Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl) benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the α7 nicotinic acetylcholine receptor

Journal of Medicinal Chemistry

Volumn 52, Issue 10, 2009, Pages 3377-3384

  Faghih, Ramin ^a   Gopalakrishnan, Sujatha M ^a   Gronlien, Jens Halvard ^a   Malysz, John ^a   Briggs, Clark A ^a   Wetterstrand, Caroline ^a   Ween, Hilde ^a   Curtis, Michael P ^a   Sarris, Kathy A ^a   Gfesser, Gregory A ^a   El Kouhen, Rachid ^a   Robb, Holly M ^a   Radek, Richard J ^a   Marsh, Kennan C ^a   Bunnelle, William H ^a   Gopalakrishnan, Murali ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 CHLOROPHENYL) 2 METHYL 3 PROPIONYL 1H PYRROL 1 YL]BENZENESULFONAMIDE; A 867744; BUNGAROTOXIN RECEPTOR; SULFONAMIDE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; MOUSE; NONHUMAN; RAT;

ALLOSTERIC REGULATION; ANIMALS; BRAIN; CELLS, CULTURED; DRUG DISCOVERY; MICE; MICROSOMES; OOCYTES; PATCH-CLAMP TECHNIQUES; PHARMACOKINETICS; PYRROLES; RECEPTORS, NICOTINIC; SENSORY GATING; SULFONAMIDES; XENOPUS LAEVIS;

EID: 66349096318     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9003818     Document Type: Article

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