Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors hα2β2, hα2β4, hα3β2, hα3β4, hα4β2, hα4β4 and hα7 expressed in xenopus oocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 1, 1997, Pages 346-356

  Chavez Noriega, Laura E ^a   Crona, James H ^a   Washburn, Mark S ^a   Urrutia, Arturo ^a   Elliott, Kathryn J ^a   Johnson, Edwin C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM; ACETYLCHOLINE; ATROPINE; CYTISINE; DIHYDRO BETA ERYTHROIDINE; MECAMYLAMINE; NICOTINE; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; TUBOCURARINE CHLORIDE;

ANIMAL CELL; ARTICLE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG SENSITIVITY; GENE EXPRESSION; NEUROTRANSMISSION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; OOCYTES; RECEPTORS, NICOTINIC; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 0030941561     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. ALKONDON, M. AND ALBUQUERQUE, E. X.: Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes. J. Pharmacol. Exp. Ther. 265: 1455-1473, 1993.
2. ANAND, R., CONROY, W. G., SCHOEPFER, R., WHITING, P., LINDSTROM, J.: Neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes have a pentameric quaternary structure. J. Biol. Chem. 266: 11192-11198, 1991.
3. ANAND, R. AND LINDSTROM, J.: Nucleotide sequence of the human nicotinic acetylcholine receptor β2 subunit gene. Nucleic Acids Res. 18: 4272, 1990.
4. BARON, J. A.: Cigarette smoking and Parkinson's disease. Neurology 36: 1490-1496, 1986.
5. BERTRAND, D., DEVILLERS-THIERY, F., REVAH, F., GALZI, J.-L., HUSSY, N., MULLLE, C., BERTRAND, S., BALLIVET, M. AND CHANGEUX, J. P.: Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain. Proc. Natl. Acad. Sci. U.S.A. 89: 1261-1265, 1992a.
6. BERTRAND, D., BERTRAND, S. AND BALLIVET, M.: Pharmacological properties of the homomeric α7 receptor. Neurosci. Lett. 146: 87-90, 1992b.
7. CACHELIN, A. B. AND JAGGI, R.: β subunits determine the time course of desensitization in rat neuronal nicotinic acetylcholine receptors, Pflugers Arch. 419: 579-582, 1991.
8. CHINI, B., CLEMENTI, F., HUKOVIC, N. AND SHER, E.: Neuronal-type alpha- bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines. Proc. Natl. Acad. Sci. U.S.A. 89: 1572-1576, 1992.
9. CLARKE, P. B. S.: Nicotinic receptors and cholinergic neurotransmission in the central nervous system. Ann. N.Y. Acad. Sci. 757: 73-83, 1995.
10. CLARKE, P. B. S. AND KUMAR, R.: The effects of nicotine on locomotor activity in non-tolerant and tolerant rats. Br. J. Pharmac. 78: 329-337, 1983.
11. 125I]-α-bungarotoxin. J. Neurosci. 5: 1307-1315, 1985.
12. COHEN, B. N., FIGL, A., QUICK, M. W., LABARCA, C., DAVIDSON, N. AND LESTER, H. A.: Regions of β2 and β4 responsible for differences between the steady state dose-response relationships of the α3β2 and α3β4 neuronal nicotinic receptors. J. Gen. Physiol. 105: 745-764, 1995.
13. 2 and other nicotinic acetylcholine receptor subtypes as targets of psychoactive and addictive drugs. Br. J. Pharmacol. 105: 657-666, 1992.
14. CUNNOLLY, J. G., GIBB, A. J. AND COLQUHOUN, D.: Heterogeneity of neuronal nicotinic acetylcholine receptors in thin slices of rat medial habenula. J. Physiol. (Lond.) 484: 87-105, 1995.
15. COOPER, E., COUTURIER, S. AND BALLIVET, M.: Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor. Nature 350: 235-238, 1991.
16. COUTURIER, S., BERTRAND, D., MATTER, J. M., HERNANDEZ, M. C., BERTRAND, S., MILLAR, N., VALERA, S., BARKAS, T. AND BALLIVET, M.: A neuronal nicotinic acetylcholine receptor subunit (alpha 7) is developmentally regulated and forms a homo-oligomeric channel blocked by alpha-BTX. Neuron 5: 847-856, 1990.
17. COVERNTON, P. J. O., KOJIMA, H., SIVILOTTI, L. G., GlBB, A. J. AND COLQUHOUN, D.: Comparison of neuronal nicotinic receptors in rat sympathetic neurones with subunit pairs expressed in Xenopus oocytes. J. Physiol. (Lond.) 481: 27-34, 1994.
18. DINELEY-MILLER, K. AND PATRICK, J.: Gene transcripts for the nicotinic acetylcholine receptor subunit, beta4, are distributed in multiple areas of the rat central nervous system. Brain Res. Mol. Brain Res. 16: 339-344, 1992.
19. DOUCETTE-STAMM, L., MONTEGGIA, L. M., DONNELLY-ROBERTS, D., WANG, M. T., LEE, J., TIAN, J. AND GIORDANO, T.: Cloning and sequence of the human α7 nicotinic acetylcholine receptor. Drug Dev. Res. 30: 252-256, 1993.
20. ELGOYHEN, A. B., JOHNSON, D. S., BOULTER, J., VETTER, D. E. AND HEINEMANN, S.: α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell 79: 705-715, 1994.
21. ELLIOTT, K. J., ELLIS, S. B., BERCKHAN, K. J., URRUTIA, A., CHAVEZ-NORIEGA, L. E., JOHNSON, E. C., VELICELEBI, G. AND HARPOLD, M.: Comparative structure of human neuronal α2-α7 and β2-β4 nicotinic acetylcholine receptor subunits and functional expression of the α2, α3, α4, α7, β2 and β4 subunits. J. Mol. Neurosci. 7: 217-228, 1996.
22. FORNASARI, D., CHINI, B., TARRONI, P. AND CLEMENTI, F.: Molecular cloning of human neuronal nicotinic receptor alpha 3-subunit. Neurosci. Lett. 111: 351-356, 1990.
23. GALZI, J.-L., BERTRAND, D., DEVILLERS-THIERY, A., REVAH, F., BERTRAND, S. AND CHANGEUX, J.-P.: Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site-directed mutagenesis. FEBS Lett. 294: 198-202, 1991.
24. GERZANICH, V., ANAND, R. AND LINDSTROM, J.: Homomers of alpha 8 and alpha 7 subunits of nicotinic receptors exhibit similar channel but contrasting binding site properties. Mol. Pharmacol. 45: 212-220, 1994.
25. GERZANICH, V., PENG, X., WANG, F., WELLS, G., ANAND, R., FLETCHER, S. AND LINDSTROM, J.: Comparative pharmacology of epibatidine: A potent agonist for neuronal nicotinic acetylcholine receptors. Mol. Pharmacol. 48: 774-782, 1995.
26. GOPALAKRISHNAN, M., BUISSON, B., TOUMA, E., GIORDANO, T., CAMPBELL, J. E., HU, I. C., DONNELY-ROBERTS, D., ARNERIC, S. P., BERTRAND, D. AND SULLIVAN, J. P.: Stable expression and pharmacological properties of the human α7 nicotinic acetylcholine receptor. Eur. J. Pharmacol. Mol. Pharmacol. 290: 237-246, 1995.
27. 2 receptor. J. Pharmacol. Exp. Ther. 276: 289-297, 1996.
28. HARVEY, S. C. AND LUETJE, C. W.: Determinants of competitive antagonist sensitivity on neuronal nicotinic receptor β subunits. J. Neurosci. 16: 3798-3806, 1996.
29. HUSSY, N., BALLIVET, M. AND BERTRAND, D.: Agonist and antagonist effects of nicotine on chick neuronal nicotinic receptors are defined by alpha and beta subunits. J. Neurophysiol. 72: 1317-1326, 1994.
30. JONES, M. V. AND WESTBROOK, G.: The impact of receptor desensitization on fast synaptic transmission. Trends Neurosci. 19: 96-101, 1996.
31. KOZAK, M.: An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15: 8125-8148, 1987.
32. LEFF., P. AND DOUGALL, G.: Further concerns over Cheng-Prusoff analysis. Trends Pharmacol. Sci. 14: 110-112, 1993.
33. LEVIN, E. D., CHRISTOPHER, N. C., BRIGGS, S. J. AND ROSE, J. E.: Chronic nicotine reverses working memory deficits caused by lesions of the fimbria or medial basalocortical projection. Cognitive Brain Res. 1: 137-143, 1993.
34. LUETJE, C. W. AND PATRICK, J.: Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors. J. Neurosci 11: 837-845, 1991.
35. LUKAS, R. J., NORMAN, S. A. AND LUCERO, L.: Characterization of nicotinic acetylcholine receptors expressed by cells of the SH-SY5Y human neuroblastome clonal line. Mol. Cell. Neurosci. 4: 1-12, 1993.
36. MACONOCHIE, D. J AND KNIGHT, D. E.: A study of the bovine adrenal chromaffin nicotinic receptor using patch clamp and concentration jump techniques J. Physiol. (Lond.) 454: 129-153, 1992.
37. 2+. Soc. Neurosci. Abstr. 22: p. 1526, 1996.
38. McGEHEE, D. S. AND ROLE, L. W.: Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons. Annu. Rev. Physiol. 57: 521-546-, 1995.
39. MILEDI, R. AND PARKER, I.: Chloride current induced by injection of calcium into Xenopus oocytes. J. Physiol. (Lond.) 357: 173-183, 1984.
40. MOSS, D. E., MANDERSCHEID, P. Z., MONTGOMERY, S. P., NORMAN, A. B. AND SANBERG, P. R.: Nicotine and cannabinoids as adjuncts to neuroleptics in the treatment of Tourette syndrome and other motor disorders. Life Sci. 44: 1521-1525, 1989.
41. MULLE, C., VIDAL, C., BENOIT, P. AND CHANGEUX, J. P.: Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulointerpeduncular system. J. Neurosci. 11: 2588-2597, 1991.
42. MULLE, C., LENA, C. AND CHANGEUX, J.-P.: Potentiation of nicotinic receptor response by external calcium in rat central neurons. Neuron 8: 937-945, 1992.
43. NEWHOUSE, P. A., SUNDERLAND, T., TARIOT, P. N., BLUMHARDT, C. L., WEINGARTNER, H., MELLOW, A. AND MURPHY, D. L.: Intravenous nicotine in Alzheimer's disease: A pilot study. Psychopharmacology 95: 171-175, 1988.
44. NORDBERG, A.: Human nicotinic receptors-Their role in aging and dementia. Neurochem. Int. 25: 93-97, 1994.
45. PAPKE, R. L.: The kinetic properties of neuronal nicotinic receptors: Genetic basis of functional diversity. Prog. Neurobiol. 41: 509-531, 1993.
46. PENG, X., KATZ, M., GERZANICH, V., ANAND, R. AND LINDSTROM, J.: Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes. Mol. Pharmacol. 45: 546-554, 1994.
47. RINNE, J. O., MYLLYKYLÄ, T., LÖNNBERG, P. AND MARJAMÄKI, P.: A postmortem study of brain nicotinic receptors in Parkinson's and Alzheimer's disease. Brain Res. 547: 167-170, 1991.
48. RUBBOLI, F., COURT, J. A., SALA, C., MORRIS, C., PERRY, E. AND CLEMENTI, F.: Distribution of neuronal nicotinic receptor subunits in human brain. Neurochem. Int. 25: 69-71, 1994.
49. SARGENT, P. B.: The diversity of neuronal nicotinic acetylcholine receptors. Annu. Rev. Neurosci. 16: 403-443, 1993.
50. 7: A nicotinic cation channel highly permeable to calcium. J. Neurosci. 13: 596-604, 1993.
51. STEINLEIN, O. K., MULLEY, J. C., PROPPING, P., WALLACE, R. H., PHILLIPS, H. A., SUTHERLAND, G. R., SCHEFFER, I. E. AND BERKOVIC, S. F.: A missense mutation in the neuronal nicotinic acetylcholine receptor α4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nature Genet. 11: 201-203, 1995.
52. TARRONI, P., RUBBOLI, F., CHINI, B., ZWART, R., OORTGIESEN, M., SHER, E. AND CLEMENTI, F.: Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines. FEBS Lett. 312: 66-70, 1992.
53. VERNINO, S., AMADOR, M., LUETJE, C. W., PATRICK, J. AND DANI, J. A.: Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors. Neuron 8: 127-134, 1992.
54. WADA, E., WADA, K., BOULTER, J., DENERIS, E., HEINEMANN, S., PATRICK, J. AND SWANSON, L. W.: Distribution of Alpha2, Alpha3, Alpha4 and Beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: A hybridization histochemical study in the rat. J. Compar. Neurol. 284: 314-335, 1989.
55. WlLLOUGHBY, J. J., NlNKINA, N. N., BEECH, M. M., LATCHMAN, D. S. AND WOOD, J. N.: Molecular cloning of a human neuronal nicotinic acetylcholine receptor beta 3-like subunit. Neurosci. Lett. 105: 136-139, 1993.
56. WONG, E. T., HOLSTAD, S. G., MENNERICK, S. J., HONG, S. E., ZORUMSKI, C. F. AND ISENBERG, K. E.: Pharmacological and physiological properties of a Putative ganglionic nicotinic receptor, α3β4, expressed in transfected eukaryotic cells. Mol. Brain Res. 28: 101-109, 1995.
57. ZHANG, Z. W., VIJAYARAGHAVAN, S. AND BERG, D. K.: Neuronal acetylcholine receptors that bind alpha-bungarotoxin with high affinity function as ligandgated ion channels. Neuron 12: 167-177, 1994.