Desensitization of nicotinic acetylcholine receptors as a strategy for drug development

Journal of Pharmacology and Experimental Therapeutics

Volumn 328, Issue 2, 2009, Pages 364-370

  Buccafusco, Jerry J ^a,b   Beach, J Warren ^c   Terry Jr , Alvin V ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM; 2 [4 (PYRIDIN 3 YLMETHYL)PIPERAZIN 1 YL]ETHANOL; 2 [METHYL (PYRIDIN 3 YLMETHYL)AMINO]ETHANOL; APOMORPHINE; COTININE; GALANTAMINE; JAY 22233; JWB 1841; NICOTINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; PNU 120596; SAZETIDINE A; UNCLASSIFIED DRUG;

ALLOSTERISM; BINDING AFFINITY; DRUG ACTIVITY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG TISSUE LEVEL; LOW DRUG DOSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; REVIEW;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; CHOLINE; DRUG DESIGN; HUMANS; ISOXAZOLES; NICOTINE; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PHENYLUREA COMPOUNDS; PIPERAZINES; PYRIDINES; RATS; RECEPTORS, NICOTINIC;

EID: 59649098711     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.145292     Document Type: Review

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