Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Pavlovicz, Ryan E ^a   Henderson, Brandon J ^a   Bonnell, Andrew B ^a   Boyd, R Thomas ^a   McKay, Dennis B ^a   Li, Chenglong ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA3BETA4 NICOTINIC ACETYLCHOLINE RECEPTOR; LEUCINE; LYSINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4BETA2; PHENYLALANINE; PROTEIN SUBUNIT; THREONINE; UNCLASSIFIED DRUG; CALCIUM; NICOTINIC AGENT; NICOTINIC RECEPTOR ALPHA3BETA4; NICOTINIC RECEPTOR BLOCKING AGENT;

ARTICLE; BINDING SITE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; RECEPTOR BINDING; WILD TYPE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; GENETICS; KIDNEY; METABOLISM; MUTATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC SITE; CALCIUM; CELLS, CULTURED; HUMANS; KIDNEY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052866353     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024949     Document Type: Article

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