Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists

Neuropharmacology

Volumn 37, Issue 12, 1998, Pages 1515-1525

  Khan, Imran M ^a   Buerkle, Hartmut ^b   Taylor, Palmer ^a   Yaksh, Tony L ^a,b  

^a University of California San Diego   (United States)

^b School of Medicine   (United States)

Author keywords

Antinociception; Epibatidine; Intrathecal; Nicotinic receptors; Nociception

Indexed keywords

ATROPINE; CYTISINE; DIHYDRO BETA ERYTHROIDINE; EPIBATIDINE; LOBELINE; MECAMYLAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NALOXAZONE; NICOTINE; NICOTINIC RECEPTOR;

AGITATION; ANALGESIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BEHAVIOR; CONTROLLED STUDY; INTRATHECAL DRUG ADMINISTRATION; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; THERMAL STIMULATION;

ALKALOIDS; ANALGESIA; ANIMALS; AZOCINES; BICYCLO COMPOUNDS, HETEROCYCLIC; ESCAPE REACTION; HEAT; HINDLIMB; INJECTIONS, SPINAL; LOBELINE; MALE; MECAMYLAMINE; MICROINJECTIONS; NICOTINE; NICOTINIC AGONISTS; PAIN; PYRIDINES; QUINOLIZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; VALINE; VOCALIZATION, ANIMAL;

EID: 0032403103     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00143-9     Document Type: Article

References (42)

1. Abood L.G., Salles K.S., Maiti A. Structure-activity studies of carbamate and other esters: agonists and antagonists to nicotine. Pharmacol. Biochem. Behav. 30:1988;403-408.
2. Abram S.E., Winne R.P. Intrathecal acetylcholinesterase inhibitors produce analgesia that is synergistic with morphine and clonidine in rats. Anesth. Analg. 81:1995;501-507.
3. Alkondon M., Albuquerque E.X. Initial characterization of the nicotinic acetylcholine receptors in rat hippocampal neurons. J. Receptor Res. 11:1991;1001-1021.
4. Badio B., Daly J.W. Epibatidine, a potent analgetic and nicotinic agonist. Mol. Pharmacol. 45:1994;563-569.
5. Barlow R.B., Johnson O. Relationships between structure and nicotine-like activity: X-ray crystal structure and analysis of (-)-cytisine and (-)-lobeline hydrochloride and a comparison with (-)-nicotine and other nicotine-like compounds. Br. J. Pharmacol. 98:1989;799-808.
6. Bonhaus D.W., Bley K.R., Broka C.A., Fontana D.J., Leung E., Lewis R., Shieh A., Wong E.K. Characterization of the electrophysiological, biochemical and behavioral actions of epibatidine. J. Pharmacol. Exp. Ther. 272:1995;1199-1203.
7. Boulter J., Connolly J., Deneris E., Goldman D., Heinemann S., Patrick J. Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family. Proc. Natl. Acad. Sci. USA. 84:1987;7763-7767.
8. Bretrand D., Ballivet M., Rungger D. Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes. Proc. Natl. Acad. Sci. USA. 87:1990;1993-1997.
9. Chapman V., Dickenson A.H. The effect of intrathecal administration of RP67580, a potent neurokinin 1 antagonist on nociceptive transmission in the rat spinal cord. Neurosci. Lett. 157:1993;149-152.
10. DeLander G.E., Mosberg H.I., Porreca F. Involvement of adenosine in antinociception produced by spinal or supraspinal receptor-selective opioid agonists: dissociation from gastrointestinal effects in mice. J. Pharmacol. Exp. Ther. 263:1993;1097-1104.
11. Gillberg P.G., Hartvig P., Gordh T., Sottile A., Jansson I., Archer T., Post C. Behavioral effects after intrathecal administration of cholinergic receptor agonists in the rat. Psychopharmacology. 100:1990;464-469.
12. Gordh T., Karlsten R., Kristensen J. Intervention with spinal NMDA, adenosine, and NO systems for pain modulation. Ann. Med. 27:1995;229-234.
13. Hargreaves K., Dubner R., Brown F., Flores C., Joris J. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain. 32:1988;77-88.
14. Iwamoto E.T., Marion L. Characterization of the antinociception produced by intrathecally administered muscarinic agonists in rats. J. Pharmacol. Exp. Ther. 266:1993;329-338.
15. Jinno S., Hua X.-Y., Yaksh T.L. Nicotine and acetylcholine induce release of calcitonin gene-related peptide from rat trachea. J. Appl. Physiol. 76:1994;1651-1656.
16. Khan I.M., Taylor P., Yaksh T.L. Cardiovascular and behavioral responses to nicotinic agonists administered intrathecally. J. Pharmacol. Exp. Ther. 270:1994;150-158.
17. Khan I.M., Taylor P., Yaksh T.L. Stimulatory pathways and sites of actions of intrathecally administered nicotinic agonists. J. Pharmacol. Exp. Ther. 271:1994;1550-1557.
18. Khan I.M., Yaksh T.L., Taylor P. Ligand specificity of nicotinic acetylcholine receptors in rats spinal cord: studies with nicotine and cytisine. J. Pharmacol. Exp. Ther. 270:1994;159-166.
19. Khan I.M., Printz M.P., Yaksh T.L., Taylor P. Augmented responses to intrathecal nicotinic agonists in spontaneous hypertension. Hypertension. 24:1994;611-619.
20. Khan I.M., Marsala M., Printz M.P., Taylor P., Yaksh T.L. Intrathecal nicotinic agonist-elicited release of excitatory amino acids as measured by in vivo spinal microdialysis in rats. J. Pharmacol. Exp. Ther. 278:1996;97-106.
21. Khan I.M., Youngblood K.L., Yaksh T.L., Printz M.P., Taylor P. Regulation of spinal nicotinic receptors in spontaneously hypertensive rats. Hypertension. 28:1996;1093-1098.
22. Khan I.M., Yaksh T.L., Taylor P. Epibatidine binding sites and activity in the spinal cord. Brain Res. 753:1997;269-282.
23. Killian P., Holmes B.B., Takemori A.E., Portoghese P.S., Fujimoto J.M. Cold water swim stress- and delta-2 opioid-induced analgesia are modulated by spinal gamma-aminobutyric acid A receptors. J. Pharmacol. Exp. Ther. 274:1995;730-734.
24. 3H]-nicotine binding assay. Naunyn Schmiedebergs Arch. Pharmacol. 345:1992;363-369.
25. Masters D.B., Jordan F., Beyer C., Komisaruk B.R. Release of amino acids into regional superfusates of the spinal cord by mechano-stimulation of the reproductive tract. Brain Res. 621:1993;279-290.
26. Naguib M., Yaksh T.L. Antinociceptive effects of spinal cholinesterase inhibition and isobolographic analysis of the interaction with μ and a2 receptor systems. Anesthesiology. 80:1994;1338-1348.
27. Puttfarcken P.S., Manelli A.M., Arneric S.P., Donelly-Roberts D.L. Evidence for nicotinic receptors potentially modulating nociceptive transmission at the level of the primary sensory neuron: studies with F11 cells. J. Neurochem. 69:1997;930-938.
28. Roberts R.G.D., Stevenson J.E., Westerman R.A., Pennefather J. Nicotinic acetylcholine receptors on capsaicin-sensitive nerves. NeuroReport. 6:1995;1578-1582.
29. Rupniak N.M.J., Patel S., Marwood R., Webb J., Traynor J.R., Elliott J., Freedman S.B., Flecther S.R., Hill R.G. Antinociceptive and toxic effects of (+)-epibatidine oxalate attributable to nicotinic agonist activity. Br. J. Pharmacol. 113:1994;1487-1493.
30. Sharma R., Mathur R., Nayar U. GABA B mediated analgesia in tonic pain in monkeys. Indian J. Physiol. Pharmacol. 37:1993;189-193.
31. Sivilotti L., Woolf C.J. The contribution of GABA-A and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. J. Neurophysiol. 72:1994;169-179.
32. Sluka K.A., Westlund K.N. Spinal cord amino acid release and content in an arthritis model: the effects of pretreatment with non-NMDA, NMDA, and NK-1 receptor antagonists. Brain Res. 627:1993;89-103.
33. Sorkin L.S., McAdoo D.J., Willis W.D. Raphe magnus stimulation-induced antinociception in the cat is associated with release of amino acids as well as serotonin in the lumbar dorsal horn. Brain Res. 618:1993;95-108.
34. Spande T.F., Caraffo H.M., Edwards M.W., Yeh H.J.C., Pannel L., Daly J.W. Epibatidine: a novel (chlorpyridyl)azabicycloheptane with potent analgesic activity from Ecuadorian poison frog. J. Am. Chem. Soc. 114:1992;3475-3478.
35. Tallarida, R.J., Murray, R.B., 1986. Manual of Pharmacologic Calculations with Computer Programs, 2nd ed. Springer-Verlag, New York.
36. Ueda M., Kuraishi Y., Sugimoto K., Satoh M. Evidence that glutamate is released from capsaicin-sensitive primary afferent fibers in rats: study with on-line continuous monitoring of glutamate. Neurosci. Res. 20:1994;231-237.
37. Wonnacott, S., 1992. Functional properties of nicotinic acetylcholine receptors. In: Lipiello, P.M., Collins, A.C., Gray, J.A., Robinson, J.H. (Eds.), The Biology of Nicotine: Current Research Issue. Raven Press, New York, pp. 13-22.
38. Yaksh T.L. Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of the modulatory receptor systems and excitatory amino acid antagonists. Pain. 37:1989;111-123.
39. Yaksh, T.L., Malmberg, A.B., 1994. Central pharmacology of nociceptive transmission. In: Wall, P., Melzack, R. (Eds.), Textbook of Pain, 3rd ed. Churchill Livingstone, Edinburgh, pp. 165-200.
40. Yaksh T.L., Rudy A.T. Chronic catherization of the spinal subarachnoid space. Physiol. Behav. 17:1976;1031-1036.
41. Zar, J.H., 1984. Biostatistical Analysis. Prentice Hall, Englewood Cliffs, NJ, pp. 395-403.
42. Zhuo M., Gebhart G.F. Tonic cholinergic inhibition of spinal mechanical transmission. Pain. 46:1991;211-222.