Circulating transforming growth factor-β and epidermal growth factor receptor as related to virus infection in liver carcinogenesis

Anticancer Research

Volumn 32, Issue 1, 2012, Pages 141-145

  Divella, Rosa ^a   Daniele, Antonella ^a   Gadaleta, Cosimo ^a   Tufaro, Antonio ^a   Venneri, Maria Teresa ^a   Paradiso, Angelo ^a   Quaranta, Michele ^a  

^a NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

Author keywords

EGFR in liver cancer; HCV and HBV liver infection; Hepatocellular carcinoma; TGF in liver carcinogenesis

Indexed keywords

ALPHA FETOPROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MOLECULAR MARKER; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER METASTASIS; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPACIVIRUS; HEPATITIS C; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR MARKERS, BIOLOGICAL;

EID: 84855711468     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. El-Serag HB and Rudolph L: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576, 2007. (Pubitemid 46890874)
2. Marrero CR and Marrero JA: Viral hepatitis and hepatocellular carcinoma. Arch Med Res 38: 612-620, 2007. (Pubitemid 47001566)
3. Key MC: interaction between hepatitis B and C viruses in hepatocellular carcinogenesis. J Viral Hepat 13: 145-149, 2006.
4. Lauren-Puig P, Legdix P, Bluteau O, Belghiti J, Franco D, Binot F, Monges G, Thomas G, Bioulac-Sage P and Zucman-Rossi J: Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 120: 1763-1773, 2001. (Pubitemid 32523494)
5. Shilpa J, Shashideep S, Peng L and Ruliang X: Molecular genetics of hepatocellular neoplasia. Am J Transi Res 2(1): 105-118, 2010.
6. Berasain C, Castillo J, Prieto J and Avila MA: New molecular targets for hepatocellular carcinoma: the ERBB1 signaling system. Liver Int 27(2): 174-185, 2007. (Pubitemid 46680720)
7. Giannelli G, Mazzocca A, Fransvea E, Lahn M and Antonacci S: Inhibiting TGF-b signaling in hepatocellular carcinoma. Biochim e Biophys Acta 1815: 214-223, 2011.
8. Valdes F, Alvarez AM, Losascio A, Vega S, Herrera B and Fernandez M: The epithelial-mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor beta in fetal rat hepatocytes. Mol Cancer Res 1: 68-78, 2002. (Pubitemid 36330212)
9. Valdes F, Murillo MM, Valverde AM, Herrera B, Sanchez A and Benito M: Transforming growth factor-beta activates both pro-apoptotic and survival signals in fetal rat hepatocytes. Exp Cell Res 292: 209-218, 2004. (Pubitemid 38058277)
10. Fabreagat I, Roncero C and Fernandez M: Survival and apoptosis: a dysregulated balance in liver cancer. Liver Int 27: 155-162, 2007. (Pubitemid 46680718)
11. Bersain C, Perugorria MJ, Latasa MU, Castillo J, Goni S and Santamaria M: The epidermal growth factor receptor: a link between inflammation and liver cancer. Exp Biol Med 234: 713-725, 2009.
12. Caja L, Ortiz C, Bertran E, Murillo MM, Mirò-Obradors MJ, Palacios E and Fabregat I: Differential intracellular signaling induced by TGF-β in rat adult hepatocytes and hepatoma cells: inplications in liver carcinogenesis. Cell Signal 19: 683-694, 2007. (Pubitemid 46275361)
13. Wu BW, Wu Y, Wang JL, Lin JS, Yuan SY, Li A and Cui WR: Study on the mechanism of epidermal growth factor-induced proliferation of hepatoma cells. World J Gastroenterol 9(2): 271-275, 2003. (Pubitemid 36215802)
14. Breuhahn K, Longerich T and Schirmacher P: Dysregulation of growth factor signaling in human hepatocellular. Oncogene 25: 3787-3800, 2006. (Pubitemid 43980474)
15. Quaranta M, Divella R, Daniele A, Di Tardo S, Venneri MT, Lolli I and Troccoli G: Epidermal growth factor receptor serum levels and prognostic value in malignant gliomas. Tumori 93: 275-280, 2007. (Pubitemid 47080014)
16. Sasaki H, Yukive H and Mizuno K: Elevated serum epidermal growth factor receptor levels is correlated with lymph node metastasis in lung cancer. Int J Clin Oncol 8: 79-82, 2003. (Pubitemid 36548475)
17. Zampino MG, Magni E, Santoro L, Zorzino L, Dell'Orto P, Sonzogni A, Fazio N, Monfardini L, Chiappa A, Biffi R and de Braud F: Epidermal growth factor receptor serum (sEGFR) level may predict response in patients with EGFR-positive advanced colorectal cancer treated with gefitinib. Cancer Chemother Pharmacol 63(1): 139-148, 2008.
18. Nannini M, Pantaleo MA, Paterini P, Piazzi G, Ceccarelli C, La Rovere S, Maleddu A and Biasco G: Molecular detection of epidermal growth factor receptor in colorectal cancer: Does it still make sense? Colorectal Dis 13(5): 542-548, 2011.
19. Pitteri SJ, Amon LM, Busald Buson T, Zhang Y, Johnson MM, Chin A, Kennedy J, Wong CH, Zhang Q, Wang H, Lampe PD, Prentice RL, Mcintosh MW, Hanash SM and Li CI: Detection of elevated plasma levels of epidermal growth factor receptor before breast cancer diagnosis among hormone therapy users. Cancer Res 70(21): 8598-806, 2010.
20. El-Houseini ME, Mohammed MS, Elshemey WM, Hussein T, Desouhy Os and Elsayed A: Enhanced detection of hepatocellular carcinoma. Cancer Control 12(4): 248-253, 2005. (Pubitemid 41552317)
21. Gotoh M, Nakatani T, Masuda T, Mizuguchi Y, Sakamoto M, Tsuchiya R and Kato H: Prediction of invasive activities in hepatocellular carcinomas with special reference to alpha-fetoprotein and des-gamma-carboxyprothrombin. Jpn J Clin Oncol 33(10): 522-526, 2003. (Pubitemid 43115246)
22. Dong ZZ, Yao DF, Yao M, Qiu LW, Zong L, Wu W, Wu XH, Yao DB and Meng XY: Clinical impact of plasma TGF-beta1 and circulating TGF-beta1 mRNA in diagnosis of hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 7(3): 288-295, 2008. (Pubitemid 351895389)
23. Okumoto K, Hattori E, Tamura K, Kiso S, Watanabe H, Saito K, Saito T, Togashi H and Kawata S: Possible contribution of circulating transforming growth factor-beta1 to immunity and prognosis in unresectable hepatocellular carcinoma. Liver Int 24(1): 21-28, 2004. (Pubitemid 38351210)
24. Song BC, Chung YA, Kim JA, Choi WB, Suh DD, Shin JW, Lee HC, Lee YS and Suh DJ: Transforming growth factor-b1 as a useful serologic marker of small hepatocellular carcinoma. Cancer 94(1): 175-180, 2002. (Pubitemid 34049056)
25. Biernacka A, Dobaczewski M and Frangogiannis NG: TGF-β signaling in fibrosis. Growth Factor 29(5): 196-202, 2011.
26. Yamazaki K, Masugi Y and Sakamoto M: Molecular pathogenesis of hepatocellular carcinoma: altering transforming growth factor-ß signaling in hepatocarcinogenesis. Dig Dis 29(3): 284-288, 2011.
27. Matsuzaki K and Okazaki K: Transforming growth factor-beta during carcinogenesis: the shift from epithelial to mesenchymal signaling. J Gastroenterol 41(4): 295-303, 2006. (Pubitemid 43834371)
28. Matsuzaki K: Modulation of TGF-beta signaling during progression of chronic liver diseases. Front Biosci 14: 2923-2934, 2009.
29. Taniai E, Kawai M, Dewa Y, Nishimura J, Harada T, Saegusa Y, Matsumoto S, Takahashi M, Mitsumori K and Shibutani M: Crosstalk between Pten/Akt2 and Tgf beta signaling involving Egf receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model. Cancer Sci 100(5): 813-820, 2009.
30. Caja L, Sancho P, Bertran E and Fabregat I: Dissecting the effect of targeting the epidermal growth factor receptor on TGF-b-induced-apoptosis in human hepatocellular carcinoma cells. Hepatology 55: 351-358, 2011.
31. Caja L, Sancho P, Bertran E, Ortiz C, Campbell JS, Fausto N and Fabregat I: The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms. Biochem Pharmacol 1(82): 1583-1592, 2011.
32. Mazzocca A, Fransvea E, Dituri F, Lupo L, Antonaci S and Giannelli G: Down-regulation of connective tissue growth factor by inhibition of transforming growth factor beta blocks the tumor-stroma cross-talk and tumor progression in hepatocellular carcinoma. Hepatology 51(2): 523-534, 2010.
33. Zemel R, Issachar A and Tur-Kaspa R: The role of oncogenic viruses in the pathogenesis of hepatocellular carcinoma. Clin Liver Dis 15(2): 261-279, 2011.
34. Woo HG, Park ES, Thorgeirsson SS and Kim YJ: Exploring genomic profiles of hepatocellular carcinoma. Mol Carcinog 50(4): 235-243, 2011.
35. Matsuzaki K, Murata M, Yoshida K, Sekimoto G, Sakaida N, Kaibori M, Kamiyama Y, Nishizawa M, Fujisawa J, Okazaki K and Seki T: Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma. Hepatology 46(1): 48-57, 2007. (Pubitemid 47171920)
36. Janczewska-Kazek E, Marek B, Kajdaniuk D and Borgiel-marek H: Effect of interferon alpha and ribavirin treatment on serum levels of transforming growth factor-beta1, vascular endothelial growth factor, and basic fibroblast growth factor in patients with chronic hepatitis C. World J Gastroenterol 12: 961-965, 2006.