메뉴 건너뛰기




Volumn 4, Issue 12, 2012, Pages 342-355

Hepatitis C virus-related hepatocellular carcinoma: An insight into molecular mechanisms and therapeutic strategies

Author keywords

Carcinogenesis; Cirrhosis; Fibrosis; Hepatitis C virus; Hepatocellular carcinoma; Inflammation

Indexed keywords


EID: 84880938142     PISSN: None     EISSN: 19485182     Source Type: Journal    
DOI: 10.4254/wjh.v4.i12.342     Document Type: Review
Times cited : (34)

References (218)
  • 1
    • 80051676859 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews
    • Nelson PK, Mathers BM, Cowie B, Hagan H, Des Jarlais D, Horyniak D, Degenhardt L. Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews. Lancet 2011; 378: 571-583
    • (2011) Lancet , vol.378 , pp. 571-583
    • Nelson, P.K.1    Mathers, B.M.2    Cowie, B.3    Hagan, H.4    Des Jarlais, D.5    Horyniak, D.6    Degenhardt, L.7
  • 2
    • 84857065456 scopus 로고    scopus 로고
    • Establishment of a novel permissive cell line for the propagation of hepatitis C virus by expression of microRNA miR122
    • Kambara H, Fukuhara T, Shiokawa M, Ono C, Ohara Y, Kamitani W, Matsuura Y. Establishment of a novel permissive cell line for the propagation of hepatitis C virus by expression of microRNA miR122. J Virol 2012; 86: 1382-1393
    • (2012) J Virol , vol.86 , pp. 1382-1393
    • Kambara, H.1    Fukuhara, T.2    Shiokawa, M.3    Ono, C.4    Ohara, Y.5    Kamitani, W.6    Matsuura, Y.7
  • 3
    • 33750804220 scopus 로고    scopus 로고
    • Replication of a hepatitis C virus replicon clone in mouse cells
    • Uprichard SL, Chung J, Chisari FV, Wakita T. Replication of a hepatitis C virus replicon clone in mouse cells. Virol J 2006; 3: 89
    • (2006) Virol J , vol.3 , pp. 89
    • Uprichard, S.L.1    Chung, J.2    Chisari, F.V.3    Wakita, T.4
  • 6
    • 79955898445 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection
    • Yamashita T, Honda M, Kaneko S. Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection. J Gastroenterol Hepatol 2011; 26: 960-964
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 960-964
    • Yamashita, T.1    Honda, M.2    Kaneko, S.3
  • 7
    • 79952126737 scopus 로고    scopus 로고
    • Oncogenic potential of hepatitis C virus proteins
    • Banerjee A, Ray RB, Ray R. Oncogenic potential of hepatitis C virus proteins. Viruses 2010; 2: 2108-2133
    • (2010) Viruses , vol.2 , pp. 2108-2133
    • Banerjee, A.1    Ray, R.B.2    Ray, R.3
  • 8
    • 84865109737 scopus 로고    scopus 로고
    • Viral and host inflammation-related factors that can predict the prognosis of hepatocellular carcinoma
    • Chen L, Zhang Q, Chang W, Du Y, Zhang H, Cao G. Viral and host inflammation-related factors that can predict the prognosis of hepatocellular carcinoma. Eur J Cancer 2012; 48: 1977-1987
    • (2012) Eur J Cancer , vol.48 , pp. 1977-1987
    • Chen, L.1    Zhang, Q.2    Chang, W.3    Du, Y.4    Zhang, H.5    Cao, G.6
  • 9
    • 0037171936 scopus 로고    scopus 로고
    • Identification, using cDNA macroarray analysis, of distinct gene expression profiles associated with pathological and virological features of hepatocellular carcinoma
    • Delpuech O, Trabut JB, Carnot F, Feuillard J, Brechot C, Kremsdorf D. Identification, using cDNA macroarray analysis, of distinct gene expression profiles associated with pathological and virological features of hepatocellular carcinoma. Oncogene 2002; 21: 2926-2937
    • (2002) Oncogene , vol.21 , pp. 2926-2937
    • Delpuech, O.1    Trabut, J.B.2    Carnot, F.3    Feuillard, J.4    Brechot, C.5    Kremsdorf, D.6
  • 10
    • 84859320193 scopus 로고    scopus 로고
    • Effects of ethnicity and socioeconomic status on survival and severity of fibrosis in liver transplant recipients with hepatitis C virus
    • Verna EC, Valadao R, Farrand E, Pichardo EM, Lai JC, Terrault NA, Brown RS. Effects of ethnicity and socioeconomic status on survival and severity of fibrosis in liver transplant recipients with hepatitis C virus. Liver Transpl 2012; 18: 461-467
    • (2012) Liver Transpl , vol.18 , pp. 461-467
    • Verna, E.C.1    Valadao, R.2    Farrand, E.3    Pichardo, E.M.4    Lai, J.C.5    Terrault, N.A.6    Brown, R.S.7
  • 13
    • 79961181997 scopus 로고    scopus 로고
    • Hepatitis C virus infection causes cell cycle arrest at the level of initiation of mitosis
    • Kannan RP, Hensley LL, Evers LE, Lemon SM, McGivern DR. Hepatitis C virus infection causes cell cycle arrest at the level of initiation of mitosis. J Virol 2011; 85: 7989-8001
    • (2011) J Virol , vol.85 , pp. 7989-8001
    • Kannan, R.P.1    Hensley, L.L.2    Evers, L.E.3    Lemon, S.M.4    McGivern, D.R.5
  • 14
    • 79955485187 scopus 로고    scopus 로고
    • Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer
    • McGivern DR, Lemon SM. Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer. Oncogene 2011; 30: 1969-1983
    • (2011) Oncogene , vol.30 , pp. 1969-1983
    • McGivern, D.R.1    Lemon, S.M.2
  • 15
    • 84870914324 scopus 로고    scopus 로고
    • The role of chemokine CC ligand 20 in patients with liver cirrhosis and hepatocellular carcinoma
    • Soliman HH, Nagy H, Kotb N, Alm El-Din MA. The role of chemokine CC ligand 20 in patients with liver cirrhosis and hepatocellular carcinoma. Int J Biol Markers 2012; 27: e125-e131
    • (2012) Int J Biol Markers , vol.27
    • Soliman, H.H.1    Nagy, H.2    Kotb, N.3    Alm El-Din, M.A.4
  • 16
    • 44649101911 scopus 로고    scopus 로고
    • Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis
    • Gurtsevitch VE. Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis. Biochemistry (Mosc) 2008; 73: 504-513
    • (2008) Biochemistry (Mosc) , vol.73 , pp. 504-513
    • Gurtsevitch, V.E.1
  • 17
    • 13844265988 scopus 로고    scopus 로고
    • Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the stimulation of hepatitis C virus (HCV) non-structural protein 3 (NS3)-mediated cell growth
    • Hassan M, Ghozlan H, Abdel-Kader O. Activation of c-Jun NH2-terminal kinase (JNK) signaling pathway is essential for the stimulation of hepatitis C virus (HCV) non-structural protein 3 (NS3)-mediated cell growth. Virology 2005; 333: 324-336
    • (2005) Virology , vol.333 , pp. 324-336
    • Hassan, M.1    Ghozlan, H.2    Abdel-Kader, O.3
  • 18
    • 77149172874 scopus 로고    scopus 로고
    • p21/Wafl/Cipl cellular expression in chronic long-lasting hepatitis C: correlation with HCV proteins (C, NS3, NS5A), other cell-cycle related proteins and selected clinical data
    • Kasprzak A, Adamek A, Przybyszewska W, Olejniczak K, Biczysko W, Mozer-Lisewska I, Zabel M. p21/Wafl/Cipl cellular expression in chronic long-lasting hepatitis C: correlation with HCV proteins (C, NS3, NS5A), other cell-cycle related proteins and selected clinical data. Folia Histochem Cytobiol 2009; 47: 385-394
    • (2009) Folia Histochem Cytobiol , vol.47 , pp. 385-394
    • Kasprzak, A.1    Adamek, A.2    Przybyszewska, W.3    Olejniczak, K.4    Biczysko, W.5    Mozer-Lisewska, I.6    Zabel, M.7
  • 19
    • 0037348046 scopus 로고    scopus 로고
    • Hepatocyte transformation and tumor development induced by hepatitis C virus NS3 c-terminal deleted protein
    • He QQ, Cheng RX, Sun Y, Feng DY, Chen ZC, Zheng H. Hepatocyte transformation and tumor development induced by hepatitis C virus NS3 c-terminal deleted protein. World J Gastroenterol 2003; 9: 474-478
    • (2003) World J Gastroenterol , vol.9 , pp. 474-478
    • He, Q.Q.1    Cheng, R.X.2    Sun, Y.3    Feng, D.Y.4    Chen, Z.C.5    Zheng, H.6
  • 20
    • 0042668538 scopus 로고    scopus 로고
    • Hepatitis C virus core protein expression leads to biphasic regulation of the p21 cdk inhibitor and modulation of hepatocyte cell cycle
    • Nguyen H, Mudryj M, Guadalupe M, Dandekar S. Hepatitis C virus core protein expression leads to biphasic regulation of the p21 cdk inhibitor and modulation of hepatocyte cell cycle. Virology 2003; 312: 245-253
    • (2003) Virology , vol.312 , pp. 245-253
    • Nguyen, H.1    Mudryj, M.2    Guadalupe, M.3    Dandekar, S.4
  • 21
    • 4644276886 scopus 로고    scopus 로고
    • Activation of RB/ E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells
    • Hassan M, Ghozlan H, Abdel-Kader O. Activation of RB/ E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells. Cell Signal 2004; 16: 1375-1385
    • (2004) Cell Signal , vol.16 , pp. 1375-1385
    • Hassan, M.1    Ghozlan, H.2    Abdel-Kader, O.3
  • 22
    • 9244239811 scopus 로고    scopus 로고
    • G1 cell-cycle control and cancer
    • Massagué J. G1 cell-cycle control and cancer. Nature 2004; 432: 298-306
    • (2004) Nature , vol.432 , pp. 298-306
    • Massagué, J.1
  • 23
    • 0032578407 scopus 로고    scopus 로고
    • pRB plays an essential role in cell cycle arrest induced by DNA damage
    • Harrington EA, Bruce JL, Harlow E, Dyson N. pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc Natl Acad Sci USA 1998; 95: 11945-11950
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11945-11950
    • Harrington, E.A.1    Bruce, J.L.2    Harlow, E.3    Dyson, N.4
  • 24
    • 0028980494 scopus 로고
    • p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts
    • Agarwal ML, Agarwal A, Taylor WR, Stark GR. p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci USA 1995; 92: 8493-8497
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8493-8497
    • Agarwal, M.L.1    Agarwal, A.2    Taylor, W.R.3    Stark, G.R.4
  • 26
    • 38849184816 scopus 로고    scopus 로고
    • PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
    • Tanaka N, Moriya K, Kiyosawa K, Koike K, Gonzalez FJ, Aoyama T. PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice. J Clin Invest 2008; 118: 683-694
    • (2008) J Clin Invest , vol.118 , pp. 683-694
    • Tanaka, N.1    Moriya, K.2    Kiyosawa, K.3    Koike, K.4    Gonzalez, F.J.5    Aoyama, T.6
  • 29
    • 0034713462 scopus 로고    scopus 로고
    • Hepatitis C virus core protein promotes immortalization of primary human hepatocytes
    • Ray RB, Meyer K, Ray R. Hepatitis C virus core protein promotes immortalization of primary human hepatocytes. Virology 2000; 271: 197-204
    • (2000) Virology , vol.271 , pp. 197-204
    • Ray, R.B.1    Meyer, K.2    Ray, R.3
  • 30
    • 33847772075 scopus 로고    scopus 로고
    • STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review)
    • Katoh M, Katoh M. STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review). Int J Mol Med 2007; 19: 273-278
    • (2007) Int J Mol Med , vol.19 , pp. 273-278
    • Katoh, M.1    Katoh, M.2
  • 31
    • 33845700383 scopus 로고    scopus 로고
    • Induction of high-molecular-weight (HMW) tumor necrosis factor(TNF) alpha by hepatitis C virus (HCV) non-structural protein 3 (NS3) in liver cells is AP-1 and NF-kappaB-dependent activation
    • Hassan M, Selimovic D, Ghozlan H, Abdel-Kader O. Induction of high-molecular-weight (HMW) tumor necrosis factor(TNF) alpha by hepatitis C virus (HCV) non-structural protein 3 (NS3) in liver cells is AP-1 and NF-kappaB-dependent activation. Cell Signal 2007; 19: 301-311
    • (2007) Cell Signal , vol.19 , pp. 301-311
    • Hassan, M.1    Selimovic, D.2    Ghozlan, H.3    Abdel-Kader, O.4
  • 32
    • 0035975595 scopus 로고    scopus 로고
    • Hepatitis C virus core protein modulates the interferon-induced transacting factors of Jak/Stat signaling pathway but does not affect the activation of downstream IRF- 1 or 561 gene
    • Basu A, Meyer K, Ray RB, Ray R. Hepatitis C virus core protein modulates the interferon-induced transacting factors of Jak/Stat signaling pathway but does not affect the activation of downstream IRF- 1 or 561 gene. Virology 2001; 288: 379-390
    • (2001) Virology , vol.288 , pp. 379-390
    • Basu, A.1    Meyer, K.2    Ray, R.B.3    Ray, R.4
  • 33
    • 0029063640 scopus 로고
    • Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells
    • Sakamuro D, Furukawa T, Takegami T. Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. J Virol 1995; 69: 3893-3896
    • (1995) J Virol , vol.69 , pp. 3893-3896
    • Sakamuro, D.1    Furukawa, T.2    Takegami, T.3
  • 34
    • 33750344724 scopus 로고    scopus 로고
    • Different transformation pathways of murine fibroblast NIH 3T3 cells by hepatitis C virus core and NS3 proteins
    • Smirnova IS, Aksenov ND, Vonsky MS, Isaguliants MG. Different transformation pathways of murine fibroblast NIH 3T3 cells by hepatitis C virus core and NS3 proteins. Cell Biol Int 2006; 30: 915-919
    • (2006) Cell Biol Int , vol.30 , pp. 915-919
    • Smirnova, I.S.1    Aksenov, N.D.2    Vonsky, M.S.3    Isaguliants, M.G.4
  • 36
    • 0036058267 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line
    • Erhardt A, Hassan M, Heintges T, Häussinger D. Hepatitis C virus core protein induces cell proliferation and activates ERK, JNK, and p38 MAP kinases together with the MAP kinase phosphatase MKP-1 in a HepG2 Tet-Off cell line. Virology 2002; 292: 272-284
    • (2002) Virology , vol.292 , pp. 272-284
    • Erhardt, A.1    Hassan, M.2    Heintges, T.3    Häussinger, D.4
  • 37
    • 0032570876 scopus 로고    scopus 로고
    • Hepatitis C virus core protein represses p21WAF1/Cip1/ Sid1 promoter activity
    • Ray RB, Steele R, Meyer K, Ray R. Hepatitis C virus core protein represses p21WAF1/Cip1/ Sid1 promoter activity. Gene 1998; 208: 331-336
    • (1998) Gene , vol.208 , pp. 331-336
    • Ray, R.B.1    Steele, R.2    Meyer, K.3    Ray, R.4
  • 38
    • 0037152313 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3
    • Qadri I, Iwahashi M, Simon F. Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3. Biochim Biophys Acta 2002; 1592: 193-204
    • (2002) Biochim Biophys Acta , vol.1592 , pp. 193-204
    • Qadri, I.1    Iwahashi, M.2    Simon, F.3
  • 40
    • 0035148645 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A physically associates with p53 and regulates p21/ waf1 gene expression in a p53-dependent manner
    • Majumder M, Ghosh AK, Steele R, Ray R, Ray RB. Hepatitis C virus NS5A physically associates with p53 and regulates p21/ waf1 gene expression in a p53-dependent manner. J Virol 2001; 75: 1401-1407
    • (2001) J Virol , vol.75 , pp. 1401-1407
    • Majumder, M.1    Ghosh, A.K.2    Steele, R.3    Ray, R.4    Ray, R.B.5
  • 41
    • 57649165394 scopus 로고    scopus 로고
    • Hepatitis C virus NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway
    • Wu SC, Chang SC, Wu HY, Liao PJ, Chang MF. Hepatitis C virus NS5A protein down-regulates the expression of spindle gene Aspm through PKR-p38 signaling pathway. J Biol Chem 2008; 283: 29396-29404
    • (2008) J Biol Chem , vol.283 , pp. 29396-29404
    • Wu, S.C.1    Chang, S.C.2    Wu, H.Y.3    Liao, P.J.4    Chang, M.F.5
  • 43
    • 29144483321 scopus 로고    scopus 로고
    • Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase
    • Munakata T, Nakamura M, Liang Y, Li K, Lemon SM. Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase. Proc Natl Acad Sci USA 2005; 102: 18159-18164
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18159-18164
    • Munakata, T.1    Nakamura, M.2    Liang, Y.3    Li, K.4    Lemon, S.M.5
  • 44
    • 0015910446 scopus 로고
    • Inhibition of tumor initiation and promotion by anti-inflammatory agents
    • Slaga TJ, Scribner JD. Inhibition of tumor initiation and promotion by anti-inflammatory agents. J Natl Cancer Inst 1973; 51: 1723-1725
    • (1973) J Natl Cancer Inst , vol.51 , pp. 1723-1725
    • Slaga, T.J.1    Scribner, J.D.2
  • 45
    • 63749088064 scopus 로고    scopus 로고
    • Dysregulation of apoptosis in hepatocellular carcinoma cells
    • Fabregat I. Dysregulation of apoptosis in hepatocellular carcinoma cells. World J Gastroenterol 2009; 15: 513-520
    • (2009) World J Gastroenterol , vol.15 , pp. 513-520
    • Fabregat, I.1
  • 48
    • 0018954858 scopus 로고
    • Tumor promotion by abrasion induced epidermal hyperplasia in the skin of mice
    • Argyris TS. Tumor promotion by abrasion induced epidermal hyperplasia in the skin of mice. J Invest Dermatol 1980; 75: 360-362
    • (1980) J Invest Dermatol , vol.75 , pp. 360-362
    • Argyris, T.S.1
  • 49
    • 79959947025 scopus 로고    scopus 로고
    • Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome
    • Jin X, Moskophidis D, Mivechi NF. Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome. Cell Metab 2011; 14: 91-103
    • (2011) Cell Metab , vol.14 , pp. 91-103
    • Jin, X.1    Moskophidis, D.2    Mivechi, N.F.3
  • 51
    • 0025325866 scopus 로고
    • Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years
    • Lennard-Jones JE, Melville DM, Morson BC, Ritchie JK, Williams CB. Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years. Gut 1990; 31: 800-806
    • (1990) Gut , vol.31 , pp. 800-806
    • Lennard-Jones, J.E.1    Melville, D.M.2    Morson, B.C.3    Ritchie, J.K.4    Williams, C.B.5
  • 52
    • 0032898360 scopus 로고    scopus 로고
    • Effect of interferon therapy on hepatocellular carcinogenesis in patients with chronic hepatitis type C: A long-term observation study of 1, 643 patients using statistical bias correction with proportional hazard analysis
    • Ikeda K, Saitoh S, Arase Y, Chayama K, Suzuki Y, Kobayashi M, Tsubota A, Nakamura I, Murashima N, Kumada H, Kawanishi M. Effect of interferon therapy on hepatocellular carcinogenesis in patients with chronic hepatitis type C: A long-term observation study of 1, 643 patients using statistical bias correction with proportional hazard analysis. Hepatology 1999; 29: 1124-1130
    • (1999) Hepatology , vol.29 , pp. 1124-1130
    • Ikeda, K.1    Saitoh, S.2    Arase, Y.3    Chayama, K.4    Suzuki, Y.5    Kobayashi, M.6    Tsubota, A.7    Nakamura, I.8    Murashima, N.9    Kumada, H.10    Kawanishi, M.11
  • 53
    • 77950576593 scopus 로고    scopus 로고
    • Prevention of gastric cancer by Helicobacter pylori eradication
    • Asaka M, Kato M, Graham DY. Prevention of gastric cancer by Helicobacter pylori eradication. Intern Med 2010; 49: 633-636
    • (2010) Intern Med , vol.49 , pp. 633-636
    • Asaka, M.1    Kato, M.2    Graham, D.Y.3
  • 54
    • 66149084790 scopus 로고    scopus 로고
    • Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways
    • Hassan M, Selimovic D, Ghozlan H, Abdel-kader O. Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways. Hepatology 2009; 49: 1469-1482
    • (2009) Hepatology , vol.49 , pp. 1469-1482
    • Hassan, M.1    Selimovic, D.2    Ghozlan, H.3    Abdel-kader, O.4
  • 58
  • 59
    • 34547905022 scopus 로고    scopus 로고
    • Upregulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis
    • Huang XX, McCaughan GW, Shackel NA, Gorrell MD. Upregulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis. Liver Int 2007; 27: 960-968
    • (2007) Liver Int , vol.27 , pp. 960-968
    • Huang, X.X.1    McCaughan, G.W.2    Shackel, N.A.3    Gorrell, M.D.4
  • 62
    • 30444461349 scopus 로고    scopus 로고
    • Role of interleukin-18 and its receptor in hepatocellular carcinoma associated with hepatitis C virus infection
    • Asakawa M, Kono H, Amemiya H, Matsuda M, Suzuki T, Maki A, Fujii H. Role of interleukin-18 and its receptor in hepatocellular carcinoma associated with hepatitis C virus infection. Int J Cancer 2006; 118: 564-570
    • (2006) Int J Cancer , vol.118 , pp. 564-570
    • Asakawa, M.1    Kono, H.2    Amemiya, H.3    Matsuda, M.4    Suzuki, T.5    Maki, A.6    Fujii, H.7
  • 63
    • 0037864153 scopus 로고    scopus 로고
    • Impact of interleukin-1beta genetic polymorphisms on the development of hepatitis C virus-related hepatocellular carcinoma in Japan
    • Tanaka Y, Furuta T, Suzuki S, Orito E, Yeo AE, Hirashima N, Sugauchi F, Ueda R, Mizokami M. Impact of interleukin-1beta genetic polymorphisms on the development of hepatitis C virus-related hepatocellular carcinoma in Japan. J Infect Dis 2003; 187: 1822-1825
    • (2003) J Infect Dis , vol.187 , pp. 1822-1825
    • Tanaka, Y.1    Furuta, T.2    Suzuki, S.3    Orito, E.4    Yeo, A.E.5    Hirashima, N.6    Sugauchi, F.7    Ueda, R.8    Mizokami, M.9
  • 66
    • 84867212593 scopus 로고    scopus 로고
    • Chronic inflammation, immune escape, and oncogenesis in the liver: a unique neighborhood for novel intersections
    • Stauffer JK, Scarzello AJ, Jiang Q, Wiltrout RH. Chronic inflammation, immune escape, and oncogenesis in the liver: a unique neighborhood for novel intersections. Hepatology 2012; 56: 1567-1574
    • (2012) Hepatology , vol.56 , pp. 1567-1574
    • Stauffer, J.K.1    Scarzello, A.J.2    Jiang, Q.3    Wiltrout, R.H.4
  • 70
    • 80054972498 scopus 로고    scopus 로고
    • Clinical implications of chemokines in acute and chronic hepatitis C virus infection
    • Kang W, Shin EC. Clinical implications of chemokines in acute and chronic hepatitis C virus infection. Yonsei Med J 2011; 52: 871-878
    • (2011) Yonsei Med J , vol.52 , pp. 871-878
    • Kang, W.1    Shin, E.C.2
  • 73
    • 0027982876 scopus 로고
    • Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm
    • Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994; 76: 301-314
    • (1994) Cell , vol.76 , pp. 301-314
    • Springer, T.A.1
  • 74
    • 0030001675 scopus 로고    scopus 로고
    • Lymphocyte homing and homeostasis
    • Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science 1996; 272: 60-66
    • (1996) Science , vol.272 , pp. 60-66
    • Butcher, E.C.1    Picker, L.J.2
  • 75
    • 0035138173 scopus 로고    scopus 로고
    • Enhanced expression of interferon-regulated genes in the liver of patients with chronic hepatitis C virus infection: detection by suppression-subtractive hybridization
    • Patzwahl R, Meier V, Ramadori G, Mihm S. Enhanced expression of interferon-regulated genes in the liver of patients with chronic hepatitis C virus infection: detection by suppression-subtractive hybridization. J Virol 2001; 75: 1332-1338
    • (2001) J Virol , vol.75 , pp. 1332-1338
    • Patzwahl, R.1    Meier, V.2    Ramadori, G.3    Mihm, S.4
  • 76
    • 0033485942 scopus 로고    scopus 로고
    • Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver
    • Shields PL, Morland CM, Salmon M, Qin S, Hubscher SG, Adams DH. Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver. J Immunol 1999; 163: 6236-6243
    • (1999) J Immunol , vol.163 , pp. 6236-6243
    • Shields, P.L.1    Morland, C.M.2    Salmon, M.3    Qin, S.4    Hubscher, S.G.5    Adams, D.H.6
  • 80
    • 0036841051 scopus 로고    scopus 로고
    • Increased expression of T cell chemokines and their receptors in chronic hepatitis C:relationship with the histological activity of liver disease
    • Apolinario A, Majano PL, Alvarez-Pérez E, Saez A, Lozano C, Vargas J, García-Monzón C. Increased expression of T cell chemokines and their receptors in chronic hepatitis C:relationship with the histological activity of liver disease. Am J Gastroenterol 2002; 97: 2861-2870
    • (2002) Am J Gastroenterol , vol.97 , pp. 2861-2870
    • Apolinario, A.1    Majano, P.L.2    Alvarez-Pérez, E.3    Saez, A.4    Lozano, C.5    Vargas, J.6    García-Monzón, C.7
  • 81
    • 13244270115 scopus 로고    scopus 로고
    • Gene expression profile of T-cell-specific chemokines in human hepatocyte-derived cells: evidence for a synergistic inducer effect of cytokines and hepatitis C virus proteins
    • Apolinario A, Majano PL, Lorente R, Núñez O, Clemente G, García-Monzón C. Gene expression profile of T-cell-specific chemokines in human hepatocyte-derived cells: evidence for a synergistic inducer effect of cytokines and hepatitis C virus proteins. J Viral Hepat 2005; 12: 27-37
    • (2005) J Viral Hepat , vol.12 , pp. 27-37
    • Apolinario, A.1    Majano, P.L.2    Lorente, R.3    Núñez, O.4    Clemente, G.5    García-Monzón, C.6
  • 82
    • 51349102719 scopus 로고    scopus 로고
    • Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis
    • Muhanna N, Doron S, Wald O, Horani A, Eid A, Pappo O, Friedman SL, Safadi R. Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis. Hepatology 2008; 48: 963-977
    • (2008) Hepatology , vol.48 , pp. 963-977
    • Muhanna, N.1    Doron, S.2    Wald, O.3    Horani, A.4    Eid, A.5    Pappo, O.6    Friedman, S.L.7    Safadi, R.8
  • 83
    • 34347332337 scopus 로고    scopus 로고
    • Immunopathogenesis of hepatitis C virus infection and hepatic fibrosis: New insights into antifibrotic therapy in chronic hepatitis C
    • Teixeira R, Marcos LA, Friedman SL. Immunopathogenesis of hepatitis C virus infection and hepatic fibrosis: New insights into antifibrotic therapy in chronic hepatitis C. Hepatol Res 2007; 37: 579-595
    • (2007) Hepatol Res , vol.37 , pp. 579-595
    • Teixeira, R.1    Marcos, L.A.2    Friedman, S.L.3
  • 84
    • 0036172292 scopus 로고    scopus 로고
    • Insights into the pathobiology of hepatitis C virus-associated cirrhosis: analysis of intrahepatic differential gene expression
    • Shackel NA, McGuinness PH, Abbott CA, Gorrell MD, Mc-Caughan GW. Insights into the pathobiology of hepatitis C virus-associated cirrhosis: analysis of intrahepatic differential gene expression. Am J Pathol 2002; 160: 641-654
    • (2002) Am J Pathol , vol.160 , pp. 641-654
    • Shackel, N.A.1    McGuinness, P.H.2    Abbott, C.A.3    Gorrell, M.D.4    Mc-Caughan, G.W.5
  • 85
    • 34948827036 scopus 로고    scopus 로고
    • Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C
    • Tanaka A, Uegaki S, Kurihara H, Aida K, Mikami M, Nagashima I, Shiga J, Takikawa H. Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C. World J Gastroenterol 2007; 13: 5180-5187
    • (2007) World J Gastroenterol , vol.13 , pp. 5180-5187
    • Tanaka, A.1    Uegaki, S.2    Kurihara, H.3    Aida, K.4    Mikami, M.5    Nagashima, I.6    Shiga, J.7    Takikawa, H.8
  • 86
    • 78650810019 scopus 로고    scopus 로고
    • Role of insulin resistance and hepatic steatosis in the progression of fibrosis and response to treatment in hepatitis C
    • Sanyal AJ. Role of insulin resistance and hepatic steatosis in the progression of fibrosis and response to treatment in hepatitis C. Liver Int 2011; 31 Suppl 1: 23-28
    • (2011) Liver Int , vol.31 , Issue.SUPPL. 1 , pp. 23-28
    • Sanyal, A.J.1
  • 89
    • 84855717628 scopus 로고    scopus 로고
    • TNF-alpha and CXCL-10 correlation with insulin resistance in patients with chronic hepatitis C virus infection
    • Sayed-Ahmed L, Kotb N, El-Serogy H, El-Shazly S, Eid M. TNF-alpha and CXCL-10 correlation with insulin resistance in patients with chronic hepatitis C virus infection. Egypt J Immunol 2010; 17: 101-111
    • (2010) Egypt J Immunol , vol.17 , pp. 101-111
    • Sayed-Ahmed, L.1    Kotb, N.2    El-Serogy, H.3    El-Shazly, S.4    Eid, M.5
  • 90
    • 67650501133 scopus 로고    scopus 로고
    • Association of inflammatory and antiinflammatory cytokines with insulin resistance in chronic hepatitis C
    • Hung CH, Lee CM, Chen CH, Hu TH, Jiang SR, Wang JH, Lu SN, Wang PW. Association of inflammatory and antiinflammatory cytokines with insulin resistance in chronic hepatitis C. Liver Int 2009; 29: 1086-1093
    • (2009) Liver Int , vol.29 , pp. 1086-1093
    • Hung, C.H.1    Lee, C.M.2    Chen, C.H.3    Hu, T.H.4    Jiang, S.R.5    Wang, J.H.6    Lu, S.N.7    Wang, P.W.8
  • 91
    • 34248181878 scopus 로고    scopus 로고
    • Elevated circulating transforming growth factor beta-1 may explain poorer renal survival in type II diabetics with chronic hepatitis C
    • Peterson MC. Elevated circulating transforming growth factor beta-1 may explain poorer renal survival in type II diabetics with chronic hepatitis C. Med Sci Monit 2007; 13: RA81-RA85
    • (2007) Med Sci Monit , vol.13
    • Peterson, M.C.1
  • 94
    • 77954758503 scopus 로고    scopus 로고
    • Cyclic AMP suppresses matrix metalloproteinase-1 expression through inhibition of MAPK and GSK-3beta
    • Park CH, Moon Y, Shin CM, Chung JH. Cyclic AMP suppresses matrix metalloproteinase-1 expression through inhibition of MAPK and GSK-3beta. J Invest Dermatol 2010; 130: 2049-2056
    • (2010) J Invest Dermatol , vol.130 , pp. 2049-2056
    • Park, C.H.1    Moon, Y.2    Shin, C.M.3    Chung, J.H.4
  • 95
    • 29644441703 scopus 로고    scopus 로고
    • Human CC chemokine CCL23 enhances expression of matrix metalloproteinase-2 and invasion of vascular endothelial cells
    • Son KN, Hwang J, Kwon BS, Kim J. Human CC chemokine CCL23 enhances expression of matrix metalloproteinase-2 and invasion of vascular endothelial cells. Biochem Biophys Res Commun 2006; 340: 498-504
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 498-504
    • Son, K.N.1    Hwang, J.2    Kwon, B.S.3    Kim, J.4
  • 96
    • 34249727056 scopus 로고    scopus 로고
    • [Roles of serine proteases and matrix metalloproteinases in tumor invasion and angiogenesis]
    • Masson V. [Roles of serine proteases and matrix metalloproteinases in tumor invasion and angiogenesis]. Bull Mem Acad R Med Belg 2006; 161: 320-326
    • (2006) Bull Mem Acad R Med Belg , vol.161 , pp. 320-326
    • Masson, V.1
  • 97
    • 39849101882 scopus 로고    scopus 로고
    • Effect of angiotensin-converting enzyme inhibition on experimental hepatic fibrogenesis
    • Türkay C, Yönem O, Arici S, Koyuncu A, Kanbay M. Effect of angiotensin-converting enzyme inhibition on experimental hepatic fibrogenesis. Dig Dis Sci 2008; 53: 789-793
    • (2008) Dig Dis Sci , vol.53 , pp. 789-793
    • Türkay, C.1    Yönem, O.2    Arici, S.3    Koyuncu, A.4    Kanbay, M.5
  • 98
    • 33846837590 scopus 로고    scopus 로고
    • Mechanisms of fibrinolysis in chronic liver injury (with special emphasis on MMPs and TIMPs)
    • Roderfeld M, Hemmann S, Roeb E. Mechanisms of fibrinolysis in chronic liver injury (with special emphasis on MMPs and TIMPs). Z Gastroenterol 2007; 45: 25-33
    • (2007) Z Gastroenterol , vol.45 , pp. 25-33
    • Roderfeld, M.1    Hemmann, S.2    Roeb, E.3
  • 99
    • 16644402719 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis
    • Zhou X, Hovell CJ, Pawley S, Hutchings MI, Arthur MJ, Iredale JP, Benyon RC. Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis. Liver Int 2004; 24: 492-501
    • (2004) Liver Int , vol.24 , pp. 492-501
    • Zhou, X.1    Hovell, C.J.2    Pawley, S.3    Hutchings, M.I.4    Arthur, M.J.5    Iredale, J.P.6    Benyon, R.C.7
  • 100
    • 1442301501 scopus 로고    scopus 로고
    • Circulating matrix metalloproteinases 1, 2, 9 and their inhibitors TIMP-1 and TIMP-2 as serum markers of liver fibrosis in patients with chronic hepatitis C: comparison with PIIINP and hyaluronic acid
    • Leroy V, Monier F, Bottari S, Trocme C, Sturm N, Hilleret MN, Morel F, Zarski JP. Circulating matrix metalloproteinases 1, 2, 9 and their inhibitors TIMP-1 and TIMP-2 as serum markers of liver fibrosis in patients with chronic hepatitis C: comparison with PIIINP and hyaluronic acid. Am J Gastroenterol 2004; 99: 271-279
    • (2004) Am J Gastroenterol , vol.99 , pp. 271-279
    • Leroy, V.1    Monier, F.2    Bottari, S.3    Trocme, C.4    Sturm, N.5    Hilleret, M.N.6    Morel, F.7    Zarski, J.P.8
  • 102
    • 80052279738 scopus 로고    scopus 로고
    • A polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation
    • Bisht S, Khan MA, Bekhit M, Bai H, Cornish T, Mizuma M, Rudek MA, Zhao M, Maitra A, Ray B, Lahiri D, Maitra A, Anders RA. A polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation. Lab Invest 2011; 91: 1383-1395
    • (2011) Lab Invest , vol.91 , pp. 1383-1395
    • Bisht, S.1    Khan, M.A.2    Bekhit, M.3    Bai, H.4    Cornish, T.5    Mizuma, M.6    Rudek, M.A.7    Zhao, M.8    Maitra, A.9    Ray, B.10    Lahiri, D.11    Maitra, A.12    Anders, R.A.13
  • 104
    • 77952321489 scopus 로고    scopus 로고
    • Hypoxia-induced phenotypic switch of fibroblasts to myofibroblasts through a matrix metalloproteinase 2/tissue inhibitor of metalloproteinase-mediated pathway: implications for venous neointimal hyperplasia in hemodialysis access
    • Misra S, Fu AA, Misra KD, Shergill UM, Leof EB, Mukhopadhyay D. Hypoxia-induced phenotypic switch of fibroblasts to myofibroblasts through a matrix metalloproteinase 2/tissue inhibitor of metalloproteinase-mediated pathway: implications for venous neointimal hyperplasia in hemodialysis access. J Vasc Interv Radiol 2010; 21: 896-902
    • (2010) J Vasc Interv Radiol , vol.21 , pp. 896-902
    • Misra, S.1    Fu, A.A.2    Misra, K.D.3    Shergill, U.M.4    Leof, E.B.5    Mukhopadhyay, D.6
  • 107
    • 77952722154 scopus 로고    scopus 로고
    • Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner
    • Lin W, Tsai WL, Shao RX, Wu G, Peng LF, Barlow LL, Chung WJ, Zhang L, Zhao H, Jang JY, Chung RT. Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner. Gastroenterology 2010; 138: 2509-2518, 2518.e1
    • (2010) Gastroenterology , vol.138
    • Lin, W.1    Tsai, W.L.2    Shao, R.X.3    Wu, G.4    Peng, L.F.5    Barlow, L.L.6    Chung, W.J.7    Zhang, L.8    Zhao, H.9    Jang, J.Y.10    Chung, R.T.11
  • 108
    • 64849090779 scopus 로고    scopus 로고
    • End-organ damage in a mouse model of fulminant liver inflammation requires CD4+ T cell production of IFN-gamma but is independent of Fas
    • Robinson RT, Wang J, Cripps JG, Milks MW, English KA, Pearson TA, Gorham JD. End-organ damage in a mouse model of fulminant liver inflammation requires CD4+ T cell production of IFN-gamma but is independent of Fas. J Immunol 2009; 182: 3278-3284
    • (2009) J Immunol , vol.182 , pp. 3278-3284
    • Robinson, R.T.1    Wang, J.2    Cripps, J.G.3    Milks, M.W.4    English, K.A.5    Pearson, T.A.6    Gorham, J.D.7
  • 109
    • 0346433816 scopus 로고    scopus 로고
    • Up-regulation of hepatocyte growth factor caused by an over-expression of transforming growth factor beta, in the rat model of fulminant hepatic failure
    • Nozato E, Shiraishi M, Nishimaki T. Up-regulation of hepatocyte growth factor caused by an over-expression of transforming growth factor beta, in the rat model of fulminant hepatic failure. J Surg Res 2003; 115: 226-234
    • (2003) J Surg Res , vol.115 , pp. 226-234
    • Nozato, E.1    Shiraishi, M.2    Nishimaki, T.3
  • 111
    • 0031752720 scopus 로고    scopus 로고
    • Levels of transforming growth factor beta and transforming growth factor beta receptors in rat liver during growth, regression by apoptosis and neoplasia
    • Grasl-Kraupp B, Rossmanith W, Ruttkay-Nedecky B, Müllauer L, Kammerer B, Bursch W, Schulte-Hermann R. Levels of transforming growth factor beta and transforming growth factor beta receptors in rat liver during growth, regression by apoptosis and neoplasia. Hepatology 1998; 28: 717-726
    • (1998) Hepatology , vol.28 , pp. 717-726
    • Grasl-Kraupp, B.1    Rossmanith, W.2    Ruttkay-Nedecky, B.3    Müllauer, L.4    Kammerer, B.5    Bursch, W.6    Schulte-Hermann, R.7
  • 112
    • 80955176384 scopus 로고    scopus 로고
    • Reversal of TGF-β1 stimulation of a-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren' s-derived fibroblasts
    • Satish L, Gallo PH, Baratz ME, Johnson S, Kathju S. Reversal of TGF-β1 stimulation of a-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren' s-derived fibroblasts. BMC Musculoskelet Disord 2011; 12: 113
    • (2011) BMC Musculoskelet Disord , vol.12 , pp. 113
    • Satish, L.1    Gallo, P.H.2    Baratz, M.E.3    Johnson, S.4    Kathju, S.5
  • 113
    • 78650656196 scopus 로고    scopus 로고
    • Simultaneous stimulation with TGF-β1 and TNF-a induces epithelial mesenchymal transition in bronchial epithelial cells
    • Kamitani S, Yamauchi Y, Kawasaki S, Takami K, Takizawa H, Nagase T, Kohyama T. Simultaneous stimulation with TGF-β1 and TNF-a induces epithelial mesenchymal transition in bronchial epithelial cells. Int Arch Allergy Immunol 2011; 155: 119-128
    • (2011) Int Arch Allergy Immunol , vol.155 , pp. 119-128
    • Kamitani, S.1    Yamauchi, Y.2    Kawasaki, S.3    Takami, K.4    Takizawa, H.5    Nagase, T.6    Kohyama, T.7
  • 114
    • 73349136974 scopus 로고    scopus 로고
    • Role of free radicals in liver diseases
    • Muriel P. Role of free radicals in liver diseases. Hepatol Int 2009; 3: 526-536
    • (2009) Hepatol Int , vol.3 , pp. 526-536
    • Muriel, P.1
  • 115
    • 4644253503 scopus 로고    scopus 로고
    • Superoxide-induced apoptosis of activated rat hepatic stellate cells
    • Thirunavukkarasu C, Watkins S, Harvey SA, Gandhi CR. Superoxide-induced apoptosis of activated rat hepatic stellate cells. J Hepatol 2004; 41: 567-575
    • (2004) J Hepatol , vol.41 , pp. 567-575
    • Thirunavukkarasu, C.1    Watkins, S.2    Harvey, S.A.3    Gandhi, C.R.4
  • 116
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • Zavadil J, Böttinger EP. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005; 24: 5764-5774
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Böttinger, E.P.2
  • 118
    • 2342450078 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line
    • Sugioka Y, Watanabe T, Inagaki Y, Kushida M, Niioka M, Endo H, Higashiyama R, Okazaki I. c-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line. Int J Cancer 2004; 109: 867-874
    • (2004) Int J Cancer , vol.109 , pp. 867-874
    • Sugioka, Y.1    Watanabe, T.2    Inagaki, Y.3    Kushida, M.4    Niioka, M.5    Endo, H.6    Higashiyama, R.7    Okazaki, I.8
  • 120
    • 33845908212 scopus 로고    scopus 로고
    • TGF-beta during human colorectal carcinogenesis: the shift from epithelial to mesenchymal signaling
    • Matsuzaki K, Seki T, Okazaki K. TGF-beta during human colorectal carcinogenesis: the shift from epithelial to mesenchymal signaling. Inflammopharmacology 2006; 14: 198-203
    • (2006) Inflammopharmacology , vol.14 , pp. 198-203
    • Matsuzaki, K.1    Seki, T.2    Okazaki, K.3
  • 121
    • 33744803766 scopus 로고    scopus 로고
    • Transforming growth factor-beta during carcinogenesis: the shift from epithelial to mesenchymal signaling
    • Matsuzaki K, Okazaki K. Transforming growth factor-beta during carcinogenesis: the shift from epithelial to mesenchymal signaling. J Gastroenterol 2006; 41: 295-303
    • (2006) J Gastroenterol , vol.41 , pp. 295-303
    • Matsuzaki, K.1    Okazaki, K.2
  • 122
    • 0035872426 scopus 로고    scopus 로고
    • Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation
    • Ellenrieder V, Hendler SF, Boeck W, Seufferlein T, Menke A, Ruhland C, Adler G, Gress TM. Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. Cancer Res 2001; 61: 4222-4228
    • (2001) Cancer Res , vol.61 , pp. 4222-4228
    • Ellenrieder, V.1    Hendler, S.F.2    Boeck, W.3    Seufferlein, T.4    Menke, A.5    Ruhland, C.6    Adler, G.7    Gress, T.M.8
  • 125
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003; 425: 577-584
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 126
    • 26944444737 scopus 로고    scopus 로고
    • Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway
    • Pavio N, Battaglia S, Boucreux D, Arnulf B, Sobesky R, Hermine O, Brechot C. Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathway. Oncogene 2005; 24: 6119-6132
    • (2005) Oncogene , vol.24 , pp. 6119-6132
    • Pavio, N.1    Battaglia, S.2    Boucreux, D.3    Arnulf, B.4    Sobesky, R.5    Hermine, O.6    Brechot, C.7
  • 127
    • 7644239154 scopus 로고    scopus 로고
    • Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation
    • Cheng PL, Chang MH, Chao CH, Lee YH. Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation. Oncogene 2004; 23: 7821-7838
    • (2004) Oncogene , vol.23 , pp. 7821-7838
    • Cheng, P.L.1    Chang, M.H.2    Chao, C.H.3    Lee, Y.H.4
  • 128
    • 0035865440 scopus 로고    scopus 로고
    • Biology of transforming growth factor beta in hepatocarcinogenesis
    • Rossmanith W, Schulte-Hermann R. Biology of transforming growth factor beta in hepatocarcinogenesis. Microsc Res Tech 2001; 52: 430-436
    • (2001) Microsc Res Tech , vol.52 , pp. 430-436
    • Rossmanith, W.1    Schulte-Hermann, R.2
  • 130
    • 80055051353 scopus 로고    scopus 로고
    • Chronic hepatitis c genotype-4 infection: role of insulin resistance in hepatocellular carcinoma
    • Mohamed AA, Loutfy SA, Craik JD, Hashem AG, Siam I. Chronic hepatitis c genotype-4 infection: role of insulin resistance in hepatocellular carcinoma. Virol J 2011; 8: 496
    • (2011) Virol J , vol.8 , pp. 496
    • Mohamed, A.A.1    Loutfy, S.A.2    Craik, J.D.3    Hashem, A.G.4    Siam, I.5
  • 133
    • 84859939821 scopus 로고    scopus 로고
    • Incidence and risk factors for hepatocellular carcinoma in Texas Latinos: implications for prevention research
    • Ramirez AG, Weiss NS, Holden AE, Suarez L, Cooper SP, Munoz E, Naylor SL. Incidence and risk factors for hepatocellular carcinoma in Texas Latinos: implications for prevention research. PLoS One 2012; 7: e35573
    • (2012) PLoS One , vol.7
    • Ramirez, A.G.1    Weiss, N.S.2    Holden, A.E.3    Suarez, L.4    Cooper, S.P.5    Munoz, E.6    Naylor, S.L.7
  • 134
    • 84862181086 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in nonalcoholic fatty liver cirrhosis and alcoholic cirrhosis: risk factor analysis in liver transplant recipients
    • Jain D, Nayak NC, Saigal S. Hepatocellular carcinoma in nonalcoholic fatty liver cirrhosis and alcoholic cirrhosis: risk factor analysis in liver transplant recipients. Eur J Gastroenterol Hepatol 2012; 24: 840-848
    • (2012) Eur J Gastroenterol Hepatol , vol.24 , pp. 840-848
    • Jain, D.1    Nayak, N.C.2    Saigal, S.3
  • 135
    • 84863115964 scopus 로고    scopus 로고
    • Statins and the risk of hepatocellular carcinoma in patients with hepatitis B virus infection
    • Tsan YT, Lee CH, Wang JD, Chen PC. Statins and the risk of hepatocellular carcinoma in patients with hepatitis B virus infection. J Clin Oncol 2012; 30: 623-630
    • (2012) J Clin Oncol , vol.30 , pp. 623-630
    • Tsan, Y.T.1    Lee, C.H.2    Wang, J.D.3    Chen, P.C.4
  • 137
    • 84864285304 scopus 로고    scopus 로고
    • Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation
    • Wang L, Huang J, Jiang M, Lin H. Tissue-specific transplantation antigen P35B (TSTA3) immune response-mediated metabolism coupling cell cycle to postreplication repair network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by biocomputation. Immunol Res 2012; 52: 258-268
    • (2012) Immunol Res , vol.52 , pp. 258-268
    • Wang, L.1    Huang, J.2    Jiang, M.3    Lin, H.4
  • 138
    • 28244483929 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells
    • Herzer K, Weyer S, Krammer PH, Galle PR, Hofmann TG. Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells. Cancer Res 2005; 65: 10830-10837
    • (2005) Cancer Res , vol.65 , pp. 10830-10837
    • Herzer, K.1    Weyer, S.2    Krammer, P.H.3    Galle, P.R.4    Hofmann, T.G.5
  • 139
    • 70450195105 scopus 로고    scopus 로고
    • Hepatitis C virus causes uncoupling of mitotic checkpoint and chromosomal polyploidy through the Rb pathway
    • Machida K, Liu JC, McNamara G, Levine A, Duan L, Lai MM. Hepatitis C virus causes uncoupling of mitotic checkpoint and chromosomal polyploidy through the Rb pathway. J Virol 2009; 83: 12590-12600
    • (2009) J Virol , vol.83 , pp. 12590-12600
    • Machida, K.1    Liu, J.C.2    McNamara, G.3    Levine, A.4    Duan, L.5    Lai, M.M.6
  • 141
    • 0035809057 scopus 로고    scopus 로고
    • HCV core protein modulates Rb pathway through pRb downregulation and E2F-1 up-regulation
    • Cho J, Baek W, Yang S, Chang J, Sung YC, Suh M. HCV core protein modulates Rb pathway through pRb downregulation and E2F-1 up-regulation. Biochim Biophys Acta 2001; 1538: 59-66
    • (2001) Biochim Biophys Acta , vol.1538 , pp. 59-66
    • Cho, J.1    Baek, W.2    Yang, S.3    Chang, J.4    Sung, Y.C.5    Suh, M.6
  • 143
    • 77954877140 scopus 로고    scopus 로고
    • Protein kinase C alpha location and the expression of phospho-MEK and MDR1 in hepatitis virus-related hepatocellular carcinoma biopsies
    • Lin CC, Hwang JM, Tsai MT, Su WW, Chen LM, Lai TY, Hsu HH, Yen SK, Huang CY, Liu JY. Protein kinase C alpha location and the expression of phospho-MEK and MDR1 in hepatitis virus-related hepatocellular carcinoma biopsies.Chin J Physiol 2010; 53: 112-118
    • (2010) Chin J Physiol , vol.53 , pp. 112-118
    • Lin, C.C.1    Hwang, J.M.2    Tsai, M.T.3    Su, W.W.4    Chen, L.M.5    Lai, T.Y.6    Hsu, H.H.7    Yen, S.K.8    Huang, C.Y.9    Liu, J.Y.10
  • 145
    • 42449088547 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus (HCV) core protein-induced cell growth by non-structural protein 4A (NS4A) is mediated by mitochondrial dysregulation
    • Selimovic D, Hassan M. Inhibition of hepatitis C virus (HCV) core protein-induced cell growth by non-structural protein 4A (NS4A) is mediated by mitochondrial dysregulation. Bosn J Basic Med Sci 2008; 8: 4-11
    • (2008) Bosn J Basic Med Sci , vol.8 , pp. 4-11
    • Selimovic, D.1    Hassan, M.2
  • 147
    • 1642464020 scopus 로고    scopus 로고
    • Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1
    • Qadri I, Iwahashi M, Capasso JM, Hopken MW, Flores S, Schaack J, Simon FR. Induced oxidative stress and activated expression of manganese superoxide dismutase during hepatitis C virus replication: role of JNK, p38 MAPK and AP-1. Biochem J 2004; 378: 919-928
    • (2004) Biochem J , vol.378 , pp. 919-928
    • Qadri, I.1    Iwahashi, M.2    Capasso, J.M.3    Hopken, M.W.4    Flores, S.5    Schaack, J.6    Simon, F.R.7
  • 148
    • 84863158653 scopus 로고    scopus 로고
    • Activation of the Ras/Raf/MEK pathway facilitates hepatitis C virus replication via attenuation of the interferon-JAK-STAT pathway
    • Zhang Q, Gong R, Qu J, Zhou Y, Liu W, Chen M, Liu Y, Zhu Y, Wu J. Activation of the Ras/Raf/MEK pathway facilitates hepatitis C virus replication via attenuation of the interferon-JAK-STAT pathway. J Virol 2012; 86: 1544-1554
    • (2012) J Virol , vol.86 , pp. 1544-1554
    • Zhang, Q.1    Gong, R.2    Qu, J.3    Zhou, Y.4    Liu, W.5    Chen, M.6    Liu, Y.7    Zhu, Y.8    Wu, J.9
  • 149
    • 79960401766 scopus 로고    scopus 로고
    • Hepatitis C virus co-opts Ras-GTPaseactivating protein-binding protein 1 for its genome replication
    • Yi Z, Pan T, Wu X, Song W, Wang S, Xu Y, Rice CM, Macdonald MR, Yuan Z. Hepatitis C virus co-opts Ras-GTPaseactivating protein-binding protein 1 for its genome replication. J Virol 2011; 85: 6996-7004
    • (2011) J Virol , vol.85 , pp. 6996-7004
    • Yi, Z.1    Pan, T.2    Wu, X.3    Song, W.4    Wang, S.5    Xu, Y.6    Rice, C.M.7    Macdonald, M.R.8    Yuan, Z.9
  • 150
    • 33749079186 scopus 로고    scopus 로고
    • Subproteomic study of hepatitis C virus replicon reveals Ras-GTPaseactivating protein binding protein 1 as potential HCV RC component
    • Yi Z, Fang C, Pan T, Wang J, Yang P, Yuan Z. Subproteomic study of hepatitis C virus replicon reveals Ras-GTPaseactivating protein binding protein 1 as potential HCV RC component. Biochem Biophys Res Commun 2006; 350: 174-178
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 174-178
    • Yi, Z.1    Fang, C.2    Pan, T.3    Wang, J.4    Yang, P.5    Yuan, Z.6
  • 152
    • 49749092090 scopus 로고    scopus 로고
    • The hepatitis C virus nonstructural protein NS5A alters the trafficking profile of the epidermal growth factor receptor
    • Mankouri J, Griffin S, Harris M. The hepatitis C virus nonstructural protein NS5A alters the trafficking profile of the epidermal growth factor receptor. Traffic 2008; 9: 1497-1509
    • (2008) Traffic , vol.9 , pp. 1497-1509
    • Mankouri, J.1    Griffin, S.2    Harris, M.3
  • 153
    • 33745727578 scopus 로고    scopus 로고
    • Immunohistochemical expression of CD95 (Fas), c-myc and epidermal growth factor receptor in hepatitis C virus infection, cirrhotic liver disease and hepatocellular carcinoma
    • El-Bassiouni A, Nosseir M, Zoheiry M, El-Ahwany E, Ghali A, El-Bassiouni N. Immunohistochemical expression of CD95 (Fas), c-myc and epidermal growth factor receptor in hepatitis C virus infection, cirrhotic liver disease and hepatocellular carcinoma. APMIS 2006; 114: 420-427
    • (2006) APMIS , vol.114 , pp. 420-427
    • El-Bassiouni, A.1    Nosseir, M.2    Zoheiry, M.3    El-Ahwany, E.4    Ghali, A.5    El-Bassiouni, N.6
  • 154
    • 84855711468 scopus 로고    scopus 로고
    • Circulating transforming growth factor-β and epidermal growth factor receptor as related to virus infection in liver carcinogenesis
    • Divella R, Daniele A, Gadaleta C, Tufaro A, Venneri MT, Paradiso A, Quaranta M. Circulating transforming growth factor-β and epidermal growth factor receptor as related to virus infection in liver carcinogenesis. Anticancer Res 2012; 32: 141-145
    • (2012) Anticancer Res , vol.32 , pp. 141-145
    • Divella, R.1    Daniele, A.2    Gadaleta, C.3    Tufaro, A.4    Venneri, M.T.5    Paradiso, A.6    Quaranta, M.7
  • 157
    • 40949086754 scopus 로고    scopus 로고
    • Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells
    • Kim M, Lee HC, Tsedensodnom O, Hartley R, Lim YS, Yu E, Merle P, Wands JR. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol 2008; 48: 780-791
    • (2008) J Hepatol , vol.48 , pp. 780-791
    • Kim, M.1    Lee, H.C.2    Tsedensodnom, O.3    Hartley, R.4    Lim, Y.S.5    Yu, E.6    Merle, P.7    Wands, J.R.8
  • 160
    • 4544301860 scopus 로고    scopus 로고
    • High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 and beta-catenin mutations
    • Peng SY, Chen WJ, Lai PL, Jeng YM, Sheu JC, Hsu HC. High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 and beta-catenin mutations. Int J Cancer 2004; 112: 44-50
    • (2004) Int J Cancer , vol.112 , pp. 44-50
    • Peng, S.Y.1    Chen, W.J.2    Lai, P.L.3    Jeng, Y.M.4    Sheu, J.C.5    Hsu, H.C.6
  • 161
    • 0032761853 scopus 로고    scopus 로고
    • Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection
    • Huang H, Fujii H, Sankila A, Mahler-Araujo BM, Matsuda M, Cathomas G, Ohgaki H. Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am J Pathol 1999; 155: 1795-1801
    • (1999) Am J Pathol , vol.155 , pp. 1795-1801
    • Huang, H.1    Fujii, H.2    Sankila, A.3    Mahler-Araujo, B.M.4    Matsuda, M.5    Cathomas, G.6    Ohgaki, H.7
  • 162
    • 84869408630 scopus 로고    scopus 로고
    • Potential Antioxidant Role of Tridham in Managing Oxidative Stress against Aflatoxin-B(1)-Induced Experimental Hepatocellular Carcinoma
    • Ravinayagam V, Jaganathan R, Panchanadham S, Palanivelu S. Potential Antioxidant Role of Tridham in Managing Oxidative Stress against Aflatoxin-B(1)-Induced Experimental Hepatocellular Carcinoma. Int J Hepatol 2012; 2012: 428373
    • (2012) Int J Hepatol , vol.2012 , pp. 428373
    • Ravinayagam, V.1    Jaganathan, R.2    Panchanadham, S.3    Palanivelu, S.4
  • 163
    • 0034953664 scopus 로고    scopus 로고
    • CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1
    • Devereux TR, Stern MC, Flake GP, Yu MC, Zhang ZQ, London SJ, Taylor JA. CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1. Mol Carcinog 2001; 31: 68-73
    • (2001) Mol Carcinog , vol.31 , pp. 68-73
    • Devereux, T.R.1    Stern, M.C.2    Flake, G.P.3    Yu, M.C.4    Zhang, Z.Q.5    London, S.J.6    Taylor, J.A.7
  • 165
    • 18544372089 scopus 로고    scopus 로고
    • A comparative study of P53/ MDM2 genes alterations and P53/ MDM2 proteins immunoreactivity in liver cirrhosis and hepatocellular carcinoma
    • Jablkowski M, Bocian A, Bialkowska J, Bartkowiak J. A comparative study of P53/ MDM2 genes alterations and P53/ MDM2 proteins immunoreactivity in liver cirrhosis and hepatocellular carcinoma. J Exp Clin Cancer Res 2005; 24: 117-125
    • (2005) J Exp Clin Cancer Res , vol.24 , pp. 117-125
    • Jablkowski, M.1    Bocian, A.2    Bialkowska, J.3    Bartkowiak, J.4
  • 166
    • 36949005417 scopus 로고    scopus 로고
    • DNA damage signalling guards against activated oncogenes and tumour progression
    • Bartek J, Bartkova J, Lukas J. DNA damage signalling guards against activated oncogenes and tumour progression. Oncogene 2007; 26: 7773-7779
    • (2007) Oncogene , vol.26 , pp. 7773-7779
    • Bartek, J.1    Bartkova, J.2    Lukas, J.3
  • 167
    • 77957353301 scopus 로고    scopus 로고
    • Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival
    • Hsieh TC, Nicolay BN, Frolov MV, Moon NS. Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival. PLoS Genet 2010; 6: e1001071
    • (2010) PLoS Genet , vol.6
    • Hsieh, T.C.1    Nicolay, B.N.2    Frolov, M.V.3    Moon, N.S.4
  • 168
  • 169
    • 0037360095 scopus 로고    scopus 로고
    • Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKICDK-cyclin and pRb-related protein-E2F complexes
    • Singh RP, Agarwal C, Agarwal R. Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKICDK-cyclin and pRb-related protein-E2F complexes. Carcinogenesis 2003; 24: 555-563
    • (2003) Carcinogenesis , vol.24 , pp. 555-563
    • Singh, R.P.1    Agarwal, C.2    Agarwal, R.3
  • 171
    • 0036073373 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein induces the cyclin-dependent kinase inhibitor p21(waf1) and the tumor suppressor Rb
    • Mazière C, Marcheux V, Louandre C, Mazière JC. Oxidized low density lipoprotein induces the cyclin-dependent kinase inhibitor p21(waf1) and the tumor suppressor Rb. Biochem Biophys Res Commun 2002; 293: 1327-1332
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 1327-1332
    • Mazière, C.1    Marcheux, V.2    Louandre, C.3    Mazière, J.C.4
  • 172
    • 0033624329 scopus 로고    scopus 로고
    • P53 but not p16INK4a induces growth arrest in retinoblastoma-deficient hepatocellular carcinoma cells
    • Morel AP, Unsal K, Cagatay T, Ponchel F, Carr B, Ozturk M. P53 but not p16INK4a induces growth arrest in retinoblastoma-deficient hepatocellular carcinoma cells. J Hepatol 2000; 33: 254-265
    • (2000) J Hepatol , vol.33 , pp. 254-265
    • Morel, A.P.1    Unsal, K.2    Cagatay, T.3    Ponchel, F.4    Carr, B.5    Ozturk, M.6
  • 173
    • 0033945531 scopus 로고    scopus 로고
    • Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1
    • Aoki H, Hayashi J, Moriyama M, Arakawa Y, Hino O. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. J Virol 2000; 74: 1736-1741
    • (2000) J Virol , vol.74 , pp. 1736-1741
    • Aoki, H.1    Hayashi, J.2    Moriyama, M.3    Arakawa, Y.4    Hino, O.5
  • 174
    • 0031963692 scopus 로고    scopus 로고
    • Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha
    • Santoni-Rugiu E, Jensen MR, Thorgeirsson SS. Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. Cancer Res 1998; 58: 123-134
    • (1998) Cancer Res , vol.58 , pp. 123-134
    • Santoni-Rugiu, E.1    Jensen, M.R.2    Thorgeirsson, S.S.3
  • 175
    • 0029884168 scopus 로고    scopus 로고
    • Pathogenesis of hepatocellular carcinoma: a review from the viewpoint of molecular analysis
    • Kasai Y, Takeda S, Takagi H. Pathogenesis of hepatocellular carcinoma: a review from the viewpoint of molecular analysis. Semin Surg Oncol 1996; 12: 155-159
    • (1996) Semin Surg Oncol , vol.12 , pp. 155-159
    • Kasai, Y.1    Takeda, S.2    Takagi, H.3
  • 176
    • 0034805144 scopus 로고    scopus 로고
    • Hepatitis C virus core protein potentiates TNF-alpha-induced NFkappaB activation through TRAF2-IKKbeta-dependent pathway
    • Chung YM, Park KJ, Choi SY, Hwang SB, Lee SY. Hepatitis C virus core protein potentiates TNF-alpha-induced NFkappaB activation through TRAF2-IKKbeta-dependent pathway. Biochem Biophys Res Commun 2001; 284: 15-19
    • (2001) Biochem Biophys Res Commun , vol.284 , pp. 15-19
    • Chung, Y.M.1    Park, K.J.2    Choi, S.Y.3    Hwang, S.B.4    Lee, S.Y.5
  • 177
    • 0032906988 scopus 로고    scopus 로고
    • Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha
    • You LR, Chen CM, Lee YH. Hepatitis C virus core protein enhances NF-kappaB signal pathway triggering by lymphotoxin-beta receptor ligand and tumor necrosis factor alpha. J Virol 1999; 73: 1672-1681
    • (1999) J Virol , vol.73 , pp. 1672-1681
    • You, L.R.1    Chen, C.M.2    Lee, Y.H.3
  • 178
    • 0035799529 scopus 로고    scopus 로고
    • Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein
    • Giambartolomei S, Covone F, Levrero M, Balsano C. Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein. Oncogene 2001; 20: 2606-2610
    • (2001) Oncogene , vol.20 , pp. 2606-2610
    • Giambartolomei, S.1    Covone, F.2    Levrero, M.3    Balsano, C.4
  • 179
    • 33744958372 scopus 로고    scopus 로고
    • Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1
    • Spaziani A, Alisi A, Sanna D, Balsano C. Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1. J Biol Chem 2006; 281: 10983-10989
    • (2006) J Biol Chem , vol.281 , pp. 10983-10989
    • Spaziani, A.1    Alisi, A.2    Sanna, D.3    Balsano, C.4
  • 180
    • 77953967458 scopus 로고    scopus 로고
    • Hepatitis C virus core protein induces malignant transformation of biliary epithelial cells by activating nuclear factor-kappaB pathway
    • Li ZH, Tang QB, Wang J, Zhou L, Huang WL, Liu RY, Chen RF. Hepatitis C virus core protein induces malignant transformation of biliary epithelial cells by activating nuclear factor-kappaB pathway. J Gastroenterol Hepatol 2010; 25: 1315-1320
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 1315-1320
    • Li, Z.H.1    Tang, Q.B.2    Wang, J.3    Zhou, L.4    Huang, W.L.5    Liu, R.Y.6    Chen, R.F.7
  • 181
    • 33845436329 scopus 로고    scopus 로고
    • Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor alpha expression via activation of nuclear factor-kappaB
    • Sato Y, Kato J, Takimoto R, Takada K, Kawano Y, Miyanishi K, Kobune M, Sato Y, Takayama T, Matunaga T, Niitsu Y. Hepatitis C virus core protein promotes proliferation of human hepatoma cells through enhancement of transforming growth factor alpha expression via activation of nuclear factor-kappaB. Gut 2006; 55: 1801-1808
    • (2006) Gut , vol.55 , pp. 1801-1808
    • Sato, Y.1    Kato, J.2    Takimoto, R.3    Takada, K.4    Kawano, Y.5    Miyanishi, K.6    Kobune, M.7    Sato, Y.8    Takayama, T.9    Matunaga, T.10    Niitsu, Y.11
  • 182
    • 0030785082 scopus 로고    scopus 로고
    • Epidemiological characteristics and risk factors of hepatocellular carcinoma
    • Chen CJ, Yu MW, Liaw YF. Epidemiological characteristics and risk factors of hepatocellular carcinoma. J Gastroenterol Hepatol 1997; 12: S294-S308
    • (1997) J Gastroenterol Hepatol , vol.12
    • Chen, C.J.1    Yu, M.W.2    Liaw, Y.F.3
  • 184
    • 0042968962 scopus 로고    scopus 로고
    • Molecular viral oncology of hepatocellular carcinoma
    • Block TM, Mehta AS, Fimmel CJ, Jordan R. Molecular viral oncology of hepatocellular carcinoma. Oncogene 2003; 22: 5093-5107
    • (2003) Oncogene , vol.22 , pp. 5093-5107
    • Block, T.M.1    Mehta, A.S.2    Fimmel, C.J.3    Jordan, R.4
  • 186
    • 79953760414 scopus 로고    scopus 로고
    • Systemic treatment and targeted therapy in patients with advanced hepatocellular carcinoma
    • Taziel M, Essadi I, M'rabti H, Touyar A, Errihani PH. Systemic treatment and targeted therapy in patients with advanced hepatocellular carcinoma. N Am J Med Sci 2011; 3: 167-175
    • (2011) N Am J Med Sci , vol.3 , pp. 167-175
    • Taziel, M.1    Essadi, I.2    M'rabti, H.3    Touyar, A.4    Errihani, P.H.5
  • 187
    • 78149336711 scopus 로고    scopus 로고
    • Sunitinib in patients with advanced hepatocellular carcinoma after progression under sorafenib treatment
    • Wörns MA, Schuchmann M, Düber C, Otto G, Galle PR, Weinmann A. Sunitinib in patients with advanced hepatocellular carcinoma after progression under sorafenib treatment. Oncology 2010; 79: 85-92
    • (2010) Oncology , vol.79 , pp. 85-92
    • Wörns, M.A.1    Schuchmann, M.2    Düber, C.3    Otto, G.4    Galle, P.R.5    Weinmann, A.6
  • 196
    • 80053557082 scopus 로고    scopus 로고
    • High circulating endothelial progenitor levels associated with poor survival of advanced hepatocellular carcinoma patients receiving sorafenib combined with metronomic chemotherapy
    • Shao YY, Lin ZZ, Chen TJ, Hsu C, Shen YC, Hsu CH, Cheng AL. High circulating endothelial progenitor levels associated with poor survival of advanced hepatocellular carcinoma patients receiving sorafenib combined with metronomic chemotherapy. Oncology 2011; 81: 98-103
    • (2011) Oncology , vol.81 , pp. 98-103
    • Shao, Y.Y.1    Lin, Z.Z.2    Chen, T.J.3    Hsu, C.4    Shen, Y.C.5    Hsu, C.H.6    Cheng, A.L.7
  • 197
    • 84860249359 scopus 로고    scopus 로고
    • Sorafenib in combination with transarterial chemoembolization and bronchial arterial chemoinfusion in the treatment of hepatocellular carcinoma with pulmonary metastasis
    • Duan F, Wang MQ, Liu FY, Wang ZJ, Song P, Wang Y. Sorafenib in combination with transarterial chemoembolization and bronchial arterial chemoinfusion in the treatment of hepatocellular carcinoma with pulmonary metastasis. Asia Pac J Clin Oncol 2012; 8: 156-163
    • (2012) Asia Pac J Clin Oncol , vol.8 , pp. 156-163
    • Duan, F.1    Wang, M.Q.2    Liu, F.Y.3    Wang, Z.J.4    Song, P.5    Wang, Y.6
  • 198
    • 84863283404 scopus 로고    scopus 로고
    • Molecular targeted therapies for cancer: sorafenib mono-therapy and its combination with other therapies (review)
    • Ibrahim N, Yu Y, Walsh WR, Yang JL. Molecular targeted therapies for cancer: sorafenib mono-therapy and its combination with other therapies (review). Oncol Rep 2012; 27: 1303-1311
    • (2012) Oncol Rep , vol.27 , pp. 1303-1311
    • Ibrahim, N.1    Yu, Y.2    Walsh, W.R.3    Yang, J.L.4
  • 202
    • 58149175849 scopus 로고    scopus 로고
    • Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
    • Huynh H, Ngo VC, Fargnoli J, Ayers M, Soo KC, Koong HN, Thng CH, Ong HS, Chung A, Chow P, Pollock P, Byron S, Tran E. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. ClinCancer Res 2008; 14: 6146-6153
    • (2008) ClinCancer Res , vol.14 , pp. 6146-6153
    • Huynh, H.1    Ngo, V.C.2    Fargnoli, J.3    Ayers, M.4    Soo, K.C.5    Koong, H.N.6    Thng, C.H.7    Ong, H.S.8    Chung, A.9    Chow, P.10    Pollock, P.11    Byron, S.12    Tran, E.13
  • 203
    • 83255164275 scopus 로고    scopus 로고
    • NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma
    • Chen W, Shen X, Xia X, Xu G, Ma T, Bai X, Liang T. NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma. Liver Int 2012; 32: 70-77
    • (2012) Liver Int , vol.32 , pp. 70-77
    • Chen, W.1    Shen, X.2    Xia, X.3    Xu, G.4    Ma, T.5    Bai, X.6    Liang, T.7
  • 205
    • 84860266164 scopus 로고    scopus 로고
    • Does antiviral therapy reduce the risk of hepatocellular carcinoma in patients with chronic hepatitis C?
    • Michielsen P, Ho E, Francque S. Does antiviral therapy reduce the risk of hepatocellular carcinoma in patients with chronic hepatitis C? Minerva Gastroenterol Dietol 2012; 58: 65-79
    • (2012) Minerva Gastroenterol Dietol , vol.58 , pp. 65-79
    • Michielsen, P.1    Ho, E.2    Francque, S.3
  • 206
    • 80055065090 scopus 로고    scopus 로고
    • Sustained HCV clearance by interferon-based therapy reduces hepatocellular carcinoma in hepatitis B and C dually-infected patients
    • Hung CH, Lu SN, Wang JH, Hu TH, Chen CH, Huang CM, Lee CM. Sustained HCV clearance by interferon-based therapy reduces hepatocellular carcinoma in hepatitis B and C dually-infected patients. Antivir Ther 2011; 16: 959-968
    • (2011) Antivir Ther , vol.16 , pp. 959-968
    • Hung, C.H.1    Lu, S.N.2    Wang, J.H.3    Hu, T.H.4    Chen, C.H.5    Huang, C.M.6    Lee, C.M.7
  • 207
    • 77954478947 scopus 로고    scopus 로고
    • Interferon reduces the risk of hepatocellular carcinoma in hepatitis C virus-related chronic hepatitis/liver cirrhosis
    • Masuzaki R, Yoshida H, Omata M. Interferon reduces the risk of hepatocellular carcinoma in hepatitis C virus-related chronic hepatitis/liver cirrhosis. Oncology 2010; 78 Suppl 1: 17-23
    • (2010) Oncology , vol.78 , Issue.SUPPL. 1 , pp. 17-23
    • Masuzaki, R.1    Yoshida, H.2    Omata, M.3
  • 212
    • 20044376484 scopus 로고    scopus 로고
    • Decreased risk of hepatocellular carcinoma in patients with chronic hepatitis C whose serum alanine aminotransferase levels became less than twice the upper limit of normal following interferon therapy
    • Moriyama M, Matsumura H, Aoki H, Shimizu T, Yamagami H, Shioda A, Kaneko M, Goto I, Tanaka N, Arakawa Y. Decreased risk of hepatocellular carcinoma in patients with chronic hepatitis C whose serum alanine aminotransferase levels became less than twice the upper limit of normal following interferon therapy. Liver Int 2005; 25: 85-90
    • (2005) Liver Int , vol.25 , pp. 85-90
    • Moriyama, M.1    Matsumura, H.2    Aoki, H.3    Shimizu, T.4    Yamagami, H.5    Shioda, A.6    Kaneko, M.7    Goto, I.8    Tanaka, N.9    Arakawa, Y.10
  • 213
    • 0346731027 scopus 로고    scopus 로고
    • The impact of antiviral therapy on the course of chronic HCV infection. A systematic review
    • Almasio PL, Venezia G, Craxì A. The impact of antiviral therapy on the course of chronic HCV infection. A systematic review. Panminerva Med 2003; 45: 175-182
    • (2003) Panminerva Med , vol.45 , pp. 175-182
    • Almasio, P.L.1    Venezia, G.2    Craxì, A.3
  • 214
    • 84355162285 scopus 로고    scopus 로고
    • Hepatitis C core protein impairs insulin downstream signalling and regulatory role of IGFBP-1 expression
    • Alberstein M, Zornitzki T, Zick Y, Knobler H. Hepatitis C core protein impairs insulin downstream signalling and regulatory role of IGFBP-1 expression. J Viral Hepat 2012; 19: 65-71
    • (2012) J Viral Hepat , vol.19 , pp. 65-71
    • Alberstein, M.1    Zornitzki, T.2    Zick, Y.3    Knobler, H.4
  • 215
    • 0037430012 scopus 로고    scopus 로고
    • Focal overexpression of insulin-like growth factor 2 by hepatocytes and cholangiocytes in viral liver cirrhosis
    • Sedlaczek N, Hasilik A, Neuhaus P, Schuppan D, Herbst H. Focal overexpression of insulin-like growth factor 2 by hepatocytes and cholangiocytes in viral liver cirrhosis. Br J Cancer 2003; 88: 733-739
    • (2003) Br J Cancer , vol.88 , pp. 733-739
    • Sedlaczek, N.1    Hasilik, A.2    Neuhaus, P.3    Schuppan, D.4    Herbst, H.5
  • 218
    • 0025507639 scopus 로고
    • Minor parenting stresses with young children
    • Crnic KA, Greenberg MT. Minor parenting stresses with young children. Child Dev 1990; 61: 1628-1637
    • (1990) Child Dev , vol.61 , pp. 1628-1637
    • Crnic, K.A.1    Greenberg, M.T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.