TGF-β during human colorectal carcinogenesis: The shift from epithelial to mesenchymal signaling

Inflammopharmacology

Volumn 14, Issue 5-6, 2006, Pages 198-203

  Matsuzaki, K ^a   Seki, T ^a   Okazaki, K ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Colorectal cancer; Epithelial to mesenchymal transition (EMT); JNK; Smad

Indexed keywords

SMAD3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA;

CANCER CELL; CANCER INVASION; COLON CARCINOGENESIS; COLORECTAL CANCER; CONFERENCE PAPER; EPITHELIUM CELL; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER CELL; LIVER INJURY; MESENCHYME CELL; METASTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

ANIMALS; CELL DIFFERENTIATION; COLORECTAL NEOPLASMS; EPITHELIUM; HUMANS; MESODERM; NEOPLASM INVASIVENESS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 33845908212     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-006-1536-2     Document Type: Conference Paper

References (20)

1. Bissell, D. M., Roulot, D. and George, J. (2001). Transforming growth factor β and the liver. Hepatology 34, 859-867.
2. Derynck, R. and Zhang, Y. E. (2003). Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425, 577-584.
3. Dérijard, B., Hibi, M., Wu, I. H. et al. (1994). JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037.
4. Furukawa, F., Matsuzaki, K., Mori, S. et al. (2003). p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts. Hepatology 38, 879-889.
5. Heldin, C. H., Miyazono, K., ten Dijke, P. (1997) TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471.
6. Massagué, J. (1998). TGF-β signal transduction. Annu. Rev. Biochem. 67, 753-791.
7. Matsuzaki, K., Date, M., Furukawa, F. et al. (2000). Autocrine stimulatory mechanism by transforming growth factor β in human hepatocellular carcinoma. Cancer Res. 60, 1394-1402.
8. Matsuzaki, K. (2006). Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis. Histol. Histopathol. 21, 645-662.
9. Michalopoulos, G. K. and DeFrances, M. C. (1997). Liver regeneration. Science 276, 60-66.
10. Mori, S., Matsuzaki, K., Yoshida, K. et al. (2004). TGF-β and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions. Oncogene 23, 7416-7429.
11. Moses, H. L., Yang, E. Y. and Pietenpol, J. A. (1990). TGF-β stimulation and inhibition of cell proliferation: new mechanistic insights. Cell 63, 245-247.
12. Mulder, K. M. (2000). Role of Ras and Mapks in TGF-β signaling. Cytokine Growth Factor Rev. 11, 23-35.
13. Roberts, A. B. and Sporn, M. B. (2000). The Transforming Growth Factor-βs, In: Peptide Growth Factors and their receptors-Handbook of Experimental Pharmacology, Sporn, M. B. and Roberts, A. B. (Eds), pp. 419-472. Springer, Heidelberg, Germany.
14. Saika, S., Kono-Saika, S., Ohnishi, Y. et al. (2004). Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury. Am. J. Pathol. 164, 651-663.
15. Vogelstein, B., Fearon, E. R., Hamilton, S. R. et al. (1988). Genetic alterations during colorectal-tumor development. N. Engl. J. Med. 319, 525-532.
16. Wrana, J. L. (2000). Crossing Smads. Sci. STKE. 23, RE1.
17. Yamagata, H., Matsuzaki, K., Mori, S. et al. (2005). Acceleration of Smad2 and Smad3 phosphorylation via c-Jun NH(2)-terminal kinase during human colorectal carcinogenesis. Cancer Res. 65, 157-165.
18. Yang, C., Zeisberg, M., Mosterman, B. et al. (2003). Liver fibrosis: insights into migration of hepatic stellate cells in response to extracellular matrix and growth factors. Gastroenterology 124, 147-159.
19. Yoshida, K., Matsuzaki, K., Mori, S. et al. (2005). Transforming growth factor-β and platelet-derived growth factor signal via c-Jun N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury. Am. J. Pathol. 66, 1029-1039.
20. Zavadil, J. and Bottinger, E. P. (2005). TGF-β and epithelial-to-mesenchymal transitions. Oncogene 24, 5764-5774.