Bachinskaya N, Kravtsova G, Soldatkina M, et al. The presence and origin of autoantibodies against alpha4 and alpha7 nicotinic acetylcholine receptors in the human blood: possible relevance to Alzheimer's pathology. J Alzheimers Dis 2011;25:747-61.
    • (2011) J Alzheimers Dis , vol.25 , pp. 747-761
    • Koval, L.1    Lykhmus, O.2    Kalashnyk, O.3    Bachinskaya, N.4    Kravtsova, G.5    Soldatkina, M.6
  • 30
    • 80051517622 scopus 로고    scopus 로고
    • Nicotinic excitation of serotonergic projections from dorsal raphe to the nucleus accumbens
    • Chang B, Daniele CA, Gallagher K, Madonia M, Mitchum RD, Barrett L, et al. Nicotinic excitation of serotonergic projections from dorsal raphe to the nucleus accumbens. J Neurophysiol 2011;106:801-8.
    • (2011) J Neurophysiol , vol.106 , pp. 801-8208
    • Chang, B.1    Daniele, C.A.2    Gallagher, K.3    Madonia, M.4    Mitchum, R.D.5    Barrett, L.6
  • 31
    • 33746256838 scopus 로고    scopus 로고
    • Excitation of rat hippocampal interneurons via modulation of endogenous agonist activity at the α7 nicotinic ACh receptor
    • DOI 10.1113/jphysiol.2006.104794
    • Mok MH, Kew JN. Excitation of rat hippocampal interneurons via modulation of endogenous agonist activity at the alpha7 nicotinic ACh receptor. J Physiol 2006;574:699-710. (Pubitemid 44089068)
    • (2006) Journal of Physiology , vol.574 , Issue.3 , pp. 699-710
    • Selina Mok, M.H.1    Kew, J.N.C.2
  • 32
    • 79960193224 scopus 로고    scopus 로고
    • Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity
    • Gu Z, Yakel JL. Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity. Neuron 2011;71:155-65.
    • (2011) Neuron , vol.71 , pp. 155-165
    • Gu, Z.1    Yakel, J.L.2
  • 33
    • 80052033738 scopus 로고    scopus 로고
    • Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in alzheimer's disease
    • Parri HR, Hernandez CM, Dineley KT. Research update: alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease. Biochem Pharmacol 2011;82:931-42.
    • (2011) Biochem Pharmacol , vol.82 , pp. 931-942
    • Parri, H.R.1    Hernandez, C.M.2    Dineley, K.T.3
  • 34
    • 11844276603 scopus 로고    scopus 로고
    • Neuronal nicotinic receptors: From structure to pathology
    • DOI 10.1016/j.pneurobio.2004.09.006, PII S0301008204001777
    • Gotti C, Clementi F. Neuronal nicotinic receptors: from structure to pathology. Prog Neurobiol 2004;74:363-96. (Pubitemid 40092737)
    • (2004) Progress in Neurobiology , vol.74 , Issue.6 , pp. 363-396
    • Gotti, C.1    Clementi, F.2
  • 35
    • 35148881616 scopus 로고    scopus 로고
    • Nicotine and synaptic plasticity in prefrontal cortex
    • McGehee DS. Nicotine and synaptic plasticity in prefrontal cortex. Sci STKE 2007;2007:pe44.
    • (2007) Sci STKE , vol.2007
    • McGehee, D.S.1
  • 36
    • 0032495515 scopus 로고    scopus 로고
    • Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine
    • Picciotto MR, Zoli M, Rimondini R, Lena C, Marubio LM, Pich EM, et al. Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. Nature 1998;391:173-7.
    • (1998) Nature , vol.391 , pp. 173-117
    • Picciotto, M.R.1    Zoli, M.2    Rimondini, R.3    Lena, C.4    Marubio, L.M.5    Pich, E.M.6
  • 37
    • 0036582715 scopus 로고    scopus 로고
    • Neuronal systems underlying behaviors related to nicotine addiction: Neural circuits and molecular genetics
    • Picciotto MR, Corrigall WA. Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics. J Neurosci 2002;22:3338-41. (Pubitemid 37465738)
    • (2002) Journal of Neuroscience , vol.22 , Issue.9 , pp. 3338-3341
    • Picciotto, M.R.1    Corrigall, W.A.2
  • 38
    • 79960968745 scopus 로고    scopus 로고
    • Allosteric modulator desformylflustrabromine relieves the inhibition of alpha2beta2 and alpha4beta2 nicotinic acetylcholine receptors by beta-Amyloid(1-42) peptide
    • Pandya A, Yakel JL. Allosteric modulator Desformylflustrabromine relieves the inhibition of alpha2beta2 and alpha4beta2 nicotinic acetylcholine receptors by beta-Amyloid(1-42) peptide. J Mol Neurosci 2011;45:42-7.
    • (2011) J Mol Neurosci , vol.45 , pp. 42-47
    • Pandya, A.1    Yakel, J.L.2
  • 39
    • 0034732104 scopus 로고    scopus 로고
    • Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease
    • DOI 10.1016/S0014-2999(00)00093-5, PII S0014299900000935
    • Maelicke A, Albuquerque EX. Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease. Eur J Pharmacol 2000;393:165-70. (Pubitemid 30193413)
    • (2000) European Journal of Pharmacology , vol.393 , Issue.1-3 , pp. 165-170
    • Maelicke, A.1    Albuquerque, E.X.2
  • 40
    • 0030723590 scopus 로고    scopus 로고
    • 2+ permeability, conductance, and gating of human α4β2 nicotinic acetylcholine receptors
    • Kuryatov A, Gerzanich V, Nelson M, Olale F, Lindstrom J. Mutation causing autosomal dominant nocturnal frontal lobe epilepsy alters Ca2+ permeability, conductance, and gating of human alpha4beta2 nicotinic acetylcholine receptors. J Neurosci 1997;17:9035-47. (Pubitemid 27498431)
    • (1997) Journal of Neuroscience , vol.17 , Issue.23 , pp. 9035-9047
    • Kuryatov, A.1    Gerzanich, V.2    Nelson, M.3    Olale, F.4    Lindstrom, J.5
  • 41
    • 34548688700 scopus 로고    scopus 로고
    • The role of the nicotinic acetylcholine receptors in sleep-related epilepsy
    • DOI 10.1016/j.bcp.2007.06.030, PII S000629520700408X
    • Marini C, Guerrini R. The role of the nicotinic acetylcholine receptors in sleeprelated epilepsy. Biochem Pharmacol 2007;74:1308-14. (Pubitemid 47417923)
    • (2007) Biochemical Pharmacology , vol.74 , Issue.8 , pp. 1308-1314
    • Marini, C.1    Guerrini, R.2
  • 44
    • 3142761435 scopus 로고    scopus 로고
    • Alpha-7 nicotinic receptor agonists: Potential new candidates for the treatment of schizophrenia
    • Martin LF, Kem WR, Freedman R. Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia. Psychopharmacology (Berl) 2004;174:54-64. (Pubitemid 38925091)
    • (2004) Psychopharmacology , vol.174 , Issue.1 , pp. 54-64
    • Martin, L.F.1    Kem, W.R.2    Freedman, R.3
  • 45
    • 0026664965 scopus 로고
    • Cholinergic gating of response to auditory stimuli in rat hippocampus
    • Luntz-Leybman V, Bickford PC, Freedman R. Cholinergic gating of response to auditory stimuli in rat hippocampus. Brain Res 1992;587:130-6.
    • (1992) Brain Res , vol.587 , pp. 130-136
    • Luntz-Leybman, V.1    Bickford, P.C.2    Freedman, R.3
  • 46
    • 0027404595 scopus 로고
    • α-bungarotoxin binding to hippocampal interneurons: Immunocytochemical characterization and effects on growth factor expression
    • Freedman R, Wetmore C, Stromberg I, Leonard S, Olson L. Alpha-bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression. J Neurosci 1993;13: 1965-75. (Pubitemid 23113409)
    • (1993) Journal of Neuroscience , vol.13 , Issue.5 , pp. 1965-1975
    • Freedman, R.1    Wetmore, C.2    Stromberg, I.3    Leonard, S.4    Olson, L.5
  • 47
    • 1642273411 scopus 로고    scopus 로고
    • Molecular analysis of nicotinic receptor expression in autism
    • DOI 10.1016/j.molbrainres.2004.01.003, PII S0169328X0400035X
    • Martin-Ruiz CM, Lee M, Perry RH, Baumann M, Court JA, Perry EK. Molecular analysis of nicotinic receptor expression in autism. Brain Res Mol Brain Res 2004;123:81-90. (Pubitemid 38392067)
    • (2004) Molecular Brain Research , vol.123 , Issue.1-2 , pp. 81-90
    • Martin-Ruiz, C.M.1    Lee, M.2    Perry, R.H.3    Baumann, M.4    Court, J.A.5    Perry, E.K.6
  • 49
    • 22044434861 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptor subunits in autism: An immunohistochemical investigation in the thalamus
    • DOI 10.1016/j.nbd.2005.01.017, PII S0969996105000288
    • Ray MA, Graham AJ, Lee M, Perry RH, Court JA, Perry EK. Neuronal nicotinic acetylcholine receptor subunits in autism: an immunohistochemical investigation in the thalamus. Neurobiol Dis 2005;19:366-77. (Pubitemid 40968050)
    • (2005) Neurobiology of Disease , vol.19 , Issue.3 , pp. 366-377
    • Ray, M.A.1    Graham, A.J.2    Lee, M.3    Perry, R.H.4    Court, J.A.5    Perry, E.K.6
  • 50
    • 77954473188 scopus 로고    scopus 로고
    • The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy
    • Bailey CD, De Biasi M, Fletcher PJ, Lambe EK. The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy. J Neurosci 2010;30:9241-52.
    • (2010) J Neurosci , vol.30 , pp. 9241-9252
    • Bailey, C.D.1    De Biasi, M.2    Fletcher, P.J.3    Lambe, E.K.4
  • 52
    • 33750613621 scopus 로고    scopus 로고
    • Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task
    • DOI 10.1007/s00213-006-0549-2
    • Hoyle E, Genn RF, Fernandes C, Stolerman IP. Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task. Psychopharmacology (Berl) 2006;189:211-23. (Pubitemid 44691543)
    • (2006) Psychopharmacology , vol.189 , Issue.2 , pp. 211-223
    • Hoyle, E.1    Genn, R.F.2    Fernandes, C.3    Stolerman, I.P.4
  • 53
    • 0036009144 scopus 로고    scopus 로고
    • Effects of (+/-)-4-{[2-(1-methyl-2-pyrrolidinyl)ethyl]thio}phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys
    • DOI 10.1124/jpet.301.1.284
    • Terry Jr. AV, Risbrough VB, Buccafusco JJ, Menzaghi F. Effects of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys. J Pharmacol Exp Ther 2002;301: 284-92. (Pubitemid 34250306)
    • (2002) Journal of Pharmacology and Experimental Therapeutics , vol.301 , Issue.1 , pp. 284-292
    • Terry Jr., A.V.1    Risbrough, V.B.2    Buccafusco, J.J.3    Menzaghi, F.4
  • 54
    • 84877001163 scopus 로고    scopus 로고
    • Activation of the alpha7 nicotinic ach receptor induces anxiogenic effects in rats which is blocked by a 5-ht(1a) receptor antagonist
    • Pandya AA, Yakel JL. Activation of the alpha7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT(1a) receptor antagonist. Neuropharmacology 2013;70C:35-42.
    • (2013) Neuropharmacology , vol.70 C , pp. 35-42
    • Pandya, A.A.1    Yakel, J.L.2
  • 55
    • 0031928549 scopus 로고    scopus 로고
    • Nicotinic acetylcholine involvement in cogitive function in animals
    • DOI 10.1007/s002130050667
    • Levin ED, Simon BB. Nicotinic acetylcholine involvement in cognitive function in animals. Psychopharmacology (Berl) 1998;138:217-30. (Pubitemid 28365487)
    • (1998) Psychopharmacology , vol.138 , Issue.3-4 , pp. 217-230
    • Levin, E.D.1    Simon, B.B.2
  • 56
    • 84865414244 scopus 로고    scopus 로고
    • The alpha7 nicotinic ach receptor agonist compound b and positive allosteric modulator pnu-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat
    • Munro G, Hansen R, Erichsen H, Timmermann D, Christensen J, Hansen H. The alpha7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat. Br J Pharmacol 2012;167:421-35.
    • (2012) Br J Pharmacol , vol.167 , pp. 421-435
    • Munro, G.1    Hansen, R.2    Erichsen, H.3    Timmermann, D.4    Christensen, J.5    Hansen, H.6
  • 57
    • 84868694819 scopus 로고    scopus 로고
    • Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: Correlation with desensitization of alpha4beta2 receptors
    • Zhang J, Xiao YD, Jordan KG, Hammond PS, Van Dyke KM, Mazurov AA, et al. Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: correlation with desensitization of alpha4beta2 receptors. Eur J Pharm Sci 2012;47:813-23.
    • (2012) Eur J Pharm Sci , vol.47 , pp. 813-8723
    • Zhang, J.1    Xiao, Y.D.2    Jordan, K.G.3    Hammond, P.S.4    Van Dyke, K.M.5    Mazurov, A.A.6
  • 58
    • 84864441216 scopus 로고    scopus 로고
    • Activation of the alpha-7 nicotinic acetylcholine receptor (alpha7 nachr) reverses referred mechanical hyperalgesia induced by colonic inflammation in mice
    • Costa R, Motta EM, Manjavachi MN, Cola M, Calixto JB. Activation of the alpha-7 nicotinic acetylcholine receptor (alpha7 nAchR) reverses referred mechanical hyperalgesia induced by colonic inflammation in mice. Neuropharmacology 2012;63:798-805.
    • (2012) Neuropharmacology , vol.63 , pp. 798-805
    • Costa, R.1    Motta, E.M.2    Manjavachi, M.N.3    Cola, M.4    Calixto, J.B.5
  • 59
    • 84877822730 scopus 로고    scopus 로고
    • In vivo pharmacological interactions between a type ii positive allosteric modulator of alpha7 nicotinic acetylcholine receptors and nicotinic agonists in a murine tonic pain model
    • Freitas K, Negus SS, Carroll FI, Damaj MI. In vivo pharmacological interactions between a type ii positive allosteric modulator of alpha7 nicotinic acetylcholine receptors and nicotinic agonists in a murine tonic pain model. Br J Pharmacol 2012;169:567-79.
    • (2012) Br J Pharmacol , vol.169 , pp. 567-579
    • Freitas, K.1    Negus, S.S.2    Carroll, F.I.3    Damaj, M.I.4
  • 60
    • 84871672849 scopus 로고    scopus 로고
    • The antinociceptive effects of nicotinic receptors alpha7-positive allosteric modulators in murine acute and tonic pain models
    • Freitas K, Carroll FI, Damaj MI. The antinociceptive effects of nicotinic receptors alpha7-positive allosteric modulators in murine acute and tonic pain models. J Pharmacol Exp Ther 2013;344:264-75.
    • (2013) J Pharmacol Exp Ther , vol.344 , pp. 264-275
    • Freitas, K.1    Carroll, F.I.2    Damaj, M.I.3
  • 61
    • 84870895846 scopus 로고    scopus 로고
    • Effects of alpha 7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models
    • Freitas K, Ghosh S, Ivy Carroll F, Lichtman AH, Imad Damaj M. Effects of alpha 7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models. Neuropharmacology 2013;65:156-64.
    • (2013) Neuropharmacology , vol.65 , pp. 156-164
    • Freitas, K.1    Ghosh, S.2    Ivy Carroll, F.3    Lichtman, A.H.4    Imad Damaj, M.5
  • 63
    • 80052030619 scopus 로고    scopus 로고
    • Potentiation of analgesic efficacy but not side effects: Co-Administration of an alpha4beta2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats
    • Zhu CZ, Chin CL, Rustay NR, Zhong C, Mikusa J, Chandran P, et al. Potentiation of analgesic efficacy but not side effects: co-Administration of an alpha4beta2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats. Biochem Pharmacol 2011;82:967-76.
    • (2011) Biochem Pharmacol , vol.82 , pp. 967-976
    • Zhu, C.Z.1    Chin, C.L.2    Rustay, N.R.3    Zhong, C.4    Mikusa, J.5    Chandran, P.6
  • 64
    • 80052027395 scopus 로고    scopus 로고
    • Alpha4-beta2 neuronal nicotinic receptor positive allosteric modulation: An approach for improving the therapeutic index of alpha4beta2 nachr agonists in pain
    • Lee CH, Zhu C, Malysz J, Campbell T, Shaughnessy T, Honore P, et al. alpha4-beta2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of alpha4beta2 nAChR agonists in pain. Biochem Pharmacol 2011;82:959-66.
    • (2011) Biochem Pharmacol , vol.82 , pp. 959-966
    • Lee, C.H.1    Zhu, C.2    Malysz, J.3    Campbell, T.4    Shaughnessy, T.5    Honore, P.6
  • 65
    • 84864724117 scopus 로고    scopus 로고
    • Augmentation of cognitive function by ns9283, a stoichiometry-dependent positive allosteric modulator of alpha2-And alpha4-containing nicotinic acetylcholine receptors
    • Timmermann DB, Sandager-Nielsen K, Dyhring T, Smith M, Jacobsen AM, Nielsen EO, et al. Augmentation of cognitive function by NS9283, a stoichiometry-dependent positive allosteric modulator of alpha2-And alpha4-containing nicotinic acetylcholine receptors. Br J Pharmacol 2012;167:164-82.
    • (2012) Br J Pharmacol , vol.167 , pp. 164-182
    • Timmermann, D.B.1    Sandager-Nielsen, K.2    Dyhring, T.3    Smith, M.4    Jacobsen, A.M.5    Nielsen, E.O.6
  • 66
    • 0032407322 scopus 로고    scopus 로고
    • Bimodal modulation by nicotine of anxiety in the social interaction test: Role of the dorsal hippocampus
    • DOI 10.1037/0735-7044.112.6.1423
    • File SE, Kenny PJ, Ouagazzal AM. Bimodal modulation by nicotine of anxiety in the social interaction test: role of the dorsal hippocampus. Behav Neurosci 1998;112:1423-9. (Pubitemid 29052629)
    • (1998) Behavioral Neuroscience , vol.112 , Issue.6 , pp. 1423-1429
    • File, S.E.1    Kenny, P.J.2    Ouagazzal, A.-M.3
  • 67
    • 82455209094 scopus 로고    scopus 로고
    • Neuronal nicotinic receptor antagonist reduces anxietylike behavior in mice
    • Roni MA, Rahman S. Neuronal nicotinic receptor antagonist reduces anxietylike behavior in mice. Neurosci Lett 2011;504:237-41.
    • (2011) Neurosci Lett , vol.504 , pp. 237-241
    • Roni, M.A.1    Rahman, S.2
  • 68
    • 0037007969 scopus 로고    scopus 로고
    • Effect of nicotine and nicotinic receptors on anxiety and depression
    • Picciotto MR, Brunzell DH, Caldarone BJ. Effect of nicotine and nicotinic receptors on anxiety and depression. Neuroreport 2002;13:1097-106. (Pubitemid 34722033)
    • (2002) NeuroReport , vol.13 , Issue.9 , pp. 1097-1106
    • Picciotto, M.R.1    Brunzell, D.H.2    Caldarone, B.J.3
  • 69
    • 0038720467 scopus 로고    scopus 로고
    • Altered anxiety-related responses in mutant mice lacking the β4 subunit of the nicotinic receptor
    • Salas R, Pieri F, Fung B, Dani JA, De Biasi M. Altered anxiety-related responses in mutant mice lacking the beta4 subunit of the nicotinic receptor. J Neurosci 2003;23:6255-63. (Pubitemid 36875627)
    • (2003) Journal of Neuroscience , vol.23 , Issue.15 , pp. 6255-6263
    • Salas, R.1    Pieri, F.2    Fung, B.3    Dani, J.A.4    De Biasi, M.5
  • 70
    • 36148929426 scopus 로고    scopus 로고
    • Chronologically overlapping occurrences of nicotine-induced anxiety-And depression-related behavioral symptoms: Effects of anxiolytic and cannabinoid drugs
    • Hayase T. Chronologically overlapping occurrences of nicotine-induced anxiety-And depression-related behavioral symptoms: effects of anxiolytic and cannabinoid drugs. BMC Neurosci 2007;8:76.
    • (2007) BMC Neurosci , vol.8 , pp. 76
    • Hayase, T.1
  • 71
    • 84874506923 scopus 로고    scopus 로고
    • Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety-And depression-like behavior
    • Mineur YS, Obayemi A, Wigestrand MB, Fote GM, Calarco CA, Li AM, et al. Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety-And depression-like behavior. Proc Natl Acad Sci USA 2013;110:3573-8.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 3573-3578
    • Mineur, Y.S.1    Obayemi, A.2    Wigestrand, M.B.3    Fote, G.M.4    Calarco, C.A.5    Li, A.M.6
  • 72
    • 67549125013 scopus 로고    scopus 로고
    • Allosteric activation mechanism of the cys-loop receptors
    • Chang YC, Wu W, Zhang JL, Huang Y. Allosteric activation mechanism of the cys-loop receptors. Acta Pharmacol Sin 2009;30:663-72.
    • (2009) Acta Pharmacol Sin , vol.30 , pp. 663-672
    • Chang, Y.C.1    Wu, W.2    Zhang, J.L.3    Huang, Y.4
  • 74
    • 0030281174 scopus 로고    scopus 로고
    • A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions
    • Edelstein SJ, Schaad O, Henry E, Bertrand D, Changeux JP. A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions. Biol Cybern 1996;75:361-79. (Pubitemid 126676898)
    • (1996) Biological Cybernetics , vol.75 , Issue.5 , pp. 361-379
    • Edelstein, S.J.1    Schaad, O.2    Henry, E.3    Bertrand, D.4    Changeux, J.-P.5
  • 75
    • 0027536977 scopus 로고
    • Allosteric modulations of the nicotinic acetylcholine receptor
    • DOI 10.1016/0166-2236(93)90150-K
    • Lena C, Changeux JP. Allosteric modulations of the nicotinic acetylcholine receptor. Trends Neurosci 1993;16:181-6. (Pubitemid 23105324)
    • (1993) Trends in Neurosciences , vol.16 , Issue.5 , pp. 181-186
    • Lena, C.1    Changeux, J.-P.2
  • 78
    • 34548677767 scopus 로고    scopus 로고
    • Allosteric modulation of nicotinic acetylcholine receptors
    • DOI 10.1016/j.bcp.2007.07.011, PII S0006295207004637
    • Bertrand D, Gopalakrishnan M. Allosteric modulation of nicotinic acetylcholine receptors. Biochem Pharmacol 2007;74:1155-63. (Pubitemid 47417931)
    • (2007) Biochemical Pharmacology , vol.74 , Issue.8 , pp. 1155-1163
    • Bertrand, D.1    Gopalakrishnan, M.2
  • 79
    • 0035449919 scopus 로고    scopus 로고
    • The C terminus of the human nicotinic α4β2 receptor forms a binding site required for potentiation by an estrogenic steroid
    • Paradiso K, Zhang J, Steinbach JH. The C terminus of the human nicotinic alpha4beta2 receptor forms a binding site required for potentiation by an estrogenic steroid. J Neurosci 2001;21:6561-8. (Pubitemid 32781100)
    • (2001) Journal of Neuroscience , vol.21 , Issue.17 , pp. 6561-6568
    • Paradiso, K.1    Zhang, J.2    Steinbach, J.H.3
  • 80
    • 34547515400 scopus 로고    scopus 로고
    • Synthesis of desformylflustrabromine and its evaluation as an α4β2 and α7 nACh receptor modulator
    • DOI 10.1016/j.bmcl.2007.06.047, PII S0960894X07007275
    • Kim JS, Padnya A, Weltzin M, Edmonds BW, Schulte MK, Glennon RA. Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator. Bioorg Med Chem Lett 2007;17: 4855-60. (Pubitemid 47187695)
    • (2007) Bioorganic and Medicinal Chemistry Letters , vol.17 , Issue.17 , pp. 4855-4860
    • Kim, J.-S.1    Padnya, A.2    Weltzin, M.3    Edmonds, B.W.4    Schulte, M.K.5    Glennon, R.A.6
  • 81
    • 80054897758 scopus 로고    scopus 로고
    • Deconstruction of the alpha4beta2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine
    • German N, Kim JS, Jain A, Dukat M, Pandya A, Ma Y, et al. Deconstruction of the alpha4beta2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromine. J Med Chem 2011;54:7259-67.
    • (2011) J Med Chem , vol.54 , pp. 7259-7267
    • German, N.1    Kim, J.S.2    Jain, A.3    Dukat, M.4    Pandya, A.5    Ma, Y.6
  • 82
    • 80053618320 scopus 로고    scopus 로고
    • Competitive binding at a nicotinic receptor transmembrane site of two alpha7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization
    • Collins T, Young GT, Millar NS. Competitive binding at a nicotinic receptor transmembrane site of two alpha7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization. Neuropharmacology 2011;61:1306-13.
    • (2011) Neuropharmacology , vol.61 , pp. 1306-1313
    • Collins, T.1    Young, G.T.2    Millar, N.S.3
  • 84
    • 55749111553 scopus 로고    scopus 로고
    • Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site
    • Young GT, Zwart R, Walker AS, Sher E, Millar NS. Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc Natl Acad Sci USA 2008;105:14686-91.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14686-14691
    • Young, G.T.1    Zwart, R.2    Walker, A.S.3    Sher, E.4    Millar, N.S.5
  • 85
    • 79958830196 scopus 로고    scopus 로고
    • Novel positive allosteric modulators of the human alpha7 nicotinic acetylcholine receptor
    • Arias HR, Gu RX, Feuerbach D, Guo BB, Ye Y, Wei DQ. Novel positive allosteric modulators of the human alpha7 nicotinic acetylcholine receptor. Biochemistry 2011;50:5263-78.
    • (2011) Biochemistry , vol.50 , pp. 5263-52678
    • Arias, H.R.1    Gu, R.X.2    Feuerbach, D.3    Guo, B.B.4    Ye, Y.5    Wei, D.Q.6
  • 86
    • 80052866353 scopus 로고    scopus 로고
    • Identification of a negative allosteric site on human alpha4beta2 and alpha3beta4 neuronal nicotinic acetylcholine receptors
    • Pavlovicz RE, Henderson BJ, Bonnell AB, Boyd RT, McKay DB, Li C. Identification of a negative allosteric site on human alpha4beta2 and alpha3beta4 neuronal nicotinic acetylcholine receptors. PLoS ONE 2011;6:e24949.
    • (2011) PLoS ONE , vol.6
    • Pavlovicz, R.E.1    Henderson, B.J.2    Bonnell, A.B.3    Boyd, R.T.4    McKay, D.B.5    Li, C.6
  • 87
    • 69949159308 scopus 로고    scopus 로고
    • Nicotinic receptors: Allosteric transitions and therapeutic targets in the nervous system
    • Taly A, Corringer PJ, Guedin D, Lestage P, Changeux JP. Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov 2009;8:733-50.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 733-750
    • Taly, A.1    Corringer, P.J.2    Guedin, D.3    Lestage, P.4    Changeux, J.P.5
  • 88
    • 40649084279 scopus 로고    scopus 로고
    • Nicotinic receptors, allosteric proteins and medicine
    • Changeux JP, Taly A. Nicotinic receptors, allosteric proteins and medicine. Trends Mol Med 2008;14:93-102.
    • (2008) Trends Mol Med , vol.14 , pp. 93-102
    • Changeux, J.P.1    Taly, A.2
  • 89
    • 0038469953 scopus 로고    scopus 로고
    • Cholinergic nicotinic receptors: Competitive ligands, allosteric modulators, and their potential applications
    • DOI 10.1002/med.10037
    • Romanelli MN, Gualtieri F. Cholinergic nicotinic receptors: competitive ligands, allosteric modulators, and their potential applications. Med Res Rev 2003;23:393-426. (Pubitemid 36706510)
    • (2003) Medicinal Research Reviews , vol.23 , Issue.4 , pp. 393-426
    • Romanelli, M.N.1    Gualtieri, F.2
  • 90
    • 0031780511 scopus 로고    scopus 로고
    • Agonist-induced up-regulation of α4β2 nicotinic acetylcholine receptors in M10 cells: Pharmacological and spatial definition
    • Whiteaker P, Sharples CG, Wonnacott S. Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition. Mol Pharmacol 1998;53:950-62. (Pubitemid 28244084)
    • (1998) Molecular Pharmacology , vol.53 , Issue.5 , pp. 950-962
    • Whiteaker, P.1    Sharples, C.G.V.2    Wonnacott, S.3
  • 91
    • 59649098711 scopus 로고    scopus 로고
    • Desensitization of nicotinic acetylcholine receptors as a strategy for drug development
    • Buccafusco JJ, Beach JW, Terry Jr. AV. Desensitization of nicotinic acetylcholine receptors as a strategy for drug development. J Pharmacol Exp Ther 2009;328:364-70.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 364-370
    • Buccafusco, J.J.1    Beach, J.W.2    Terry Jr., A.V.3
  • 92
    • 0032747785 scopus 로고    scopus 로고
    • Desensitization of nicotinic agonist-induced [3h] gamma-Aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists
    • Lu Y, Marks MJ, Collins AC. Desensitization of nicotinic agonist-induced [3H]gamma-Aminobutyric acid release from mouse brain synaptosomes is produced by subactivating concentrations of agonists. J Pharmacol Exp Ther 1999;291:1127-34.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 1127-1134
    • Lu, Y.1    Marks, M.J.2    Collins, A.C.3
  • 94
    • 84869204435 scopus 로고    scopus 로고
    • Effects of the novel alpha7 nicotinic acetylcholine receptor agonist abt-107 on sensory gating in dba/2 mice: Pharmacodynamic characterization
    • Radek RJ, Robb HM, Stevens KE, Gopalakrishnan M, Bitner RS. Effects of the novel alpha7 nicotinic acetylcholine receptor agonist ABT-107 on sensory gating in DBA/2 mice: pharmacodynamic characterization. J Pharmacol Exp Ther 2012;343:736-45.
    • (2012) J Pharmacol Exp Ther , vol.343 , pp. 736-745
    • Radek, R.J.1    Robb, H.M.2    Stevens, K.E.3    Gopalakrishnan, M.4    Bitner, R.S.5
  • 95
    • 30744457894 scopus 로고    scopus 로고
    • Cotinine, a neuroactive metabolite of nicotine: Potential for treating disorders of impaired cognition
    • Terry Jr. AV, Hernandez CM, Hohnadel EJ, Bouchard KP, Buccafusco JJ. Cotinine, a neuroactive metabolite of nicotine: potential for treating disorders of impaired cognition. CNS Drug Rev 2005;11:229-52. (Pubitemid 43100463)
    • (2005) CNS Drug Reviews , vol.11 , Issue.3 , pp. 229-252
    • Terry Jr., A.V.1    Hernandez, C.M.2    Hohnadel, E.J.3    Bouchard, K.P.4    Buccafusco, J.J.5
  • 96
    • 14344251489 scopus 로고    scopus 로고
    • The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats
    • DOI 10.1124/jpet.104.076968
    • Hajos M, Hurst RS, Hoffmann WE, Krause M, Wall TM, Higdon NR, et al. The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. J Pharmacol Exp Ther 2005;312:1213-22. (Pubitemid 40293783)
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.312 , Issue.3 , pp. 1213-1222
    • Hajos, M.1    Hurst, R.S.2    Hoffmann, W.E.3    Krause, M.4    Wall, T.M.5    Higdon, N.R.6    Groppi, V.E.7
  • 97
    • 77953738220 scopus 로고    scopus 로고
    • Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice
    • Jackson KJ, Marks MJ, Vann RE, Chen X, Gamage TF, Warner JA, et al. Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther 2010;334:137-46.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 137-146
    • Jackson, K.J.1    Marks, M.J.2    Vann, R.E.3    Chen, X.4    Gamage, T.F.5    Warner, J.A.6
  • 99
    • 67650484613 scopus 로고    scopus 로고
    • Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of alzheimer's disease
    • Dziewczapolski G, Glogowski CM, Masliah E, Heinemann SF. Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease. J Neurosci 2009;29:8805-15.
    • (2009) J Neurosci , vol.29 , pp. 8805-8815
    • Dziewczapolski, G.1    Glogowski, C.M.2    Masliah, E.3    Heinemann, S.F.4
  • 100
    • 84864921721 scopus 로고    scopus 로고
    • Optimizing cholinergic tone through lynx modulators of nicotinic receptors: Implications for plasticity and nicotine addiction
    • Miwa JM, Lester HA, Walz A. Optimizing cholinergic tone through lynx modulators of nicotinic receptors: implications for plasticity and nicotine addiction. Physiology (Bethesda) 2012;27:187-99.
    • (2012) Physiology (Bethesda , vol.27 , pp. 187-199
    • Miwa, J.M.1    Lester, H.A.2    Walz, A.3
  • 102
    • 62449113374 scopus 로고    scopus 로고
    • Old and new pharmacology: Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2b/c) receptor antagonist sb-206553 (3,5-dihydro-5-methyl-n-3-pyridinylbenzo[1,2-b:4,5-b0]di pyrrole-1(2h)-carboxamide
    • Dunlop J, Lock T, Jow B, Sitzia F, Grauer S, Jow F, et al. Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b0]di pyrrole-1(2H)-carboxamide). J Pharmacol Exp Ther 2009;328:766-76.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 766-776
    • Dunlop, J.1    Lock, T.2    Jow, B.3    Sitzia, F.4    Grauer, S.5    Jow, F.6
  • 103
    • 78751507926 scopus 로고    scopus 로고
    • Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4- pyridinyl)-5-Thiazolemethanol (jnj-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor
    • Dinklo T, Shaban H, Thuring JW, Lavreysen H, Stevens KE, Zheng L, et al. Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4- pyridinyl)-5-Thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor. J Pharmacol Exp Ther 2011;336:560-74.
    • (2011) J Pharmacol Exp Ther , vol.336 , pp. 560-574
    • Dinklo, T.1    Shaban, H.2    Thuring, J.W.3    Lavreysen, H.4    Stevens, K.E.5    Zheng, L.6
  • 104
    • 80655141560 scopus 로고    scopus 로고
    • Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats
    • Thomsen MS, El-Sayed M, Mikkelsen JD. Differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats. PLoS ONE 2011;6:e27014.
    • (2011) PLoS ONE , vol.6
    • Thomsen, M.S.1    El-Sayed, M.2    Mikkelsen, J.D.3
  • 105
    • 84865025138 scopus 로고    scopus 로고
    • Pnu-120596, a positive allosteric modulator of alpha7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats
    • McLean SL, Idris NF, Grayson B, Gendle DF, Mackie C, Lesage AS, et al. PNU-120596, a positive allosteric modulator of alpha7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats. J Psychopharmacol 2012;26:1265-70.
    • (2012) J Psychopharmacol , vol.26 , pp. 1265-1270
    • McLean, S.L.1    Idris, N.F.2    Grayson, B.3    Gendle, D.F.4    Mackie, C.5    Lesage, A.S.6
  • 107
    • 0030051877 scopus 로고    scopus 로고
    • Acute and chronic nicotine effects on working memory in aged rats
    • DOI 10.1007/BF02246285
    • Levin ED, Torry D. Acute and chronic nicotine effects on working memory in aged rats. Psychopharmacology (Berl) 1996;123:88-97. (Pubitemid 26040256)
    • (1996) Psychopharmacology , vol.123 , Issue.1 , pp. 88-97
    • Levin, E.D.1    Torry, D.2
  • 108
    • 84873355827 scopus 로고    scopus 로고
    • Positive allosteric modulator of alpha 7 nicotinic-Acetylcholine receptors, pnu-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates
    • Callahan PM, Hutchings EJ, Kille NJ, Chapman JM, Terry Jr. AV. Positive allosteric modulator of alpha 7 nicotinic-Acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates. Neuropharmacology 2013;67:201-12.
    • (2013) Neuropharmacology , vol.67 , pp. 201-212
    • Callahan, P.M.1    Hutchings, E.J.2    Kille, N.J.3    Chapman, J.M.4    Terry Jr., A.V.5
  • 109
    • 34250707704 scopus 로고    scopus 로고
    • Improved pre-Attention and short-Term memory via positive allosteric modulation of the alpha7 neuronal nicotinic receptor
    • Kohlhaas KL, Robb BR, Radek H, Markosyan RS. M. G. Improved pre-Attention and short-Term memory via positive allosteric modulation of the alpha7 neuronal nicotinic receptor. Int J Neuropsychopharmacol 2006.
    • (2006) Int J Neuropsychopharmacol
    • Kohlhaas, K.L.1    Robb, B.R.2    Radek, H.3    Markosyan, R.S.M.G.4
  • 110
    • 66349096318 scopus 로고    scopus 로고
    • Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1h-pyrrol-1-yl) benzenesulfonamide (a-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor
    • Faghih R, Gopalakrishnan SM, Gronlien JH, Malysz J, Briggs CA, Wetterstrand C, et al. Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl- 1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. J Med Chem 2009;52:3377-84.
    • (2009) J Med Chem , vol.52 , pp. 3377-3384
    • Faghih, R.1    Gopalakrishnan, S.M.2    Gronlien, J.H.3    Malysz, J.4    Briggs, C.A.5    Wetterstrand, C.6
  • 114
    • 79951968691 scopus 로고    scopus 로고
    • Allosteric modulation of related ligand-gated ion channels synergistically induces long-Term potentiation in the hippocampus and enhances cognition
    • Johnstone TB, Gu Z, Yoshimura RF, Villegier AS, Hogenkamp DJ, Whittemore ER, et al. Allosteric modulation of related ligand-gated ion channels synergistically induces long-Term potentiation in the hippocampus and enhances cognition. J Pharmacol Exp Ther 2010;336:908-15.
    • (2010) J Pharmacol Exp Ther , vol.336 , pp. 908-915
    • Johnstone, T.B.1    Gu, Z.2    Yoshimura, R.F.3    Villegier, A.S.4    Hogenkamp, D.J.5    Whittemore, E.R.6
  • 115
    • 0032403103 scopus 로고    scopus 로고
    • Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists
    • DOI 10.1016/S0028-3908(98)00143-9, PII S0028390898001439
    • Khan IM, Buerkle H, Taylor P, Yaksh TL. Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists. Neuropharmacology 1998;37:1515-25. (Pubitemid 28550425)
    • (1998) Neuropharmacology , vol.37 , Issue.12 , pp. 1515-1525
    • Khan, I.M.1    Buerkle, H.2    Taylor, P.3    Yaksh, T.L.4
  • 119
    • 0026738827 scopus 로고
    • Progesterone modulates a neuronal nicotinic acetylcholine receptor
    • Valera S, Ballivet M, Bertrand D. Progesterone modulates a neuronal nicotinic acetylcholine receptor. Proc Natl Acad Sci USA 1992;89:9949-53.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9949-9953
    • Valera, S.1    Ballivet, M.2    Bertrand, D.3
  • 120
    • 20544460348 scopus 로고    scopus 로고
    • Long-lasting cognitive improvement with nicotinic receptor agonists: Mechanisms of pharmacokinetic-pharmacodynamic discordance
    • DOI 10.1016/j.tips.2005.05.007, PII S0165614705001288
    • Buccafusco JJ, Letchworth SR, Bencherif M, Lippiello PM. Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic-pharmacodynamic discordance. Trends Pharmacol Sci 2005;26:352-60. (Pubitemid 40848496)
    • (2005) Trends in Pharmacological Sciences , vol.26 , Issue.7 , pp. 352-360
    • Buccafusco, J.J.1    Letchworth, S.R.2    Bencherif, M.3    Lippiello, P.M.4
  • 121
    • 34250626050 scopus 로고    scopus 로고
    • Galantamine effects on memory, spatial cue utilization, and neurotrophic factors in aged female rats
    • French KL, Bimonte-Nelson HA, Granholm AC. Galantamine effects on memory, spatial cue utilization, and neurotrophic factors in aged female rats. Cell Transplant 2007;16:197-205. (Pubitemid 47300227)
    • (2007) Cell Transplantation , vol.16 , Issue.3 , pp. 197-205
    • French, K.L.1    Bimonte-Nelson, H.A.2    Granholm, A.-Ch.3
  • 122
    • 27544456195 scopus 로고    scopus 로고
    • Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice
    • DOI 10.1038/sj.npp.1300761, PII 1300761
    • Csernansky JG, Martin M, Shah R, Bertchume A, Colvin J, Dong H. Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice. Neuropsychopharmacology 2005;30:2135-43. (Pubitemid 41643964)
    • (2005) Neuropsychopharmacology , vol.30 , Issue.12 , pp. 2135-2143
    • Csernansky, J.G.1    Martin, M.2    Shah, R.3    Bertchume, A.4    Colvin, J.5    Dong, H.6
  • 123
    • 0038519585 scopus 로고    scopus 로고
    • The anthelmintic levamisole is an allosteric modulator of human neuronal nicotinic acetylcholine receptors
    • DOI 10.1016/S0014-2999(03)01796-5
    • Levandoski MM, Piket B, Chang J. The anthelmintic levamisole is an allosteric modulator of human neuronal nicotinic acetylcholine receptors. Eur J Pharmacol 2003;471:9-20. (Pubitemid 36694854)
    • (2003) European Journal of Pharmacology , vol.471 , Issue.1 , pp. 9-20
    • Levandoski, M.M.1    Piket, B.2    Chang, J.3
  • 124
    • 47949088448 scopus 로고    scopus 로고
    • Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors
    • WuTY, Smith CM, Sine SM, Levandoski MM.Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors. Mol Pharmacol 2008;74:466-75.
    • (2008) Mol Pharmacol , vol.74 , pp. 466-475
    • Wu, T.Y.1    Smith, C.M.2    Sine, S.M.3    Levandoski, M.M.4
  • 126
    • 79960696877 scopus 로고    scopus 로고
    • Alpha4beta2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties
    • Mineur YS, Einstein EB, Seymour PA, Coe JW, O'Neill BT, Rollema H, et al. alpha4beta2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties. Behav Pharmacol 2011;22:291-9.
    • (2011) Behav Pharmacol , vol.22 , pp. 291-299
    • Mineur, Y.S.1    Einstein, E.B.2    Seymour, P.A.3    Coe, J.W.4    O'Neill, B.T.5    Rollema, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.