Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: Correlation with desensitization of α4β2* receptors

European Journal of Pharmaceutical Sciences

Volumn 47, Issue 5, 2012, Pages 813-823

  Zhang, Jiahui ^a   Xiao, Yun De ^a   Jordan, Kristen G ^a   Hammond, Phil S ^a   Van Dyke, Katherine M ^a   Mazurov, Anatoly A ^a   Speake, Jason D ^a   Lippiello, Patrick M ^a   James, John W ^a   Letchworth, Sharon R ^a   Bencherif, Merouane ^a   Hauser, Terry A ^a  

^a TARGACEPT INC   (United States)

Author keywords

4 2* Neuronal nicotinic acetylcholine receptors; Analgesic effect; Formalin assay; Receptor desensitization

Indexed keywords

AZETIDINE; MORPHINE; NICOTINIC RECEPTOR ALPHA4BETA2; SOFINICLINE;

ANALGESIA; ANALGESIC ACTIVITY; ANTINOCICEPTION; ARTICLE; DESENSITIZATION; DOSE RESPONSE; DRUG EFFICACY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MOLECULAR MODEL; MOUSE; MULTIPLE LINEAR REGRESSION ANALYSIS; NONHUMAN; PAIN; PRIORITY JOURNAL;

ANALGESICS; ANIMALS; BINDING, COMPETITIVE; CELL LINE; CELL LINE, TUMOR; FORMALDEHYDE; HEK293 CELLS; HUMANS; MALE; MICE; MOTOR ACTIVITY; NICOTINIC AGONISTS; PAIN; PC12 CELLS; RATS; RECEPTORS, NICOTINIC;

EID: 84868694819     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.09.014     Document Type: Article

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