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Volumn 34, Issue 1, 2007, Pages 126-132

Matrix metalloproteinase-3 secretion from human pancreatic periacinar myofibroblasts in response to inflammatory mediators

Author keywords

Chronic pancreatitis; Extracellular matrix; Fibrosis; NF B

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; I KAPPA B ALPHA; INTERLEUKIN 17; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; STROMELYSIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 33845978070     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpa.0000246662.23128.57     Document Type: Article
Times cited : (14)

References (51)
  • 1
    • 0032954505 scopus 로고    scopus 로고
    • Pancreatic stellate cells are activated by proinflammatory cytokines: Implications for pancreatic fibrogenesis
    • Apte MV, Haber PS, Darby SJ, et al. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut. 1999;44:534-541.
    • (1999) Gut , vol.44 , pp. 534-541
    • Apte, M.V.1    Haber, P.S.2    Darby, S.J.3
  • 2
    • 0032829703 scopus 로고    scopus 로고
    • Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis
    • Haber PS, Keogh GW, Apte MV, et al. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am J Pathol. 1999;155:1087-1095.
    • (1999) Am J Pathol , vol.155 , pp. 1087-1095
    • Haber, P.S.1    Keogh, G.W.2    Apte, M.V.3
  • 3
    • 0036282292 scopus 로고    scopus 로고
    • Pancreatic stellate cells respond to inflammatory cytokines: Potential role in chronic pancreatitis
    • Mews P, Phillips P, Fahmy R, et al. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut. 2002;50:535-541.
    • (2002) Gut , vol.50 , pp. 535-541
    • Mews, P.1    Phillips, P.2    Fahmy, R.3
  • 4
    • 0030947307 scopus 로고    scopus 로고
    • Morphological and immunocytochemical identification of periacinar fibroblast-like cells derived from human pancreatic acini
    • Saotome T, Inoue H, Fujimiya M, et al. Morphological and immunocytochemical identification of periacinar fibroblast-like cells derived from human pancreatic acini. Pancreas. 1997;14:373-382.
    • (1997) Pancreas , vol.14 , pp. 373-382
    • Saotome, T.1    Inoue, H.2    Fujimiya, M.3
  • 5
    • 0033618337 scopus 로고    scopus 로고
    • Matrix metalloproteinases
    • Nagase H, Woessner JF Jr. Matrix metalloproteinases. J Biol Chem. 1999;274:21491-21494.
    • (1999) J Biol Chem , vol.274 , pp. 21491-21494
    • Nagase, H.1    Woessner Jr., J.F.2
  • 6
    • 0029150795 scopus 로고
    • Proteolytic remodeling of extracellular matrix
    • Birkedal-Hansen H. Proteolytic remodeling of extracellular matrix. Curr Opin Cell Biol. 1995;7:728-735.
    • (1995) Curr Opin Cell Biol , vol.7 , pp. 728-735
    • Birkedal-Hansen, H.1
  • 8
    • 0027442510 scopus 로고
    • Matrix metalloproteinase-3 (stromelysin-1). Identification as the cartilage acid metalloprotease and effect of pH on catalytic properties and calcium affinity
    • Wilhelm SM, Shao ZH, Housley TJ, et al. Matrix metalloproteinase-3 (stromelysin-1). Identification as the cartilage acid metalloprotease and effect of pH on catalytic properties and calcium affinity. J Biol Chem. 1993;268:21906-21913.
    • (1993) J Biol Chem , vol.268 , pp. 21906-21913
    • Wilhelm, S.M.1    Shao, Z.H.2    Housley, T.J.3
  • 9
    • 0034234599 scopus 로고    scopus 로고
    • Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts
    • Andoh A, Takaya H, Saotome T, et al. Cytokine regulation of chemokine (IL-8, MCP-1, and RANTES) gene expression in human pancreatic periacinar myofibroblasts. Gastroenterology. 2000;119:211-219.
    • (2000) Gastroenterology , vol.119 , pp. 211-219
    • Andoh, A.1    Takaya, H.2    Saotome, T.3
  • 10
    • 0037080031 scopus 로고    scopus 로고
    • IL-6 secretion by human pancreatic periacinar myofibroblasts in response to inflammatory mediators
    • Shimada M, Andoh A, Hata K, et al. IL-6 secretion by human pancreatic periacinar myofibroblasts in response to inflammatory mediators. J Immunol. 2002;168:861-868.
    • (2002) J Immunol , vol.168 , pp. 861-868
    • Shimada, M.1    Andoh, A.2    Hata, K.3
  • 11
    • 0242657563 scopus 로고    scopus 로고
    • Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts
    • Tasaki K, Shintani Y, Saotome T, et al. Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts. Pancreatology. 2003;3:414-421.
    • (2003) Pancreatology , vol.3 , pp. 414-421
    • Tasaki, K.1    Shintani, Y.2    Saotome, T.3
  • 12
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls JK, Linden A. Interleukin-17 family members and inflammation. Immunity. 2004;21:467-476.
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 13
    • 27544469550 scopus 로고    scopus 로고
    • Wynn TA. T(H)-17: a giant step from T(H)1 and T(H)2. Nat Immunol. 2005;6:1069-1070.
    • Wynn TA. T(H)-17: a giant step from T(H)1 and T(H)2. Nat Immunol. 2005;6:1069-1070.
  • 14
    • 33646164439 scopus 로고    scopus 로고
    • Expanding the effector CD4 T-cell repertoire: The Th17 lineage
    • Harrington LE, Mangan PR, Weaver CT. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol. 2006;18:349-356.
    • (2006) Curr Opin Immunol , vol.18 , pp. 349-356
    • Harrington, L.E.1    Mangan, P.R.2    Weaver, C.T.3
  • 15
    • 33744984785 scopus 로고    scopus 로고
    • Th17: An effector CD4 T cell lineage with regulatory T cell ties
    • Weaver CT, Harrington LE, Mangan PR, et al. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity. 2006;24:677-688.
    • (2006) Immunity , vol.24 , pp. 677-688
    • Weaver, C.T.1    Harrington, L.E.2    Mangan, P.R.3
  • 16
    • 0023942417 scopus 로고
    • The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin
    • Saus J, Quinones S, Otani Y, et al. The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin. J Biol Chem. 1988;263:6742-6745.
    • (1988) J Biol Chem , vol.263 , pp. 6742-6745
    • Saus, J.1    Quinones, S.2    Otani, Y.3
  • 17
    • 0001704868 scopus 로고
    • Primary structure and cDNA cloning of human fibroblast collagenase inhibitor
    • Carmichael DF, Sommer A, Thompson RC, et al. Primary structure and cDNA cloning of human fibroblast collagenase inhibitor. Proc Natl Acad Sci U S A. 1986;83:2407-2411.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 2407-2411
    • Carmichael, D.F.1    Sommer, A.2    Thompson, R.C.3
  • 18
    • 0026621977 scopus 로고
    • DNA sequencing with chain-terminating inhibitors. 1977
    • Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain-terminating inhibitors. 1977. Biotechnology. 1992;24:104-108.
    • (1992) Biotechnology , vol.24 , pp. 104-108
    • Sanger, F.1    Nicklen, S.2    Coulson, A.R.3
  • 19
    • 0033623317 scopus 로고    scopus 로고
    • Overexpression of truncated IkappaBalpha induces TNF-alpha-dependent apoptosis in human vascular smooth muscle cells
    • Obara H, Takayanagi A, Hirahashi J, et al. Overexpression of truncated IkappaBalpha induces TNF-alpha-dependent apoptosis in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2000;20:2198-2204.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 2198-2204
    • Obara, H.1    Takayanagi, A.2    Hirahashi, J.3
  • 20
    • 0031842971 scopus 로고    scopus 로고
    • Periacinar stellate shaped cells in rat pancreas: Identification, isolation, and culture
    • Apte MV, Haber PS, Applegate TL, et al. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 1998;43:128-133.
    • (1998) Gut , vol.43 , pp. 128-133
    • Apte, M.V.1    Haber, P.S.2    Applegate, T.L.3
  • 21
    • 5444247172 scopus 로고    scopus 로고
    • Identification, culture, and characterization of pancreatic stellate cells in rats and humans
    • Bachem MG, Schneider E, Gross H, et al. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology. 1998;115:421-432.
    • (1998) Gastroenterology , vol.115 , pp. 421-432
    • Bachem, M.G.1    Schneider, E.2    Gross, H.3
  • 22
    • 0034758720 scopus 로고    scopus 로고
    • Increased matrix metalloproteinase expression and activation following experimental acute pancreatitis
    • Muhs BE, Patel S, Yee H, et al. Increased matrix metalloproteinase expression and activation following experimental acute pancreatitis. J Surg Res. 2001;101:21-28.
    • (2001) J Surg Res , vol.101 , pp. 21-28
    • Muhs, B.E.1    Patel, S.2    Yee, H.3
  • 23
    • 33644515695 scopus 로고    scopus 로고
    • Serum matrix metalloproteinase 9 as a marker for the assessment of severe acute pancreatitis
    • Chen P, Yuan Y, Wang S, et al. Serum matrix metalloproteinase 9 as a marker for the assessment of severe acute pancreatitis. Tohoku J Exp Med. 2006;208:261-266.
    • (2006) Tohoku J Exp Med , vol.208 , pp. 261-266
    • Chen, P.1    Yuan, Y.2    Wang, S.3
  • 24
    • 0037374036 scopus 로고    scopus 로고
    • Matrix metalloproteinase-1 and cytokines in patients with acute pancreatitis
    • Nakae H, Endo S, Inoue Y, et al. Matrix metalloproteinase-1 and cytokines in patients with acute pancreatitis. Pancreas. 2003;26:134-138.
    • (2003) Pancreas , vol.26 , pp. 134-138
    • Nakae, H.1    Endo, S.2    Inoue, Y.3
  • 25
    • 0031737953 scopus 로고    scopus 로고
    • Immunohistochemical study of transforming growth factor-beta 1, matrix metalloproteinase-2,9, tissue inhibitors of metalloproteinase-1,2, and basement membrane components at pancreatic ducts in chronic pancreatitis
    • Ishihara T, Hayasaka A, Yamaguchi T, et al. Immunohistochemical study of transforming growth factor-beta 1, matrix metalloproteinase-2,9, tissue inhibitors of metalloproteinase-1,2, and basement membrane components at pancreatic ducts in chronic pancreatitis. Pancreas. 1998;17:412-418.
    • (1998) Pancreas , vol.17 , pp. 412-418
    • Ishihara, T.1    Hayasaka, A.2    Yamaguchi, T.3
  • 26
    • 0036098613 scopus 로고    scopus 로고
    • Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis
    • Shek FW, Benyon RC, Walker FM, et al. Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. Am J Pathol. 2002;160:1787-1798.
    • (2002) Am J Pathol , vol.160 , pp. 1787-1798
    • Shek, F.W.1    Benyon, R.C.2    Walker, F.M.3
  • 27
    • 0033999308 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Biologic activity and clinical implications
    • Nelson AR, Fingleton B, Rothenberg ML, et al. Matrix metalloproteinases: biologic activity and clinical implications. J Clin Oncol. 2000;18:1135-1149.
    • (2000) J Clin Oncol , vol.18 , pp. 1135-1149
    • Nelson, A.R.1    Fingleton, B.2    Rothenberg, M.L.3
  • 28
    • 0037302934 scopus 로고    scopus 로고
    • Rat pancreatic stellate cells secrete matrix metalloproteinases: Implications for extracellular matrix turnover
    • Phillips PA, McCarroll JA, Park S, et al. Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut. 2003;52:275-282.
    • (2003) Gut , vol.52 , pp. 275-282
    • Phillips, P.A.1    McCarroll, J.A.2    Park, S.3
  • 29
    • 1542513705 scopus 로고    scopus 로고
    • Role of fibroblast growth factor-2 in the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human intestinal myofibroblasts
    • Yasui H, Andoh A, Bamba S, et al. Role of fibroblast growth factor-2 in the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human intestinal myofibroblasts. Digestion. 2004;69:34-44.
    • (2004) Digestion , vol.69 , pp. 34-44
    • Yasui, H.1    Andoh, A.2    Bamba, S.3
  • 30
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • Sutton C, Brereton C, Keogh B, et al. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med. 2006;203:1685-1691.
    • (2006) J Exp Med , vol.203 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3
  • 31
    • 27544490377 scopus 로고    scopus 로고
    • + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • + effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6:1123-1132.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3
  • 32
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H, Li Z, Yang XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6:1133-1141.
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3
  • 33
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of interleukin 17 in inflammatory bowel disease
    • Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 2003;52:65-70.
    • (2003) Gut , vol.52 , pp. 65-70
    • Fujino, S.1    Andoh, A.2    Bamba, S.3
  • 34
    • 0037283459 scopus 로고    scopus 로고
    • Immunological findings in acute and chronic pancreatitis
    • Bhatnagar A, Wig JD, Majumdar S. Immunological findings in acute and chronic pancreatitis. ANZ J Surg. 2003;73:59-64.
    • (2003) ANZ J Surg , vol.73 , pp. 59-64
    • Bhatnagar, A.1    Wig, J.D.2    Majumdar, S.3
  • 35
    • 1542285218 scopus 로고    scopus 로고
    • Oligoclonal T-cell populations in an inflammatory pseudotumor of the pancreas possibly related to autoimmune pancreatitis: An immunohistochemical and molecular analysis
    • Esposito I, Bergmann F, Penzel R, et al. Oligoclonal T-cell populations in an inflammatory pseudotumor of the pancreas possibly related to autoimmune pancreatitis: an immunohistochemical and molecular analysis. Virchows Arch. 2004;444:119-126.
    • (2004) Virchows Arch , vol.444 , pp. 119-126
    • Esposito, I.1    Bergmann, F.2    Penzel, R.3
  • 36
    • 19944399111 scopus 로고    scopus 로고
    • Increased central memory T cells in patients with chronic pancreatitis
    • Grundsten M, Liu GZ, Permert J, et al. Increased central memory T cells in patients with chronic pancreatitis. Pancreatology. 2005;5:177-182.
    • (2005) Pancreatology , vol.5 , pp. 177-182
    • Grundsten, M.1    Liu, G.Z.2    Permert, J.3
  • 37
    • 0034101822 scopus 로고    scopus 로고
    • Loss of TGF-beta signaling contributes to autoimmune pancreatitis
    • Hahm KB, Im YH, Lee C, et al. Loss of TGF-beta signaling contributes to autoimmune pancreatitis. J Clin Invest. 2000;105:1057-1065.
    • (2000) J Clin Invest , vol.105 , pp. 1057-1065
    • Hahm, K.B.1    Im, Y.H.2    Lee, C.3
  • 38
    • 25844529989 scopus 로고    scopus 로고
    • Autoimmune pancreatitis: Pathological findings
    • Kloppel G, Luttges J, Sipos B, et al. Autoimmune pancreatitis: pathological findings. JOP. 2005;6:97-101.
    • (2005) JOP , vol.6 , pp. 97-101
    • Kloppel, G.1    Luttges, J.2    Sipos, B.3
  • 39
    • 33644875851 scopus 로고    scopus 로고
    • FT-720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration
    • Okamoto T, Yamada T, Kuno A, et al. FT-720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration. Pancreas. 2005;30:e64-e70.
    • (2005) Pancreas , vol.30
    • Okamoto, T.1    Yamada, T.2    Kuno, A.3
  • 40
    • 0034048657 scopus 로고    scopus 로고
    • Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response
    • Okazaki K, Uchida K, Ohana M, et al. Autoimmune-related pancreatitis is associated with autoantibodies and a Th1/Th2-type cellular immune response. Gastroenterology. 2000;118:573-581.
    • (2000) Gastroenterology , vol.118 , pp. 573-581
    • Okazaki, K.1    Uchida, K.2    Ohana, M.3
  • 41
    • 0037340325 scopus 로고    scopus 로고
    • Serum antigen(s) drive the proinflammatory T cell response in acute pancreatitis
    • Sweeney KJ, Kell MR, Coates C, et al. Serum antigen(s) drive the proinflammatory T cell response in acute pancreatitis. Br J Surg. 2003;90:313-319.
    • (2003) Br J Surg , vol.90 , pp. 313-319
    • Sweeney, K.J.1    Kell, M.R.2    Coates, C.3
  • 42
    • 0038265856 scopus 로고    scopus 로고
    • Autoimmune pancreatitis: Pathological, clinical, and immunological features
    • Kloppel G, Luttges J, Lohr M, et al. Autoimmune pancreatitis: pathological, clinical, and immunological features. Pancreas. 2003;27:14-19.
    • (2003) Pancreas , vol.27 , pp. 14-19
    • Kloppel, G.1    Luttges, J.2    Lohr, M.3
  • 43
    • 0033593447 scopus 로고    scopus 로고
    • Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3)
    • Borghaei RC, Sullivan C, Mochan E. Identification of a cytokine-induced repressor of interleukin-1 stimulated expression of stromelysin 1 (MMP-3). J Biol Chem. 1999;274:2126-2131.
    • (1999) J Biol Chem , vol.274 , pp. 2126-2131
    • Borghaei, R.C.1    Sullivan, C.2    Mochan, E.3
  • 44
    • 0034456102 scopus 로고    scopus 로고
    • Progesterone exposure prevents matrix metalloproteinase-3 (MMP-3) stimulation by interleukin-1alpha in human endometrial stromal cells
    • Keller NR, Sierra-Rivera E, Eisenberg E, et al. Progesterone exposure prevents matrix metalloproteinase-3 (MMP-3) stimulation by interleukin-1alpha in human endometrial stromal cells. J Clin Endocrinol Metab. 2000;85:1611-1619.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1611-1619
    • Keller, N.R.1    Sierra-Rivera, E.2    Eisenberg, E.3
  • 45
    • 1542315627 scopus 로고    scopus 로고
    • NF-kappaB binds to a polymorphic repressor element in the MMP-3 promoter
    • Borghaei RC, Rawlings PL Jr, Javadi M, et al. NF-kappaB binds to a polymorphic repressor element in the MMP-3 promoter. Biochem Biophys Res Commun. 2004;316:182-188.
    • (2004) Biochem Biophys Res Commun , vol.316 , pp. 182-188
    • Borghaei, R.C.1    Rawlings Jr, P.L.2    Javadi, M.3
  • 46
    • 0033669058 scopus 로고    scopus 로고
    • Differential regulation of metalloproteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, interleukin-1beta and TNF-alpha
    • Sasaki M, Kashima M, Ito T, et al. Differential regulation of metalloproteinase production, proliferation and chemotaxis of human lung fibroblasts by PDGF, interleukin-1beta and TNF-alpha. Mediators Inflamm. 2000;9:155-160.
    • (2000) Mediators Inflamm , vol.9 , pp. 155-160
    • Sasaki, M.1    Kashima, M.2    Ito, T.3
  • 47
    • 0030292766 scopus 로고    scopus 로고
    • TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages
    • Saren P, Welgus HG, Kovanen PT. TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages. J Immunol. 1996;157:4159-4165.
    • (1996) J Immunol , vol.157 , pp. 4159-4165
    • Saren, P.1    Welgus, H.G.2    Kovanen, P.T.3
  • 48
    • 0029043582 scopus 로고
    • How MAP kinases are regulated
    • Cobb MH, Goldsmith EJ. How MAP kinases are regulated. J Biol Chem. 1995;270:14843-14846.
    • (1995) J Biol Chem , vol.270 , pp. 14843-14846
    • Cobb, M.H.1    Goldsmith, E.J.2
  • 50
    • 0032530336 scopus 로고    scopus 로고
    • Structural basis of inhibitor selectivity in MAP kinases
    • Wang Z, Canagarajah BJ, Boehm JC, et al. Structural basis of inhibitor selectivity in MAP kinases. Structure. 1998;6:1117-1128.
    • (1998) Structure , vol.6 , pp. 1117-1128
    • Wang, Z.1    Canagarajah, B.J.2    Boehm, J.C.3
  • 51
    • 0033914594 scopus 로고    scopus 로고
    • The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes
    • Newton R, Cambridge L, Hart LA, et al. The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes. Br J Pharmacol. 2000;130:1353-1361.
    • (2000) Br J Pharmacol , vol.130 , pp. 1353-1361
    • Newton, R.1    Cambridge, L.2    Hart, L.A.3


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