The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 312, Issue 3, 2005, Pages 1213-1222

  Hajos M ^a,d   Hurst, R S ^a   Hoffmann, W E ^a   Krause, M ^a,c   Wall, T M ^a,d   Higdon, N R ^a,d   Groppi, V E ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b Division of Neuroscience ^*

^c MPI Cardlon Laboratories   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2,4 DIMETHOXYBENZYLIDENE)ANABASEINE; AMPHETAMINE; CHLORAL HYDRATE; METHYLLYCACONITINE; N [1 AZABICYCLO[2.2.2]OCT 3 YL] 4 CHLOROBENZAMIDE HYDROCHLORIDE; NICOTINE; NICOTINIC AGENT; PNU 282987; UNCLASSIFIED DRUG; 3-(2,4-DIMETHOXYBENZYLIDENE)ANABASEINE; 4 AMINOBUTYRIC ACID; ALPHA-BUNGAROTOXIN RECEPTOR; BENZAMIDE DERIVATIVE; BENZYLIDENE DERIVATIVE; BICYCLO COMPOUND; BUNGAROTOXIN RECEPTOR; NICOTINIC RECEPTOR; PNU-282987; PYRIDINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUDITORY NERVOUS SYSTEM; BRAIN NERVE CELL; BRAIN SLICE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG SELECTIVITY; ELECTROENCEPHALOGRAM; ELECTROPHYSIOLOGY; EVOKED AUDITORY RESPONSE; GABAERGIC TRANSMISSION; HIPPOCAMPUS; HIPPOCAMPUS POTENTIAL; MALE; NERVE CELL CULTURE; NEUROTRANSMISSION; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; SYNAPTIC TRANSMISSION; THALAMUS; WHOLE CELL; ANIMAL; CELL CULTURE; DRUG EFFECT; ELECTROENCEPHALOGRAPHY; PHYSIOLOGY; SECRETION; SPRAGUE DAWLEY RAT; SYNAPSE; THALAMUS INTRALAMINAR NUCLEUS;

ANIMALS; BENZAMIDES; BENZYLIDENE COMPOUNDS; BICYCLO COMPOUNDS; CELLS, CULTURED; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS, AUDITORY; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; INTRALAMINAR THALAMIC NUCLEI; NICOTINIC AGONISTS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NICOTINIC; SYNAPSES;

EID: 14344251489     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.076968     Document Type: Article

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