β-Catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection

American Journal of Pathology

Volumn 155, Issue 6, 1999, Pages 1795-1801

  Huang, Huatao ^a   Fujii, Hideki ^b   Sankila, Anna ^a   Mahler Araujo, Betania M ^a   Matsuda, Masanori ^b   Cathomas, Gieri ^c   Ohgaki, Hiroko ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b UNIVERSITY OF YAMANASHI   (Japan)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DNA SEQUENCE; FEMALE; GENE MUTATION; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; MALE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0032761853     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65496-X     Document Type: Article

References (58)

1. Barth AI, Nathke IS, Nelson WJ: Cadherins, catenins, and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr Opin Cell Biol 1997, 9:683-690
2. Behrens J, von Kries JP, Kuhl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W: Functional interaction of β-catenin with the transcription factor LEF-1. Nature 1996, 382:638-642
3. Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P: Binding of GSK3b to the APC-β-catenin complex and regulation of complex assembly. Science 1996, 272:1023-1026
4. Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P: Regulation of intracellular β-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci USA 1995, 92: 3046-3050
5. Aberle H, Bauer A, Stappert J, Kispert A, Kemler R: β-Catenin is a target for the ubiquitin-proteasome pathway. EMBO J 1997, 16:3797-3804
6. Orford K, Crockett C, Jensen JP, Weissman AM, Byers SW: Serine phosphorylation-regulated ubiquitination and degradation of β-catenin. J Biol Chem 1997, 272:24735-24738
7. Polakis P: The oncogenic activation of β-catenin. Curr Opin Genet Dev 1999, 9:15-21
8. Kinzler KW, Vogelstein B: Lessons from hereditary colorectal cancer. Cell 1996, 87:159-170
9. Sparks AB, Morin PJ, Vogelstein B, Kinzler KW: Mutational analysis of the APC/β-catenin/Tcf pathway in colorectal cancer. Cancer Res 1998, 58:1130-1134
10. Buendia MA: Hepatitis B viruses and hepatocellular carcinoma. Adv Cancer Res 1992, 59:167-226
11. Ng IO, Clung LP, Tsang SW, Lam CL, Lai EC, Fan ST, Ng M: p53 gene mutation spectrum in hepatocellular carcinomas in Hong Kong Chinese. Oncogene 1994, 9:985-990
12. Caselmann WH, Alt M: Hepatitis C virus infection as a major risk factor for hepatocellular carcinoma. J Hepatol 1996, 24:61-66
13. Idilman R, De Maria N, Colantoni A, Van Thiel DH: Pathogenesis of hepatitis B and C-induced hepatocellular carcinoma. J Viral Hepatol 1998, 5:285-299
14. Montesano R, Hainaut P, Wild CP: Hepatocellular carcinoma: from gene to public health. J Natl Cancer Inst 1997, 89:1844-1851
15. Brechot C: Hepatitis B, C viruses, and primary liver cancer. Baillieres Clin Gastroenterol 1996, 10:335-373
16. Bisceglie AM: Hepatitis C and hepatocellular carcinoma. Hepatology 1997, 26:34S-38S
17. Tabor E: Viral hepatitis and liver cancer. Pathology of Viral Hepatitis. Edited by RD Goldin, HC Thomas, MA Gerber, London, Arnold, 1998, pp 161-177
18. Wang XW, Forrester K, Yen H, Feitelson MA, Gu JR, Harris CC: Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci USA 1994, 91:2230-2234
19. Okuda K: Hepatitis C virus and hepatocellular carcinoma. Etiology, Pathology, and Treatment of Hepatocellular Carcinoma in North America. Edited by E Tabor, AM Di Bisceglie, RH Purcell. Houston, London, Paris, Zurich, Tokyo, Gulf Publishing Company, 1991, p 119
20. Ray RB, Lagging LM, Meyer K, Ray R: Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J Virol 1996, 70:4438-4443
21. Ray RB, Meyer K, Ray R: Suppression of apoptotic cell death by hepatitis C virus core protein. Virology 1996, 226:176-182
22. Ray RB, Steele R, Meyer K, Ray R: Transcriptional repression of p53 promoter by hepatitis C virus core protein. J Biol Chem 1997, 272: 10983-10986
23. Moriya K, Fujie H, Shintani Y, Yotsuyanagi H, Tsutsumi T, Ishibashi K, Matsuura Y, Kimura S, Miyamura T, Koike K: The core protein of hepatitis C virus induces hepatocelular carcinoma in transgenic mice. Nature Med 1998, 4:1065-1067
24. Nishida N, Fukuda Y, Komeda T, Kita R, Sando T, Furukawa M, Amenomori M, Shibagaki I, Nakao K, Ikenaga M: Amplification and overexpression of the cyclin D1 gene in aggressive human hepatocellular carcinoma. Cancer Res 1994, 54:3107-3110
25. Peng SY, Lai PL, Hsu HC: Amplification of the c-myc gene in human hepatocellular carcinoma: biologic significance. J Formos Med Assoc 1993, 92:866-870
26. Kanai Y, Ushijima S, Hui AM, Ochiai A, Tsuda H, Sakamoto M, Hirohashi S: The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas. Int J Cancer 1997, 71:355-359
27. Hirohashi S: Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol 1998, 153:333-339
28. Miyoshi Y, Iwao K, Nagasawa Y, Aihara T, Sasaki Y, Imaoka S, Murata M, Shimano T, Nakamura Y: Activation of the β-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res 1998, 58:2524-2527
29. De La Coste A, Romagnolo B, Billuart P, Renard CA, Buendia MA, Soubrane O, Fabre M, Chelly J, Beldjord C, Kahn A, Perret C: Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinomas. Proc Natl Acad Sci USA 1998, 95:8847-8851
30. Ishak KG, Anthony PP, Sobin LH: Histological typing of tumors of the liver. International Histological Classification of Tumors. World Health Organization 1994. Berlin, Heidelberg, Springer-Verlag.
31. Watanabe K, Tachibana O, Sato K, Yonekawa Y, Kleihues P, Ohgaki H: Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 1996, 6:217-224
32. Miyoshi Y, Ando H, Nagase H, Nishisho I, Horii A, Miki Y, Mori T, Utsunomiya J, Baba S, Petersen G, Hamilton SR, Kinzler KW, Vogelstein B, Nakamura Y: Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients. Proc Natl Acad Sci USA 1992, 89:4452-4456
33. Miyoshi Y, Nagase H, Ando H, Horii A, Ichii S, Nakatsuru S, Aoki T, Miki Y, Mori T, Nakamura Y: Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1992, 1:229-233
34. Miyaki M, Konishi M, Kikuchi-Yanoshita R, Enomoto M, Igari T, Tanaka K, Muraoka M, Takahashi H, Amaoa Y, Fukayama M, Maeda Y, Iwama T, Mishima Y, Mori T, Koike M: Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors. Cancer Res 1994, 54:3011-3020
35. Iwao K, Nakamori S, Kameyama M, Imaoka S, Kinoshita M, Fuku: T, Ishiguro S, Nakamura Y, Miyoshi Y: Activation of the β-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations. Cancer Res 1998, 58:1021-1026
36. Samowitz WS, Powers MD, Spirio LN, Nollet F, Van Roy F, Slattery ML: β-Catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. Cancer Res 1999, 59:1442-1444
37. Fukuchi T, Sakamoto M, Tsuda H, Maruyama K, Nozawa S, Hirohashi S: β-Catenin mutation in carcinoma of the uterine endometrium. Cancer Res 1998, 58:3526-3528
38. Palacios J, Gamallo C: Mutations in the β-caten n gene (CTNNB1) in endometrioid ovarian carcinomas. Cancer Res 1998, 58:1344-1347
39. Zurawel RH, Chiappa SA, Allen C, Raffel C: Sporadic medulloblastomas contain oncogenic β-catenin mutations. Cancer Res 1998, 58: 896-899
40. Voeller HJ, Truica CI, Gelmann EP: Beta-catenin mutations in human prostate cancer. Cancer Res 1998, 58:2520-2523
41. Iwao K, Miyoshi Y, Nawa G, Yoshikawa H, Ochi T, Nakamura Y: Frequent β-catenin abnormalities in bone and soft-tissue tumors. Jpn J Cancer Res 1999, 90:205-209
42. Chan EF, Gat U, McNiff JM, Fuchs E: A common human skin tumour is caused by activating mutations in β-catenin. Nature Genet 1999, 21:410-413
43. Garcia-Rostan G, Tallini G, Herrero A, D'Aquila TG, Carcangiu ML, Rimm DL: Frequent mutation and nuclear localization of β-catenin in anaplastic thyroid carcinoma. Cancer Res 1999, 59:1811-1815
44. Koch A, Denkhaus D, Albrecht S, Leuschner I, von Schweinitz D, Pietsch T: Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the β-catenin gene. Cancer Res 1999, 59:269-273
45. Anna CH, Foley JF, White CM, Sills RC, Barrett JC, Devereux TR: β-Catenin mutations in chemically induced mouse hepatocellular adenomas and carcinomas. Proc Am Assoc Cancer Res 1999, 40:505 (Abstract)
46. Sheu JC: Molecular mechanism of hepatocarcinogenesis. J Gastroenterol Hepatol 1997, 12:S309-S313
47. Kawai S, Imazeki F, Yokosuka O Ohto M, Shiina S, Kato N, Omata M: Clonality in hepatocellular carcinoma: analysis of methylation pattern of polymorphic X-chromosome-linked phosphog ycerate kinase gene in females. Hepatology 1995, 22:112-117
48. Aihara T, Noguchi S, Sasaki Y, Nakano H, Imaoka S: C onal analysis of regenerative nodules in hepatitis C virus-induced liver cirrhosis. Gastroenterology 1994, 107:1805-1811
49. Sheu JC, Huang GT, Chou HC, Lee PH, Wang JT, Lee HS, Chen DS: Multiple hepatocellular carcinomas at the early stage have different clonality. Gastroenterology 1993, 105:1471-1476
50. Blum HE, Offensperger WB, Walter E, Offensperger S, Wahl A, Zeschnigk C, Gerok W: Hepatocellular carcinoma and hepatitis B virus infection: molecular evidence for monoclonal origin and expansion of malignantly transformed hepatocytes. J Cancer Res Clin Oncol 1987, 113:466-472
51. Willert K, Nusse R: β-Catenin: a key mediator of Wnt signaling. Curr Opin Genet Dev 1998, 8:95-102
52. Ding SF, Habib NA, Dooley J, Wood C, Bowles L, Delhanty JD: Loss of constitutional heterozygosity on chromosome 5q in hepatocellular carcinoma without cirrhosis. Br J Cancer 1991, 64 1083-1087
53. Ding SF, Delhanty JD, Docley JS, Bowles L, Wood CB, Habib NA: The putative tumor suppressor gene on chromosome 5q for hepatocellular carcinoma is distinct from the MCC and APC genes. Cancer Detect Prev 1993, 17:405-409
54. Fujimori M, Tokino T, Hino O, Kitagawa T, Imamura T, Okamoto E, Mitsunobu M, Ishikawa T, Nakagama H, Harada H: Allelotype study of primary hepatocellular carcinoma. Cancer Res 1991, 51:89-93
55. Horii A, Nakatsuru S, Miyoshi Y, Ichii S, Nagase H, Ando H, Yanagisawa A, Tsuchiya E, Kato Y, Nakamura Y: Frequent somatic mutations of the APC gene in human pancreatic cancer. Cancer Res 1992, 52:6696-6698
56. Laken SJ, Petersen GM, Gruber SB, Oddoux C, Ostrer H, Giardiello FM, Hamilton SR, Hampel H, Markcwitz A, Klimstra D, Jhanwar S, Winawer S, Offit K, Luce MC, Kinzler KW, Vogelstein B: Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nature Genet 1997, 17:79-83
57. Laurent-Puig P, Beroud C, Soussi T: APC gene: database of germline and somatic mutations in human tumors and cell lines. Nucleic Acids Res 1998, 26:269-270
58. White RL: Excess risk of colon cancer associated with a polymorphism of the APC gene? Cancer Res 1998, 58:4038-4039