Levels of transforming growth factor β and transforming growth factor β receptors in rat liver during growth, regression by apoptosis and neoplasia

Hepatology

Volumn 28, Issue 3, 1998, Pages 717-726

  Grasl Kraupp, Bettina ^a,c   Rossmanith, Walter ^a   Ruttkay Nedecky, Branislav ^a   Mullauer, Leonhard ^b   Kammerer, Bettina ^a   Bursch, Wilfried ^a   Schulte Hermann, Rolf ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b Inst für Klinische Pathologie   (Austria)

^c Inst F Tumorbiologie K   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON TETRACHLORIDE; CYPROTERONE ACETATE; DNA; GLUTAMATE DEHYDROGENASE; NAFENOPIN; RECEPTOR SUBTYPE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FEMALE; LIVER CELL CARCINOMA; LIVER HYPERPLASIA; LIVER REGENERATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031752720     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510280318     Document Type: Article

References (19)

1. Pitot HC, Dragan YP. Facts and theories concerning the mechanisms of carcinogenesis. FASEB J 1991;5:2280-2286.
2. Schulte-Hermann R, Bursch W, Grasl-Kraupp B. Active cell death (apoptosis) in liver biology and disease. In: Boyer JL, Ockner RK, eds. Progress in Liver Diseases. Philadelphia: Saunders, 1995:1-35.
3. Michalopoulos GK, DeFrances MC. Liver regeneration. Science 1997; 276:60-66.
4. Que FG, Gores GJ. Cell death by apoptosis: basic concepts and disease relevance for the gastroenterologist. Gastroenterology 1996;110:1238-1243.
5. Bursch W, Taper HS, Lauer B, Schulte-Hermann R. Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia. Virch Arch Cell Pathol 1985;50:153-166.
6. Bursch W, Lauer B, Timmermann-Trosiener I, Barthel G, Schuppler J, Schulte-Hermann R. Controlled cell death (apoptosis) in normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters. Carcinogenesis 1984;5:453-458.
7. Schulte-Hermann R, Timmermann-Trosiener I, Barthel G, Bursch W. DNA synthesis, apoptosis, and phenotype expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. Cancer Res 1990;50:5127-5135.
8. Grasl-Kraupp B, Bursch W, Ruttkay-Nedecky B, Wagner A, Lauer B, Schulte-Hermann R. Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver. Proc Natl Acad Sci U S A 1994;91:9996-9999.
9. Grasl-Kraupp B, Ruttkay-Nedecky B, Müllauer L, Taper H, Huber W, Bursch W, Schulte-Hermann R. Inherent increase of apoptosis in liver tumors: implications for carcinogenesis and tumor regression. HEPATOLOGY 1997;25:906-912.
10. Jakowlew SB, Mead JE, Danielpour D, Wu J, Roberts AB, Fausto N. Transforming growth factor-β (TGF-β) isoforms in rat liver regeneration: messenger RNA expression and activation of latent TGF-β. Cell Regulation 1991;2:535-548.
11. Wakefield L, Kim SJ, Click A, Winokur T, Colletta A, Sporn M. Regulation of transforming growth factor-β subtypes by members of the steroid homone superfamily. J Cell Sci Suppl 1990;13:139-148.
12. Perry RR, Kang Y, Greaves BR. Relationship between tamoxifen-induced transforming growth factor β1 expression, cytostasis and apoptosis in human breast cancer cells. Br J Cancer 1995;72(6):1441-1446.
13. Assoian RK, Fleurdelys BE, Stevenson HC, Miller PJ, Madtes DK, Raines EW, Ross R, et al. Expression and secretion of type-β transforming growth factor by activated human macrophages. Proc Natl Acad Sci U S A 1987;84:6020-6024.
14. Kim SJ, Park P, Koeller D, Kim KY, Wakefield LM, Sporn MB, Roberts AB. Post-transcriptional regulation of the human transforming growth factor-β1 gene. J Biol Chem 1992;267:13702-13707.
15. Nakao A, Roijer E, Imamura T, Souchelnytskyi S, Stenman G, Heldin CH, ten Dijke P. Identification of Smad2, a human Mad-related protein in the transforming growth factor β signaling pathway. J Biol Chem 1997;272(5):2896-2900.
16. Inagaki M, Moustakas A, Lin MY, Lodish HF, Carr BI. Growth inhibition by transforming growth factor β (TGF-β) type I is restored in TGF-β-resistant hepatoma cells after expression of TGF-β receptor type II cDNA. Proc Natl Acad Sci U S A 1993;90:5359-5363.
17. Bassing CH, Yingling JM, Howe DJ, Wang T, He WW, Gustafson ML, Shah P, Donahoe PK, et al. A transforming growth factor β type I receptor that signals to activate gene expression. Science 1994;263:87-89.
18. Tsuchida K, Lewis KA, Mathews LS, Vale WW. Molecular characterization of rat transforming growth factor-β type II receptor. Biochem Biophys Res Comm 1993;191:790-795.
19. Wang XF, Lin HY, Ng-Eaton E, Downward J, Lodish HF, Weinberg RA. Expression cloning and characterization of the TGF-β Type III receptor. Cell 1991;67:797-805.