Novel positive allosteric modulators of the human α7 nicotinic acetylcholine receptor

Biochemistry

Volumn 50, Issue 23, 2011, Pages 5263-5278

  Arias, Hugo R ^b   Gu, Ruo Xu ^a   Feuerbach, Dominik ^c   Guo, Bao Bao ^d   Ye, Yong ^d   Wei, Dong Qing ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b MIDWESTERN UNIVERSITY   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d ZHENGZHOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE GROUPS; ANTAGONISTIC ACTIVITY; DIRECT INTERACTIONS; EPIBATIDINE; HYDROGEN BOND INTERACTION; ION CHANNEL; NICOTINIC ACETYLCHOLINE RECEPTORS; PHARMACOLOGICAL ACTIVITY; POSITIVE ALLOSTERIC MODULATOR; RADIOLIGAND BINDING;

AMIDES; HYDROGEN; HYDROGEN BONDS; MOLECULAR DYNAMICS; TOBACCO;

BINDING SITES;

2 (PYRIDIN 4 YLSULFANYL) N (2 TOLYLACETAMIDE); 2 (PYRIDIN 4 YLSULFANYL) N (4 TOLYLACETAMIDE); 3 FURAN 2 YL N (1 PHENYLETHYL)ACRYLAMIDE; 3 FURAN 2 YL N (2 TOLYLACRYLAMIDE); 3 FURAN 2 YL N (4 TOLYLACRYLAMIDE); 3 FURAN 2 YL N PHENYLACRYLAMIDE; 7,3 NITRO N (1 PHENYLETHYL)BENZAMIDE; AMIDE; BUNGAROTOXIN RECEPTOR; EPIBATIDINE; IMIPRAMINE; METHYLLYCACONITINE; N (1 BENZYL 2 HYDROXYETHYL) 3 NITROBENZAMIDE; N (1 PHENYLETHYL) 2 (PYRIDIN 4 YLSULFANYL)ACETAMIDE; N [2 (3,4 DIMETHOXYPHENYL)ETHYL] 2 (PYRIDIN 4 YLSULFANYL)ACETAMIDE; N [2 (3,4 DIMETHOXYPHENYL)ETHYL] 3 (1H INDOL 3 YL)ACRYLAMIDE; N [2 (3,4 DIMETHOXYPHENYL)ETHYL] 3 NITROBENZAMIDE; NICOTINIC RECEPTOR BLOCKING AGENT; PHENCYCLIDINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BETA SHEET; BINDING COMPETITION; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; RADIOASSAY;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; CELLS, CULTURED; HUMANS; HYDROGEN BONDING; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC; TORPEDO;

EID: 79958830196     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi102001m     Document Type: Article

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