Viral and host inflammation-related factors that can predict the prognosis of hepatocellular carcinoma

European Journal of Cancer

Volumn 48, Issue 13, 2012, Pages 1977-1987

  Chen, Liping ^a   Zhang, Qi ^a   Chang, Wenjun ^a   Du, Yan ^a   Zhang, Hongwei ^a   Cao, Guangwen ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Hepatitis B virus; Hepatitis C virus; Hepatocellular carcinoma; Inflammation; Prognosis

Indexed keywords

ASPARTYL(ASPARAGINYL)HYDROXYLASE; BECLIN 1; BETA CATENIN; C REACTIVE PROTEIN; CALPAIN 1; CD24 ANTIGEN; DICKKOPF 1 PROTEIN; GLYPICAN 3; GRHL2 PROTEIN; HEPATITIS B(E) ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 5A; INTERLEUKIN 10; INTERLEUKIN 8; KRUPPEL LIKE FACTOR 8; MACROPHAGE COLONY STIMULATING FACTOR 1 RECEPTOR; MACROPHAGE ELASTASE; MACROPHAGE MIGRATION INHIBITION FACTOR; METASTATIC TUMOR ANTIGEN 1; OSTEOPONTIN; PLACENTAL GROWTH FACTOR; PROTEIN; PROTEIN P28; SECRETORY COMPONENT; STAT3 PROTEIN; STEROL REGULATORY ELEMENT BINDING FACTOR 1; TUMOR ANTIGEN; UNCLASSIFIED DRUG; UNINDEXED DRUG; WNT PROTEIN;

CANCER INVASION; CANCER RECURRENCE; CANCER SURGERY; CARCINOGENESIS; CD8+ T LYMPHOCYTE; CELL DENSITY; CELL GROWTH; CELL SURVIVAL; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; INFLAMMATION; LIVER CELL CARCINOMA; LYMPHOCYTE COUNT; MAST CELL; NATURAL KILLER CELL; NEUTROPHIL COUNT; PREDICTION; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; STELLATE CELL; TH1 CELL; TH17 CELL; TH2 CELL; VIRUS CELL INTERACTION; VIRUS LOAD; VIRUS MUTATION;

EID: 84865109737     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2012.01.015     Document Type: Article

References (125)

1. A.S. Lok Does antiviral therapy for hepatitis B and C prevent hepatocellular carcinoma? J Gastroenterol Hepatol 26 2011 221 227
2. Y.T. Huang, C.L. Jen, and H.I. Yang Lifetime risk and sex difference of hepatocellular carcinoma among patients with chronic hepatitis B and C J Clin Oncol 29 2011 3643 3650
3. J.M. Llovet, M. Schwartz, and V. Mazzaferro Resection and liver transplantation for hepatocellular carcinoma Semin Liver Dis 25 2005 181 200 (Pubitemid 40781071)
4. H. Imamura, Y. Matsuyama, and E. Tanaka Risk factors contributing to early and late phase intrahepatic recurrence of hepatocellular carcinoma after hepatectomy J Hepatol 38 2003 200 207 (Pubitemid 36169630)
5. J.C. Wu, Y.H. Huang, and G.Y. Chau Risk factors for early and late recurrence in hepatitis B-related hepatocellular carcinoma J Hepatol 51 2009 890 897
6. K.K. Choi, S.H. Kim, and S.B. Choi Portal venous invasion: the single most independent risk factor for immediate postoperative recurrence of hepatocellular carcinoma J Gastroenterol Hepatol 26 2011 1646 1651
7. K.C. Lim, P.K. Chow, and J.C. Allen Microvascular invasion is a better predictor of tumor recurrence and overall survival following surgical resection for hepatocellular carcinoma compared to the Milan criteria Ann Surg 254 2011 108 113
8. T. Maeda, M. Shimada, and N. Harimoto Prognosis of early hepatocellular carcinoma after hepatic resection Hepatogastroenterology 55 2008 1428 1432
9. M. Ishizuka, K. Kubota, and J. Kita Usefulness of a modified inflammation-based prognostic system for predicting postoperative mortality of patients undergoing surgery for primary hepatocellular carcinoma J Surg Oncol 103 2011 801 806
10. W.Y. Kao, C.W. Su, and G.Y. Chau A comparison of prognosis between patients with hepatitis B and C virus-related hepatocellular carcinoma undergoing resection surgery World J Surg 35 2011 858 867
11. S.H. Kim, S.B. Choi, and J.G. Lee Prognostic factors and 10-year survival in patients with hepatocellular carcinoma after curative hepatectomy J Gastrointest Surg 15 2011 598 607
12. H.C. Sun, W. Zhang, and L.X. Qin Positive serum hepatitis B e antigen is associated with higher risk of early recurrence and poorer survival in patients after curative resection of hepatitis B-related hepatocellular carcinoma J Hepatol 47 2007 684 690 (Pubitemid 47503431)
13. T. Hosaka, F. Suzuki, and M. Kobayashi HBcrAg is a predictor of post-treatment recurrence of hepatocellular carcinoma during antiviral therapy Liver Int 30 2010 1461 1470
14. Y.F. Han, J. Zhao, and L.Y. Ma Factors predicting occurrence and prognosis of hepatitis-B-virus-related hepatocellular carcinoma World J Gastroenterol 17 2011 4258 4270
15. I.F. Hung, R.T. Poon, and C.L. Lai Recurrence of hepatitis B-related hepatocellular carcinoma is associated with high viral load at the time of resection Am J Gastroenterol 103 2008 1663 1673
16. W. Yeo, F.K. Mo, and S.L. Chan Hepatitis B viral load predicts survival of HCC patients undergoing systemic chemotherapy Hepatology 45 2007 1382 1389 (Pubitemid 46918322)
17. J.W. Jang, J.Y. Choi, and S.H. Bae The impact of hepatitis B viral load on recurrence after complete necrosis in patients with hepatocellular carcinoma who receive transarterial chemolipiodolization: implications for viral suppression to reduce the risk of cancer recurrence Cancer 110 2007 1760 1767
18. M.R. Li, G.H. Chen, C.J. Cai, G.Y. Wang, and H. Zhao High hepatitis B virus DNA level in serum before liver transplantation increases the risk of hepatocellular carcinoma recurrence Digestion 84 2011 134 141
19. C.T. Yeh, M. So, and J. Ng Hepatitis B virus-DNA level and basal core promoter A1762T/G1764A mutation in liver tissue independently predict postoperative survival in hepatocellular carcinoma Hepatology 52 2010 1922 1933
20. H.J. An, J.W. Jang, and S.H. Bae Sustained low hepatitis B viral load predicts good outcome after curative resection in patients with hepatocellular carcinoma J Gastroenterol Hepatol 25 2010 1876 1882
21. G.W. Cao Clinical relevance and public health significance of hepatitis B virus genomic variations World J Gastroenterol 15 2009 5761 5769
22. H.W. Zhang, J.H. Yin, and Y.T. Li Risk factors for acute hepatitis B and its progression to chronic hepatitis in Shanghai, China Gut 57 2008 1713 1720
23. J. Yin, H. Zhang, and C. Li Role of hepatitis B virus genotype mixture, subgenotypes C2 and B2 on hepatocellular carcinoma: compared with chronic hepatitis B and asymptomatic carrier state in the same area Carcinogenesis 29 2008 1685 1691
24. T.J. Liang, K.T. Mok, and S.I. Liu Hepatitis B genotype C correlated with poor surgical outcomes for hepatocellular carcinoma J Am Coll Surg 211 2010 580 586
25. Y. Huang, Z. Wang, and S. An Role of hepatitis B virus genotypes and quantitative HBV DNA in metastasis and recurrence of hepatocellular carcinoma J Med Virol 80 2008 591 597 (Pubitemid 351358554)
26. Y. Qin, X. Tang, and T. Garcia Hepatitis B virus genotype C isolates with wild-type core promoter sequence replicate less efficiently than genotype B isolates but possess higher virion secretion capacity J Virol 85 2011 10167 10177
27. J. Yin, J. Xie, and H. Zhang Significant association of different preS mutations with hepatitis B-related cirrhosis or hepatocellular carcinoma J Gastroenterol 45 2010 1063 1071
28. J. Yin, J. Xie, and S. Liu Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma Am J Gastroenterol 106 2011 81 92
29. Z.L. Fang, C.A. Sabin, and B.Q. Dong HBV A1762T, G1764A mutations are a valuable biomarker for identifying a subset of male HBsAg carriers at extremely high risk of hepatocellular carcinoma: a prospective study Am J Gastroenterol 103 2008 2254 2262
30. J.P. Vartanian, M. Henry, and A. Marchio Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis PLoS Pathog 6 2010 e1000928
31. T.F. Baumert, C. Rösler, M.H. Malim, and F. von Weizsäcker Hepatitis B virus DNA is subject to extensive editing by the human deaminase APOBEC3C Hepatology 46 2007 682 689 (Pubitemid 47436113)
32. R. Xu, X. Zhang, and W. Zhang Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma Hepatology 46 2007 1810 1820
33. S. Liu, H. Zhang, and C. Gu Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis J Natl Cancer Inst 101 2009 1066 1082
34. Y. Maman, A. Blancher, and J. Benichou Immune-induced evolutionary selection focused on a single reading frame in overlapping hepatitis B virus proteins J Virol 85 2011 4558 4566
35. H.W. Tsai, Y.J. Lin, and P.W. Lin A clustered ground-glass hepatocyte pattern represents a new prognostic marker for the recurrence of hepatocellular carcinoma after surgery Cancer 117 2011 2951 2960
36. Y. Huang, S. Tong, A.W. Tai, M. Hussain, and A.S. Lok Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21 Gastroenterology 141 2011 1412 1421
37. H.S. Mun, S.A. Lee, and H. Kim Novel F141L pre-S2 mutation in hepatitis B virus increases the risk of hepatocellular carcinoma in patients with chronic genotype C infections J Virol 85 2011 123 132
38. P. Simmonds, J. Bukh, and C. Combet Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes Hepatology 42 2005 962 973 (Pubitemid 41401136)
39. S. Nakamoto, F. Imazeki, and K. Fukai Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development J Hepatol 52 2010 72 78
40. H. Toyoda, T. Kumada, Y. Kaneoka, and A. Maeda Amino acid substitutions in the hepatitis C virus core region are associated with postoperative recurrence and survival of patients with HCV genotype 1b-associated hepatocellular carcinoma Ann Surg 254 2011 326 332
41. Huang L, Li J, Lau WY, et al. Perioperative reactivation of hepatitis B virus replication in patients undergoing partial hepatectomy for hepatocellular carcinoma. J Gastroenterol Hepatol. doi:10.1111/j.1440-1746.2011.06888.x.
42. A.C. Chan, K.S. Chok, and W.K. Yuen Impact of antiviral therapy on the survival of patients after major hepatectomy for hepatitis B virus-related hepatocellular carcinoma Arch Surg 146 2011 675 681
43. N. Li, E.C. Lai, and J. Shi A comparative study of antiviral therapy after resection of hepatocellular carcinoma in the immune-active phase of hepatitis B virus infection Ann Surg Oncol 17 2010 179 185
44. C.T. Yeh, T. Chen, and C.W. Hsu Emergence of the rtA181T/sW172 mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B BMC Cancer 11 2011 398
45. C.H. Zhang, G.L. Xu, and W.D. Jia Effects of interferon treatment on development and progression of hepatocellular carcinoma in patients with chronic virus infection: a meta-analysis of randomized controlled trials Int J Cancer 129 2011 1254 1264
46. H. Hagihara, K. Nouso, and Y. Kobayashi Effect of pegylated interferon therapy on intrahepatic recurrence after curative treatment of hepatitis C virus-related hepatocellular carcinoma Int J Clin Oncol 16 2011 210 220
47. Tanimoto Y, Tashiro H, Aikata H, et al. Impact of pegylated interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellular carcinoma after curative hepatic resection. Ann Surg Oncol. doi:10.1245/s10434- 011-1866-1.
48. R.Y. Miao, H.T. Zhao, and H.Y. Yang Postoperative adjuvant antiviral therapy for hepatitis B/C virus-related hepatocellular carcinoma: a meta-analysis World J Gastroenterol 16 2010 2931 2942
49. L.S. Qu, F. Jin, X.W. Huang, and X.Z. Shen Interferon-α therapy after curative resection prevents early recurrence and improves survival in patients with hepatitis B virus-related hepatocellular carcinoma J Surg Oncol 102 2010 796 801
50. M.D. Thompson, M.J. Dar, and S.P. Monga Pegylated interferon alpha targets Wnt signaling by inducing nuclear export of β-catenin J Hepatol 54 2011 506 512
51. X.D. Zhu, J.B. Zhang, and P.Y. Zhuang High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma J Clin Oncol 26 2008 2707 2716
52. J.B. Jia, W.Q. Wang, and H.C. Sun High expression of macrophage colony-stimulating factor-1 receptor in peritumoral liver tissue is associated with poor outcome in hepatocellular carcinoma after curative resection Oncologist 15 2010 732 743
53. E. Hira, T. Ono, and D.K. Dhar Overexpression of macrophage migration inhibitory factor induces angiogenesis and deteriorates prognosis after radical resection for hepatocellular carcinoma Cancer 103 2005 588 598
54. Y. Ren, H.T. Tsui, and R.T. Poon Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma Int J Cancer 107 2003 22 29 (Pubitemid 37100081)
55. Y.M. Zhao, L. Wang, and Z. Dai Validity of plasma macrophage migration inhibitory factor for diagnosis and prognosis of hepatocellular carcinoma Int J Cancer 129 2011 2463 2472
56. Y. Ren, R.T. Poon, and H.T. Tsui Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinicopathological features and prognosis Clin Cancer Res 9 16 Pt. 1 2003 5996 6001 (Pubitemid 38018086)
57. V. Chew, C. Tow, and M. Teo Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients J Hepatol 52 2010 370 379
58. Y.W. Li, S.J. Qiu, and J. Fan Intratumoral neutrophils: a poor prognostic factor for hepatocellular carcinoma following resection J Hepatol 54 2011 497 505
59. D. Gomez, S. Farid, and H.Z. Malik Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma World J Surg 32 2008 1757 1762
60. V.R. Bertuzzo, M. Cescon, and M. Ravaioli Analysis of factors affecting recurrence of hepatocellular carcinoma after liver transplantation with a special focus on inflammation markers Transplantation 91 2011 1279 1285
61. G.Y. Wang, Y. Yang, and H. Li A scoring model based on neutrophil to lymphocyte ratio predicts recurrence of HBV-associated hepatocellular carcinoma after liver transplantation PLoS One 6 2011 e25295
62. K.J. Halazun, M.A. Hardy, and A.A. Rana Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma Ann Surg 250 2009 141 151
63. Chen TM, Lin CC, Huang PT, Wen CF. Neutrophil-to-lymphocyte ratio associated with mortality in early hepatocellular carcinoma patients after radiofrequency ablation. J Gastroenterol Hepatol. doi:10.1111/j.1440-1746.2011. 06910.x.
64. A. Budhu, M. Forgues, and Q.H. Ye Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment Cancer Cell 10 2006 99 111 (Pubitemid 44202603)
65. H. Zhou, H. Huang, and J. Shi Prognostic value of interleukin 2 and interleukin 15 in peritumoral hepatic tissues for patients with hepatitis B-related hepatocellular carcinoma after curative resection Gut 59 2010 1699 1708
66. C.Y. Hsia, T.I. Huo, and S.Y. Chiang Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma Eur J Surg Oncol 33 2007 208 212
67. G.Y. Chau, C.W. Wu, and W.Y. Lui Serum interleukin-10 but not interleukin-6 is related to clinical outcome in patients with resectable hepatocellular carcinoma Ann Surg 231 2000 552 558
68. J.N. Stoop, R.G. van der Molen, and C.C. Baan Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection Hepatology 41 2005 771 778 (Pubitemid 40462939)
69. T. Boettler, H.C. Spangenberg, and C. Neumann-Haefelin T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection J Virol 79 2005 7860 7867 (Pubitemid 40756821)
70. J. Fu, D. Xu, and Z. Liu Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients Gastroenterology 132 2007 2328 2339 (Pubitemid 46890865)
71. Q. Gao, S.J. Qiu, and J. Fan Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection J Clin Oncol 25 2007 2586 2593 (Pubitemid 47041232)
72. M.J. Ju, S.J. Qiu, and J. Fan Peritumoral activated hepatic stellate cells predict poor clinical outcome in hepatocellular carcinoma after curative resection Am J Clin Pathol 131 2009 498 510
73. M.J. Ju, S.J. Qiu, and Q. Gao Combination of peritumoral mast cells and T-regulatory cells predicts prognosis of hepatocellular carcinoma Cancer Sci 100 2009 1267 1274
74. D.M. Kuang, C. Peng, and Q. Zhao Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells Hepatology 51 2010 154 164
75. J.P. Zhang, J. Yan, and J. Xu Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients J Hepatol 50 2009 980 989
76. Y. Ye, X. Xie, and J. Yu Involvement of Th17 and Th1 effector responses in patients with hepatitis B J Clin Immunol 30 2010 546 555
77. Q.H. Ye, L.X. Qin, and M. Forgues Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning Nat Med 9 2003 416 423 (Pubitemid 36460075)
78. J.S. Lee, I.S. Chu, and J. Heo Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling Hepatology 40 2004 667 676 (Pubitemid 39265589)
79. H.G. Woo, E.S. Park, and J.H. Cheon Gene expression-based recurrence prediction of hepatitis B virus-related human hepatocellular carcinoma Clin Cancer Res 14 2008 2056 2064 (Pubitemid 351551116)
80. T. Yamashita, M. Forgues, and W. Wang EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma Cancer Res 68 2008 1451 1461 (Pubitemid 351346853)
81. S. Yoshioka, I. Takemasa, and H. Nagano Molecular prediction of early recurrence after resection of hepatocellular carcinoma Eur J Cancer 45 2009 881 889
82. S.M. Wang, L.L. Ooi, and K.M. Hui Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma Clin Cancer Res 13 2007 6275 6283 (Pubitemid 350075015)
83. S. Boyault, D.S. Rickman, and A. de Reynies Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets Hepatology 45 2007 42 52 (Pubitemid 46144363)
84. Y. Hoshida, A. Villanueva, and M. Kobayashi Gene expression in fixed tissues and outcome in hepatocellular carcinoma N Engl J Med 359 2008 1995 2004
85. M. Okamoto, T. Utsunomiya, and S. Wakiyama Specific gene-expression profiles of noncancerous liver tissue predict the risk for multicentric occurrence of hepatocellular carcinoma in hepatitis C virus-positive patients Ann Surg Oncol 13 2006 947 954
86. M. Tsuchiya, J.S. Parker, and H. Kono Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma Mol Cancer 9 2010 74
87. A. Villanueva, Y. Hoshida, and C. Battiston Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma Gastroenterology 140 2011 1501 1512
88. S.I. Grivennikov, F.R. Greten, and M. Karin Immunity, inflammation, and cancer Cell 140 2010 883 899
89. H. Yokoo, J. Yasuda, and K. Nakanishi Clinicopathological significance of nuclear factor-κB activation in hepatocellular carcinoma Hepatol Res 41 2011 240 249
90. P. Rajendran, T.H. Ong, and L. Chen Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo Clin Cancer Res 17 2011 1425 1439
91. Zhang CH, Xu GL, Jia WD, et al. Activation of STAT3 signal pathway correlates with Twist and E-cadherin expression in hepatocellular carcinoma and their clinical significance. J Surg Res. doi:10.1016/j.jss.2010.10.030.
92. H. van Malenstein, O. Gevaert, and L. Libbrecht A seven-gene set associated with chronic hypoxia of prognostic importance in hepatocellular carcinoma Clin Cancer Res 16 2010 4278 4288
93. X.R. Yang, Y. Xu, and B. Yu High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma Gut 59 2010 953 962
94. C.X. Dai, Q. Gao, and S.J. Qiu Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery BMC Cancer 9 2009 418
95. T.M. Bui-Nguyen, S.B. Pakala, and R.D. Sirigiri NF-kappaB signaling mediates the induction of MTA1 by hepatitis B virus transactivator protein HBx Oncogene 29 2010 1179 1189
96. S.H. Ryu, Y.H. Chung, and H. Lee Metastatic tumor antigen 1 is closely associated with frequent postoperative recurrence and poor survival in patients with hepatocellular carcinoma Hepatology 47 2008 929 936 (Pubitemid 351449684)
97. V.W. Keng, B.R. Tschida, J.B. Bell, and D.A. Largaespada Modeling hepatitis B virus X-induced hepatocellular carcinoma in mice with the Sleeping Beauty transposon system Hepatology 53 2011 781 790
98. L. Liu, X.D. Zhu, and W.Q. Wang Activation of beta-catenin by hypoxia in hepatocellular carcinoma contributes to enhanced metastatic potential and poor prognosis Clin Cancer Res 16 2010 2740 2750
99. H.H. Lee, Y.H. Uen, and Y.F. Tian Wnt-1 protein as a prognostic biomarker for hepatitis B-related and hepatitis C-related hepatocellular carcinoma after surgery Cancer Epidemiol Biomarkers Prev 18 2009 1562 1569
100. B.K. Yoo, D. Chen, and Z.Z. Su Molecular mechanism of chemoresistance by astrocyte elevated gene-1 Cancer Res 70 2010 3249 3258
101. B.K. Yoo, L. Emdad, and Z.Z. Su Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression J Clin Invest 119 2009 465 477
102. B. Yu, X. Yang, and Y. Xu Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas J Hepatol 50 2009 948 957
103. J. Fu, Y. Chen, and J. Cao P28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1alpha pathways Hepatology 53 2011 181 192
104. J.P. Lai, A.M. Oseini, and C.D. Moser The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3-dependent Wnt activation Hepatology 52 2010 1680 1689
105. Yu MC, Lee YS, Lin SE, et al. Recurrence and poor prognosis following resection of small hepatitis B-related hepatocellular carcinoma lesions are associated with aberrant tumor expression profiles of glypican 3 and osteopontin. Ann Surg Oncol. doi:10.1245/s10434-011-1946-2.
106. M.C. Cantarini, S.M. de la Monte, and M. Pang Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms Hepatology 44 2006 446 457 (Pubitemid 44214884)
107. K. Wang, J. Liu, and Z.L. Yan Overexpression of aspartyl-(asparaginyl)- beta- hydroxylase in hepatocellular carcinoma is associated with worse surgical outcome Hepatology 52 2010 164 173
108. T.K. Lee, A. Castilho, and V.C. Cheung CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation Cell Stem Cell 9 2011 50 63
109. X.R. Yang, Y. Xu, and B. Yu CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery Clin Cancer Res 15 2009 5518 5527
110. N.P. Lee, F.H. Tsang, and F.H. Shek Prognostic significance and therapeutic potential of eukaryotic translation initiation factor 5A (eIF5A) in hepatocellular carcinoma Int J Cancer 127 2010 968 976
111. D.S. Bai, Z. Dai, and J. Zhou Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma Hepatology 49 2009 460 470
112. J.C. Li, X.R. Yang, and H.X. Sun Up-regulation of Kruppel-like factor 8 promotes tumor invasion and indicates poor prognosis for hepatocellular carcinoma Gastroenterology 139 2010 2146-57.e2
113. T. Yamashita, M. Honda, and H. Takatori Activation of lipogenic pathway correlates with cell proliferation and poor prognosis in hepatocellular carcinoma J Hepatol 50 2009 100 110
114. Y. Tanaka, F. Kanai, and M. Tada Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma J Hepatol 49 2008 746 757
115. J. Ai, Q. Tang, and Y. Wu The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma J Natl Cancer Inst 103 2011 1696 1712
116. Z.B. Ding, Y.H. Shi, and J. Zhou Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma Cancer Res 68 2008 9167 9175
117. K.M. Sze, K.L. Wong, and G.K. Chu Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance Hepatology 53 2011 1558 1569
118. H.X. Xu, X.D. Zhu, and P.Y. Zhuang Expression and prognostic significance of placental growth factor in hepatocellular carcinoma and peritumoral liver tissue Int J Cancer 128 2011 1559 1569
119. W. Sieghart, X. Wang, and K. Schmid Osteopontin expression predicts overall survival after liver transplantation for hepatocellular carcinoma in patients beyond the Milan criteria J Hepatol 54 2011 89 97
120. J. Sun, H.M. Xu, and H.J. Zhou The prognostic significance of preoperative plasma levels of osteopontin in patients with TNM stage-I of hepatocellular carcinoma J Cancer Res Clin Oncol 136 2010 1 7
121. K.T. Ng, X. Qi, and K.L. Kong Overexpression of matrix metalloproteinase-12 (MMP-12) correlates with poor prognosis of hepatocellular carcinoma Eur J Cancer 47 2011 2299 2305
122. V. Ozenne, V. Paradis, and S. Pernot Tolerance and outcome of patients with unresectable hepatocellular carcinoma treated with sorafenib Eur J Gastroenterol Hepatol 22 2010 1106 1110
123. Singhal A, Jayaraman M, Dhanasekaran DN, Kohli V. Molecular and serum markers in hepatocellular carcinoma: predictive tools for prognosis and recurrence. Crit Rev Oncol Hematol. doi:10.1016/j.critrevonc.2011.05.005.
124. C.D. Mann, C.P. Neal, and G. Garcea Prognostic molecular markers in hepatocellular carcinoma: a systematic review Eur J Cancer 43 2007 979 992 (Pubitemid 46483030)
125. J.M. Llovet, S. Ricci, and V. Mazzaferro Sorafenib in advanced hepatocellular carcinoma N Engl J Med 359 2008 378 390