-
1
-
-
77949422530
-
Neuronal nicotinic acetylcholine receptors - targets for the development of drugs to treat cognitive impairment associated with schizophrenia and Alzheimer's disease
-
Haydar SN, Dunlop J, (2010) Neuronal nicotinic acetylcholine receptors- targets for the development of drugs to treat cognitive impairment associated with schizophrenia and Alzheimer's disease. Curr Top Med Chem 10: 144-52.
-
(2010)
Curr Top Med Chem
, vol.10
, pp. 144-152
-
-
Haydar, S.N.1
Dunlop, J.2
-
2
-
-
39749152191
-
Allosteric modulators of the alpha7 nicotinic acetylcholine receptor
-
Faghih R, Gopalakrishnan M, Briggs CA, (2008) Allosteric modulators of the alpha7 nicotinic acetylcholine receptor. J Med Chem 51: 701-12.
-
(2008)
J Med Chem
, vol.51
, pp. 701-712
-
-
Faghih, R.1
Gopalakrishnan, M.2
Briggs, C.A.3
-
3
-
-
0026595812
-
Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain
-
Bertrand D, Devillers-Thiéry A, Revah F, Galzi JL, Hussy N, et al. (1992) Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain. Proc Natl Acad Sci U S A 89: 1261-5.
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 1261-1265
-
-
Bertrand, D.1
Devillers-Thiéry, A.2
Revah, F.3
Galzi, J.L.4
Hussy, N.5
-
4
-
-
0034732322
-
Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areas
-
Dani JA, Radcliffe KA, Pidoplichko VI, (2000) Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areas. Eur J Pharmacol 393: 31-8.
-
(2000)
Eur J Pharmacol
, vol.393
, pp. 31-38
-
-
Dani, J.A.1
Radcliffe, K.A.2
Pidoplichko, V.I.3
-
5
-
-
40049095834
-
First administration of cytidine diphosphocholine and galantamine in schizophrenia: a sustained alpha7 nicotinic agonist strategy
-
Deutsch SI, Schwartz BL, Schooler NR, Rosse RB, Mastropaolo J, et al. (2008) First administration of cytidine diphosphocholine and galantamine in schizophrenia: a sustained alpha7 nicotinic agonist strategy. Clin Neuropharmacol 31: 34-9.
-
(2008)
Clin Neuropharmacol
, vol.31
, pp. 34-39
-
-
Deutsch, S.I.1
Schwartz, B.L.2
Schooler, N.R.3
Rosse, R.B.4
Mastropaolo, J.5
-
6
-
-
65649102955
-
Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine
-
Papke RL, Kem WR, Soti F, López-Hernández GY, Horenstein NA, (2009) Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine. J Pharmacol Exp Ther 329: 791-807.
-
(2009)
J Pharmacol Exp Ther
, vol.329
, pp. 791-807
-
-
Papke, R.L.1
Kem, W.R.2
Soti, F.3
López-Hernández, G.Y.4
Horenstein, N.A.5
-
7
-
-
77949462775
-
Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology
-
Thomsen MS, Hansen HH, Timmermann DB, Mikkelsen JD, (2010) Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology. Curr Pharm Des 16: 323-43.
-
(2010)
Curr Pharm Des
, vol.16
, pp. 323-343
-
-
Thomsen, M.S.1
Hansen, H.H.2
Timmermann, D.B.3
Mikkelsen, J.D.4
-
8
-
-
0030482929
-
Long-term treatment with GTS-21 or nicotine enhances water maze performance in aged rats without affecting the density of nicotinic receptor subtypes in neocortex
-
Bjugstad KB, Mahnir VM, Kem WR, Socci DJ, Arendash GW, (1996) Long-term treatment with GTS-21 or nicotine enhances water maze performance in aged rats without affecting the density of nicotinic receptor subtypes in neocortex. Drug Development Research 39: 19-28.
-
(1996)
Drug Development Research
, vol.39
, pp. 19-28
-
-
Bjugstad, K.B.1
Mahnir, V.M.2
Kem, W.R.3
Socci, D.J.4
Arendash, G.W.5
-
9
-
-
0031596817
-
Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice
-
Stevens KE, Kem WR, Mahnir VM, Freedman R, (1998) Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology (Berl) 136: 320-7.
-
(1998)
Psychopharmacology (Berl)
, vol.136
, pp. 320-327
-
-
Stevens, K.E.1
Kem, W.R.2
Mahnir, V.M.3
Freedman, R.4
-
10
-
-
0033237390
-
AR-R17779, an alpha7 nicotinic agonist, improves learning and memory in rats
-
Levin ED, Bettegowda C, Blosser J, Gordon J, (1999) AR-R17779, an alpha7 nicotinic agonist, improves learning and memory in rats. Behav Pharmacol 10: 675-80.
-
(1999)
Behav Pharmacol
, vol.10
, pp. 675-680
-
-
Levin, E.D.1
Bettegowda, C.2
Blosser, J.3
Gordon, J.4
-
11
-
-
34848925196
-
Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways
-
Bitner RS, Bunnelle WH, Anderson DJ, Briggs CA, Buccafusco J, et al. (2007) Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. J Neurosci 27: 10578-87.
-
(2007)
J Neurosci
, vol.27
, pp. 10578-10587
-
-
Bitner, R.S.1
Bunnelle, W.H.2
Anderson, D.J.3
Briggs, C.A.4
Buccafusco, J.5
-
12
-
-
33845719612
-
SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia
-
Pichat P, Bergis OE, Terranova J-P, Urani A, Duarte C, et al. (2007) SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology 32: 17-34.
-
(2007)
Neuropsychopharmacology
, vol.32
, pp. 17-34
-
-
Pichat, P.1
Bergis, O.E.2
Terranova, J.-P.3
Urani, A.4
Duarte, C.5
-
13
-
-
53949092571
-
Nicotinic acetylcholine receptors and modulation of learning in 4- and 27-month-old rabbits
-
Li J-G, Lehr M, Liu-Chen L-Y, Woodruff-Pak DS, (2008) Nicotinic acetylcholine receptors and modulation of learning in 4- and 27-month-old rabbits. Neuropsychopharmacology 33: 2820-30.
-
(2008)
Neuropsychopharmacology
, vol.33
, pp. 2820-2830
-
-
Li, J.-G.1
Lehr, M.2
Liu-Chen, L.-Y.3
Woodruff-Pak, D.S.4
-
14
-
-
68349148342
-
TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia
-
Hauser TA, Kucinski A, Jordan KG, Gatto GJ, Wersinger SR, et al. (2009) TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia. Biochem Pharmacol 78: 803-12.
-
(2009)
Biochem Pharmacol
, vol.78
, pp. 803-812
-
-
Hauser, T.A.1
Kucinski, A.2
Jordan, K.G.3
Gatto, G.J.4
Wersinger, S.R.5
-
15
-
-
20544460348
-
Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic-pharmacodynamic discordance
-
Buccafusco JJ, Letchworth SR, Bencherif M, Lippiello PM, (2005) Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic-pharmacodynamic discordance. Trends Pharmacol Sci 26: 352-60.
-
(2005)
Trends Pharmacol Sci
, vol.26
, pp. 352-360
-
-
Buccafusco, J.J.1
Letchworth, S.R.2
Bencherif, M.3
Lippiello, P.M.4
-
16
-
-
0031003185
-
Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo
-
Briggs CA, Anderson DJ, Brioni JD, Buccafusco JJ, Buckley MJ, et al. (1997) Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol Biochem Behav 57: 231-41.
-
(1997)
Pharmacol Biochem Behav
, vol.57
, pp. 231-241
-
-
Briggs, C.A.1
Anderson, D.J.2
Brioni, J.D.3
Buccafusco, J.J.4
Buckley, M.J.5
-
17
-
-
0030005801
-
Relationship between up-regulation of nicotine binding sites in rat brain and delayed cognitive enhancement observed after chronic or acute nicotinic receptor stimulation
-
Abdulla FA, Bradbury E, Calaminici MR, Lippiello PM, Wonnacott S, et al. (1996) Relationship between up-regulation of nicotine binding sites in rat brain and delayed cognitive enhancement observed after chronic or acute nicotinic receptor stimulation. Psychopharmacology (Berl) 124: 323-31.
-
(1996)
Psychopharmacology (Berl)
, vol.124
, pp. 323-331
-
-
Abdulla, F.A.1
Bradbury, E.2
Calaminici, M.R.3
Lippiello, P.M.4
Wonnacott, S.5
-
18
-
-
79957981800
-
Ultra-low exposure to alpha-7 nicotinic acetylcholine receptor partial agonists elicits an improvement in cognition that corresponds with an increase in alpha-7 receptor expression in rodents: implications for low dose clinical efficacy
-
Werkheiser JL, Sydserff S, Hubbs SJ, Ding M, Eisman MS, et al. (2011) Ultra-low exposure to alpha-7 nicotinic acetylcholine receptor partial agonists elicits an improvement in cognition that corresponds with an increase in alpha-7 receptor expression in rodents: implications for low dose clinical efficacy. Neuroscience 186: 76-87.
-
(2011)
Neuroscience
, vol.186
, pp. 76-87
-
-
Werkheiser, J.L.1
Sydserff, S.2
Hubbs, S.J.3
Ding, M.4
Eisman, M.S.5
-
19
-
-
78649994788
-
Immediate and sustained improvements in working memory after selective stimulation of α7 nicotinic acetylcholine receptors
-
Castner SA, Smagin GN, Piser TM, Wang Y, Smith JS, et al. (2011) Immediate and sustained improvements in working memory after selective stimulation of α7 nicotinic acetylcholine receptors. Biol Psychiatry 69: 12-8.
-
(2011)
Biol Psychiatry
, vol.69
, pp. 12-18
-
-
Castner, S.A.1
Smagin, G.N.2
Piser, T.M.3
Wang, Y.4
Smith, J.S.5
-
20
-
-
34548301101
-
Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes
-
Grønlien JH, Håkerud M, Ween H, Thorin-Hagene K, Briggs CA, et al. (2007) Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. Mol Pharmacol 72: 715-24.
-
(2007)
Mol Pharmacol
, vol.72
, pp. 715-724
-
-
Grønlien, J.H.1
Håkerud, M.2
Ween, H.3
Thorin-Hagene, K.4
Briggs, C.A.5
-
21
-
-
20944441082
-
A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization
-
Hurst RS, Hajós M, Raggenbass M, Wall TM, Higdon NR, et al. (2005) A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J Neurosci 25: 4396-405.
-
(2005)
J Neurosci
, vol.25
, pp. 4396-4405
-
-
Hurst, R.S.1
Hajós, M.2
Raggenbass, M.3
Wall, T.M.4
Higdon, N.R.5
-
22
-
-
34249947698
-
Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators
-
Ng HJ, Whittemore ER, Tran MB, Hogenkamp DJ, Broide RS, et al. (2007) Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proc Natl Acad Sci U S A 104: 8059-64.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 8059-8064
-
-
Ng, H.J.1
Whittemore, E.R.2
Tran, M.B.3
Hogenkamp, D.J.4
Broide, R.S.5
-
23
-
-
34548689531
-
An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo
-
Timmermann DB, Grønlien JH, Kohlhaas KL, Nielsen EØ, Dam E, et al. (2007) An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J Pharmacol Exp Ther 323: 294-307.
-
(2007)
J Pharmacol Exp Ther
, vol.323
, pp. 294-307
-
-
Timmermann, D.B.1
Grønlien, J.H.2
Kohlhaas, K.L.3
Nielsen, E.Ø.4
Dam, E.5
-
24
-
-
62449113374
-
Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b′]di pyrrole-1(2H)-carboxamide)
-
Dunlop J, Lock T, Jow B, Sitzia F, Grauer S, et al. (2009) Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b′]di pyrrole-1(2H)-carboxamide). J Pharmacol Exp Ther 328: 766-76.
-
(2009)
J Pharmacol Exp Ther
, vol.328
, pp. 766-776
-
-
Dunlop, J.1
Lock, T.2
Jow, B.3
Sitzia, F.4
Grauer, S.5
-
25
-
-
78751507926
-
Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor
-
Dinklo T, Shaban H, Thuring JW, Lavreysen H, Stevens KE, et al. (2011) Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor. J Pharmacol Exp Ther 336: 560-74.
-
(2011)
J Pharmacol Exp Ther
, vol.336
, pp. 560-574
-
-
Dinklo, T.1
Shaban, H.2
Thuring, J.W.3
Lavreysen, H.4
Stevens, K.E.5
-
26
-
-
77954755620
-
Repeated administration of alpha7 nicotinic acetylcholine receptor (nAChR) agonists, but not positive allosteric modulators, increases alpha7 nAChR levels in the brain
-
Christensen DZ, Mikkelsen JD, Hansen HH, Thomsen MS, (2010) Repeated administration of alpha7 nicotinic acetylcholine receptor (nAChR) agonists, but not positive allosteric modulators, increases alpha7 nAChR levels in the brain. J Neurochem 114: 1205-16.
-
(2010)
J Neurochem
, vol.114
, pp. 1205-1216
-
-
Christensen, D.Z.1
Mikkelsen, J.D.2
Hansen, H.H.3
Thomsen, M.S.4
-
27
-
-
36849055179
-
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711
-
Hashimoto K, Ishima T, Fujita Y, Matsuo M, Kobashi T, et al. (2008) Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711. Biol Psychiatry 63: 92-7.
-
(2008)
Biol Psychiatry
, vol.63
, pp. 92-97
-
-
Hashimoto, K.1
Ishima, T.2
Fujita, Y.3
Matsuo, M.4
Kobashi, T.5
-
28
-
-
19444368101
-
Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task
-
Keller JJ, Keller AB, Bowers BJ, Wehner JM, (2005) Performance of alpha7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task. Behav Brain Res 162: 143-52.
-
(2005)
Behav Brain Res
, vol.162
, pp. 143-152
-
-
Keller, J.J.1
Keller, A.B.2
Bowers, B.J.3
Wehner, J.M.4
-
29
-
-
33751334112
-
Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice
-
Young JW, Crawford N, Kelly JS, Kerr LE, Marston HM, et al. (2007) Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice. Eur Neuropsychopharmacol 17: 145-55.
-
(2007)
Eur Neuropsychopharmacol
, vol.17
, pp. 145-155
-
-
Young, J.W.1
Crawford, N.2
Kelly, J.S.3
Kerr, L.E.4
Marston, H.M.5
-
30
-
-
80255135633
-
What we have learned from crystal structures of proteins to receptor function
-
In press
-
Reymond J-L, van Deursen R, Bertrand D, (2011) What we have learned from crystal structures of proteins to receptor function. Biochem Pharmacol In press.
-
(2011)
Biochem Pharmacol
-
-
Reymond, J.-L.1
van Deursen, R.2
Bertrand, D.3
-
31
-
-
0842304285
-
Changes in acetylcholine extracellular levels during cognitive processes
-
Pepeu G, Giovannini MG, (2004) Changes in acetylcholine extracellular levels during cognitive processes. Learn Mem 11: 21-7.
-
(2004)
Learn Mem
, vol.11
, pp. 21-27
-
-
Pepeu, G.1
Giovannini, M.G.2
-
32
-
-
40349085614
-
RIC-3: a nicotinic acetylcholine receptor chaperone
-
Millar NS, (2008) RIC-3: a nicotinic acetylcholine receptor chaperone. Br J Pharmacol 153 (Suppl): S177-83.
-
(2008)
Br J Pharmacol
, vol.153
, Issue.SUPPL.
-
-
Millar, N.S.1
-
33
-
-
59049089858
-
RIC-3 and nicotinic acetylcholine receptors: biogenesis, properties, and diversity
-
Treinin M, (2008) RIC-3 and nicotinic acetylcholine receptors: biogenesis, properties, and diversity. Biotechnol J 3: 1539-47.
-
(2008)
Biotechnol J
, vol.3
, pp. 1539-1547
-
-
Treinin, M.1
-
34
-
-
79953805191
-
Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses
-
Miwa JM, Freedman R, Lester HA, (2011) Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses. Neuron 70: 20-33.
-
(2011)
Neuron
, vol.70
, pp. 20-33
-
-
Miwa, J.M.1
Freedman, R.2
Lester, H.A.3
-
35
-
-
84862026837
-
The α7 nicotinic acetylcholine receptor complex: one, two or multiple drug targets?
-
in press
-
Thomsen MS, Mikkelsen JD, (2011) The α7 nicotinic acetylcholine receptor complex: one, two or multiple drug targets? Curr Drug Targets in press.
-
(2011)
Curr Drug Targets
-
-
Thomsen, M.S.1
Mikkelsen, J.D.2
-
36
-
-
63149187256
-
A role for LYNX2 in anxiety-related behavior
-
Tekinay AB, Nong Y, Miwa JM, Lieberam I, Ibanez-Tallon I, et al. (2009) A role for LYNX2 in anxiety-related behavior. Proc Natl Acad Sci U S A 106: 4477-82.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 4477-4482
-
-
Tekinay, A.B.1
Nong, Y.2
Miwa, J.M.3
Lieberam, I.4
Ibanez-Tallon, I.5
-
37
-
-
0029059223
-
Social discrimination procedure: an alternative method to investigate juvenile recognition abilities in rats
-
Engelmann M, Wotjak CT, Landgraf R, (1995) Social discrimination procedure: an alternative method to investigate juvenile recognition abilities in rats. Physiol Behav 58: 315-21.
-
(1995)
Physiol Behav
, vol.58
, pp. 315-321
-
-
Engelmann, M.1
Wotjak, C.T.2
Landgraf, R.3
-
38
-
-
44949231424
-
Analyzing real-time PCR data by the comparative CT method
-
Schmittgen TD, Livak KJ, (2008) Analyzing real-time PCR data by the comparative CT method. Nature Protocols 3: 1101-1108.
-
(2008)
Nature Protocols
, vol.3
, pp. 1101-1108
-
-
Schmittgen, T.D.1
Livak, K.J.2
-
39
-
-
0142154251
-
Antidepressant drug treatment induces Arc gene expression in the rat brain
-
Pei Q, (2003) Antidepressant drug treatment induces Arc gene expression in the rat brain. Neuroscience 121: 975-982.
-
(2003)
Neuroscience
, vol.121
, pp. 975-982
-
-
Pei, Q.1
-
40
-
-
0029943197
-
Prolonged induction of c-fos in neuropeptide Y- and somatostatin-immunoreactive neurons of the rat dentate gyrus after electroconvulsive stimulation
-
Woldbye DP, Greisen MH, Bolwig TG, Larsen PJ, Mikkelsen JD, (1996) Prolonged induction of c-fos in neuropeptide Y- and somatostatin-immunoreactive neurons of the rat dentate gyrus after electroconvulsive stimulation. Brain Res 720: 111-9.
-
(1996)
Brain Res
, vol.720
, pp. 111-119
-
-
Woldbye, D.P.1
Greisen, M.H.2
Bolwig, T.G.3
Larsen, P.J.4
Mikkelsen, J.D.5
|