Oncogenic role of the frizzled-7/β-catenin pathway in hepatocellular carcinoma

Journal of Hepatology

Volumn 43, Issue 5, 2005, Pages 854-862

  Merle, Philippe ^a,b   Kim, Miran ^a   Herrmann, Marc ^a   Gupte, Anand ^a   Lefrançois, Lydie ^b   Califano, Sophia ^a   Trépo, Christian ^b   Tanaka, Shinji ^c   Vitvitski, Ludmila ^b   De La Monte, Suzanne ^a   Wands, Jack R ^a  

^a BROWN UNIVERSITY   (United States)

^b INSERM   (France)

^c NATIONAL CANCER CENTER   (Japan)

Author keywords

Frizzled receptors; Hepatocellular carcinoma; Liver dysplasia; Signaling

Indexed keywords

BETA CATENIN; FRIZZLED PROTEIN; INSULIN RECEPTOR; TRANSFORMING PROTEIN; VIRUS PROTEIN; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL LINE; CELL NUCLEUS; DYSPLASIA; LIVER CELL CARCINOMA; MEASUREMENT; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BETA CATENIN; CARCINOMA, HEPATOCELLULAR; CELL FRACTIONATION; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; ONCOGENES; PHOSPHORYLATION; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 26244447326     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.05.018     Document Type: Article

References (36)

1. C.J. Murray, and A.D. Lopez Mortality by cause for eight regions of the world: global burden of disease study Lancet 349 1997 1269 1276
2. W.H. Caselmann, and M. Alt Hepatitis C virus infection as a major risk factor for hepatocellular carcinoma J Hepatol 24 1996 61 66
3. P.P. Anthony Hepatocellular carcinoma: an overview Histopathology 39 2001 109 118
4. H.B. El-Serag, and A.C. Mason Rising incidence of hepatocellular carcinoma in the United States N Engl J Med 340 10 1999 745 750
5. H. Nagai, P. Pineau, P. Tiollais, M.A. Buendia, and A. Dejean A comprehensive allelotyping of human hepatocellular carcinoma Oncogene 14 1997 2927 2933
6. R. Idilman, N. De Maria, A. Colantoni, and D. Van Thiel Pathogenesis of hepatitis B and C-induced hepatocellular carcinoma J Viral Hepat 5 1998 285 299
7. A. de la Coste, B. Romagnolo, P. Billuart, C.A. Renard, M.A. Buendia, and O. Soubrane Somatic mutations of the β-catenin gene are frequent in mouse and human hepatocellular carcinoma Proc Natl Acad Sci USA 95 1998 8847 8851
8. D.F. Calvisi, V.M. Factor, R. Loi, and S.S. Thorgeirsson Activation of β-catenin during hepatocarcinogenesis in transgenic mouse models Cancer Res 61 2001 2085 2091
9. M. Torbenson, J.H. Lee, M. Choti, W. Gag, S.C. Abraham, and E. Montgomery Hepatic adenomas: analysis of sex steroid receptor status and the Wnt signaling pathway Mod Pathol 15 3 2002 189 196
10. H.C. Hsu, Y.M. Jeng, T.L. Mao, J.S. Chu, P.L. Lai, and S.Y. Peng β-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis Am J Pathol 157 2000 763 770
11. T.R. Devereux, M.C. Stern, G.P. Flake, M.C. Yu, Z.Q. Zhang, and S.J. London CTNNB1 mutations and beta-catenin protein accumulation in human hepatocellular carcinomas associated with high exposure to aflatoxin B1 Mol Carcinog 31 2001 68 73
12. C.M. Wong, S.T. Fan, and I.O. Ng β-catenin mutation and over-expression in hepatocellular carcinoma: clinicopathologic and prognostic significance Cancer 92 2001 136 145
13. P. Merle, S.M. de la Monte, M. Kim, M. Herrmann, S. Tanaka, and A. von dem Bussche Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma Gastroenterology 127 4 2004 1110 1122
14. P. Bhanot, M. Brink, C.H. Samos, J.C. Hsieh, Y. Wang, and J.P. Macke A new member of the frizzled family from Drosophila functions as a Wingless receptor Nature 38 1996 225 230
15. S.E. Jones, and C. Jomary Secreted frizzled-related proteins: searching for relationships and patterns BioEssays 24 2002 811 820
16. S. Tanaka, T. Akiyoshi, M. Mori, J.R. Wands, and K. Sugimachi A novel frizzled gene identified in human esophageal carcinoma mediates APC/β-catenin signals Proc Natl Acad Sci USA 95 1998 10164 10169
17. N. Dubois, M. Bennoun, I. Allemand, T. Molina, G. Grimber, and M. Daudet-Monsac Time-course development of differentiated hepatocarcinoma and lung metastasis in transgenic mice J Hepatol 13 1991 227 239
18. M. Moore, A.K. Teresky, A.J. Levine, and M. Seiberg p53 mutations are not selected for in simian virus 40 T-antigen-induced tumors from transgenic mice J Virol 66 1992 641 649
19. J. Etiemble, C. Degott, C.A. Renard, G. Fourel, B. Shamoon, and L. Vitvitski-Trepo Liver-specific expression and high oncogenic efficiency of a c-myc transgene activated by woodchuck hepatitis virus insertion Oncogene 9 1994 727 737
20. O. Terradillos, O. Billet, C.A. Renard, R. Levy, T. Molina, and P. Briand The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice Oncogene 14 1997 395 404
21. L. Mohr, S. Tanaka, and J.R. Wands Ethanol inhibits hepatocyte proliferation in insulin receptor substrate-1 transgenic mice Gastroenterology 115 1998 1558 1565
22. P. Merle, L. Barraud, L. Lefrançois, M. Chevallier, M. Maisonnas, and I. Bordes Interferon-alpha therapy dose- and time-dependently delays Hepadnavirus-related hepatocarcinogenesis in X/myc transgenic mice Oncogene 22 2003 2762 2771
23. P. Merle, M. Chevallier, R. Levy, M. Maisonnas, O. Terradillos, and S.N. Si Ahmed Preliminary results of interferon-alpha therapy on woodchuck hepatitis virus-induced hepatocarcinogenesis: possible benefit in female transgenic mice J Hepatol 34 2001 562 569
24. C.H. Frith, J.M. Ward, and V.S. Turusov V. Turusov U. Mohr Tumors of the liver Pathology of tumors in laboratory animals vol. 2 1994 223 270
25. J.A. Maloney, O. Tsygankova, A. Szot, L. Yang, Q. Li, and J.R. Williamson Differential translication of protein kinase C isozymes by phorbol esters, EGF, and ANG II in rat liver WB cells Am J Physiol 274 1998 C974 C982
26. J. Tran Van Nhieu, C.A. Renard, Y. Wei, D. Cherqui, E.S. Zafrani, and M.A. Buendia Nuclear accumulation of mutated β-catenin in hepatocellular carcinoma is associated with increased cell proliferation Am J Pathol 155 1999 703 710
27. R.H. Giles, J.H. van Es, and H. Clever Caught up in a Wnt storm: Wnt signaling in cancer Biochim Biophys Acta 1653 2003 1 24
28. K.C. Ban, H. Singh, R. Krishnan, and H.F. Seow GSK-3β phosphorylation and alteration of β-catenin in hepatocellular carcinoma Cancer letters 199 2003 201 208
29. D.B. Zimonjic, C.L. Keck, S.S. Thorgeirsson, and N.C. Popescu Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization Hepatology 29 1999 1208 1214
30. D.F. Calvisi, V.M. Factor, S. Ladu, E.A. Conner, and S.S. Thorgeirsson Disruption of β-catenin pathway or genomic instability define two distinct categories of liver cancer in transgenic mice Gastroenterology 126 2004 1374 1386
31. P. Legoix, O. Bluteau, J. Bayer, C. Perret, C. Balabaud, and J. Belghiti Beta-catenin mutations in hepatocellular carcinoma correlate with a low rate of loss of heterozygosity Oncogene 18 1999 4044 4046
32. P. Laurent-Puig, P. Legoix, O. Bluteau, J. Belghiti, D. Franco, and F. Binot Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis Gastroenterology 120 2001 1763 1773
33. C.H. Anna, M. Iida, R.C. Sills, and T.R. Devereux Expression of potential beta-catenin targets, cyclin D1, c-Jun, c-myc, E-cadherin, and EGFR in chemically induced hepatocellular neoplasms from B6C3F1 mice Toxicol Appl Pharmacol 190 2003 135 145
34. H. Huang, H. Fuji, A. Sankila, B.M. Mahler-Araujo, M. Matsuda, and G. Cathomas Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection Am J Pathol 155 1999 1795 1801
35. S. Satoh, Y. Daigo, Y. Furukawa, T. Kato, N. Miwa, and T. Nishiwaki AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 Nat Genet 24 2000 245 250
36. M. Lisovsky, K. Itoh, and S.Y. Sokol Frizzled receptors activate a novel JNK-dependent pathway that may lead to apoptosis Curr Biol 12 2002 53 58