메뉴 건너뛰기




Volumn 6, Issue 9, 2011, Pages

Gene signatures derived from a c-MET-driven liver cancer mouse model predict survival of patients with hepatocellular carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; SCATTER FACTOR RECEPTOR; WNT PROTEIN; TRANSCRIPTOME;

EID: 80052841535     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024582     Document Type: Article
Times cited : (30)

References (41)
  • 2
    • 1242307281 scopus 로고    scopus 로고
    • Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome
    • Poon RT, Fan ST, (2004) Hepatectomy for hepatocellular carcinoma: patient selection and postoperative outcome. Liver Transpl 10: S39-45.
    • (2004) Liver Transpl , vol.10 , pp. 39-45
    • Poon, R.T.1    Fan, S.T.2
  • 3
    • 71549154370 scopus 로고    scopus 로고
    • Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parameters
    • Hao K, Luk JM, Lee NP, Mao M, Zhang C, et al. (2009) Predicting prognosis in hepatocellular carcinoma after curative surgery with common clinicopathologic parameters. BMC Cancer 9: 389.
    • (2009) BMC Cancer , vol.9 , pp. 389
    • Hao, K.1    Luk, J.M.2    Lee, N.P.3    Mao, M.4    Zhang, C.5
  • 4
    • 67649314730 scopus 로고    scopus 로고
    • Genomic and proteomic biomarkers for diagnosis and prognosis of hepatocellular carcinoma
    • Lee NP, Cheung ST, Poon RT, Fan ST, Luk JM, (2007) Genomic and proteomic biomarkers for diagnosis and prognosis of hepatocellular carcinoma. Biomarkers in medicine 1: 273-284.
    • (2007) Biomarkers in Medicine , vol.1 , pp. 273-284
    • Lee, N.P.1    Cheung, S.T.2    Poon, R.T.3    Fan, S.T.4    Luk, J.M.5
  • 6
    • 79952532529 scopus 로고    scopus 로고
    • AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma
    • Xu MZ, Chan SW, Liu AM, Wong KF, Fan ST, et al. (2011) AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma. Oncogene 30: 1229-1240.
    • (2011) Oncogene , vol.30 , pp. 1229-1240
    • Xu, M.Z.1    Chan, S.W.2    Liu, A.M.3    Wong, K.F.4    Fan, S.T.5
  • 7
    • 70349295967 scopus 로고    scopus 로고
    • Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma
    • Xu MZ, Yao TJ, Lee NP, Ng IO, Chan YT, et al. (2009) Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma. Cancer 115: 4576-4585.
    • (2009) Cancer , vol.115 , pp. 4576-4585
    • Xu, M.Z.1    Yao, T.J.2    Lee, N.P.3    Ng, I.O.4    Chan, Y.T.5
  • 8
    • 77950647292 scopus 로고    scopus 로고
    • Proteomics of hepatocellular carcinoma: serum vimentin as a surrogate marker for small tumors (
    • Sun S, Poon RT, Lee NP, Yeung C, Chan KL, et al. (2010) Proteomics of hepatocellular carcinoma: serum vimentin as a surrogate marker for small tumors (
    • (2010) Journal of Proteome Research , vol.9 , pp. 1923-1930
    • Sun, S.1    Poon, R.T.2    Lee, N.P.3    Yeung, C.4    Chan, K.L.5
  • 9
    • 79956126873 scopus 로고    scopus 로고
    • Proteomics of hepatocellular carcinoma in Chinese patients
    • Luk JM, Liu AM, (2011) Proteomics of hepatocellular carcinoma in Chinese patients. Omics: a journal of integrative biology 15: 261-266.
    • (2011) Omics: A Journal of Integrative Biology , vol.15 , pp. 261-266
    • Luk, J.M.1    Liu, A.M.2
  • 11
    • 54449083925 scopus 로고    scopus 로고
    • Molecular targeted therapies in hepatocellular carcinoma
    • Llovet JM, Bruix J, (2008) Molecular targeted therapies in hepatocellular carcinoma. Hepatology 48: 1312-1327.
    • (2008) Hepatology , vol.48 , pp. 1312-1327
    • Llovet, J.M.1    Bruix, J.2
  • 12
    • 56349121125 scopus 로고    scopus 로고
    • An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer
    • Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, et al. (2008) An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell 135: 852-864.
    • (2008) Cell , vol.135 , pp. 852-864
    • Zender, L.1    Xue, W.2    Zuber, J.3    Semighini, C.P.4    Krasnitz, A.5
  • 14
    • 72949084408 scopus 로고    scopus 로고
    • Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma
    • Liu LX, Lee NP, Chan VW, Xue W, Zender L, et al. (2009) Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology 50: 1453-1463.
    • (2009) Hepatology , vol.50 , pp. 1453-1463
    • Liu, L.X.1    Lee, N.P.2    Chan, V.W.3    Xue, W.4    Zender, L.5
  • 15
    • 34548217651 scopus 로고    scopus 로고
    • Maximizing mouse cancer models
    • Frese KK, Tuveson DA, (2007) Maximizing mouse cancer models. Nat Rev Cancer 7: 645-658.
    • (2007) Nat Rev Cancer , vol.7 , pp. 645-658
    • Frese, K.K.1    Tuveson, D.A.2
  • 16
    • 33644746131 scopus 로고    scopus 로고
    • Comparison of gene expression and DNA copy number changes in a murine model of lung cancer
    • Sweet-Cordero A, Tseng GC, You H, Douglass M, Huey B, et al. (2006) Comparison of gene expression and DNA copy number changes in a murine model of lung cancer. Genes Chromosomes Cancer 45: 338-348.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 338-348
    • Sweet-Cordero, A.1    Tseng, G.C.2    You, H.3    Douglass, M.4    Huey, B.5
  • 18
    • 0035947770 scopus 로고    scopus 로고
    • Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice
    • Wang R, Ferrell LD, Faouzi S, Maher JJ, Bishop JM, (2001) Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice. J Cell Biol 153: 1023-1034.
    • (2001) J Cell Biol , vol.153 , pp. 1023-1034
    • Wang, R.1    Ferrell, L.D.2    Faouzi, S.3    Maher, J.J.4    Bishop, J.M.5
  • 19
    • 35548966020 scopus 로고    scopus 로고
    • Distinct pathways of genomic progression to benign and malignant tumors of the liver
    • Tward AD, Jones KD, Yant S, Cheung ST, Fan ST, et al. (2007) Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A 104: 14771-14776.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 14771-14776
    • Tward, A.D.1    Jones, K.D.2    Yant, S.3    Cheung, S.T.4    Fan, S.T.5
  • 20
    • 34047210411 scopus 로고    scopus 로고
    • TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer
    • Hussain SP, Schwank J, Staib F, Wang XW, Harris CC, (2007) TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene 26: 2166-2176.
    • (2007) Oncogene , vol.26 , pp. 2166-2176
    • Hussain, S.P.1    Schwank, J.2    Staib, F.3    Wang, X.W.4    Harris, C.C.5
  • 21
    • 53549102755 scopus 로고    scopus 로고
    • The tumor microenvironment and its role in promoting tumor growth
    • Whiteside TL, (2008) The tumor microenvironment and its role in promoting tumor growth. Oncogene 27: 5904-5912.
    • (2008) Oncogene , vol.27 , pp. 5904-5912
    • Whiteside, T.L.1
  • 22
    • 34247611828 scopus 로고    scopus 로고
    • Microarray-based analysis for hepatocellular carcinoma: from gene expression profiling to new challenges
    • Midorikawa Y, Makuuchi M, Tang W, Aburatani H, (2007) Microarray-based analysis for hepatocellular carcinoma: from gene expression profiling to new challenges. World J Gastroenterol 13: 1487-1492.
    • (2007) World J Gastroenterol , vol.13 , pp. 1487-1492
    • Midorikawa, Y.1    Makuuchi, M.2    Tang, W.3    Aburatani, H.4
  • 23
    • 33745577640 scopus 로고    scopus 로고
    • Comparative and integrative functional genomics of HCC
    • Lee JS, Thorgeirsson SS, (2006) Comparative and integrative functional genomics of HCC. Oncogene 25: 3801-3809.
    • (2006) Oncogene , vol.25 , pp. 3801-3809
    • Lee, J.S.1    Thorgeirsson, S.S.2
  • 24
    • 80052245751 scopus 로고    scopus 로고
    • DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stem-like subtype of hepatocellular carcinoma associated with poor survival
    • In Press
    • Luk JM, Burchard J, Zhang C, Liu AM, Wong KF, et al. (2011) DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stem-like subtype of hepatocellular carcinoma associated with poor survival. J Biol Chem In Press.
    • (2011) J Biol Chem
    • Luk, J.M.1    Burchard, J.2    Zhang, C.3    Liu, A.M.4    Wong, K.F.5
  • 25
    • 39749200037 scopus 로고    scopus 로고
    • Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence
    • Yi X, Luk JM, Lee NP, Peng J, Leng X, et al. (2008) Association of mortalin (HSPA9) with liver cancer metastasis and prediction for early tumor recurrence. Mol Cell Proteomics 7: 315-325.
    • (2008) Mol Cell Proteomics , vol.7 , pp. 315-325
    • Yi, X.1    Luk, J.M.2    Lee, N.P.3    Peng, J.4    Leng, X.5
  • 26
    • 79960000200 scopus 로고    scopus 로고
    • Predictive Genes in Adjacent Normal Tissue Are Preferentially Altered by sCNV during Tumorigenesis in Liver Cancer and May Rate Limiting
    • Lamb JR, Zhang C, Xie T, Wang K, Zhang B, et al. (2011) Predictive Genes in Adjacent Normal Tissue Are Preferentially Altered by sCNV during Tumorigenesis in Liver Cancer and May Rate Limiting. PloS one 6: e20090.
    • (2011) PloS One , vol.6
    • Lamb, J.R.1    Zhang, C.2    Xie, T.3    Wang, K.4    Zhang, B.5
  • 27
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, et al. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102: 15545-15550.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.K.3    Mukherjee, S.4    Ebert, B.L.5
  • 28
    • 77950341123 scopus 로고    scopus 로고
    • Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials
    • Juul N, Szallasi Z, Eklund AC, Li Q, Burrell RA, et al. (2010) Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials. Lancet Oncol 11: 358-365.
    • (2010) Lancet Oncol , vol.11 , pp. 358-365
    • Juul, N.1    Szallasi, Z.2    Eklund, A.C.3    Li, Q.4    Burrell, R.A.5
  • 29
    • 34347219009 scopus 로고    scopus 로고
    • Metagene projection for cross-platform, cross-species characterization of global transcriptional states
    • Tamayo P, Scanfeld D, Ebert BL, Gillette MA, Roberts CW, et al. (2007) Metagene projection for cross-platform, cross-species characterization of global transcriptional states. Proc Natl Acad Sci U S A 104: 5959-5964.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 5959-5964
    • Tamayo, P.1    Scanfeld, D.2    Ebert, B.L.3    Gillette, M.A.4    Roberts, C.W.5
  • 30
    • 0034069495 scopus 로고    scopus 로고
    • Gene ontology: tool for the unification of biology. The Gene Ontology Consortium
    • Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, et al. (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25: 25-29.
    • (2000) Nat Genet , vol.25 , pp. 25-29
    • Ashburner, M.1    Ball, C.A.2    Blake, J.A.3    Botstein, D.4    Butler, H.5
  • 32
    • 77956407882 scopus 로고    scopus 로고
    • HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology
    • Gille C, Bolling C, Hoppe A, Bulik S, Hoffmann S, et al. (2010) HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. Mol Syst Biol 6: 411.
    • (2010) Mol Syst Biol , vol.6 , pp. 411
    • Gille, C.1    Bolling, C.2    Hoppe, A.3    Bulik, S.4    Hoffmann, S.5
  • 33
    • 77956417789 scopus 로고    scopus 로고
    • Computational reconstruction of tissue-specific metabolic models: application to human liver metabolism
    • Jerby L, Shlomi T, Ruppin E, (2010) Computational reconstruction of tissue-specific metabolic models: application to human liver metabolism. Mol Syst Biol 6: 401.
    • (2010) Mol Syst Biol , vol.6 , pp. 401
    • Jerby, L.1    Shlomi, T.2    Ruppin, E.3
  • 34
    • 58249087390 scopus 로고    scopus 로고
    • New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening
    • Major MB, Roberts BS, Berndt JD, Marine S, Anastas J, et al. (2008) New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Sci Signal 1: ra12.
    • (2008) Sci Signal , vol.1
    • Major, M.B.1    Roberts, B.S.2    Berndt, J.D.3    Marine, S.4    Anastas, J.5
  • 35
    • 40949086754 scopus 로고    scopus 로고
    • Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells
    • Kim M, Lee HC, Tsedensodnom O, Hartley R, Lim YS, et al. (2008) Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol 48: 780-791.
    • (2008) J Hepatol , vol.48 , pp. 780-791
    • Kim, M.1    Lee, H.C.2    Tsedensodnom, O.3    Hartley, R.4    Lim, Y.S.5
  • 36
    • 60549106714 scopus 로고    scopus 로고
    • Identification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses
    • Chau BN, Diaz RL, Saunders MA, Cheng C, Chang AN, et al. (2009) Identification of SULF2 as a novel transcriptional target of p53 by use of integrated genomic analyses. Cancer Res 69: 1368-1374.
    • (2009) Cancer Res , vol.69 , pp. 1368-1374
    • Chau, B.N.1    Diaz, R.L.2    Saunders, M.A.3    Cheng, C.4    Chang, A.N.5
  • 37
    • 9644254191 scopus 로고    scopus 로고
    • Application of comparative functional genomics to identify best-fit mouse models to study human cancer
    • Lee JS, Chu IS, Mikaelyan A, Calvisi DF, Heo J, et al. (2004) Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Nat Genet 36: 1306-1311.
    • (2004) Nat Genet , vol.36 , pp. 1306-1311
    • Lee, J.S.1    Chu, I.S.2    Mikaelyan, A.3    Calvisi, D.F.4    Heo, J.5
  • 39
    • 0027393921 scopus 로고
    • Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma
    • Nishida N, Fukuda Y, Kokuryu H, Toguchida J, Yandell DW, et al. (1993) Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma. Cancer Res 53: 368-372.
    • (1993) Cancer Res , vol.53 , pp. 368-372
    • Nishida, N.1    Fukuda, Y.2    Kokuryu, H.3    Toguchida, J.4    Yandell, D.W.5
  • 40
    • 33745220780 scopus 로고    scopus 로고
    • Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
    • Kaposi-Novak P, Lee JS, Gomez-Quiroz L, Coulouarn C, Factor VM, et al. (2006) Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. J Clin Invest 116: 1582-1595.
    • (2006) J Clin Invest , vol.116 , pp. 1582-1595
    • Kaposi-Novak, P.1    Lee, J.S.2    Gomez-Quiroz, L.3    Coulouarn, C.4    Factor, V.M.5
  • 41
    • 77956249298 scopus 로고    scopus 로고
    • microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma
    • Burchard J, Zhang C, Liu AM, Poon RT, Lee NP, et al. (2010) microRNA-122 as a regulator of mitochondrial metabolic gene network in hepatocellular carcinoma. Mol Syst Biol 6: 402.
    • (2010) Mol Syst Biol , vol.6 , pp. 402
    • Burchard, J.1    Zhang, C.2    Liu, A.M.3    Poon, R.T.4    Lee, N.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.