Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization

Neuropharmacology

Volumn 61, Issue 8, 2011, Pages 1306-1313

  Collins, Toby ^a   Young, Gareth T ^b   Millar, Neil S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Acetylcholine receptor; Ligand gated ion channel; Nicotinic receptor; Positive allosteric modulator

Indexed keywords

BUNGAROTOXIN RECEPTOR; CHOLINERGIC RECEPTOR AFFECTING AGENT; NS 1738; PNU 120596; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING COMPETITION; BINDING SITE; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG BINDING SITE; MOLECULAR DOCKING; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SITE DIRECTED MUTAGENESIS;

ACETYLCHOLINE; ALLOSTERIC REGULATION; ANIMALS; BINDING, COMPETITIVE; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ISOXAZOLES; MEMBRANE POTENTIALS; MICROINJECTIONS; MODELS, MOLECULAR; MUTATION; NICOTINIC AGONISTS; OOCYTES; PATCH-CLAMP TECHNIQUES; PHENYLUREA COMPOUNDS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NICOTINIC; XENOPUS LAEVIS;

EID: 80053618320     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.07.035     Document Type: Article

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