Synthesis of desformylflustrabromine and its evaluation as an α4β2 and α7 nACh receptor modulator

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 17, 2007, Pages 4855-4860

  Kim, Jin Sung ^a   Padnya, Anshul ^b   Weltzin, Maegan ^b   Edmonds, Brian W ^c   Schulte, Marvin K ^b   Glennon, Richard A ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF ALASKA FAIRBANKS   (United States)

^c UNIVERSITY OF ALASKA SOUTHEAST   (United States)

Author keywords

Allosteric modulators; Nicotinic cholinergic receptors

Indexed keywords

BROMINE DERIVATIVE; DESFORMYLFLUSTRABROMINE; DESFORMYLFLUSTRABROMINE B; NICOTINIC RECEPTOR; TRYPTAMINE; UNCLASSIFIED DRUG;

ARTICLE; BRYOZOA; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; FLUSTRA FOLIACEA; IN VITRO STUDY; NONHUMAN; OOCYTE; RECEPTOR AFFINITY; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION; VOLTAGE CLAMP; XENOPUS;

ALLOSTERIC SITE; ANIMALS; BROMINE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; HYDROCARBONS, BROMINATED; INDOLE ALKALOIDS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; NICOTINIC ANTAGONISTS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, NICOTINIC; WATER; XENOPUS;

EID: 34547515400     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.047     Document Type: Article

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