메뉴 건너뛰기




Volumn 27, Issue 5, 2012, Pages 1303-1311

Molecular targeted therapies for cancer: Sorafenib monotherapy and its combination with other therapies (Review)

Author keywords

Cancer; Combination therapy; Review; Sorafenib; Targeted therapy

Indexed keywords

ALPHA INTERFERON; ALPHA2A INTERFERON; ALPHA2B INTERFERON; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CISPLATIN; DACARBAZINE; DOCETAXEL; DOXORUBICIN; ERLOTINIB; EVEROLIMUS; GEFITINIB; GEMCITABINE; INTERLEUKIN 2; IRINOTECAN; LETROZOLE; PACLITAXEL; PEGINTERFERON ALPHA2B; PLACEBO; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN MCL 1; RAF PROTEIN; SORAFENIB; TEMOZOLOMIDE; TIPIFARNIB; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

EID: 84863283404     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1675     Document Type: Review
Times cited : (94)

References (60)
  • 2
    • 51049098909 scopus 로고    scopus 로고
    • Selected combination therapy with sorafenib: A review of clinical data and perspectives in advanced solid tumors
    • Dal Lago L, D'Hondt V and Awada A: Selected combination therapy with sorafenib: a review of clinical data and perspectives in advanced solid tumors. Oncologist 13: 845-858, 2008.
    • (2008) Oncologist , vol.13 , pp. 845-858
    • Dal Lago, L.1    D'Hondt, V.2    Awada, A.3
  • 3
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • DOI 10.1158/0008-5472.CAN-06-1377
    • Liu L, Cao Y, Chen C, et al: Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tum or angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 66: 11851-11858, 2006. (Pubitemid 46094197)
    • (2006) Cancer Research , vol.66 , Issue.24 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3    Zhang, X.4    McNabola, A.5    Wilkie, D.6    Wilhelm, S.7    Lynch, M.8    Carter, C.9
  • 4
    • 36549055697 scopus 로고    scopus 로고
    • Will targeted therapy hold its promise? An evidence-based review
    • DOI 10.1097/CCO.0b013e3282f44b12, PII 0000162220080100000016
    • Murdoch D and Sager J: Will targeted therapy hold its promise? An evidence-based review. Curr Opin Oncol 20: 104-111, 2008. (Pubitemid 350190989)
    • (2008) Current Opinion in Oncology , vol.20 , Issue.1 , pp. 104-111
    • Murdoch, D.1    Sager, J.2
  • 5
    • 55749088393 scopus 로고    scopus 로고
    • Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
    • Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM and Lynch M: Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 7: 3129-3140, 2008.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3129-3140
    • Wilhelm, S.M.1    Adnane, L.2    Newell, P.3    Villanueva, A.4    Llovet, J.M.5    Lynch, M.6
  • 6
    • 43749110700 scopus 로고    scopus 로고
    • Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: A report from the 11715 Study Group
    • McDermott DF, Sosman JA, Gonzalez R, et al: Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group. J Clin Oncol 26: 2178-2185, 2008.
    • (2008) J Clin Oncol , vol.26 , pp. 2178-2185
    • McDermott, D.F.1    Sosman, J.A.2    Gonzalez, R.3
  • 8
    • 34248386965 scopus 로고    scopus 로고
    • Challenges for patient selection with VEGF inhibitors
    • DOI 10.1007/s00280-006-0403-6
    • Longo R and Gasparini G: Challenges for patient selection with VEGF inhibitors. Cancer Chemother Pharmacol 60: 151-170, 2007. (Pubitemid 46742547)
    • (2007) Cancer Chemotherapy and Pharmacology , vol.60 , Issue.2 , pp. 151-170
    • Longo, R.1    Gasparini, G.2
  • 12
    • 78649312166 scopus 로고    scopus 로고
    • Impact of sorafenib on health-related quality of life in Japanese patients with metastatic renal cell carcinoma: A prospective evaluation
    • Miyake H, Kurahashi T, Yamanaka K, et al: Impact of sorafenib on health-related quality of life in Japanese patients with metastatic renal cell carcinoma: a prospective evaluation. BJU Int 106: 1643-1647, 2010.
    • (2010) BJU Int , vol.106 , pp. 1643-1647
    • Miyake, H.1    Kurahashi, T.2    Yamanaka, K.3
  • 13
    • 34250026980 scopus 로고    scopus 로고
    • Effects of sorafenib on symptoms and quality of life: Results from a large randomized placebo-controlled study in renal cancer
    • DOI 10.1097/01.coc.0000258732.80710.05, PII 0000042120070600000002
    • Bukowski R, Cella D, Gondek K and Escudier B; Sorafenib TARGETs Clinical Trial Group: Effects of sorafenib on symptoms and quality of life: results from a large randomized placebo-controlled study in renal cancer. Am J Clin Oncol 30: 220-227, 2007. (Pubitemid 46884139)
    • (2007) American Journal of Clinical Oncology: Cancer Clinical Trials , vol.30 , Issue.3 , pp. 220-227
    • Bukowski, R.1    Cella, D.2    Gondek, K.3    Escudier, B.4
  • 14
    • 77953689504 scopus 로고    scopus 로고
    • The present and the future landscape of treatment of advanced hepatocellular carcinoma
    • Rimassa L and Santoro A: The present and the future landscape of treatment of advanced hepatocellular carcinoma. Dig Liver Dis 42: S273-S280, 2010.
    • (2010) Dig Liver Dis , vol.42
    • Rimassa, L.1    Santoro, A.2
  • 15
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z, et al: Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 10: 25-34, 2009.
    • (2009) Lancet Oncol , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 16
    • 78651412820 scopus 로고    scopus 로고
    • Sorafenib: Activity and clinical application in patients with hepatocellular carcinoma
    • Guan YS and He Q: Sorafenib: activity and clinical application in patients with hepatocellular carcinoma. Exp Opin Pharmacother 12: 303-313, 2011.
    • (2011) Exp Opin Pharmacother , vol.12 , pp. 303-313
    • Guan, Y.S.1    He, Q.2
  • 17
    • 79960348649 scopus 로고    scopus 로고
    • An investigation of the effect of sorafenib on tumour growth and recurrence after liver cancer resection in nude mice independent of phosphorylated extracellular signal-regulated kinase levels
    • Wang Z, Hu J, Qiu SJ, et al: An investigation of the effect of sorafenib on tumour growth and recurrence after liver cancer resection in nude mice independent of phosphorylated extracellular signal-regulated kinase levels. Exp Opin Invest Drugs 20: 1039-1045, 2011.
    • (2011) Exp Opin Invest Drugs , vol.20 , pp. 1039-1045
    • Wang, Z.1    Hu, J.2    Qiu, S.J.3
  • 19
    • 50649095250 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in advanced thyroid cancer
    • Gupta-Abramson V, Troxel AB, Nellore A, et al: Phase II trial of sorafenib in advanced thyroid cancer. J Clin Oncol 26: 4714-4719, 2008.
    • (2008) J Clin Oncol , vol.26 , pp. 4714-4719
    • Gupta-Abramson, V.1    Troxel, A.B.2    Nellore, A.3
  • 21
    • 79959560621 scopus 로고    scopus 로고
    • Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma
    • Fedorenko IV, Paraiso KH and Smalley KS: Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma. Biochem Pharmacol 82: 201-209, 2011.
    • (2011) Biochem Pharmacol , vol.82 , pp. 201-209
    • Fedorenko, I.V.1    Paraiso, K.H.2    Smalley, K.S.3
  • 22
    • 49249113484 scopus 로고    scopus 로고
    • Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity
    • Azad NS, Posadas EM, Kwitkowski VE, et al: Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. J Clin Oncol 26: 3709-3714, 2008.
    • (2008) J Clin Oncol , vol.26 , pp. 3709-3714
    • Azad, N.S.1    Posadas, E.M.2    Kwitkowski, V.E.3
  • 23
    • 76349087360 scopus 로고    scopus 로고
    • Combination therapy: Intermittent sorafenib with bevacizumab yields activity and decreased toxicity
    • Lee JM, Sarosy GA, Annunziata CM, et al: Combination therapy: intermittent sorafenib with bevacizumab yields activity and decreased toxicity. Br J Cancer 102: 495-499, 2010.
    • (2010) Br J Cancer , vol.102 , pp. 495-499
    • Lee, J.M.1    Sarosy, G.A.2    Annunziata, C.M.3
  • 25
    • 79959306917 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small cell lung cancer
    • Spigel DR, Burris HA III, Greco FA, et al: Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small cell lung cancer. J Clin Oncol 29: 2582-2589, 2011.
    • (2011) J Clin Oncol , vol.29 , pp. 2582-2589
    • Spigel, D.R.1    Burris III, H.A.2    Greco, F.A.3
  • 26
    • 77958058348 scopus 로고    scopus 로고
    • Synergistic antitumor activity of sorafenib in combination with epidermal growth factor receptor inhibitors in colorectal and lung cancer cells
    • Martinelli E, Troiani T, Morgillo F, et al: Synergistic antitumor activity of sorafenib in combination with epidermal growth factor receptor inhibitors in colorectal and lung cancer cells. Clin Cancer Res 16: 4990-5001, 2010.
    • (2010) Clin Cancer Res , vol.16 , pp. 4990-5001
    • Martinelli, E.1    Troiani, T.2    Morgillo, F.3
  • 29
    • 79959736969 scopus 로고    scopus 로고
    • Sorafenib and pegylated interferon-α2b in advanced metastatic melanoma: A multicenter phase II DeCOG trial
    • Egberts F, Gutzmer R, Ugurel S, et al: Sorafenib and pegylated interferon-α2b in advanced metastatic melanoma: a multicenter phase II DeCOG trial. Ann Oncol 22: 1667-1674, 2011.
    • (2011) Ann Oncol , vol.22 , pp. 1667-1674
    • Egberts, F.1    Gutzmer, R.2    Ugurel, S.3
  • 30
    • 33646204716 scopus 로고    scopus 로고
    • Results of a Phase I trial of sorafenib (BAY 43-9006) in combination with doxorubicin in patients with refractory solid tumors
    • Richly H, Henning BF, Kupsch P, et al: Results of a Phase I trial of sorafenib (BAY 43-9006) in combination with doxorubicin in patients with refractory solid tumors. Ann Oncol 17: 866-873, 2006.
    • (2006) Ann Oncol , vol.17 , pp. 866-873
    • Richly, H.1    Henning, B.F.2    Kupsch, P.3
  • 31
    • 78349298645 scopus 로고    scopus 로고
    • Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: A randomized trial
    • Abou-Alfa GK, Johnson P, Knox JJ, et al: Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA 304: 2154-2160, 2010.
    • (2010) JAMA , vol.304 , pp. 2154-2160
    • Abou-Alfa, G.K.1    Johnson, P.2    Knox, J.J.3
  • 32
    • 77954574658 scopus 로고    scopus 로고
    • Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203
    • Sun W, Powell M, O'Dwyer PJ, Catalano P, Ansari RH and Benson AB III: Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203. J Clin Oncol 28: 2947-2951, 2010.
    • (2010) J Clin Oncol , vol.28 , pp. 2947-2951
    • Sun, W.1    Powell, M.2    O'Dwyer, P.J.3    Catalano, P.4    Ansari, R.H.5    Benson III, A.B.6
  • 33
    • 78549289509 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer
    • Okamoto I, Miyazaki M, Morinaga R, et al: Phase I clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer. Invest New Drugs 28: 844-853, 2010.
    • (2010) Invest New Drugs , vol.28 , pp. 844-853
    • Okamoto, I.1    Miyazaki, M.2    Morinaga, R.3
  • 34
    • 33748901860 scopus 로고    scopus 로고
    • Sorafenib combined with carboplatin/paclitaxel for advanced non-small cell lung cancer: A phase I subset analysis
    • Schiller JH, Flaherty KT, Redlinger M, et al: Sorafenib combined with carboplatin/paclitaxel for advanced non-small cell lung cancer: a phase I subset analysis. J Clin Oncol 24: 7194, 2006.
    • (2006) J Clin Oncol , vol.24 , pp. 7194
    • Schiller, J.H.1    Flaherty, K.T.2    Redlinger, M.3
  • 35
    • 67649909568 scopus 로고    scopus 로고
    • Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
    • Hauschild A, Agarwala SS, Trefzer U, et al: Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 27: 2823-2830, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 2823-2830
    • Hauschild, A.1    Agarwala, S.S.2    Trefzer, U.3
  • 36
    • 77950312919 scopus 로고    scopus 로고
    • Activity of a multitargeted chemo-switch regimen (sorafenib, gemcitabine, and metronomic capecitabine) in metastatic renal-cell carcinoma: A phase 2 study (SOGUG-02-06)
    • Bellmunt J, Trigo JM, Calvo E, et al: Activity of a multitargeted chemo-switch regimen (sorafenib, gemcitabine, and metronomic capecitabine) in metastatic renal-cell carcinoma: a phase 2 study (SOGUG-02-06). Lancet Oncol 11: 350-357, 2010.
    • (2010) Lancet Oncol , vol.11 , pp. 350-357
    • Bellmunt, J.1    Trigo, J.M.2    Calvo, E.3
  • 37
    • 77955904732 scopus 로고    scopus 로고
    • Sorafenib and radiation: A promising combination in colorectal cancer
    • Suen AW, Galoforo S, Marples B, et al: Sorafenib and radiation: a promising combination in colorectal cancer. Int J Radiat Oncol Biol Phys 78: 213-220, 2010.
    • (2010) Int J Radiat Oncol Biol Phys , vol.78 , pp. 213-220
    • Suen, A.W.1    Galoforo, S.2    Marples, B.3
  • 38
    • 16644397086 scopus 로고    scopus 로고
    • The role of Raf-1 in radiation resistance of human hepatocellular carcinoma Hep G2 cells
    • Tang WY, Chau SP, Tsang WP, Kong SK and Kwok TT: The role of Raf-1 in radiation resistance of human hepatocellular carcinoma Hep G2 cells. Oncol Rep 12: 1349-1354, 2004.
    • (2004) Oncol Rep , vol.12 , pp. 1349-1354
    • Tang, W.Y.1    Chau, S.P.2    Tsang, W.P.3    Kong, S.K.4    Kwok, T.T.5
  • 41
    • 0036401105 scopus 로고    scopus 로고
    • BAY 43-9006: Preclinical data
    • DOI 10.2174/1381612023393026
    • Wilhelm S and Chien DS: BAY 43-9006: preclinical data. Curr Pharm Des 8: 2255-2257, 2002. (Pubitemid 35189898)
    • (2002) Current Pharmaceutical Design , vol.8 , Issue.25 , pp. 2255-2257
    • Wilhelm, S.1    Chien, D.-S.2
  • 42
    • 16844362816 scopus 로고    scopus 로고
    • V599EB-Raf regulates growth and vascular development of malignant melanoma tumors
    • DOI 10.1158/0008-5472.CAN-04-2423
    • Sharma A, Trivedi NR, Zimmerman MA, Tuveson DA, Smith CD and Robertson GP: Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res 65: 2412-2421, 2005. (Pubitemid 40490153)
    • (2005) Cancer Research , vol.65 , Issue.6 , pp. 2412-2421
    • Sharma, A.1    Trivedi, N.R.2    Zimmerman, M.A.3    Tuveson, D.A.4    Smith, C.D.5    Robertson, G.P.6
  • 43
    • 65549142508 scopus 로고    scopus 로고
    • Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines
    • Ulivi P, Arienti C, Amadori D, et al: Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines. J Cell Physiol 220: 214-221, 2009.
    • (2009) J Cell Physiol , vol.220 , pp. 214-221
    • Ulivi, P.1    Arienti, C.2    Amadori, D.3
  • 44
    • 78851468826 scopus 로고    scopus 로고
    • Multikinase inhibitor sorafenib exerts cytocidal efficacy against Non-Hodgkin lymphomas associated with inhibition of MAPK14 and AKT phosphorylation
    • Chapuy B, Schuelper N, Panse M, et al: Multikinase inhibitor sorafenib exerts cytocidal efficacy against Non-Hodgkin lymphomas associated with inhibition of MAPK14 and AKT phosphorylation. Br J Haematol 152: 401-412, 2011.
    • (2011) Br J Haematol , vol.152 , pp. 401-412
    • Chapuy, B.1    Schuelper, N.2    Panse, M.3
  • 45
    • 79955809893 scopus 로고    scopus 로고
    • Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1
    • Huber S, Oelsner M, Decker T, et al: Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia 25: 838-847, 2011.
    • (2011) Leukemia , vol.25 , pp. 838-847
    • Huber, S.1    Oelsner, M.2    Decker, T.3
  • 46
    • 70349304196 scopus 로고    scopus 로고
    • Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer
    • Blumenschein GR Jr, Gatzemeier U, Fossella F, et al: Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer. J Clin Oncol 27: 4274-4280, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 4274-4280
    • Blumenschein Jr., G.R.1    Gatzemeier, U.2    Fossella, F.3
  • 47
    • 79960343099 scopus 로고    scopus 로고
    • Long-term safety and tolerability of sorafenib in patients with advanced non-small cell lung cancer: A case-based review
    • Adjei AA, Blumenschein GR Jr, Mandrekar S, Hillman S, Gatzemeier U and Heigener D: Long-term safety and tolerability of sorafenib in patients with advanced non-small cell lung cancer: a case-based review. Clin Lung Cancer 12: 212-217, 2011.
    • (2011) Clin Lung Cancer , vol.12 , pp. 212-217
    • Adjei, A.A.1    Blumenschein Jr., G.R.2    Mandrekar, S.3    Hillman, S.4    Gatzemeier, U.5    Heigener, D.6
  • 49
    • 67650293850 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with metastatic or recurrent sarcomas
    • Maki RG, D'Adamo DR, Keohan ML, et al: Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. J Clin Oncol 27: 3133-3140, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 3133-3140
    • Maki, R.G.1    D'Adamo, D.R.2    Keohan, M.L.3
  • 51
    • 74249098818 scopus 로고    scopus 로고
    • Sorafenib in patients with advanced biliary tract carcinoma: A phase II trial
    • Bengala C, Bertolini F, Malavasi N, et al: Sorafenib in patients with advanced biliary tract carcinoma: a phase II trial. Br J Cancer 102: 68-72, 2009.
    • (2009) Br J Cancer , vol.102 , pp. 68-72
    • Bengala, C.1    Bertolini, F.2    Malavasi, N.3
  • 52
    • 77949337347 scopus 로고    scopus 로고
    • A Phase II study of sorafenib in advanced uterine carcinoma/ carcinosarcoma: A trial of the Chicago, PMH, and California Phase II Consortia
    • Nimeiri HS, Oza AM, Morgan RJ, et al: A Phase II study of sorafenib in advanced uterine carcinoma/carcinosarcoma: a trial of the Chicago, PMH, and California Phase II Consortia. Gynecol Oncol 117: 37-40, 2010.
    • (2010) Gynecol Oncol , vol.117 , pp. 37-40
    • Nimeiri, H.S.1    Oza, A.M.2    Morgan, R.J.3
  • 53
    • 72549092909 scopus 로고    scopus 로고
    • Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies
    • Hong DS, Sebti SM, Newman RA, et al: Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies. Clin Cancer Res 15: 7061-7068, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 7061-7068
    • Hong, D.S.1    Sebti, S.M.2    Newman, R.A.3
  • 55
    • 79954438593 scopus 로고    scopus 로고
    • Sorafenib with interleukin- 2 vs sorafenib alone in metastatic renal cell carcinoma: The ROSORC trial
    • Procopio G, Verzoni E, Bracarda S, et al: Sorafenib with interleukin- 2 vs sorafenib alone in metastatic renal cell carcinoma: the ROSORC trial. Br J Cancer 104: 1256-1261, 2011.
    • (2011) Br J Cancer , vol.104 , pp. 1256-1261
    • Procopio, G.1    Verzoni, E.2    Bracarda, S.3
  • 56
    • 77957702355 scopus 로고    scopus 로고
    • Synergistic activity of letrozole and sorafenib on breast cancer cells
    • Bonelli MA, Fumarola C, Alfieri RR, et al: Synergistic activity of letrozole and sorafenib on breast cancer cells. Breast Cancer Res Treat 124: 79-88, 2010.
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 79-88
    • Bonelli, M.A.1    Fumarola, C.2    Alfieri, R.R.3
  • 57
    • 79958742182 scopus 로고    scopus 로고
    • Everolimus augments the effects of sorafenib in a syngeneic orthotopic model of hepatocellular carcinoma
    • Piguet AC, Saar B, Hlushchuk R, et al: Everolimus augments the effects of sorafenib in a syngeneic orthotopic model of hepatocellular carcinoma. Mol Cancer Ther 10: 1007-1017, 2011.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1007-1017
    • Piguet, A.C.1    Saar, B.2    Hlushchuk, R.3
  • 58
    • 79960848073 scopus 로고    scopus 로고
    • Sorafenib and dacarbazine as first-line therapy for advanced melanoma: Phase I and open-label phase II studies
    • Eisen T, Marais R, Affolter A, et al: Sorafenib and dacarbazine as first-line therapy for advanced melanoma: phase I and open-label phase II studies. Br J Cancer 105: 353-359, 2011.
    • (2011) Br J Cancer , vol.105 , pp. 353-359
    • Eisen, T.1    Marais, R.2    Affolter, A.3
  • 59
    • 73349121946 scopus 로고    scopus 로고
    • Phase II trial of temozolomide and sorafenib in advanced melanoma patients with or without brain metastases
    • Amaravadi RK, Schuchter LM, McDermott DF, et al: Phase II trial of temozolomide and sorafenib in advanced melanoma patients with or without brain metastases. Clin Cancer Res 15: 7711-7718, 2009.
    • (2009) Clin Cancer Res , vol.15 , pp. 7711-7718
    • Amaravadi, R.K.1    Schuchter, L.M.2    McDermott, D.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.