Allosteric activation mechanism of the cys-loop receptors

Acta Pharmacologica Sinica

Volumn 30, Issue 6, 2009, Pages 663-672

  Chang, Yong Chang ^a   Wu, Wen ^b,c   Zhang, Jian Liang ^a   Huang, Yao ^b  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

^b ST JOSEPH'S HOSPITAL AND MEDICAL CENTER   (United States)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

ACh binding protein; Allosteric activation; Coupling; Cys loop receptors; GABA receptors; Gating domain; Glycine receptors; Nicotinic receptors; Receptor binding; Serotonin receptors

Indexed keywords

NICOTINIC AGENT; NICOTINIC RECEPTOR;

AFFINITY LABELING; ALLOSTERISM; AMINO TERMINAL SEQUENCE; BETA SHEET; CHANNEL GATING; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ELECTRON MICROSCOPY; ELECTROPHYSIOLOGY; KINETICS; MOLECULAR BIOLOGY; MUTAGENESIS; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTON TRANSPORT; RECEPTOR BINDING; RECEPTOR UPREGULATION; REVIEW;

ALLOSTERIC REGULATION; CYSTEINE; HUMANS; MODELS, BIOLOGICAL; NEUROTRANSMITTER AGENTS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC;

EID: 67549125013     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.51     Document Type: Review

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