Acute and chronic nicotine effects on working memory in aged rats

Psychopharmacology

Volumn 123, Issue 1, 1996, Pages 88-97

  Levin, Edward D ^a   Torry, Diane ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b University of Bath   (United Kingdom)

Author keywords

Aging; Memory; Nicotine; Rats

Indexed keywords

DOPAMINE RECEPTOR BLOCKING AGENT; HALOPERIDOL; MECAMYLAMINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR BLOCKING AGENT; PILOCARPINE; SCOPOLAMINE;

AGE; AGED; AGING; AMNESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; MALE; MAZE TEST; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; PROVOCATION TEST; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TASK PERFORMANCE; WORKING MEMORY;

AGE FACTORS; AGING; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HALOPERIDOL; MALE; MAZE LEARNING; MECAMYLAMINE; MEMORY; NICOTINE; RATS; RATS, SPRAGUE-DAWLEY; SCOPOLAMINE;

EID: 0030051877     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02246285     Document Type: Article

References (60)

1. Aitken D, Meaney M (1989) Temporally graded, age-related impairments in spatial memory in the rat. Neurobiol Aging 10: 273-276
2. Arendash GW, Sengstock GJ (1991) Effects of chronic nicotine administration on the cognitive performance of aged rats. Soc Neurosci Abstr 17:1236
3. Arendash GW, Sengstock GJ, Sanberg PR, Kem WR (1995) Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res 674:252-259
4. Arendash GW, Socci DJ, Nolan MF, Sanberg PR (1994) Nicotine enhances Morris water maze performance of young and aged rats. Soc Neurosci Abstr 20:151
5. Barnes CA (1987) Neurological and behavioral investigations of memory failure in aging animals. Int J Neurol 21-22:130-136
6. Bartus R, Dean R, Lippa A (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-417
7. Buccafusco JJ, Jackson WJ (1991) Beneficial effects of nicotine administered prior to a delayed matching-to-sample task in young and aged monkeys. Neurobiol Aging 12:233-238
8. Collins AC, Luo YH, Selvaag S, Marks MJ (1994) Sensitivity to nicotine and brain nicotinic receptors are altered by chronic nicotine and mecamylamine infusion. J Pharmacol Exp Ther 271:125-133
9. Cortés R, Probst A, Palacios JM (1988) Decreased densities of dopamine DI receptors in the putamen and hippocampus in senile dementia of the Alzheimer type. Brain Res 475:164-167
10. Decker MW, Majchrzak MJ (1992) Effects of systemic and intracerebroventricular administration of mecamylaminc, a nicotine cholinergic antagonist, on spatial memory in rats. Psychopharmacology 107:530-534
11. Decker MW, Majchrzak MJ, Anderson DJ (1992) Effects of nicotine on spatial memory deficits in rats with septal lesions. Brain Res 572:281-285
12. 3H(nicotine binding in human cerebral cortex: comparison between Alzheimer's disease and the normal. J Neurochem 47:1948-1954
13. Giacobini E, DeSarno P, Mellhany M, Clark B (1988) The cholinergic receptor system in the frontal lobe of Alzheimer's patients. In: Clementi F, Gotti C, Sher E (ed) Nicotinic acetylcholine receptors in the nervous system. Springer, Berlin, pp 367-378
14. Gozlan H, Daval G, Verge D, Spampinato U, Fattaccini CM, Gallissot MC, El Mestikawy S, Hamon M (1990) Aging associated changes in serotoninergic and dopaminergic pre- and postsynaptic neurochemical markers in the rat brain. Neurobiol Aging 11:437-449
15. Gray JA, Mitchell SN, Joseph MH, Grigoryan GA, Bawe S, Hodges H (1994) Neurochemical mechanisms mediating the behavioral and cognitive effects of nicotine. Drug Dev Res 31: 3-17
16. Greene E, Naranjo J (1987) Degeneration of hippocampal fibers and spatial memory deficit in the aged rat. Neurobiol Aging 8: 35-43
17. Grunberg NE, Winders SE, Popp KA (1987) Sex differences in nicotine's effects on consummatory behavior and body weight in rats. Psychopharmacology 91:221-225
18. Hodges H, Allen Y, Sinden J, Lantos PL, Gray JA (1991) Effects of cholinergic-rich neural grafts on radial maze performance of rats after excitotoxic lesions of the forebrain cholinergic projection system - II. Cholinergic drugs as probes to investigate lesion-induced deficits and transplant-induced functional recovery. Neuroscience 45:609-623
19. Jackson WJ, Elrod K, Buccafusco JJ (1989) Delayed matching-to-sample in monkeys as a model for learning and memory deficits: role of brain nicotinic receptors. In: Meyer EM, Simpkins JW, Yamamoto J (ed) Novel approaches to the treatment of Alzheimer's disease. Plenum, New York, pp 39-52.
20. Jones GMM, Sahakian BJ, Levy R, Warburton DM, Gray JA (1992) Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease. Psychopharmacology. 108:485-494
21. Jucker M, Oettinger R, Battig K (1988) Age-related changes in working and reference memory performance and locomotor activity in the male Wistar rat. Behav Neural Biol 50:24-36
22. Kellar KJ, Whitehouse PJ, Martino-Barrows AM, Marcus K, Price DL (1987) Muscarinic and nicotinic cholinergic binding sites in Alzheimer's disease. Brain Res 436:62-68
23. Levin ED (1988) Psychopharmacological effects in the radial-arm maze. Neurosci Biobehav Rev 12:169-175
24. Levin FD (1992) Nicotinic systems and cognitive function. Psychopharmacology 108:417-431
25. 2 agonists: Effects on working memory function. Drug Dev Res 31:32-37
26. Levin ED, Rose JE (1990) Anticholinergic sensitivity following chronic nicotine administration as measured by radial-arm maze performance in rats. Behav Pharmacol 1:511-520
27. Levin ED, Rose JE (1991) Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze. Brain Res Bull 27:125-128
28. 2 interactions with nicotinic and muscarinic systems. In: Levin ED, Decker MW, Butcher LL (ed) Neurotransmitier interactions and cognitive function. Berkhäuser, Boston, pp 144-158
29. Levin ED, Rose JE (1995) Acute and chronic nicotinic interactions with dopamine systems and working memory performance. In: Lajtha A, Abood L (ed) Functional diversity of interacting receptors. New York Academy of Sciences, New York, pp 218-221
30. Levin ED, Castonguay M, Ellison GD (1987) Effects of the nicotinic receptor blocker, mecamylamine, on radial arm maze performance in rats. Behav Neural Biol 48:206-212
31. 2 agonist, LY 171555. Pharmacol Biochem Behav 33:919-922
32. Levin ED, McGurk SR, South D, Butcher LL (1989b) Effects of combined muscarinic and nicotinic blockade on choice accuracy in the radial-arm maze. Behav Neural Biol 51:270-277
33. Levin ED, Lee C, Rose JE, Reyes A, Ellison G, Jaravik M, Gritz, E (1990) Chronic nicotine and withdrawal effects on radial-arm maze performance in rats. Behav Neural Biol 53:269-276
34. Levin ED, Briggs SJ, Christopher NC, Rose JE (1993a) Chronic nicotinic stimulation and blockade effects on working memory. Behav Pharmacol 4:179-182
35. Levin ED, Briggs SJ, Christopher NC, Rose JE (1993b) Sertraline attenuates hyperphagia in rats following nicotine withdrawal. Pharmacol Biochem Behav 44:51-61
36. Levin ED, Christopher NC, Briggs SJ, Rose JE (1993c) Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection. Cognit Brain Res 1:137-143
37. Levin ED, Rose JE, Abood L (1995) Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze. Pharmacol Biochem Behav 51:360-373
38. McGurk S, Levin ED, Butcher LL (1988) Cholinergic-dopaminergic interactions in radial-arm maze performance. Behav Neural Biol 49:234-239
39. McGurk SR, Levin ED, Butcher LL (1989) Nicotinic-dopaminergic relationship and radial-arm maze performance in rats. Behav Neural Biol 52:78-86
40. McGurk SR, Levin ED, Butcher LL (1991) Impairment of radial-arm maze performance in rats following lesions of the cholinergic medial pathway: reversal by arecoline and differential effects of muscarinic and nicotinic antagonists. Neuroscience 44:137-147
41. Muir JL, Everitt BJ, Robbins TW (1995) Reversal of visual attentional dysfunction following lesions of the cholinergic basal forebrain by physostigmine and nicotine but not by the 5-HT3 receptor antagonist, ondansetron. Psychopharmacology 118: 82-92
42. Newhouse PA, Sunderland T, Tariot PN, Blumhardt CL, Weingartner H, Mellow A, Murphy DL (1988) Intravenous nicotine in Alzheimer's disease: a pilot study. Psychopharmacology 95: 171-175
43. Nordberg A, Adem A, Hardy J, Winblad B (1988) Change in nicotinic receptor subtypes in temporal cortex of Alzheimer brains. Neurosci Lett 88:317-321
44. Nordberg A, Alafuzoff I, Winblad B (1992) Nicotinic and muscarinic subtypes in the human brain: changes with aging and dementia. J Neurosci Res 31:103-111
45. O'Dell TJ, Christensen BN (1988) Mecamylamine is a selective non-competitive antagonist of N-methyl-D-aspartate- and aspartate-induced currents in horizontal cells dissociated from the catfish retina. Neurosci Lett 94:93-98
46. Ohno M, Yamamoto T, Watanabe S (1993) Blockade of hippocampal nicotinic receptors impairs working memory but not reference memory in rats. Pharmacol Biochem Behav 45:89-93
47. Olton DS, Samuelson RJ (1976) Remembrance of places passed: spatial memory in rats. J Exp Psychol 2:97-116
48. Perry EK, Perry RH, Smith CJ, Dick DJ, Candy JM, Edwardson JA, Fairbairn A, Blessed G (1987) Nicotinic receptor abnormalities in Alzheimer's and Parkinson's diseases. J Neurol Neurosurg Psychiatry 50:806-809
49. Poincheval-Fuhrman S, Sara SJ (1993) Chronic nicotine ingestion improves radial-arm maze performance in rats. Behav Pharmacol 4:535-539
50. Riekkinen PJ, Sirviö J, Aaltonen M, Riekkinen P (1990) Effects of concurrent manipulations of nicotinic and muscarinic receptors on spatial and passive avoidance learning. Pharmacol Biochem Behav 37:405-410
51. Sahakian BJ, Jones GMM (1991) The effects of nicotine on attention, information processing, and working memory in patients with dementia of the Alzheimer type. In: Adlkofer F, Thruau K (ed) Effects of nicotine on biological systems. Birkhauser Verlag, Basel, pp 623-630
52. Schröder H, Giacobini E, Struble R, Zilles K, Maelicke A, Luiten P, Strosberg A (1991a) Cellular distribution and expression of cortical acetylcholine receptors in aging and Alzheimer's disease. Ann NY Acad Sci 640:189-192
53. Schröder H, Giacobini E, Struble RG, Zilles K, Maelicke A (1991b) Nicotinic cholinoceptive neurons of the frontal cortex are reuced in Alzheimer's disease. Neurobiol Aging 12:259-262
54. Spangler E, Chachich M, Curtis N, Ingram D (1989) Age-related impairment in complex maze learning in rats: relationship to neophobia and cholinergic antagonism. Neurobiol Aging 10: 133-141
55. Sugaya K, Giacobini E, Chiappinelli VA (1990) Nicotinic acetylcholine receptor subtypes in human frontal cortex: changes in Alzheimer's disease. J Neurosci Res 27:349-359
56. Turner JJ, H. H, Sinden JD, Gray JA (1992) Comparison of radial maze performance of rats after ibotenate and quisqualate lesions of the forebrain cholinergic projection system: effects of pharmacological challenge and changes in training regime. Behav Pharmacol 3:359-373
57. Whitehouse PJ, Martino AM, Antuono PG, Lowenstein PR, Coyle JT, Price DL, Kellar KJ (1986) Nicotinic acetylcholine binding sites in Alzheimer's disease. Brain Res 371:146-151
58. 3H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study. Neurology 38:720-723
59. Widzowski D, Cregan E, Bialobok P (1994) Effects of nicotinic agonists and antagonists on spatial working memory in normal adult and aged rats. Drug Dev Res 31:24-31
60. Wilson AL, Langley LK, Monley J, Bauer T, Rottunda S, Mcfalls K, Kovera C, Mccarten JR (1995) Nicotine patches in Alzheimer's disease: pilot study on learning, memory, and safety. Pharmacol Biochem Behav 51:509-514