The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat

British Journal of Pharmacology

Volumn 167, Issue 2, 2012, Pages 421-435

  Munro, G ^a   Hansen, R R ^a   Erichsen, H K ^a   Timmermann, D B ^a   Christensen, J K ^a   Hansen, H H ^a  

^a NEUROSEARCH A S   (Denmark)

Author keywords

analgesia; carrageenan; CFA; diclofenac; IL 1 ; IL 6; inflammation; NSAID; pain; TNF

Indexed keywords

1 (5 CHLORO 2,4 DIMETHOXYPHENYL) 3 (5 METHYLISOXAZOL 3 YL)UREA; CORTICOSTERONE; CYTOKINE; DICLOFENAC; INTERLEUKIN 6; MORPHINE; PNU 120596; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DRUG EFFICACY; HYPERALGESIA; INFLAMMATORY PAIN; MALE; MOTOR PERFORMANCE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AZABICYCLO COMPOUNDS; CARRAGEENAN; CYTOKINES; DICLOFENAC; FREUND'S ADJUVANT; GENE EXPRESSION REGULATION; HYPERALGESIA; INFLAMMATION; ISOXAZOLES; MALE; PHENYLUREA COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; THIOPHENES;

EID: 84865414244     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02003.x     Document Type: Article

References (48)

1. Albuquerque EX, Pereira EF, Alkondon M, Rogers SW, (2009). Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev 89: 73-120.
2. Bagdas D, Sonat FA, Hamurtekin E, Sonal S, Gurun MS, (2011). The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models. Behav Pharmacol 22: 589-598.
3. Bannon AW, Decker MW, Holladay MW, Curzon P, Donnelly-Roberts D, Puttfarcken PS, et al,. (1998). Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. Science 279: 77-81. (Pubitemid 28079158)
4. Barron SC, McLaughlin JT, See JA, Richards VL, Rosenberg RL, (2009). An allosteric modulator of alpha7 nicotinic receptors, N-(5-chloro-2,4- dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine. Mol Pharmacol 76: 253-263.
5. Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, et al,. (2008). Nociceptors are interleukin-1beta sensors. J Neurosci 28: 14062-14073.
6. Coderre TJ, Katz J, Vaccarino AL, Melzack R, (1993). Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 52: 259-285. (Pubitemid 23080546)
7. Cunha FQ, Poole S, Lorenzetti BB, Ferreira SH, (1992). The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia. Br J Pharmacol 107: 660-664.
8. Cunha TM, Verri WA Jr, Silva JS, Poole S, Cunha FQ, Ferreira SH, (2005). A cascade of cytokines mediates mechanical inflammatory hypernociception in mice. Proc Natl Acad Sci U S A 102: 1755-1760. (Pubitemid 40209240)
9. Damaj MI, Meyer EM, Martin BR, (2000). The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model. Neuropharmacology 39: 2785-2791.
10. Dickinson JA, Hanrott KE, Mok MH, Kew JN, Wonnacott S, (2007). Differential coupling of alpha7 and non-alpha7 nicotinic acetylcholine receptors to calcium-induced calcium release and voltage-operated calcium channels in PC12 cells. J Neurochem 100: 1089-1096. (Pubitemid 46213931)
11. Feuerbach D, Lingenhoehl K, Olpe HR, Vassout A, Gentsch C, Chaperon F, et al,. (2009). The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain. Neuropharmacology 56: 254-263.
12. Gan TJ, (2010). Diclofenac: an update on its mechanism of action and safety profile. Curr Med Res Opin 26: 1715-1731.
13. Gao B, Hierl M, Clarkin K, Juan T, Nguyen H, Valk M, et al,. (2010). Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain. Pain 149: 33-49.
14. Gurun MS, Parker R, Eisenach JC, Vincler M, (2009). The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor. Anesth Analg 108: 1680-1687.
15. Gusev AG, Uteshev VV, (2010). Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3- yl)-urea]. J Pharmacol Exp Ther 332: 588-598.
16. Hedo G, Laird JM, Lopez-Garcia JA, (1999). Time-course of spinal sensitization following carrageenan-induced inflammation in the young rat: a comparative electrophysiological and behavioural study in vitro and in vivo. Neuroscience 92: 309-318. (Pubitemid 29249040)
17. Henry JL, Yashpal K, Pitcher GM, Coderre TJ, (1999). Physiological evidence that the 'interphase' in the formalin test is due to active inhibition. Pain 82: 57-63. (Pubitemid 29287086)
18. Hurst RS, Hajõs M, Raggenbass M, Wall TM, Higdon NR, Lawson JA, et al,. (2005). A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J Neurosci 25: 4396-4405. (Pubitemid 40628784)
19. Jett MF, Ramesha CS, Brown CD, Chiu S, Emmett C, Voronin T, et al,. (1999). Characterization of the analgesic and anti-inflammatory activities of ketorolac and its enantiomers in the rat. J Pharmacol Exp Ther 288: 1288-1297. (Pubitemid 29254170)
20. de Jonge WJ, van der Zanden EP, The FO, Bijlsma MF, van Westerloo DJ, Bennink RJ, et al,. (2005). Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol 6: 844-851. (Pubitemid 43090471)
21. Julius D, Basbaum AI, (2001). Molecular mechanisms of nociception. Nature 413: 203-210. (Pubitemid 32867885)
22. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, (2010). NC3Rs Reporting Guidelines Working Group. Br J Pharmacol 160: 1577-1579.
23. Lazzarini R, Maiorka PC, Liu J, Papadopoulos V, Palermo-Neto J, (2006). Diazepam effects on carrageenan-induced inflammatory paw edema in rats: role of nitric oxide. Life Sci 78: 3027-3034.
24. Li J, Mathieu SL, Harris R, Ji J, Anderson DJ, Malysz J, et al,. (2011). Role of α7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-α (TNF-α) as revealed by subtype selective agonists. J Neuroimmunol 239: 37-43.
25. Liu YL, Lin HM, Zou R, Wu JC, Han R, Raymond LN, et al,. (2009). Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin. Acta Pharmacol Sin 30: 219-227.
26. Loram LC, Fuller A, Cartmell T, Mitchell B, Mitchell D, (2007a). Behavioural, histological and cytokine responses during hyperalgesia induced by carrageenan injection in the rat tail. Physiol Behav 92: 873-880. (Pubitemid 350110457)
27. Loram LC, Fuller A, Fick LG, Cartmell T, Poole S, Mitchell D, (2007b). Cytokine profiles during carrageenan-induced inflammatory hyperalgesia in rat muscle and hind paw. J Pain 8: 127-136. (Pubitemid 46188623)
28. Loram LC, Harrison JA, Chao L, Taylor FR, Reddy A, Travis CL, et al,. (2010). Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats. Brain Behav Immun 24: 959-967.
29. van Maanen MA, Lebre MC, van der Poll T, LaRosa GJ, Elbaum D, Vervoordeldonk MJ, et al,. (2009). Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice. Arthritis Rheum 60: 114-122.
30. McGrath J, Drummond G, Kilkenny C, Wainwright C, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
31. Medhurst SJ, Hatcher JP, Hille CJ, Bingham S, Clayton NM, Billinton A, et al,. (2008). Activation of the alpha7-nicotinic acetylcholine receptor reverses complete Freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action. J Pain 9: 580-587.
32. Munro G, (2009). Pharmacological assessment of the rat formalin test utilizing the clinically used analgesic drugs gabapentin, lamotrigine, morphine, duloxetine, tramadol and ibuprofen: influence of low and high formalin concentrations. Eur J Pharmacol 605: 95-102.
33. A receptor positive allosteric modulator NS11394 with diazepam, zolpidem, bretazenil and gaboxadol in rat models of inflammatory and neuropathic pain. J Pharmacol Exp Ther 327: 969-981.
34. Munro G, Erichsen HK, Rae MG, Mirza NR, (2011). A question of balance-positive versus negative allosteric modulation of GABA(A) receptor subtypes as a driver of analgesic efficacy in rat models of inflammatory and neuropathic pain. Neuropharmacology 61: 121-132.
35. Nizri E, Irony-Tur-Sinai M, Lory O, Orr-Urtreger A, Lavi E, Brenner T, (2009). Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses. J Immunol 183: 6681-6688.
36. Oka Y, Ibuki T, Matsumura K, Namba M, Yamazaki Y, Poole S, et al,. (2007). Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS. Neuroscience 145: 530-538. (Pubitemid 46341642)
37. Pacini A, Di Cesare Mannelli L, Bonaccini L, Ronzoni S, Bartolini A, Ghelardini A, (2010). Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy. Pain 150: 542-549.
38. Rosas-Ballina M, Olofsson PS, Ochani M, Valdés-Ferrer SI, Levine YA, Reardon C, et al,. (2011). Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science 334: 98-101.
39. Rowbotham MC, Duan WR, Thomas J, Nothaft W, Backonja MM, (2009). A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain. Pain 146: 245-252.
40. Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, et al,. (2001). Interleukin-1beta-mediated induction of COX-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 410: 471-475. (Pubitemid 32240046)
41. Sitzia F, Brown JT, Randall AD, Dunlop J, (2011). Voltage- and temperature-dependent allosteric modulation of α7 nicotinic receptors by PNU120596. Front Pharmacol 81: 1-9.
42. Taly A, Corringer PJ, Guedin D, Lestage P, Changeux JP, (2009). Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov 8: 733-750.
43. Tracey KJ, (2009). Reflex control of immunity. Nat Rev Immunol 9: 418-428.
44. Vajja BN, Juluri S, Kumari M, Kole L, Chakrabarti R, Joshi VD, (2004). Lipopolysaccharide-induced paw edema model for detection of cytokine modulating anti-inflammatory agents. Int Immunopharmacol 4: 901-909. (Pubitemid 38739095)
45. Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, et al,. (2003). Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421: 384-388. (Pubitemid 36157937)
46. Woolf CJ, Allchorne A, Safieh-Garabedian B, Poole S, (1997). Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor alpha. Br J Pharmacol 121: 417-424. (Pubitemid 27226293)
47. Yaksh TL, Ozaki G, McCumber D, Rathbun M, Svensson C, Malkmus S, et al,. (2001). An automated flinch detecting system for use in the formalin nociceptive bioassay. J Appl Physiol 90: 2386-2402. (Pubitemid 32467435)
48. Zimmermann M, (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110. (Pubitemid 13058546)