-
1
-
-
33749238553
-
Discovery and development of sorafenib: A multikinase inhibitor for treating cancer
-
DOI 10.1038/nrd2130, PII NRD2130
-
Wilhelm S, Carter C, Lynch M, et al: Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov 5: 835-844, 2006. (Pubitemid 44480537)
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, Issue.10
, pp. 835-844
-
-
Wilhelm, S.1
Carter, C.2
Lynch, M.3
Lowinger, T.4
Dumas, J.5
Smith, R.A.6
Schwartz, B.7
Simantov, R.8
Kelley, S.9
-
2
-
-
51049098909
-
Selected combination therapy with sorafenib: A review of clinical data and perspectives in advanced solid tumors
-
Dal Lago L, D'Hondt V and Awada A: Selected combination therapy with sorafenib: a review of clinical data and perspectives in advanced solid tumors. Oncologist 13: 845-858, 2008.
-
(2008)
Oncologist
, vol.13
, pp. 845-858
-
-
Dal Lago, L.1
D'Hondt, V.2
Awada, A.3
-
3
-
-
33846212284
-
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
-
DOI 10.1158/0008-5472.CAN-06-1377
-
Liu L, Cao Y, Chen C, et al: Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tum or angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 66: 11851-11858, 2006. (Pubitemid 46094197)
-
(2006)
Cancer Research
, vol.66
, Issue.24
, pp. 11851-11858
-
-
Liu, L.1
Cao, Y.2
Chen, C.3
Zhang, X.4
McNabola, A.5
Wilkie, D.6
Wilhelm, S.7
Lynch, M.8
Carter, C.9
-
4
-
-
36549055697
-
Will targeted therapy hold its promise? An evidence-based review
-
DOI 10.1097/CCO.0b013e3282f44b12, PII 0000162220080100000016
-
Murdoch D and Sager J: Will targeted therapy hold its promise? An evidence-based review. Curr Opin Oncol 20: 104-111, 2008. (Pubitemid 350190989)
-
(2008)
Current Opinion in Oncology
, vol.20
, Issue.1
, pp. 104-111
-
-
Murdoch, D.1
Sager, J.2
-
5
-
-
55749088393
-
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
-
Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM and Lynch M: Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 7: 3129-3140, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3129-3140
-
-
Wilhelm, S.M.1
Adnane, L.2
Newell, P.3
Villanueva, A.4
Llovet, J.M.5
Lynch, M.6
-
6
-
-
43749110700
-
Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: A report from the 11715 Study Group
-
McDermott DF, Sosman JA, Gonzalez R, et al: Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study Group. J Clin Oncol 26: 2178-2185, 2008.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2178-2185
-
-
McDermott, D.F.1
Sosman, J.A.2
Gonzalez, R.3
-
7
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
DOI 10.1158/0008-5472.CAN-04-1443
-
Wilhelm SM, Carter C, Tang L, et al: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 64: 7099-7109, 2004. (Pubitemid 39331023)
-
(2004)
Cancer Research
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
Cao, Y.11
Shujath, J.12
Gawlak, S.13
Eveleigh, D.14
Rowley, B.15
Liu, L.16
Adnane, L.17
Lynch, M.18
Auclair, D.19
Taylor, I.20
Gedrich, R.21
Voznesensky, A.22
Riedl, B.23
Post, L.E.24
Bollag, G.25
Trail, P.A.26
more..
-
8
-
-
34248386965
-
Challenges for patient selection with VEGF inhibitors
-
DOI 10.1007/s00280-006-0403-6
-
Longo R and Gasparini G: Challenges for patient selection with VEGF inhibitors. Cancer Chemother Pharmacol 60: 151-170, 2007. (Pubitemid 46742547)
-
(2007)
Cancer Chemotherapy and Pharmacology
, vol.60
, Issue.2
, pp. 151-170
-
-
Longo, R.1
Gasparini, G.2
-
10
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
DOI 10.1056/NEJMoa060655
-
Escudier B, Eisen T, Stadler WM, et al: Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 356: 125-134, 2007. (Pubitemid 46089673)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
11
-
-
33744984843
-
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
-
DOI 10.1200/JCO.2005.03.6723
-
Ratain MJ, Eisen T, Stadler WM, et al: Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 24: 2505-2512, 2006. (Pubitemid 46630627)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.16
, pp. 2505-2512
-
-
Ratain, M.J.1
Eisen, T.2
Stadler, W.M.3
Flaherty, K.T.4
Kaye, S.B.5
Rosner, G.L.6
Gore, M.7
Desai, A.A.8
Patnaik, A.9
Xiong, H.Q.10
Rowinsky, E.11
Abbruzzese, J.L.12
Xia, C.13
Simantov, R.14
Schwartz, B.15
O'Dwyer, P.J.16
-
12
-
-
78649312166
-
Impact of sorafenib on health-related quality of life in Japanese patients with metastatic renal cell carcinoma: A prospective evaluation
-
Miyake H, Kurahashi T, Yamanaka K, et al: Impact of sorafenib on health-related quality of life in Japanese patients with metastatic renal cell carcinoma: a prospective evaluation. BJU Int 106: 1643-1647, 2010.
-
(2010)
BJU Int
, vol.106
, pp. 1643-1647
-
-
Miyake, H.1
Kurahashi, T.2
Yamanaka, K.3
-
13
-
-
34250026980
-
Effects of sorafenib on symptoms and quality of life: Results from a large randomized placebo-controlled study in renal cancer
-
DOI 10.1097/01.coc.0000258732.80710.05, PII 0000042120070600000002
-
Bukowski R, Cella D, Gondek K and Escudier B; Sorafenib TARGETs Clinical Trial Group: Effects of sorafenib on symptoms and quality of life: results from a large randomized placebo-controlled study in renal cancer. Am J Clin Oncol 30: 220-227, 2007. (Pubitemid 46884139)
-
(2007)
American Journal of Clinical Oncology: Cancer Clinical Trials
, vol.30
, Issue.3
, pp. 220-227
-
-
Bukowski, R.1
Cella, D.2
Gondek, K.3
Escudier, B.4
-
14
-
-
77953689504
-
The present and the future landscape of treatment of advanced hepatocellular carcinoma
-
Rimassa L and Santoro A: The present and the future landscape of treatment of advanced hepatocellular carcinoma. Dig Liver Dis 42: S273-S280, 2010.
-
(2010)
Dig Liver Dis
, vol.42
-
-
Rimassa, L.1
Santoro, A.2
-
15
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
-
Cheng AL, Kang YK, Chen Z, et al: Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 10: 25-34, 2009.
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
-
16
-
-
78651412820
-
Sorafenib: Activity and clinical application in patients with hepatocellular carcinoma
-
Guan YS and He Q: Sorafenib: activity and clinical application in patients with hepatocellular carcinoma. Exp Opin Pharmacother 12: 303-313, 2011.
-
(2011)
Exp Opin Pharmacother
, vol.12
, pp. 303-313
-
-
Guan, Y.S.1
He, Q.2
-
17
-
-
79960348649
-
An investigation of the effect of sorafenib on tumour growth and recurrence after liver cancer resection in nude mice independent of phosphorylated extracellular signal-regulated kinase levels
-
Wang Z, Hu J, Qiu SJ, et al: An investigation of the effect of sorafenib on tumour growth and recurrence after liver cancer resection in nude mice independent of phosphorylated extracellular signal-regulated kinase levels. Exp Opin Invest Drugs 20: 1039-1045, 2011.
-
(2011)
Exp Opin Invest Drugs
, vol.20
, pp. 1039-1045
-
-
Wang, Z.1
Hu, J.2
Qiu, S.J.3
-
19
-
-
50649095250
-
Phase II trial of sorafenib in advanced thyroid cancer
-
Gupta-Abramson V, Troxel AB, Nellore A, et al: Phase II trial of sorafenib in advanced thyroid cancer. J Clin Oncol 26: 4714-4719, 2008.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4714-4719
-
-
Gupta-Abramson, V.1
Troxel, A.B.2
Nellore, A.3
-
20
-
-
33748325763
-
Sorafenib in advanced melanoma: A Phase II randomised discontinuation trial analysis
-
DOI 10.1038/sj.bjc.6603291, PII 6603291
-
Eisen T, Ahmad T, Flaherty KT, et al: Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis. Br J Cancer 95: 581-586, 2006. (Pubitemid 44325897)
-
(2006)
British Journal of Cancer
, vol.95
, Issue.5
, pp. 581-586
-
-
Eisen, T.1
Ahmad, T.2
Flaherty, K.T.3
Gore, M.4
Kaye, S.5
Marais, R.6
Gibbens, I.7
Hackett, S.8
James, M.9
Schuchter, L.M.10
Nathanson, K.L.11
Xia, C.12
Simantov, R.13
Schwartz, B.14
Poulin-Costello, M.15
O'Dwyer, P.J.16
Ratain, M.J.17
-
21
-
-
79959560621
-
Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma
-
Fedorenko IV, Paraiso KH and Smalley KS: Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma. Biochem Pharmacol 82: 201-209, 2011.
-
(2011)
Biochem Pharmacol
, vol.82
, pp. 201-209
-
-
Fedorenko, I.V.1
Paraiso, K.H.2
Smalley, K.S.3
-
22
-
-
49249113484
-
Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity
-
Azad NS, Posadas EM, Kwitkowski VE, et al: Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. J Clin Oncol 26: 3709-3714, 2008.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3709-3714
-
-
Azad, N.S.1
Posadas, E.M.2
Kwitkowski, V.E.3
-
23
-
-
76349087360
-
Combination therapy: Intermittent sorafenib with bevacizumab yields activity and decreased toxicity
-
Lee JM, Sarosy GA, Annunziata CM, et al: Combination therapy: intermittent sorafenib with bevacizumab yields activity and decreased toxicity. Br J Cancer 102: 495-499, 2010.
-
(2010)
Br J Cancer
, vol.102
, pp. 495-499
-
-
Lee, J.M.1
Sarosy, G.A.2
Annunziata, C.M.3
-
24
-
-
34548077118
-
Phase I targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors
-
DOI 10.1158/1078-0432.CCR-07-0382
-
Duran I, Hotté SJ, Hirte H, et al: Phase I targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors. Clin Cancer Res 13: 4849-4857, 2007. (Pubitemid 47294792)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.16
, pp. 4849-4857
-
-
Duran, I.1
Hotte, S.J.2
Hirte, H.3
Chen, E.X.4
MacLean, M.5
Turner, S.6
Duan, L.7
Pond, G.R.8
Lathia, C.9
Walsh, S.10
Wright, J.J.11
Dancey, J.12
Siu, L.L.13
-
25
-
-
79959306917
-
Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small cell lung cancer
-
Spigel DR, Burris HA III, Greco FA, et al: Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small cell lung cancer. J Clin Oncol 29: 2582-2589, 2011.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2582-2589
-
-
Spigel, D.R.1
Burris III, H.A.2
Greco, F.A.3
-
26
-
-
77958058348
-
Synergistic antitumor activity of sorafenib in combination with epidermal growth factor receptor inhibitors in colorectal and lung cancer cells
-
Martinelli E, Troiani T, Morgillo F, et al: Synergistic antitumor activity of sorafenib in combination with epidermal growth factor receptor inhibitors in colorectal and lung cancer cells. Clin Cancer Res 16: 4990-5001, 2010.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 4990-5001
-
-
Martinelli, E.1
Troiani, T.2
Morgillo, F.3
-
27
-
-
34250168681
-
Phase I trial of sorafenib in combination with IFN α-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma
-
DOI 10.1158/1078-0432.CCR-06-1432
-
Escudier B, Lassau N, Angevin E, et al: Phase I trial of sorafenib in combination with IFN α-2a in patients with unresectable and/or metastatic renal cell carcinoma or malignant melanoma. Clin Cancer Res 13: 1801-1809, 2007. (Pubitemid 46952949)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.6
, pp. 1801-1809
-
-
Escudier, B.1
Lassau, N.2
Angevin, E.3
Soria, J.C.4
Chami, L.5
Lamuraglia, M.6
Zafarana, E.7
Landreau, V.8
Schwartz, B.9
Brendel, E.10
Armand, J.-P.11
Robert, C.12
-
28
-
-
34548263735
-
Phase II trial of sorafenib plus interferon alfa-2b as first- or second-line therapy in patients with metastatic renal cell cancer
-
DOI 10.1200/JCO.2007.10.8613
-
Gollob JA, Rathmell WK, Richmond TM, et al: Phase II trial of sorafenib plus interferon α2b as first-or second-line therapy in patients with metastatic renal cell cancer. J Clin Oncol 25: 3288-3295, 2007. (Pubitemid 47325614)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.22
, pp. 3288-3295
-
-
Gollob, J.A.1
Rathmell, W.K.2
Richmond, T.M.3
Marino, C.B.4
Miller, E.K.5
Grigson, G.6
Watkins, C.7
Gu, L.8
Peterson, B.L.9
Wright, J.J.10
-
29
-
-
79959736969
-
Sorafenib and pegylated interferon-α2b in advanced metastatic melanoma: A multicenter phase II DeCOG trial
-
Egberts F, Gutzmer R, Ugurel S, et al: Sorafenib and pegylated interferon-α2b in advanced metastatic melanoma: a multicenter phase II DeCOG trial. Ann Oncol 22: 1667-1674, 2011.
-
(2011)
Ann Oncol
, vol.22
, pp. 1667-1674
-
-
Egberts, F.1
Gutzmer, R.2
Ugurel, S.3
-
30
-
-
33646204716
-
Results of a Phase I trial of sorafenib (BAY 43-9006) in combination with doxorubicin in patients with refractory solid tumors
-
Richly H, Henning BF, Kupsch P, et al: Results of a Phase I trial of sorafenib (BAY 43-9006) in combination with doxorubicin in patients with refractory solid tumors. Ann Oncol 17: 866-873, 2006.
-
(2006)
Ann Oncol
, vol.17
, pp. 866-873
-
-
Richly, H.1
Henning, B.F.2
Kupsch, P.3
-
31
-
-
78349298645
-
Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: A randomized trial
-
Abou-Alfa GK, Johnson P, Knox JJ, et al: Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA 304: 2154-2160, 2010.
-
(2010)
JAMA
, vol.304
, pp. 2154-2160
-
-
Abou-Alfa, G.K.1
Johnson, P.2
Knox, J.J.3
-
32
-
-
77954574658
-
Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203
-
Sun W, Powell M, O'Dwyer PJ, Catalano P, Ansari RH and Benson AB III: Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203. J Clin Oncol 28: 2947-2951, 2010.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2947-2951
-
-
Sun, W.1
Powell, M.2
O'Dwyer, P.J.3
Catalano, P.4
Ansari, R.H.5
Benson III, A.B.6
-
33
-
-
78549289509
-
Phase I clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer
-
Okamoto I, Miyazaki M, Morinaga R, et al: Phase I clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer. Invest New Drugs 28: 844-853, 2010.
-
(2010)
Invest New Drugs
, vol.28
, pp. 844-853
-
-
Okamoto, I.1
Miyazaki, M.2
Morinaga, R.3
-
34
-
-
33748901860
-
Sorafenib combined with carboplatin/paclitaxel for advanced non-small cell lung cancer: A phase I subset analysis
-
Schiller JH, Flaherty KT, Redlinger M, et al: Sorafenib combined with carboplatin/paclitaxel for advanced non-small cell lung cancer: a phase I subset analysis. J Clin Oncol 24: 7194, 2006.
-
(2006)
J Clin Oncol
, vol.24
, pp. 7194
-
-
Schiller, J.H.1
Flaherty, K.T.2
Redlinger, M.3
-
35
-
-
67649909568
-
Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
-
Hauschild A, Agarwala SS, Trefzer U, et al: Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 27: 2823-2830, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2823-2830
-
-
Hauschild, A.1
Agarwala, S.S.2
Trefzer, U.3
-
36
-
-
77950312919
-
Activity of a multitargeted chemo-switch regimen (sorafenib, gemcitabine, and metronomic capecitabine) in metastatic renal-cell carcinoma: A phase 2 study (SOGUG-02-06)
-
Bellmunt J, Trigo JM, Calvo E, et al: Activity of a multitargeted chemo-switch regimen (sorafenib, gemcitabine, and metronomic capecitabine) in metastatic renal-cell carcinoma: a phase 2 study (SOGUG-02-06). Lancet Oncol 11: 350-357, 2010.
-
(2010)
Lancet Oncol
, vol.11
, pp. 350-357
-
-
Bellmunt, J.1
Trigo, J.M.2
Calvo, E.3
-
37
-
-
77955904732
-
Sorafenib and radiation: A promising combination in colorectal cancer
-
Suen AW, Galoforo S, Marples B, et al: Sorafenib and radiation: a promising combination in colorectal cancer. Int J Radiat Oncol Biol Phys 78: 213-220, 2010.
-
(2010)
Int J Radiat Oncol Biol Phys
, vol.78
, pp. 213-220
-
-
Suen, A.W.1
Galoforo, S.2
Marples, B.3
-
38
-
-
16644397086
-
The role of Raf-1 in radiation resistance of human hepatocellular carcinoma Hep G2 cells
-
Tang WY, Chau SP, Tsang WP, Kong SK and Kwok TT: The role of Raf-1 in radiation resistance of human hepatocellular carcinoma Hep G2 cells. Oncol Rep 12: 1349-1354, 2004.
-
(2004)
Oncol Rep
, vol.12
, pp. 1349-1354
-
-
Tang, W.Y.1
Chau, S.P.2
Tsang, W.P.3
Kong, S.K.4
Kwok, T.T.5
-
39
-
-
35148842941
-
Cell cycle-dependent and schedule-dependent antitumor effects of sorafenib combined with radiation
-
DOI 10.1158/0008-5472.CAN-07-1473
-
Plastaras JP, Kim SH, Liu YY, et al: Cell cycle-dependent and schedule-dependent antitumor effects of sorafenib combined with radiation. Cancer Res 67: 9443-9454, 2007. (Pubitemid 47535934)
-
(2007)
Cancer Research
, vol.67
, Issue.19
, pp. 9443-9454
-
-
Plastaras, J.P.1
Kim, S.-H.2
Liu, Y.Y.3
Dicker, D.T.4
Dorsey, J.F.5
McDonough, J.6
Cerniglia, G.7
Rajendran, R.R.8
Gupta, A.9
Rustgi, A.K.10
Diehl, J.A.11
Smith, C.D.12
Flaherty, K.T.13
El-Deiry, W.S.14
-
40
-
-
33847118123
-
Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models
-
DOI 10.1007/s00280-006-0393-4
-
Chang YS, Adnane J, Trail PA, et al: Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models. Cancer Chemother Pharmacol 59: 561-574, 2007. (Pubitemid 46295136)
-
(2007)
Cancer Chemotherapy and Pharmacology
, vol.59
, Issue.5
, pp. 561-574
-
-
Chang, Y.S.1
Adnane, J.2
Trail, P.A.3
Levy, J.4
Henderson, A.5
Xue, D.6
Bortolon, E.7
Ichetovkin, M.8
Chen, C.9
McNabola, A.10
Wilkie, D.11
Carter, C.A.12
Taylor, I.C.A.13
Lynch, M.14
Wilhelm, S.15
-
41
-
-
0036401105
-
BAY 43-9006: Preclinical data
-
DOI 10.2174/1381612023393026
-
Wilhelm S and Chien DS: BAY 43-9006: preclinical data. Curr Pharm Des 8: 2255-2257, 2002. (Pubitemid 35189898)
-
(2002)
Current Pharmaceutical Design
, vol.8
, Issue.25
, pp. 2255-2257
-
-
Wilhelm, S.1
Chien, D.-S.2
-
42
-
-
16844362816
-
V599EB-Raf regulates growth and vascular development of malignant melanoma tumors
-
DOI 10.1158/0008-5472.CAN-04-2423
-
Sharma A, Trivedi NR, Zimmerman MA, Tuveson DA, Smith CD and Robertson GP: Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res 65: 2412-2421, 2005. (Pubitemid 40490153)
-
(2005)
Cancer Research
, vol.65
, Issue.6
, pp. 2412-2421
-
-
Sharma, A.1
Trivedi, N.R.2
Zimmerman, M.A.3
Tuveson, D.A.4
Smith, C.D.5
Robertson, G.P.6
-
43
-
-
65549142508
-
Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines
-
Ulivi P, Arienti C, Amadori D, et al: Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines. J Cell Physiol 220: 214-221, 2009.
-
(2009)
J Cell Physiol
, vol.220
, pp. 214-221
-
-
Ulivi, P.1
Arienti, C.2
Amadori, D.3
-
44
-
-
78851468826
-
Multikinase inhibitor sorafenib exerts cytocidal efficacy against Non-Hodgkin lymphomas associated with inhibition of MAPK14 and AKT phosphorylation
-
Chapuy B, Schuelper N, Panse M, et al: Multikinase inhibitor sorafenib exerts cytocidal efficacy against Non-Hodgkin lymphomas associated with inhibition of MAPK14 and AKT phosphorylation. Br J Haematol 152: 401-412, 2011.
-
(2011)
Br J Haematol
, vol.152
, pp. 401-412
-
-
Chapuy, B.1
Schuelper, N.2
Panse, M.3
-
45
-
-
79955809893
-
Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1
-
Huber S, Oelsner M, Decker T, et al: Sorafenib induces cell death in chronic lymphocytic leukemia by translational downregulation of Mcl-1. Leukemia 25: 838-847, 2011.
-
(2011)
Leukemia
, vol.25
, pp. 838-847
-
-
Huber, S.1
Oelsner, M.2
Decker, T.3
-
46
-
-
70349304196
-
Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer
-
Blumenschein GR Jr, Gatzemeier U, Fossella F, et al: Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer. J Clin Oncol 27: 4274-4280, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4274-4280
-
-
Blumenschein Jr., G.R.1
Gatzemeier, U.2
Fossella, F.3
-
47
-
-
79960343099
-
Long-term safety and tolerability of sorafenib in patients with advanced non-small cell lung cancer: A case-based review
-
Adjei AA, Blumenschein GR Jr, Mandrekar S, Hillman S, Gatzemeier U and Heigener D: Long-term safety and tolerability of sorafenib in patients with advanced non-small cell lung cancer: a case-based review. Clin Lung Cancer 12: 212-217, 2011.
-
(2011)
Clin Lung Cancer
, vol.12
, pp. 212-217
-
-
Adjei, A.A.1
Blumenschein Jr., G.R.2
Mandrekar, S.3
Hillman, S.4
Gatzemeier, U.5
Heigener, D.6
-
48
-
-
36448965291
-
A clinical phase II study with sorafenib in patients with progressive hormone-refractory prostate cancer: A study of the CESAR Central European Society for Anticancer Drug Research-EWIV
-
DOI 10.1038/sj.bjc.6604064, PII 6604064
-
Steinbild S, Mross K, Frost A, et al: A clinical phase II study with sorafenib in patients with progressive hormone-refractory prostate cancer: a study of the CESAR Central European Society for Anticancer Drug Research-EWIV. Br J Cancer 97: 1480-1485, 2007. (Pubitemid 350175850)
-
(2007)
British Journal of Cancer
, vol.97
, Issue.11
, pp. 1480-1485
-
-
Steinbild, S.1
Mross, K.2
Frost, A.3
Morant, R.4
Gillessen, S.5
Dittrich, C.6
Strumberg, D.7
Hochhaus, A.8
Hanauske, A.-R.9
Edler, L.10
Burkholder, I.11
Scheulen, M.12
-
49
-
-
67650293850
-
Phase II study of sorafenib in patients with metastatic or recurrent sarcomas
-
Maki RG, D'Adamo DR, Keohan ML, et al: Phase II study of sorafenib in patients with metastatic or recurrent sarcomas. J Clin Oncol 27: 3133-3140, 2009.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3133-3140
-
-
Maki, R.G.1
D'Adamo, D.R.2
Keohan, M.L.3
-
50
-
-
34548504810
-
Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma
-
DOI 10.1200/JCO.2006.10.2871
-
Elser C, Siu LL, Winquist E, et al: Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma. J Clin Oncol 25: 3766-3773, 2007. (Pubitemid 47372619)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.24
, pp. 3766-3773
-
-
Elser, C.1
Siu, L.L.2
Winquist, E.3
Agulnik, M.4
Pond, G.R.5
Chin, S.F.6
Francis, P.7
Cheiken, R.8
Elting, J.9
McNabola, A.10
Wilkie, D.11
Petrenciuc, O.12
Chen, E.X.13
-
51
-
-
74249098818
-
Sorafenib in patients with advanced biliary tract carcinoma: A phase II trial
-
Bengala C, Bertolini F, Malavasi N, et al: Sorafenib in patients with advanced biliary tract carcinoma: a phase II trial. Br J Cancer 102: 68-72, 2009.
-
(2009)
Br J Cancer
, vol.102
, pp. 68-72
-
-
Bengala, C.1
Bertolini, F.2
Malavasi, N.3
-
52
-
-
77949337347
-
A Phase II study of sorafenib in advanced uterine carcinoma/ carcinosarcoma: A trial of the Chicago, PMH, and California Phase II Consortia
-
Nimeiri HS, Oza AM, Morgan RJ, et al: A Phase II study of sorafenib in advanced uterine carcinoma/carcinosarcoma: a trial of the Chicago, PMH, and California Phase II Consortia. Gynecol Oncol 117: 37-40, 2010.
-
(2010)
Gynecol Oncol
, vol.117
, pp. 37-40
-
-
Nimeiri, H.S.1
Oza, A.M.2
Morgan, R.J.3
-
53
-
-
72549092909
-
Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies
-
Hong DS, Sebti SM, Newman RA, et al: Phase I trial of a combination of the multikinase inhibitor sorafenib and the farnesyltransferase inhibitor tipifarnib in advanced malignancies. Clin Cancer Res 15: 7061-7068, 2009.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7061-7068
-
-
Hong, D.S.1
Sebti, S.M.2
Newman, R.A.3
-
54
-
-
34249093653
-
Phase I trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non - Small cell lung cancer
-
DOI 10.1158/1078-0432.CCR-06-2889
-
Adjei AA, Molina JR, Mandrekar SJ, et al: Phase I trial of sorafenib in combination with gefitinib in patients with refractory or recurrent non-small cell lung cancer. Clin Cancer Res 13: 2684-2691, 2007. (Pubitemid 46788036)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.9
, pp. 2684-2691
-
-
Adjei, A.A.1
Molina, J.R.2
Mandrekar, S.J.3
Marks, R.4
Reid, J.R.5
Croghan, G.6
Hanson, L.J.7
Jett, A.R.8
Xia, C.9
Lathia, C.10
Simantov, R.11
-
55
-
-
79954438593
-
Sorafenib with interleukin- 2 vs sorafenib alone in metastatic renal cell carcinoma: The ROSORC trial
-
Procopio G, Verzoni E, Bracarda S, et al: Sorafenib with interleukin- 2 vs sorafenib alone in metastatic renal cell carcinoma: the ROSORC trial. Br J Cancer 104: 1256-1261, 2011.
-
(2011)
Br J Cancer
, vol.104
, pp. 1256-1261
-
-
Procopio, G.1
Verzoni, E.2
Bracarda, S.3
-
56
-
-
77957702355
-
Synergistic activity of letrozole and sorafenib on breast cancer cells
-
Bonelli MA, Fumarola C, Alfieri RR, et al: Synergistic activity of letrozole and sorafenib on breast cancer cells. Breast Cancer Res Treat 124: 79-88, 2010.
-
(2010)
Breast Cancer Res Treat
, vol.124
, pp. 79-88
-
-
Bonelli, M.A.1
Fumarola, C.2
Alfieri, R.R.3
-
57
-
-
79958742182
-
Everolimus augments the effects of sorafenib in a syngeneic orthotopic model of hepatocellular carcinoma
-
Piguet AC, Saar B, Hlushchuk R, et al: Everolimus augments the effects of sorafenib in a syngeneic orthotopic model of hepatocellular carcinoma. Mol Cancer Ther 10: 1007-1017, 2011.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1007-1017
-
-
Piguet, A.C.1
Saar, B.2
Hlushchuk, R.3
-
58
-
-
79960848073
-
Sorafenib and dacarbazine as first-line therapy for advanced melanoma: Phase I and open-label phase II studies
-
Eisen T, Marais R, Affolter A, et al: Sorafenib and dacarbazine as first-line therapy for advanced melanoma: phase I and open-label phase II studies. Br J Cancer 105: 353-359, 2011.
-
(2011)
Br J Cancer
, vol.105
, pp. 353-359
-
-
Eisen, T.1
Marais, R.2
Affolter, A.3
-
59
-
-
73349121946
-
Phase II trial of temozolomide and sorafenib in advanced melanoma patients with or without brain metastases
-
Amaravadi RK, Schuchter LM, McDermott DF, et al: Phase II trial of temozolomide and sorafenib in advanced melanoma patients with or without brain metastases. Clin Cancer Res 15: 7711-7718, 2009.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7711-7718
-
-
Amaravadi, R.K.1
Schuchter, L.M.2
McDermott, D.F.3
-
60
-
-
33846020023
-
Results from an in vitro and a clinical/pharmacological phase I study with the combination irinotecan and sorafenib
-
DOI 10.1016/j.ejca.2006.08.032, PII S0959804906008033
-
Mross K, Steinbild S, Baas F, et al: Results from an in vitro and a clinical/pharmacological phase I study with the combination irinotecan and sorafenib. Eur J Cancer 43: 55-63, 2007. (Pubitemid 46054474)
-
(2007)
European Journal of Cancer
, vol.43
, Issue.1
, pp. 55-63
-
-
Mross, K.1
Steinbild, S.2
Baas, F.3
Gmehling, D.4
Radtke, M.5
Voliotis, D.6
Brendel, E.7
Christensen, O.8
Unger, C.9
|