Implications of the quaternary twist allosteric model for the physiology and pathology of nicotinic acetylcholine receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 45, 2006, Pages 16965-16970

  Taly, Antoine ^a,d   Corringer, Pierre Jean ^a   Grutter, Thomas ^a   Prado De Carvalho, Lia ^a   Karplus, Martin ^b,c   Changeux, Jean Pierre ^a  

^a CNRS   (France)

^b UNIVERSITÉ LOUIS PASTEUR   (France)

^c HARVARD UNIVERSITY   (United States)

^d UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Allosteric transition; Nicotinic receptor; Normal mode perturbation scanning; Pathological mutations

Indexed keywords

NICOTINIC RECEPTOR; PROTEIN SUBUNIT;

ALLOSTERISM; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONGENITAL MYASTHENIC SYNDROME; FRONTAL LOBE EPILEPSY; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR PROBE; PATHOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; SPONTANEOUS MUTATION;

ALLOSTERIC REGULATION; ANIMALS; EPILEPSY, FRONTAL LOBE; GENES, DOMINANT; HUMANS; MODELS, MOLECULAR; MODELS, NEUROLOGICAL; MUTATION; MYASTHENIC SYNDROMES, CONGENITAL; PROTEIN STRUCTURE, QUATERNARY; PROTEIN SUBUNITS; RECEPTORS, NICOTINIC; TORPEDO;

EID: 33750942341     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0607477103     Document Type: Article

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