Positive allosteric modulator of alpha 7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates

Neuropharmacology

Volumn 67, Issue , 2013, Pages 201-212

  Callahan, Patrick M ^a   Hutchings, Elizabeth J ^a   Kille, Nancy J ^a   Chapman, James M ^b   Terry, Alvin V ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b University of South Carolina   (United States)

Author keywords

Aging; Alzheimer's disease; Cholinergic; Memory; Mild cognitive impairment; Pro cognitive

Indexed keywords

DONEPEZIL; METHYLLYCACONITINE; NOOTROPIC AGENT; PNU 120596; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENTIATION; DRUG SCREENING; FEMALE; LATENT PERIOD; MALE; MAZE TEST; MENTAL TASK; NONHUMAN; PRIMATE; PRIORITY JOURNAL; RAT; RECALL; RECOGNITION; RHESUS MONKEY; SHORT TERM MEMORY; SPATIAL LEARNING; TIME TO MAXIMUM PLASMA CONCENTRATION; WORKING MEMORY;

ALLOSTERIC REGULATION; ANIMALS; CHOLINESTERASE INHIBITORS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; INDANS; ISOXAZOLES; LEARNING; MACACA MULATTA; MALE; MEMORY; PHENYLUREA COMPOUNDS; PIPERIDINES; RATS; RATS, INBRED F344; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; SPECIES SPECIFICITY; TREATMENT OUTCOME; UP-REGULATION;

EID: 84873355827     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.10.019     Document Type: Article

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