Hepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-β pathway

Oncogene

Volumn 24, Issue 40, 2005, Pages 6119-6132

  Pavio, Nicole ^a   Battaglia, Serena ^a,c   Boucreux, Delphine ^a   Arnulf, Bertrand ^b   Sobesky, Rodolphe ^a   Hermine, Olivier ^b   Brechot, Christian ^a  

^a INSERM   (France)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Core protein; HCV; Hepatocellularcarcinoma; Smad3; TGF ; Tumor

Indexed keywords

CANCER GROWTH FACTOR; CORE PROTEIN; DNA BINDING PROTEIN; NUCLEOCAPSID PROTEIN, HEPATITIS C VIRUS; SMAD3 PROTEIN; SMAD3 PROTEIN, HUMAN; SMAD4 PROTEIN; SMAD4 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DNA BINDING; GENE CONTROL; GENE SEQUENCE; GENETIC VARIABILITY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; LIVER TUMOR; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; CELL CULTURE; COMPARATIVE STUDY; GENETICS; LIVER CELL CARCINOMA; MOLECULAR GENETICS; MUTATION; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; VIROLOGY;

HEPATITIS C VIRUS;

AMINO ACID SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; HEPACIVIRUS; HUMANS; LIVER NEOPLASMS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED; VIRAL CORE PROTEINS;

EID: 26944444737     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1208749     Document Type: Article

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